Michael Bevan

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Constitutive versus activation-dependent cross-presentation of immune complexes by CD8(+) and CD8(-) dendritic cells in vivo
    Joke M M den Haan
    Department of Immunology, Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195 7370, USA
    J Exp Med 196:817-27. 2002
  2. pmc Complete but curtailed T-cell response to very low-affinity antigen
    Dietmar Zehn
    Department of Immunology, Howard Hughes Medical Institute, University of Washington, Box 357370, Seattle, Washington 98195, USA
    Nature 458:211-4. 2009
  3. pmc Duration of the initial TCR stimulus controls the magnitude but not functionality of the CD8+ T cell response
    Martin Prlic
    Department of Immunology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    J Exp Med 203:2135-43. 2006
  4. pmc Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation
    Alena M Gallegos
    Department of Immunology, Howard Hughes Medical Institute, University of Washington, Seattle, WA 98795, USA
    J Exp Med 200:1039-49. 2004
  5. pmc The CD8 population in CD4-deficient mice is heavily contaminated with MHC class II-restricted T cells
    Aaron J Tyznik
    Howard Hughes Medical Institute, University of Washington, Seattle 98195, USA
    J Exp Med 199:559-65. 2004
  6. pmc Naive CD8+ T cells differentiate into protective memory-like cells after IL-2 anti IL-2 complex treatment in vivo
    Daisuke Kamimura
    Department of Immunology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    J Exp Med 204:1803-12. 2007
  7. pmc ITM2A is induced during thymocyte selection and T cell activation and causes downregulation of CD8 when overexpressed in CD4(+)CD8(+) double positive thymocytes
    J Kirchner
    Howard Hughes Medical Institute and the Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    J Exp Med 190:217-28. 1999
  8. ncbi request reprint Immunology. The cutting edge of T cell selection
    Michael J Bevan
    Department of Immunology, Howard Hughes Medical Institute, University of Washington, Box 357370, Seattle, WA 98195, USA
    Science 316:1291-2. 2007
  9. ncbi request reprint Cross-priming
    Michael J Bevan
    Department of Immunology, Howard Hughes Medical Center, University of Washington, Seattle, Washington 98195, USA
    Nat Immunol 7:363-5. 2006
  10. ncbi request reprint Helping the CD8(+) T-cell response
    Michael J Bevan
    Department of Immunology, Howard Hughes Medical Institute, University of Washington, 1959 NE Pacific Street, Seattle, Washington 98195 7650 USA
    Nat Rev Immunol 4:595-602. 2004

Research Grants

  1. NOTCH SIGNALING IN THYMOCYTE DEVELOPMENT
    Michael Bevan; Fiscal Year: 2001
  2. NOTCH SIGNALING IN THYMOCYTE DEVELOPMENT
    Michael Bevan; Fiscal Year: 2002
  3. CYTOTOXIC RESPONSE TO HISTOCOMPATIBILITY ANTIGENS
    Michael Bevan; Fiscal Year: 2007
  4. REPERTOIRE SELECTION OF CLASS I RESTRICTED T CELLS
    Michael Bevan; Fiscal Year: 1992
  5. CYTOTOXIC RESPONSE TO HISTOCOMPATIBILITY ANTIGENS
    Michael Bevan; Fiscal Year: 2002
  6. NOTCH SIGNALING IN THYMOCYTE DEVELOPMENT
    Michael Bevan; Fiscal Year: 2003
  7. CYTOTOXIC RESPONSE TO HISTOCOMPATIBILITY ANTIGENS
    Michael Bevan; Fiscal Year: 2003
  8. CYTOTOXIC RESPONSE TO HISTOCOMPATIBILITY ANTIGENS
    Michael Bevan; Fiscal Year: 2006
  9. CYTOTOXIC RESPONSE TO HISTOCOMPATIBILITY ANTIGENS
    Michael Bevan; Fiscal Year: 2009
  10. CYTOTOXIC RESPONSE TO HISTOCOMPATIBILITY ANTIGENS
    Michael Bevan; Fiscal Year: 2001

Collaborators

Detail Information

Publications67

  1. pmc Constitutive versus activation-dependent cross-presentation of immune complexes by CD8(+) and CD8(-) dendritic cells in vivo
    Joke M M den Haan
    Department of Immunology, Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195 7370, USA
    J Exp Med 196:817-27. 2002
    ..Cross-presentation of immune complexes may play an important role in autoimmune diseases and the therapeutic effect of antitumor antibodies...
