J Besheer

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Transient increase in alcohol self-administration following a period of chronic exposure to corticosterone
    Joyce Besheer
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 2759, USA
    Neuropharmacology 72:139-47. 2013
  2. pmc Assessment of the interoceptive effects of alcohol in rats using short-term training procedures
    Joyce Besheer
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Alcohol 46:747-55. 2012
  3. pmc The effects of repeated corticosterone exposure on the interoceptive effects of alcohol in rats
    Joyce Besheer
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Thurston Bowles Building, CB 7178, Chapel Hill, NC 27599, USA
    Psychopharmacology (Berl) 220:809-22. 2012
  4. pmc Intra-amygdala inhibition of ERK(1/2) potentiates the discriminative stimulus effects of alcohol
    Joyce Besheer
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Behav Brain Res 228:398-405. 2012
  5. pmc mGlu5 receptors are involved in the discriminative stimulus effects of self-administered ethanol in rats
    Joyce Besheer
    Bowles Center for Alcohol Studies, Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Eur J Pharmacol 551:71-5. 2006
  6. pmc Interoceptive effects of alcohol require mGlu5 receptor activity in the nucleus accumbens
    Joyce Besheer
    Bowles Center for Alcohol Studies, Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Neurosci 29:9582-91. 2009
  7. pmc Ethanol-induced alterations of c-Fos immunoreactivity in specific limbic brain regions following ethanol discrimination training
    Joyce Besheer
    Bowles Center for Alcohol Studies, Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Brain Res 1232:124-31. 2008
  8. pmc Pharmacological and anatomical evidence for an interaction between mGluR5- and GABA(A) alpha1-containing receptors in the discriminative stimulus effects of ethanol
    Joyce Besheer
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Neuropsychopharmacology 30:747-57. 2005
  9. ncbi request reprint GABA(B) receptor agonists reduce operant ethanol self-administration and enhance ethanol sedation in C57BL/6J mice
    Joyce Besheer
    Bowles Center for Alcohol Studies, Department of Psychiatry, Thurston Bowles Building, University of North Carolina at Chapel Hill, CB 7178, Chapel Hill, NC 27599, USA
    Psychopharmacology (Berl) 174:358-66. 2004
  10. ncbi request reprint Impact of nicotine withdrawal on novelty reward and related behaviors
    Joyce Besheer
    Department of Psychology, University of Nebraska Lincoln, 68588 0308, USA
    Behav Neurosci 117:327-40. 2003

