Olivier Berton

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Striatal overexpression of DeltaJunD resets L-DOPA-induced dyskinesia in a primate model of Parkinson disease
    Olivier Berton
    Department of Psychiatry, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104 3403, USA
    Biol Psychiatry 66:554-61. 2009
  2. doi request reprint Are we getting closer to valid translational models for major depression?
    Olivier Berton
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 338:75-9. 2012
  3. pmc Adult hippocampal neurogenesis is functionally important for stress-induced social avoidance
    Diane C Lagace
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Proc Natl Acad Sci U S A 107:4436-41. 2010
  4. ncbi request reprint Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions
    Vaishnav Krishnan
    Department of Psychiatry, The University of Texas Southwestern Medical Center UTSWMC, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Cell 131:391-404. 2007
  5. pmc Deep brain stimulation of the nucleus accumbens shell attenuates cocaine reinstatement through local and antidromic activation
    Fair M Vassoler
    Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 33:14446-54. 2013
  6. pmc Antidepressant-like Effects of Cortical Deep Brain Stimulation Coincide With Pro-neuroplastic Adaptations of Serotonin Systems
    Avin Veerakumar
    Department of Psychiatry, Perelman School of Medicine, Philadelphia, Pennsylvania Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania
    Biol Psychiatry 76:203-12. 2014
  7. pmc Raphe GABAergic neurons mediate the acquisition of avoidance after social defeat
    Collin Challis
    Department of Psychiatry and Neuroscience Graduate Group, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 33:13978-88, 13988a. 2013
  8. doi request reprint The use of animal models in psychiatric research and treatment
    Vaishnav Krishnan
    Department of Psychiatry, UT Southwestern Medical Center, 5323 Harry Hines Blvd, NE5 110, Dallas, TX 75390 9070, USA
    Am J Psychiatry 165:1109. 2008
  9. pmc Antidepressant-like properties of novel HDAC6-selective inhibitors with improved brain bioavailability
    Jeanine Jochems
    Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Neuropsychopharmacology 39:389-400. 2014
  10. ncbi request reprint Induction of deltaFosB in the periaqueductal gray by stress promotes active coping responses
    Olivier Berton
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Neuron 55:289-300. 2007

Collaborators

Detail Information

Publications12

  1. pmc Striatal overexpression of DeltaJunD resets L-DOPA-induced dyskinesia in a primate model of Parkinson disease
    Olivier Berton
    Department of Psychiatry, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104 3403, USA
    Biol Psychiatry 66:554-61. 2009
    ..Previous studies in rodents have shown that striatal DeltaFosB levels accurately predict dyskinesia severity and indicate that this transcription factor may play a causal role in the dyskinesia sensitization process...
  2. doi request reprint Are we getting closer to valid translational models for major depression?
    Olivier Berton
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 338:75-9. 2012
    ..We review recent progress and highlight some of the best leads to diversify and improve discovery end points for preclinical depression research...
  3. pmc Adult hippocampal neurogenesis is functionally important for stress-induced social avoidance
    Diane C Lagace
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Proc Natl Acad Sci U S A 107:4436-41. 2010
    ....
  4. ncbi request reprint Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions
    Vaishnav Krishnan
    Department of Psychiatry, The University of Texas Southwestern Medical Center UTSWMC, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Cell 131:391-404. 2007
    ....
  5. pmc Deep brain stimulation of the nucleus accumbens shell attenuates cocaine reinstatement through local and antidromic activation
    Fair M Vassoler
    Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 33:14446-54. 2013
    ....
  6. pmc Antidepressant-like Effects of Cortical Deep Brain Stimulation Coincide With Pro-neuroplastic Adaptations of Serotonin Systems
    Avin Veerakumar
    Department of Psychiatry, Perelman School of Medicine, Philadelphia, Pennsylvania Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania
    Biol Psychiatry 76:203-12. 2014
    ..Serotonin (5-HT) systems are engaged indirectly by ventromedial prefrontal cortex (vmPFC) DBS. Resulting neuroplastic changes in 5-HT systems could thus coincide with the long-term therapeutic activity of vmPFC DBS...
  7. pmc Raphe GABAergic neurons mediate the acquisition of avoidance after social defeat
    Collin Challis
    Department of Psychiatry and Neuroscience Graduate Group, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 33:13978-88, 13988a. 2013
    ..We provide the first characterization of GABA neurons in the DRN that monosynaptically inhibit 5-HT neurons and reveal their key role in neuroplastic processes underlying the development of social avoidance. ..
  8. doi request reprint The use of animal models in psychiatric research and treatment
    Vaishnav Krishnan
    Department of Psychiatry, UT Southwestern Medical Center, 5323 Harry Hines Blvd, NE5 110, Dallas, TX 75390 9070, USA
    Am J Psychiatry 165:1109. 2008
  9. pmc Antidepressant-like properties of novel HDAC6-selective inhibitors with improved brain bioavailability
    Jeanine Jochems
    Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Neuropsychopharmacology 39:389-400. 2014
    ..Our results validate new isoform-selective probes for in vivo pharmacological studies of HDAC6 in the CNS and reinforce the viability of this HDAC isoform as a potential target for antidepressant development. ..
  10. ncbi request reprint Induction of deltaFosB in the periaqueductal gray by stress promotes active coping responses
    Olivier Berton
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Neuron 55:289-300. 2007
    ..These results indicate that IS-induced accumulation of DeltaFosB in the vlPAG desensitizes substance P neurons enriched in this area and opposes behavioral despair by promoting active defense responses...
  11. ncbi request reprint Postnatal loss of methyl-CpG binding protein 2 in the forebrain is sufficient to mediate behavioral aspects of Rett syndrome in mice
    Terry Gemelli
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    Biol Psychiatry 59:468-76. 2006
    ..Methyl-CpG binding protein 2 is a transcriptional repressor that is widely expressed in all tissues...

Research Grants1

  1. Role of HDAC6 in a murine model of affective disorder and antidepressant action
    Olivier Berton; Fiscal Year: 2010
    ..In the present project we propose to evaluate, using animal models, the potential of histone deacetylase 6 (HDAC6) as a new therapeutic target for antidepressant treatments. ..