  2. pmc Complete but curtailed T-cell response to very low-affinity antigen
    Dietmar Zehn
    Department of Immunology, Howard Hughes Medical Institute, University of Washington, Box 357370, Seattle, Washington 98195, USA
    Nature 458:211-4. 2009
    ....
  3. pmc Duration of the initial TCR stimulus controls the magnitude but not functionality of the CD8+ T cell response
    Martin Prlic
    Department of Immunology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    J Exp Med 203:2135-43. 2006
    ..These results indicate that the duration of initial antigen encounter influences the magnitude of the primary response, but does not program responsiveness during the secondary challenge...
  4. pmc Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation
    Alena M Gallegos
    Department of Immunology, Howard Hughes Medical Institute, University of Washington, Seattle, WA 98795, USA
    J Exp Med 200:1039-49. 2004
    ..Although Mtecs synthesize TSAs and delete a subset of autoreactive T cells, BM-derived cells extend the range of clonal deletion by cross-presenting antigen captured from Mtecs...
  5. pmc The CD8 population in CD4-deficient mice is heavily contaminated with MHC class II-restricted T cells
    Aaron J Tyznik
    Howard Hughes Medical Institute, University of Washington, Seattle 98195, USA
    J Exp Med 199:559-65. 2004
    ..These results have implications for understanding CD4 versus CD8 lineage commitment in the thymus, and for the practical use of CD4-/- mice as models of helper deficiency...
  6. pmc Naive CD8+ T cells differentiate into protective memory-like cells after IL-2 anti IL-2 complex treatment in vivo
    Daisuke Kamimura
    Department of Immunology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    J Exp Med 204:1803-12. 2007
    ..These results suggest that intense IL-2 signals, with limited contribution from the TCR, program the differentiation of protective memory-like CD8(+) cells but are insufficient to guarantee overall cellular fitness...
  7. pmc ITM2A is induced during thymocyte selection and T cell activation and causes downregulation of CD8 when overexpressed in CD4(+)CD8(+) double positive thymocytes
    J Kirchner
    Howard Hughes Medical Institute and the Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    J Exp Med 190:217-28. 1999
    ..Possible roles for this novel activation marker in thymocyte development are discussed...
  8. ncbi request reprint Immunology. The cutting edge of T cell selection
    Michael J Bevan
    Department of Immunology, Howard Hughes Medical Institute, University of Washington, Box 357370, Seattle, WA 98195, USA
    Science 316:1291-2. 2007
  9. ncbi request reprint Cross-priming
    Michael J Bevan
    Department of Immunology, Howard Hughes Medical Center, University of Washington, Seattle, Washington 98195, USA
    Nat Immunol 7:363-5. 2006
  10. ncbi request reprint Helping the CD8(+) T-cell response
    Michael J Bevan
    Department of Immunology, Howard Hughes Medical Institute, University of Washington, 1959 NE Pacific Street, Seattle, Washington 98195 7650 USA
    Nat Rev Immunol 4:595-602. 2004
  11. pmc Memory T cells as an occupying force
    Michael J Bevan
    Department of Immunology, Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    Eur J Immunol 41:1192-5. 2011
    ..They may play key roles in protection against re-eruption of latent viral infections and at mucosal surfaces...
  12. ncbi request reprint T-cell memory: You must remember this
    M J Bevan
    Department of Immunology, Howard Hughes Medical Institute, University of Washington, Seattle, 98195, USA
    Curr Biol 10:R338-40. 2000
    ..An implication is that long-term T-cell memory does not depend on persisting antigen...
  13. pmc Cutting edge: a single MHC class Ia is sufficient for CD8 memory T cell differentiation
    Matthew A Williams
    Department of Immunology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    J Immunol 175:2066-9. 2005
    ..Therefore, we conclude that full CD8 memory differentiation requires only a single MHC class Ia chain, ruling out a requirement for MHC class Ib molecules in this process...