Collaborators

Detail Information

Publications33

  1. pmc Transient increase in alcohol self-administration following a period of chronic exposure to corticosterone
    Joyce Besheer
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 2759, USA
    Neuropharmacology 72:139-47. 2013
    ....
  2. pmc Assessment of the interoceptive effects of alcohol in rats using short-term training procedures
    Joyce Besheer
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Alcohol 46:747-55. 2012
    ....
  3. pmc The effects of repeated corticosterone exposure on the interoceptive effects of alcohol in rats
    Joyce Besheer
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Thurston Bowles Building, CB 7178, Chapel Hill, NC 27599, USA
    Psychopharmacology (Berl) 220:809-22. 2012
    ....
  4. pmc Intra-amygdala inhibition of ERK(1/2) potentiates the discriminative stimulus effects of alcohol
    Joyce Besheer
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Behav Brain Res 228:398-405. 2012
    ..These findings show that activity of the ERK signaling pathway in the amygdala can influence the discriminative stimulus effects of alcohol...
  5. pmc mGlu5 receptors are involved in the discriminative stimulus effects of self-administered ethanol in rats
    Joyce Besheer
    Bowles Center for Alcohol Studies, Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Eur J Pharmacol 551:71-5. 2006
    ..These results indicate that mGlu(5) receptors are involved in the expression of the discriminative stimulus properties of self-administered ethanol...
  6. pmc Interoceptive effects of alcohol require mGlu5 receptor activity in the nucleus accumbens
    Joyce Besheer
    Bowles Center for Alcohol Studies, Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Neurosci 29:9582-91. 2009
    ..These results show that mGlu5 receptor activity in the nucleus accumbens is required for the expression of the interoceptive effects of alcohol...
  7. pmc Ethanol-induced alterations of c-Fos immunoreactivity in specific limbic brain regions following ethanol discrimination training
    Joyce Besheer
    Bowles Center for Alcohol Studies, Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Brain Res 1232:124-31. 2008
    ..This suggests that learning about the subjective properties of ethanol produces adaptive changes in how the brain responds to acute ethanol exposure...
  8. pmc Pharmacological and anatomical evidence for an interaction between mGluR5- and GABA(A) alpha1-containing receptors in the discriminative stimulus effects of ethanol
    Joyce Besheer
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Neuropsychopharmacology 30:747-57. 2005
    ..Together, these findings suggest an interaction between mGluR5- and benzodiazepine-sensitive GABA(A) receptors in mediating ethanol discrimination...
  9. ncbi request reprint GABA(B) receptor agonists reduce operant ethanol self-administration and enhance ethanol sedation in C57BL/6J mice
    Joyce Besheer
    Bowles Center for Alcohol Studies, Department of Psychiatry, Thurston Bowles Building, University of North Carolina at Chapel Hill, CB 7178, Chapel Hill, NC 27599, USA
    Psychopharmacology (Berl) 174:358-66. 2004
    ..A growing number of studies suggest that gamma-aminobutyric acid type-B (GABA(B)) receptor agonists reduce alcohol use and craving...
  10. ncbi request reprint Impact of nicotine withdrawal on novelty reward and related behaviors
    Joyce Besheer
    Department of Psychology, University of Nebraska Lincoln, 68588 0308, USA
    Behav Neurosci 117:327-40. 2003
    ..Further investigation into the neurochemical and behavioral changes that accompany nicotine withdrawal will lead to a better understanding of the withdrawal syndrome...
  11. pmc Regulation of motivation to self-administer ethanol by mGluR5 in alcohol-preferring (P) rats
    Joyce Besheer
    Bowles Center for Alcohol Studies, Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Alcohol Clin Exp Res 32:209-21. 2008
    ..The purpose of this work was to further characterize involvement of Group I mGluRs in the reinforcing effects of ethanol using a progressive ratio schedule of reinforcement...
  12. pmc Effects of mGlu1-receptor blockade on ethanol self-administration in inbred alcohol-preferring rats
    J Besheer
    Bowles Center for Alcohol Studies, Department of Psychiatry, Thurston Bowles Building, CB 7178, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    Alcohol 42:13-20. 2008
    ..Together, these results suggest that mGlu1 receptors do not play a specific role in modulating ethanol self-administration or the self-administration of an alternate nondrug reward (i.e., sucrose)...
  13. pmc Metabotropic glutamate receptor 5 activity in the nucleus accumbens is required for the maintenance of ethanol self-administration in a rat genetic model of high alcohol intake
    Joyce Besheer
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Biol Psychiatry 67:812-22. 2010
    ..This study sought to evaluate the functional role of Group I (mGluR5) and Group II (mGluR2/3) in mesocorticolimbic brain regions in ethanol self-administration...
  14. ncbi request reprint Nicotine-conditioned locomotor activity in rats: dopaminergic and GABAergic influences on conditioned expression
    R A Bevins
    Department of Psychology, University of Nebraska Lincoln, Lincoln, NE 68588 0308, USA
    Pharmacol Biochem Behav 68:135-45. 2001
    ..Thus, the dopamine D(1) receptor subtype appears to play a role in context-elicited increases in activity conditioned by nicotine; GABA may also modulate the expression of this conditioned effect...
  15. pmc GABAA receptor regulation of voluntary ethanol drinking requires PKCepsilon
    Joyce Besheer
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, 27599, USA
    Synapse 60:411-9. 2006
    ..This suggests that PKCepsilon may be required for GABA(A) receptor regulation of chronic ethanol drinking...
  16. pmc Increased operant responding for ethanol in male C57BL/6J mice: specific regulation by the ERK1/2, but not JNK, MAP kinase pathway
    Sara Faccidomo
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Psychopharmacology (Berl) 204:135-47. 2009
    ..Extracellular signal-regulated protein kinase (ERK(1/2)) is a member of the mitogen-activated protein kinase (MAPK) signaling pathway and a key molecular target for ethanol (EtOH) and other drugs of abuse...
  17. pmc Cue-induced reinstatement of alcohol-seeking behavior is associated with increased ERK1/2 phosphorylation in specific limbic brain regions: blockade by the mGluR5 antagonist MPEP
    Jason P Schroeder
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Thurston Bowles Building CB 7178, Chapel Hill, NC 27599, USA
    Neuropharmacology 55:546-54. 2008
