John S Bertram

Summary

Affiliation: University of Hawaii
Country: USA

Publications

  1. ncbi request reprint The molecular biology of cancer
    J S Bertram
    Cancer Research Center of Hawaii, University of Hawaii at Manoa, 1236 Lauhala Street, Honolulu, HI 96813, USA
    Mol Aspects Med 21:167-223. 2000
  2. ncbi request reprint Cancer prevention by retinoids and carotenoids: independent action on a common target
    John S Bertram
    Cancer Research Center of Hawaii, University of Hawaii at Manoa, 1236 Lauhala St, Honolulu, Hawaii, USA
    Biochim Biophys Acta 1740:170-8. 2005
  3. ncbi request reprint Dietary carotenoids, connexins and cancer: what is the connection?
    J S Bertram
    Cancer Etiology Program, Cancer Research Center of Hawaii, University of Hawaii at Manoa, Honolulu, HI 9681, USA
    Biochem Soc Trans 32:985-9. 2004
  4. ncbi request reprint Induction of connexin 43 by carotenoids: functional consequences
    John S Bertram
    Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Arch Biochem Biophys 430:120-6. 2004
  5. ncbi request reprint Upregulation of connexin 43 by retinoids but not by non-provitamin A carotenoids requires RARs
    Alex L Vine
    Cancer Research Center of Hawaii, University of Hawaii at Manoa, Honolulu 96813, USA
    Nutr Cancer 52:105-13. 2005
  6. ncbi request reprint Inhibition of chemically-induced neoplastic transformation by a novel tetrasodium diphosphate astaxanthin derivative
    Laura M Hix
    Department of Cell and Molecular Biology, University of Hawaii at Manoa, Honolulu, HI 96822, USA
    Carcinogenesis 26:1634-41. 2005
  7. ncbi request reprint Transcriptional regulation of connexin 43 expression by retinoids and carotenoids: similarities and differences
    Alex L Vine
    Cancer Research Center of Hawaii, University of Hawaii at Manoa, Honolulu, Hawaii 96813, USA
    Mol Carcinog 43:75-85. 2005
  8. ncbi request reprint Bioactive carotenoids: potent antioxidants and regulators of gene expression
    Laura M Hix
    Department of Cell and Molecular Biology and Cancer Research Center of Hawaii, University of Hawaii at Manoa, 1236 Laulala Street, Honolulu, HI 96813, USA
    Redox Rep 9:181-91. 2004
  9. ncbi request reprint Cancer chemoprevention by connexins
    Alex L Vine
    Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Cancer Metastasis Rev 21:199-216. 2002
  10. ncbi request reprint Upregulation of connexin 43 protein expression and increased gap junctional communication by water soluble disodium disuccinate astaxanthin derivatives
    Laura M Hix
    Department of Cell and Molecular Biology, University of Hawaii at Manoa, Honolulu 96822, USA
    Cancer Lett 211:25-37. 2004