  14. ncbi request reprint Transgenic expression of RasGRP1 induces the maturation of double-negative thymocytes and enhances the production of CD8 single-positive thymocytes
    Anne M Norment
    Department of Immunology, University of Washington, Seattle, WA 98195, USA
    J Immunol 170:1141-9. 2003
    ....
  15. ncbi request reprint Cellular and humoral immunity against vaccinia virus infection of mice
    Rong Xu
    Department of Immunology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    J Immunol 172:6265-71. 2004
    ..However, CD4(+) T cell-dependent anti-virus Ab production plays a more important role in clearing virus following acute infection, while in the absence of Ab, CD8(+) T cells can contribute to protection against disease...
  16. pmc CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection
    Joseph C Sun
    Department of Immunology and the Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA
    Nat Immunol 5:927-33. 2004
    ..We conclude that in the context of an acute infection, CD4(+) T cells are required only during the maintenance phase of long-lived memory CD8(+) T cells...
  17. ncbi request reprint Shortening the infectious period does not alter expansion of CD8 T cells but diminishes their capacity to differentiate into memory cells
    Matthew A Williams
    Department of Immunology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    J Immunol 173:6694-702. 2004
    ....
  18. pmc Lack of original antigenic sin in recall CD8(+) T cell responses
    Dietmar Zehn
    Department of Immunology, Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    J Immunol 184:6320-6. 2010
    ..Taken together, our data show that the phenomenon of original antigenic sin does not occur in all heterologous infections...
  19. pmc From the thymus to longevity in the periphery
    Linda M Wakim
    Department of Immunology, Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    Curr Opin Immunol 22:274-8. 2010
    ..We will review recent advances in the field of memory CD8(+) T cell differentiation focusing on both intrinsic and extrinsic factors that govern the development of T cell memory...
  20. pmc Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells
    Matthew A Williams
    Howard Hughes Medical Institute and Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Nature 441:890-3. 2006
    ..These results have important implications for the development of vaccination or immunotherapeutic strategies aimed at boosting memory T-cell function...
  21. ncbi request reprint Central tolerance: good but imperfect
    Alena M Gallegos
    Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195 7370, USA
    Immunol Rev 209:290-6. 2006
    ..In addition, we recently investigated the efficiency of central tolerance to TSA during ontogeny, and we report that this process was less efficient in neonates than adult animals...
  22. pmc B7h is required for T cell activation, differentiation, and effector function
    Roza I Nurieva
    Department of Immunology, University of Washington, Seattle, WA 98195 7650, USA
    Proc Natl Acad Sci U S A 100:14163-8. 2003
    ..Therefore, B7h is required for proper Th cell activation, differentiation, and effector cytokine expression...
  23. ncbi request reprint Immunology. An antibody paradox, resolved
    Martin Prlic
    Department of Immunology and the Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195 7370, USA
    Science 311:1875-6. 2006
  24. ncbi request reprint Effector and memory CTL differentiation
    Matthew A Williams
    Howard Hughes Medical Institute, Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Annu Rev Immunol 25:171-92. 2007
    ..This review focuses on recent advances in our understanding of how effector and memory CTL differentiate and survive in vivo in response to viral or bacterial infection...
  25. pmc T cells develop normally in the absence of both Deltex1 and Deltex2
    Sophie M Lehar
    Department of Immunology and Howard Hughes Medical Institute, University of Washington, I 604D Health Science Center, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Mol Cell Biol 26:7358-71. 2006
    ..Together these data suggest that Deltex can act as a negative regulator of Notch signals in T cells but that endogenous levels of Deltex1 and Deltex2 are not important for regulating Notch signals during thymocyte development...
  26. ncbi request reprint Surface expression of Notch1 on thymocytes: correlation with the double-negative to double-positive transition
    Eugene Y Huang
    Department of Immunology, Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    J Immunol 171:2296-304. 2003
    ....
  27. ncbi request reprint Cutting edge: long-lived CD8 memory and protective immunity in the absence of CD40 expression on CD8 T cells
    Joseph C Sun
    Department of Immunology and the Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    J Immunol 172:3385-9. 2004
    ..Thus, we find no evidence that CD40 ligand-expressing CD4 T cells are required to activate CD40 on CD8 T cells directly for the full differentiation of the cytotoxic T cell response...