    ..Pharmacological compounds, such as mGluR5 antagonists, that reduce cue-induced ERK1/2 activation may be useful for treatment of relapse in alcoholics that is triggered by exposure to environmental events...
  18. pmc Abstinence following alcohol drinking produces depression-like behavior and reduced hippocampal neurogenesis in mice
    Jennie R Stevenson
    Department of Psychiatry, Bowles Center for Alcohol Studies, Curriculum in Neurobiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Neuropsychopharmacology 34:1209-22. 2009
    ..e. behavioral) and structural changes occur during abstinence from alcohol use and suggest that antidepressant treatment may alleviate some of these pathological neurobehavioral adaptations...
  19. ncbi request reprint Novelty reward as a measure of anhedonia
    Rick A Bevins
    Department of Psychology, University of Nebraska Lincoln, Lincoln, NE 68588 0308, USA
    Neurosci Biobehav Rev 29:707-14. 2005
    ....
  20. ncbi request reprint Coregulation of ethanol discrimination by the nucleus accumbens and amygdala
    Joyce Besheer
    Bowles Center for Alcohol Studies, Thurston Bowles Building CB 7178, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Alcohol Clin Exp Res 27:450-6. 2003
    ..This study was conducted to determine if GABA(A) receptors in the amygdala and nucleus accumbens interactively modulate ethanol discrimination...
  21. ncbi request reprint Timing of conditioned responding in a nicotine locomotor conditioning preparation: manipulations of the temporal arrangement between context cues and drug administration
    Rick A Bevins
    Department of Psychology, 238 Burnett Hall, University of Nebraska Lincoln, Lincoln, NE 68588 0308, USA
    Behav Brain Res 159:135-43. 2005
    ....
  22. ncbi request reprint Individual differences in rat locomotor activity are diminished by nicotine through stimulation of central nicotinic acetylcholine receptors
    R A Bevins
    Department of Psychology, University of Nebraska Lincoln, Lincoln, NE 68588 0308, USA
    Physiol Behav 72:237-44. 2001
    ..This data pattern suggests that the disruptive effects of acute and chronic nicotine on individual differences were mediated by neural nicotinic acetylcholine (nACh) receptors...
  23. pmc Preclinical evaluation of riluzole: assessments of ethanol self-administration and ethanol withdrawal symptoms
    Joyce Besheer
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7178, USA
    Alcohol Clin Exp Res 33:1460-8. 2009
    ..This study was designed to determine the preclinical efficacy of riluzole to modulate ethanol self-administration and withdrawal...
  24. ncbi request reprint 5-HT(3A) receptor subunit is required for 5-HT3 antagonist-induced reductions in alcohol drinking
    Clyde W Hodge
    Department of Psychiatry and Bowles Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Neuropsychopharmacology 29:1807-13. 2004
    ..These findings indicate that reduction of alcohol drinking produced by 5-HT3 antagonism is dependent on the presence of 5-HT(3A)-containing receptors...
  25. ncbi request reprint Novel-object place conditioning: behavioral and dopaminergic processes in expression of novelty reward
    Rick A Bevins
    Department of Psychology, University of Nebraska Lincoln, Lincoln, NE 68588 0308, USA
    Behav Brain Res 129:41-50. 2002
    ....
  26. ncbi request reprint Maternal oral intake mouse model for fetal alcohol spectrum disorders: ocular defects as a measure of effect
    Scott E Parnell
    Bowles Center for Alcohol Studies, Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Alcohol Clin Exp Res 30:1791-8. 2006
    ..The ocular defects are readily identifiable and their degree of severity is expected to correlate with concurrently developing defects of the central nervous system (CNS)...
  27. ncbi request reprint Understanding how the brain perceives alcohol: neurobiological basis of ethanol discrimination
    Clyde W Hodge
    Department of Psychiatry and Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 5679, USA
    Alcohol Clin Exp Res 30:203-13. 2006
    ....
  28. pmc The mGluR5 antagonist MPEP selectively inhibits the onset and maintenance of ethanol self-administration in C57BL/6J mice
    Clyde W Hodge
    Department of Psychiatry, Bowles Center for Alcohol Studies School of Medicine, CB 7178, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    Psychopharmacology (Berl) 183:429-38. 2006
    ..Emerging evidence implicates metabotropic glutamate receptors (mGluRs) in the biobehavioral effects of ethanol and other drugs of abuse, but there is little information regarding the role of mGluRs in the reinforcing effects of ethanol...
  29. ncbi request reprint Nicotine enhances acquisition of a T-maze visual discrimination: assessment of individual differences
    J Besheer
    Department of Psychology, University of Nebraska Lincoln, 68588 0308, USA
    Behav Pharmacol 11:613-20. 2000
    ..Overall a nicotine-induced improvement in performance is demonstrated which can be predicted by a rat's reactivity to environmental novelty...
  30. pmc Acute ethanol administration rapidly increases phosphorylation of conventional protein kinase C in specific mammalian brain regions in vivo
    Mary Beth Wilkie
    Bowles Center for Alcohol Studies, Department of Psychiatry, School of Medicine University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    Alcohol Clin Exp Res 31:1259-67. 2007
    ....
  31. ncbi request reprint Nicotine as a signal for the presence or absence of sucrose reward: a Pavlovian drug appetitive conditioning preparation in rats
    Joyce Besheer
    Department of Psychology, University of Nebraska Lincoln, Lincoln, NE 68588 0308, USA
    Psychopharmacology (Berl) 172:108-17. 2004
    ..This research has not explored the possibility that nicotine can also function as a CS...
  32. pmc Comparison of ethanol locomotor sensitization in adolescent and adult DBA/2J mice
    Rebekah A Stevenson
    Bowles Center for Alcohol Studies, Department of Psychiatry, Curriculum in Neurobiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Psychopharmacology (Berl) 197:361-70. 2008
    ..Behavioral sensitization in rodents is a model of neurobehavioral plasticity that occurs following repeated drug exposure and may underlie components of addiction...
  33. ncbi request reprint Some antiepileptic compounds impair learning by rats in a Morris water maze
    James D Churchill
    Department of Psychology, Indiana University, Bloomington 47405 7007, USA
    Integr Physiol Behav Sci 38:91-103. 2003
    ..To the extent that one might wish to minimize learning deficits associated with maintenance on antiepileptic drugs, phenytoin is definitely not the treatment of choice, while valproate or ethosuximide are apparently much less disruptive...