Collaborators

Detail Information

Publications15

  1. ncbi request reprint The molecular biology of cancer
    J S Bertram
    Cancer Research Center of Hawaii, University of Hawaii at Manoa, 1236 Lauhala Street, Honolulu, HI 96813, USA
    Mol Aspects Med 21:167-223. 2000
    ..The review concludes with a discussion of how the use of high throughput molecular arrays will allow the molecular pathologist/therapist to identify these defects and direct specific therapies to specific mutations...
  2. ncbi request reprint Cancer prevention by retinoids and carotenoids: independent action on a common target
    John S Bertram
    Cancer Research Center of Hawaii, University of Hawaii at Manoa, 1236 Lauhala St, Honolulu, Hawaii, USA
    Biochim Biophys Acta 1740:170-8. 2005
    ..Simultaneous treatment with a retinoid and beta-carotene or astaxanthin resulted in supra-additive Cx43 expression, again indicating separate mechanisms of gene regulation...
  3. ncbi request reprint Dietary carotenoids, connexins and cancer: what is the connection?
    J S Bertram
    Cancer Etiology Program, Cancer Research Center of Hawaii, University of Hawaii at Manoa, Honolulu, HI 9681, USA
    Biochem Soc Trans 32:985-9. 2004
    ..We propose a model whereby junctional communication allows the transfer of growth inhibitory signals from normal to neoplastic cells and that retinoids and carotenoids, by increasing signal transfer, act to prevent cancer...
  4. ncbi request reprint Induction of connexin 43 by carotenoids: functional consequences
    John S Bertram
    Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Arch Biochem Biophys 430:120-6. 2004
  5. ncbi request reprint Upregulation of connexin 43 by retinoids but not by non-provitamin A carotenoids requires RARs
    Alex L Vine
    Cancer Research Center of Hawaii, University of Hawaii at Manoa, Honolulu 96813, USA
    Nutr Cancer 52:105-13. 2005
    ....
  6. ncbi request reprint Inhibition of chemically-induced neoplastic transformation by a novel tetrasodium diphosphate astaxanthin derivative
    Laura M Hix
    Department of Cell and Molecular Biology, University of Hawaii at Manoa, Honolulu, HI 96822, USA
    Carcinogenesis 26:1634-41. 2005
    ..The dual properties of water dispersibility (enabling parenteral administration in vivo) and increased potency should prove extremely useful in the future development of cancer chemopreventive agents...
  7. ncbi request reprint Transcriptional regulation of connexin 43 expression by retinoids and carotenoids: similarities and differences
    Alex L Vine
    Cancer Research Center of Hawaii, University of Hawaii at Manoa, Honolulu, Hawaii 96813, USA
    Mol Carcinog 43:75-85. 2005
    ..In this construct astaxanthin and lycopene produced marginally, but not significantly higher, reporter activity than the control...
  8. ncbi request reprint Bioactive carotenoids: potent antioxidants and regulators of gene expression
    Laura M Hix
    Department of Cell and Molecular Biology and Cancer Research Center of Hawaii, University of Hawaii at Manoa, 1236 Laulala Street, Honolulu, HI 96813, USA
    Redox Rep 9:181-91. 2004
    ..The ability to deliver biologically active carotenoids at high concentration and with good reproducibility appears to have been achieved...
  9. ncbi request reprint Cancer chemoprevention by connexins
    Alex L Vine
    Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Cancer Metastasis Rev 21:199-216. 2002
    ..Restoration of connexin function offers an exciting opportunity to delay tumor progression and inhibit metastasis...
  10. ncbi request reprint Upregulation of connexin 43 protein expression and increased gap junctional communication by water soluble disodium disuccinate astaxanthin derivatives
    Laura M Hix
    Department of Cell and Molecular Biology, University of Hawaii at Manoa, Honolulu 96822, USA
    Cancer Lett 211:25-37. 2004
    ....
  11. ncbi request reprint Cloning and functional expression of a novel human connexin-25 gene
    I Bondarev
    Molecular Carcinogenesis Program, Cancer Research Center of Hawaii, University of Hawaii at Manoa, Honolulu 96813, USA
    Cell Commun Adhes 8:167-71. 2001
    ..After selection of transformants, cells were microinjected with the fluorescent dye Lucifer yellow. Transfectants but not controls successfully transferred dye, demonstrating that this new gene encodes a functional connexin...
  12. ncbi request reprint Carotenoids and human health
    John S Bertram
    Hawaii Med J 61:77-8. 2002
  13. ncbi request reprint Connexins as targets for cancer chemoprevention and chemotherapy
    Timothy J King
    Hawaii Biotech, Inc, Aiea, HI 96701, USA
    Biochim Biophys Acta 1719:146-60. 2005
    ..Here, we discuss the important role of connexins and GJC in tumorigenesis and suggest the possibility of connexins as potential anti-oncogenic targets for chemoprevention and/or chemotherapy...
  14. ncbi request reprint Inducible expression of the gap junction protein connexin43 decreases the neoplastic potential of HT-1080 human fibrosarcoma cells in vitro and in vivo
    Timothy J King
    Cancer Prevention Research Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Mol Carcinog 35:29-41. 2002
    ..This study also further supports the hypothesis that loss of Cx43/GJIC in human tumors may play an important role in the dysregulation of normal growth control...
  15. ncbi request reprint Effects of lycopene supplementation in patients with localized prostate cancer
    Omer Kucuk
    Division of Hematology and Oncology, 3990 John R, Barbara Ann Karmanos Cancer Institute, Wayne State University, 5 Hudson, Detroit, MI 48201, USA
    Exp Biol Med (Maywood) 227:881-5. 2002
    ..This pilot study suggests that lycopene may have beneficial effects in prostate cancer. Larger clinical trials are warranted to investigate the potential preventive and/or therapeutic role of lycopene in prostate cancer...