  28. ncbi request reprint The Gads (GrpL) adaptor protein regulates T cell homeostasis
    Thomas M Yankee
    Department of Microbiology, University of Washington, Seattle, WA 98195, USA
    J Immunol 173:1711-20. 2004
    ..The intracellular signaling pathways that regulate homeostasis in CD4(+) and CD8(+) T cells are clearly different, and the Gads adaptor protein is critical for homeostasis of CD4(+) T cells...
  29. pmc The surprising kinetics of the T cell response to live antigenic cells
    Aaron J Tyznik
    Department of Immunology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    J Immunol 179:4988-95. 2007
    ..We explain the delayed CD8(+) response by proposing that there is a balance between cross-presentation of Ag by helper cell-licensed dendritic cells, on the one hand, and veto suppression by live male lymphocytes on the other...
  30. ncbi request reprint Requirements for CD8 T-cell priming, memory generation and maintenance
    Martin Prlic
    Department of Immunology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    Curr Opin Immunol 19:315-9. 2007
    ..Recent advances shed light on the relative roles of TCR signals and environmental cues in guiding the development of CD8(+) effector T cells into CD8(+) memory T cells and supporting CD8(+) memory T-cell maintenance...
  31. pmc TRAIL deficiency does not rescue impaired CD8+ T cell memory generated in the absence of CD4+ T cell help
    Jilian A Sacks
    Department of Immunology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    J Immunol 180:4570-6. 2008
    ..Overall, our results suggest that CD4(+) T cell help for the CD8(+) T cell response is not contingent on the silencing of TRAIL expression and prevention of TRAIL-mediated apoptosis...
  32. pmc IPS-1 is essential for the control of West Nile virus infection and immunity
    Mehul S Suthar
    Department of Immunology, University of Washington School of Medicine, Seattle, Washington, USA
    PLoS Pathog 6:e1000757. 2010
    ..Our data define an innate/adaptive immune interface mediated through IPS-1-dependent RLR signaling that regulates the quantity, quality, and balance of the immune response to WNV infection...
  33. pmc Rapid generation of a functional NK-cell compartment
    Martin Prlic
    Department of Immunology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195 7370, USA
    Blood 110:2024-6. 2007
    ..Finally, we show that NK cells rapidly generated by IL-2 complexes kill MHC class I-deficient cells effectively in vivo. These data underline the unique therapeutic potential of IL-2 complexes...
  34. pmc Endoplasmic reticulum stress regulator XBP-1 contributes to effector CD8+ T cell differentiation during acute infection
    Daisuke Kamimura
    Department of Immunology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    J Immunol 181:5433-41. 2008
    ..These results suggest that, in the response to pathogen, activation of ER stress sensors and XBP-1 splicing contribute to the differentiation of end-stage effector CD8(+) T cells...
  35. pmc Augmented IL-7 signaling during viral infection drives greater expansion of effector T cells but does not enhance memory
    Joseph C Sun
    Department of Immunology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    J Immunol 177:4458-63. 2006
    ..The extent of contraction may be dictated by intrinsic factors related to the number of prior cell divisions...
  36. pmc ThPOK derepression is required for robust CD8 T cell responses to viral infection
    Ruka Setoguchi
    Department of Immunology and the Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    J Immunol 183:4467-74. 2009
    ..Our data reveal an unexpected role for ThPOK in CD8 T cells in promoting expansion and boosting the response to antigenic challenge...
  37. pmc Notch ligands Delta 1 and Jagged1 transmit distinct signals to T-cell precursors
    Sophie M Lehar
    Department of Immunology, University of Washington, Seattle, WA 98195, USA
    Blood 105:1440-7. 2005
    ..During these stages, Jagged1 signals can influence the differentiation of immature thymocytes along the natural killer (NK) and gamma delta T-cell lineages...
  38. pmc Positive selection of MHC class Ib-restricted CD8(+) T cells on hematopoietic cells
    Kevin B Urdahl
    Department of Immunology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    Nat Immunol 3:772-9. 2002
    ..Thus, the distinct functional properties of MHC class Ib-restricted versus MHC class Ia-restricted CD8(+) T cells may result, at least in part, from the different ways in which they are positively selected in the thymus...
