Research Topics
Species | John S BertramSummaryAffiliation: University of Hawaii Country: USA Publications
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Detail Information
Publications
The molecular biology of cancerJ S Bertram
Cancer Research Center of Hawaii, University of Hawaii at Manoa, 1236 Lauhala Street, Honolulu, HI 96813, USA
Mol Aspects Med 21:167-223. 2000..The review concludes with a discussion of how the use of high throughput molecular arrays will allow the molecular pathologist/therapist to identify these defects and direct specific therapies to specific mutations...- Cancer prevention by retinoids and carotenoids: independent action on a common targetJohn S Bertram
Cancer Research Center of Hawaii, University of Hawaii at Manoa, 1236 Lauhala St, Honolulu, Hawaii, USA
Biochim Biophys Acta 1740:170-8. 2005..Simultaneous treatment with a retinoid and beta-carotene or astaxanthin resulted in supra-additive Cx43 expression, again indicating separate mechanisms of gene regulation... - Dietary carotenoids, connexins and cancer: what is the connection?J S Bertram
Cancer Etiology Program, Cancer Research Center of Hawaii, University of Hawaii at Manoa, Honolulu, HI 9681, USA
Biochem Soc Trans 32:985-9. 2004..We propose a model whereby junctional communication allows the transfer of growth inhibitory signals from normal to neoplastic cells and that retinoids and carotenoids, by increasing signal transfer, act to prevent cancer... - Induction of connexin 43 by carotenoids: functional consequencesJohn S Bertram
Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
Arch Biochem Biophys 430:120-6. 2004 - Upregulation of connexin 43 by retinoids but not by non-provitamin A carotenoids requires RARsAlex L Vine
Cancer Research Center of Hawaii, University of Hawaii at Manoa, Honolulu 96813, USA
Nutr Cancer 52:105-13. 2005.... - Inhibition of chemically-induced neoplastic transformation by a novel tetrasodium diphosphate astaxanthin derivativeLaura M Hix
Department of Cell and Molecular Biology, University of Hawaii at Manoa, Honolulu, HI 96822, USA
Carcinogenesis 26:1634-41. 2005..The dual properties of water dispersibility (enabling parenteral administration in vivo) and increased potency should prove extremely useful in the future development of cancer chemopreventive agents... - Transcriptional regulation of connexin 43 expression by retinoids and carotenoids: similarities and differencesAlex L Vine
Cancer Research Center of Hawaii, University of Hawaii at Manoa, Honolulu, Hawaii 96813, USA
Mol Carcinog 43:75-85. 2005..In this construct astaxanthin and lycopene produced marginally, but not significantly higher, reporter activity than the control... - Bioactive carotenoids: potent antioxidants and regulators of gene expressionLaura M Hix
Department of Cell and Molecular Biology and Cancer Research Center of Hawaii, University of Hawaii at Manoa, 1236 Laulala Street, Honolulu, HI 96813, USA
Redox Rep 9:181-91. 2004..The ability to deliver biologically active carotenoids at high concentration and with good reproducibility appears to have been achieved... - Cancer chemoprevention by connexinsAlex L Vine
Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
Cancer Metastasis Rev 21:199-216. 2002..Restoration of connexin function offers an exciting opportunity to delay tumor progression and inhibit metastasis... - Upregulation of connexin 43 protein expression and increased gap junctional communication by water soluble disodium disuccinate astaxanthin derivativesLaura M Hix
Department of Cell and Molecular Biology, University of Hawaii at Manoa, Honolulu 96822, USA
Cancer Lett 211:25-37. 2004.... - Cloning and functional expression of a novel human connexin-25 geneI Bondarev
Molecular Carcinogenesis Program, Cancer Research Center of Hawaii, University of Hawaii at Manoa, Honolulu 96813, USA
Cell Commun Adhes 8:167-71. 2001..After selection of transformants, cells were microinjected with the fluorescent dye Lucifer yellow. Transfectants but not controls successfully transferred dye, demonstrating that this new gene encodes a functional connexin... - Carotenoids and human healthJohn S Bertram
Hawaii Med J 61:77-8. 2002 - Connexins as targets for cancer chemoprevention and chemotherapyTimothy J King
Hawaii Biotech, Inc, Aiea, HI 96701, USA
Biochim Biophys Acta 1719:146-60. 2005..Here, we discuss the important role of connexins and GJC in tumorigenesis and suggest the possibility of connexins as potential anti-oncogenic targets for chemoprevention and/or chemotherapy... - Inducible expression of the gap junction protein connexin43 decreases the neoplastic potential of HT-1080 human fibrosarcoma cells in vitro and in vivoTimothy J King
Cancer Prevention Research Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Mol Carcinog 35:29-41. 2002..This study also further supports the hypothesis that loss of Cx43/GJIC in human tumors may play an important role in the dysregulation of normal growth control... - Effects of lycopene supplementation in patients with localized prostate cancerOmer Kucuk
Division of Hematology and Oncology, 3990 John R, Barbara Ann Karmanos Cancer Institute, Wayne State University, 5 Hudson, Detroit, MI 48201, USA
Exp Biol Med (Maywood) 227:881-5. 2002..This pilot study suggests that lycopene may have beneficial effects in prostate cancer. Larger clinical trials are warranted to investigate the potential preventive and/or therapeutic role of lycopene in prostate cancer...