Ellen J Beswick

Summary

Affiliation: University of Texas Medical Branch
Country: USA

Publications

  1. pmc CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract
    Ellen J Beswick
    Department of Pediatrics, Children s Hospital, University of Texas Medical Branch, Galveston, TX 77555, United States
    World J Gastroenterol 15:2855-61. 2009
  2. ncbi request reprint Helicobacter pylori-induced IL-8 production by gastric epithelial cells up-regulates CD74 expression
    Ellen J Beswick
    Department of Pediatrics, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Immunol 175:171-6. 2005
  3. pmc Human colonic myofibroblasts promote expansion of CD4+ CD25high Foxp3+ regulatory T cells
    Irina V Pinchuk
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555 0655, USA
    Gastroenterology 140:2019-30. 2011
  4. pmc The Helicobacter pylori urease B subunit binds to CD74 on gastric epithelial cells and induces NF-kappaB activation and interleukin-8 production
    Ellen J Beswick
    Department of Pediatrics, Children s Hospital, Room 2 300, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA
    Infect Immun 74:1148-55. 2006
  5. ncbi request reprint H. pylori receptor MHC class II contributes to the dynamic gastric epithelial apoptotic response
    David A Bland
    Children s Hospital, Room 2 300, University of Texas Medical Branch, 301 University Blvd Galveston, TX 77555, USA
    World J Gastroenterol 12:5306-10. 2006
  6. pmc Expression of the programmed death ligand 1, B7-H1, on gastric epithelial cells after Helicobacter pylori exposure promotes development of CD4+ CD25+ FoxP3+ regulatory T cells
    Ellen J Beswick
    Departmen tof Pediatrics, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA
    Infect Immun 75:4334-41. 2007
  7. ncbi request reprint Helicobacter pylori CagA-dependent macrophage migration inhibitory factor produced by gastric epithelial cells binds to CD74 and stimulates procarcinogenic events
    Ellen J Beswick
    Department of Pediatrics, University of Texas, Galveston, TX 77555, USA
    J Immunol 176:6794-801. 2006
  8. pmc Macrophage migration inhibitory factor and interleukin-8 produced by gastric epithelial cells during Helicobacter pylori exposure induce expression and activation of the epidermal growth factor receptor
    Ellen J Beswick
    Department of Pediatrics, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA
    Infect Immun 76:3233-40. 2008
  9. pmc Stromal cells induce Th17 during Helicobacter pylori infection and in the gastric tumor microenvironment
    Irina V Pinchuk
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Texas Medical Branch, Galveston, Texas, United States of America
    PLoS ONE 8:e53798. 2013
  10. pmc PD-1 ligand expression by human colonic myofibroblasts/fibroblasts regulates CD4+ T-cell activity
    Irina V Pinchuk
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555 0366, USA
    Gastroenterology 135:1228-1237, 1237.e1-2. 2008

Collaborators

  • Yoshio Yamaoka
  • David Y Graham
  • Randy C Mifflin
  • Julia Brenmoehl
  • Irina V Pinchuk
  • Victor E Reyes
  • Giovanni Suarez
  • David A Bland
  • Johanna C Sierra
  • Don W Powell
  • Jamal I Saada
  • Taslima T Lina
  • Gushyalatha Boya
  • Gottumukkala S Raju
  • Soumita Das
  • Carlos A Barrera
  • Jeng Yih Wu
  • Robert A Nofchissey
  • Jennifer House
  • Rachel B Earley
  • Katherine T Morris
  • Thomas Y Ma
  • David Schmitt
  • Gerhard Rogler
  • Sumin M Qiu
  • John F Di Mari
  • John Winston
  • Rosario Espejo
  • Sheila E Crowe
  • David Bland
  • Patrick Adegboyega
  • Peter B Ernst