  39. ncbi request reprint Developing and maintaining protective CD8+ memory T cells
    Matthew A Williams
    Department of Immunology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    Immunol Rev 211:146-53. 2006
    ....
  40. ncbi request reprint CD8+ T cells accumulate in the lungs of Mycobacterium tuberculosis-infected Kb-/-Db-/- mice, but provide minimal protection
    Kevin B Urdahl
    Department of Pediatrics, Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    J Immunol 170:1987-94. 2003
    ..tuberculosis...
  41. pmc Defective CD8 T cell memory following acute infection without CD4 T cell help
    Joseph C Sun
    Department of Immunology and the Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    Science 300:339-42. 2003
    ..The results highlight a previously undescribed role for CD4 help in promoting protective CD8 memory development...
  42. ncbi request reprint T cell development in culture
    Sophie M Lehar
    Department of Immunology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    Immunity 17:689-92. 2002
    ..This finding should greatly enhance efforts to study T cell development and may provide a tool for generating defined T cell populations in vitro...
  43. pmc Exploring regulatory mechanisms of CD8+ T cell contraction
    Martin Prlic
    Department of Immunology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195
    Proc Natl Acad Sci U S A 105:16689-94. 2008
    ..We propose that the fate of a CD8 effector cell is predetermined before the onset of contraction and discuss possible mechanisms of regulation...
  44. pmc Cutting edge: TCR revision affects predominantly Foxp3 cells and skews them toward the Th17 lineage
    Dietmar Zehn
    Department of Immunology, University of Washington, Seattle, WA 98195, USA
    J Immunol 179:5653-7. 2007
    ..The link between Th17 differentiation and TCR revision might be highly relevant to the role of Th17 cells in promoting autoimmunity...
  45. ncbi request reprint The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens
    You Wen He
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Immunol 5:88-97. 2004
    ..Thus, mindin is essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens...
  46. pmc T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity
    Dietmar Zehn
    Department of Immunology, Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA
    Immunity 25:261-70. 2006
    ....
  47. pmc Memory T cells persisting within the brain after local infection show functional adaptations to their tissue of residence
    Linda M Wakim
    Department of Immunology, Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 107:17872-9. 2010
    ..Cumulatively, this work shows that Trm are a specialized population of memory T cells that can be deposited in tissues previously thought to be beyond routine immune surveillance...
  48. ncbi request reprint Driven to autoimmunity: the nod mouse
    Alena M Gallegos
    Howard Hughes Medical Institute and the Department of Immunology, University of Washington, Box 357370, Seattle, WA 98195, USA
    Cell 117:149-51. 2004
    ..In this issue of Cell, evidence is provided that this homeostatic proliferation, coupled with excess production of a cytokine, IL-21, is a key factor in susceptibility to autoimmune diabetes...
  49. pmc Expansion and function of Foxp3-expressing T regulatory cells during tuberculosis
    James P Scott-Browne
    Department of Pediatrics, University of Washington, Seattle, WA 98195, USA
    J Exp Med 204:2159-69. 2007
    ..Thus, after aerosol infection, T reg cells proliferate and accumulate at sites of infection, and have the capacity to suppress immune responses that contribute to the control of Mtb...
  50. pmc Promiscuity of MHC class Ib-restricted T cell responses
    Alexander Ploss
    Infectious Diseases Service, Department of Medicine and Laboratory of Antimicrobial Immunity, Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 171:5948-55. 2003
    ..monocytogenes. Although this degree of Ag receptor promiscuity is unusual for the adaptive immune system, it may be a more common feature of T cell responses restricted by nonpolymorphic MHC class Ib molecules...
  51. pmc Rapid culling of the CD4+ T cell repertoire in the transition from effector to memory
    Matthew A Williams
    Department of Pathology, University of Utah, Salt Lake City, UT 84121, USA
    Immunity 28:533-45. 2008
    ..These results support a model in which CD4+ T cell memory differentiation and longevity depend on the strength of the TCR signal during the primary response...
  52. ncbi request reprint Notch-regulated ankyrin-repeat protein inhibits Notch1 signaling: multiple Notch1 signaling pathways involved in T cell development
    Theodore J Yun
    IDEC Pharmaceuticals, San Diego, CA 92121, USA
    J Immunol 170:5834-41. 2003
    ..The different effects of Deltex-1 and Nrarp overexpression suggest that alternate Notch signaling pathways mediate T vs B lineage commitment and thymocyte maturation...
  53. pmc Cytokine requirements for acute and Basal homeostatic proliferation of naive and memory CD8+ T cells
    Ananda W Goldrath
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    J Exp Med 195:1515-22. 2002
    ..Our results show that naive and memory T lymphocytes differ in their cytokine dependence for acute homeostatic proliferation and that memory T lymphocytes have distinct requirements for proliferation in full versus empty compartments...
  54. ncbi request reprint Host-pathogen interactions
    Tom H M Ottenhoff
    Curr Opin Immunol 16:439-42. 2004
  55. ncbi request reprint T cell memory: fixed or flexible?
    Matthew A Williams
    Nat Immunol 6:752-4. 2005
  56. pmc CD8alpha+ dendritic cells selectively present MHC class I-restricted noncytolytic viral and intracellular bacterial antigens in vivo
    Gabrielle T Belz
    Division of Immunology and Cooperative Research Centre for Vaccine Technology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    J Immunol 175:196-200. 2005
    ..We show that regardless of the type of intracellular infection, CD8alpha(+) DCs are the principal DC subset that initiate CD8(+) T cell immunity...
  57. ncbi request reprint In a radiation chimaera, host H-2 antigens determine immune responsiveness of donor cytotoxic cells. Nature 1977. 269: 417-418
    Michael J Bevan
    J Immunol 176:5-6. 2006
  58. ncbi request reprint Immunology: remembrance of things past
    Michael J Bevan
    Nature 420:748-9. 2002
  59. pmc The human and mouse orthologous LIM-only proteins respectively encoded in chromosome 6 and 17 show a different expression pattern
    Armanda Casrouge
    Laboratoire de Biologie Moléculaire du Gène, Inserm U277 Institut Pasteur, 75724 Paris Cedex 15, France
    Microbes Infect 6:1063-72. 2004
    ....
  60. ncbi request reprint More promiscuity resulting in more tolerance
    Dietmar Zehn
    Nat Immunol 8:120-2. 2007
    ..Tolerance to self is engendered by multiple mechanisms. Lymph node stromal cells are now found to contribute to self-tolerance by their endogenous expression of peripheral tissue antigens...
  61. ncbi request reprint Altered self, altered world
    Michael J Bevan
    J Immunol 173:2897-8. 2004
  62. pmc Cutting edge: Lipopolysaccharide induces IL-10-producing regulatory CD4+ T cells that suppress the CD8+ T cell response
    Joke M M den Haan
    Molecular Cell Biology and Immunology, Free University Medical Center, 1007 MB Amsterdam, The Netherlands
    J Immunol 178:5429-33. 2007
    ..In this way, excessive activation of the immune system may be prevented...
  63. ncbi request reprint Immunology: polarizing a T-cell response
    Sophie M Lehar
    Nature 430:150-1. 2004
  64. ncbi request reprint Immunology: exhausted T cells perk up
    Matthew A Williams
    Nature 439:669-70. 2006

Research Grants28

  1. NOTCH SIGNALING IN THYMOCYTE DEVELOPMENT
    Michael Bevan; Fiscal Year: 2001
    ..It is hoped that the work will provide a better understanding of the integration of signals from the TCR, the glucocorticoid receptor, and Notch that developing T cells receive. ..
  2. NOTCH SIGNALING IN THYMOCYTE DEVELOPMENT
    Michael Bevan; Fiscal Year: 2002
    ..It is hoped that the work will provide a better understanding of the integration of signals from the TCR, the glucocorticoid receptor, and Notch that developing T cells receive. ..
  3. CYTOTOXIC RESPONSE TO HISTOCOMPATIBILITY ANTIGENS
    Michael Bevan; Fiscal Year: 2007
    ..The proposed studies are aimed at a greater understanding of the development of long-lived, protective immunity induced by this pathogen. ..
  4. REPERTOIRE SELECTION OF CLASS I RESTRICTED T CELLS
    Michael Bevan; Fiscal Year: 1992
    ..The information is also part of our understanding the T cell response to any infectious agent and in autoimmune diseases...