Detail Information

Publications17

  1. pmc CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract
    Ellen J Beswick
    Department of Pediatrics, Children s Hospital, University of Texas Medical Branch, Galveston, TX 77555, United States
    World J Gastroenterol 15:2855-61. 2009
    ..This review provides an up-to-date account of the functions of CD74 and how it might be involved in inflammation and cancer within the gastrointestinal tract...
  2. ncbi request reprint Helicobacter pylori-induced IL-8 production by gastric epithelial cells up-regulates CD74 expression
    Ellen J Beswick
    Department of Pediatrics, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Immunol 175:171-6. 2005
    ..pylori. These studies demonstrate how H. pylori up-regulates one of its own receptors via an autocrine mechanism involving one of the products induced from host cells...
  3. pmc Human colonic myofibroblasts promote expansion of CD4+ CD25high Foxp3+ regulatory T cells
    Irina V Pinchuk
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555 0655, USA
    Gastroenterology 140:2019-30. 2011
    ..We studied CMF suppressive capacity and evaluated the ability of CMF to induce Treg cells...
  4. pmc The Helicobacter pylori urease B subunit binds to CD74 on gastric epithelial cells and induces NF-kappaB activation and interleukin-8 production
    Ellen J Beswick
    Department of Pediatrics, Children s Hospital, Room 2 300, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA
    Infect Immun 74:1148-55. 2006
    ..pylori urease B subunit to CD74 expressed on gastric epithelial cells presents a novel insight into a previously unrecognized H. pylori interaction that may contribute to the proinflammatory immune response seen during infection...
  5. ncbi request reprint H. pylori receptor MHC class II contributes to the dynamic gastric epithelial apoptotic response
    David A Bland
    Children s Hospital, Room 2 300, University of Texas Medical Branch, 301 University Blvd Galveston, TX 77555, USA
    World J Gastroenterol 12:5306-10. 2006
    ..To investigate the role of MHC class II in the modulation of gastric epithelial cell apoptosis induced by H pylori infection...
  6. pmc Expression of the programmed death ligand 1, B7-H1, on gastric epithelial cells after Helicobacter pylori exposure promotes development of CD4+ CD25+ FoxP3+ regulatory T cells
    Ellen J Beswick
    Departmen tof Pediatrics, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA
    Infect Immun 75:4334-41. 2007
    ..The functional role of these Treg cells was assessed in proliferation assays when the cells were cocultured with activated T cells, which effectively decreased proliferation of the cells...
  7. ncbi request reprint Helicobacter pylori CagA-dependent macrophage migration inhibitory factor produced by gastric epithelial cells binds to CD74 and stimulates procarcinogenic events
    Ellen J Beswick
    Department of Pediatrics, University of Texas, Galveston, TX 77555, USA
    J Immunol 176:6794-801. 2006
    ..This data describes a novel system in which an H. pylori virulence factor contributes to the production of a host factor that in turn up-regulates procarcinogenic events by the gastric epithelium...
  8. pmc Macrophage migration inhibitory factor and interleukin-8 produced by gastric epithelial cells during Helicobacter pylori exposure induce expression and activation of the epidermal growth factor receptor
    Ellen J Beswick
    Department of Pediatrics, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA
    Infect Immun 76:3233-40. 2008
    ..The overall role of EGFR in these responses to H. pylori exposure was assessed by knocking down EGFR expression by small interfering RNA...
  9. pmc Stromal cells induce Th17 during Helicobacter pylori infection and in the gastric tumor microenvironment
    Irina V Pinchuk
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Texas Medical Branch, Galveston, Texas, United States of America
    PLoS ONE 8:e53798. 2013
    ..These studies suggest that Th17 are induced during both H. pylori infection and gastric cancer in the inflammatory milieu of gastric stroma and may be an important link between inflammation and carcinogenesis...
  10. pmc PD-1 ligand expression by human colonic myofibroblasts/fibroblasts regulates CD4+ T-cell activity
    Irina V Pinchuk
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555 0366, USA
    Gastroenterology 135:1228-1237, 1237.e1-2. 2008
    ..In the normal human colon, CMFs represent a distinct population of major histocompatibility complex class II(+) cells involved in the regulation of mucosal CD4(+) T-cell responses...
  11. ncbi request reprint H pylori receptor MHC class II contributes to the dynamic gastric epithelial apoptotic response
    David A Bland
    Department of Pediatrics, GI Immunology Core, Texas Gulf Coast Digestive Diseases Center, Technical Director, Child Health Research Center, The University of Texas Medical Branch at Galveston, Galveston, TX 77555 0366, USA
    World J Gastroenterol 12:4689-93. 2006
    ..To investigate the role of MHC class II in the modulation of gastric epithelial cell apoptosis induced by H pylori infection...
  12. pmc CagA-dependent downregulation of B7-H2 expression on gastric mucosa and inhibition of Th17 responses during Helicobacter pylori infection
    Taslima T Lina
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555
    J Immunol 191:3838-46. 2013
    ..Our data suggest that CagA contributes to the ability of H. pylori to evade Th17-mediated clearance by modulating expression of B7-H2 and, thus, to the establishment of the H. pylori chronic infection. ..
  13. ncbi request reprint Monocyte chemoattractant protein-1 production by intestinal myofibroblasts in response to staphylococcal enterotoxin a: relevance to staphylococcal enterotoxigenic disease
    Irina V Pinchuk
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Immunol 178:8097-106. 2007
    ..Thus, MCP-1 may play a leading role in initiation of inflammatory injury associated with staphylococcal enterotoxigenic disease...
  14. ncbi request reprint Polarized expression of CD74 by gastric epithelial cells
    Carlos A Barrera
    Department of Pediatrics, University of Texas Medical Branch, Galveston, USA
    J Histochem Cytochem 53:1481-9. 2005
    ..Interestingly, these cells have a high level expression of surface Ii, which is polarized to the apical surface. These studies are the first to demonstrate the constitutive expression of Ii by human GEC...
  15. ncbi request reprint Expression of B7-H1 on gastric epithelial cells: its potential role in regulating T cells during Helicobacter pylori infection
    Soumita Das
    Department of Pediatrics, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Immunol 176:3000-9. 2006
    ..Using blocking Abs to B7-H1 revealed that B7-H1 was involved in the suppression of T cell proliferation and IL-2 synthesis, and thus suggested a role for B7-H1 on the epithelium as a contributor in the chronicity of H. pylori infection...
  16. pmc Staphylococcal enterotoxins
    Irina V Pinchuk
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555 0655, USA
    Toxins (Basel) 2:2177-97. 2010
    ..aureus and these are a concern in the clinical setting as they are a common cause of antibiotic-associated diarrhea in hospitalized patients. In this review, we provide an overview of the current understanding of these proteins...
  17. pmc Helicobacter pylori binds to CD74 on gastric epithelial cells and stimulates interleukin-8 production
    Ellen J Beswick
    Children s Hospital, Room 2 300, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA
    Infect Immun 73:2736-43. 2005
    ..The binding of H. pylori to CD74 presents a novel insight into an initial interaction of H. pylori with the gastric epithelium that leads to upregulation of inflammatory responses...