  5. CYTOTOXIC RESPONSE TO HISTOCOMPATIBILITY ANTIGENS
    Michael Bevan; Fiscal Year: 2002
    ..The investigator aims to shed more light on how MHC class Ia- and class Ib-restricted bacterial antigens are presented to cytotoxic T-cell precursors to initiate a response in vivo. ..
  6. NOTCH SIGNALING IN THYMOCYTE DEVELOPMENT
    Michael Bevan; Fiscal Year: 2003
    ..It is hoped that the work will provide a better understanding of the integration of signals from the TCR, the glucocorticoid receptor, and Notch that developing T cells receive. ..
  7. CYTOTOXIC RESPONSE TO HISTOCOMPATIBILITY ANTIGENS
    Michael Bevan; Fiscal Year: 2003
    ..The proposed studies are aimed at a greater understanding of the development of long-lived, protective immunity induced by this pathogen. ..
  8. CYTOTOXIC RESPONSE TO HISTOCOMPATIBILITY ANTIGENS
    Michael Bevan; Fiscal Year: 2006
    ..The proposed studies are aimed at a greater understanding of the development of long-lived, protective immunity induced by this pathogen. ..
  9. CYTOTOXIC RESPONSE TO HISTOCOMPATIBILITY ANTIGENS
    Michael Bevan; Fiscal Year: 2009
    ..Vaccination against infectious disease is the most cost-effective strategy in promoting human health. Our research is aimed at discovering the conditions that make long-term protection possible following vaccine delivery. ..
  10. CYTOTOXIC RESPONSE TO HISTOCOMPATIBILITY ANTIGENS
    Michael Bevan; Fiscal Year: 2001
    ..The investigator aims to shed more light on how MHC class Ia- and class Ib-restricted bacterial antigens are presented to cytotoxic T-cell precursors to initiate a response in vivo. ..
  11. NOTCH SIGNALING IN THYMOCYTE DEVELOPMENT
    Michael Bevan; Fiscal Year: 1999
    ..It is hoped that the work will provide a better understanding of the integration of signals from the TCR, the glucocorticoid receptor, and Notch that developing T cells receive. ..
  12. CYTOTOXIC RESPONSE TO HISTOCOMPATIBILITY ANTIGENS
    Michael Bevan; Fiscal Year: 1999
    ..The investigator aims to shed more light on how MHC class Ia- and class Ib-restricted bacterial antigens are presented to cytotoxic T-cell precursors to initiate a response in vivo. ..
  13. REPERTOIRE SELECTION OF CLASS I RESTRICTED T CELLS
    Michael Bevan; Fiscal Year: 1991
    ..The information is also part of our understanding the T cell response to any infectious agent and in autoimmune diseases...
  14. REPERTOIRE SELECTION OF CLASS I RESTRICTED T CELLS
    Michael Bevan; Fiscal Year: 1993
    ..The information is also part of our understanding the T cell response to any infectious agent and in autoimmune diseases...
  15. REPERTOIRE SELECTION OF CLASS I RESTRICTED T CELLS
    Michael Bevan; Fiscal Year: 1990
    ..The information is also part of our understanding the T cell response to any infectious agent and in autoimmune diseases...
  16. CYTOTOXIC RESPONSE TO HISTOCOMPATIBILITY ANTIGENS
    Michael Bevan; Fiscal Year: 2000
    ..The investigator aims to shed more light on how MHC class Ia- and class Ib-restricted bacterial antigens are presented to cytotoxic T-cell precursors to initiate a response in vivo. ..
  17. NOTCH SIGNALING IN THYMOCYTE DEVELOPMENT
    Michael Bevan; Fiscal Year: 2000
    ..It is hoped that the work will provide a better understanding of the integration of signals from the TCR, the glucocorticoid receptor, and Notch that developing T cells receive. ..
  18. CYTOTOXIC RESPONSE TO HISTOCOMPATIBILITY ANTIGENS
    Michael J Bevan; Fiscal Year: 2010
    ..Vaccination against infectious disease is the most cost-effective strategy in promoting human health. Our research is aimed at discovering the conditions that make long-term protection possible following vaccine delivery. ..