V M Berthoud
Affiliation: University of Chicago
Berthoud V, Singh R, Minogue P, Ragsdale C, Beyer E. Highly restricted pattern of connexin36 expression in chick somite development. Anat Embryol (Berl). 2004;209:11-8 pubmed
Berthoud V, Minogue P, Guo J, Williamson E, Xu X, Ebihara L, et al
. Loss of function and impaired degradation of a cataract-associated mutant connexin50. Eur J Cell Biol. 2003;82:209-21 pubmed
..Taken together, these results suggest that the P to S mutation at amino acid residue 88 causes a defect that leads to decreased degradation and subsequent accumulation of hCx50P88S in a cellular structure different from aggresomes. ..
Berthoud V, Minogue P, Lambert P, Snabb J, Beyer E. The Cataract-linked Mutant Connexin50D47A Causes Endoplasmic Reticulum Stress in Mouse Lenses. J Biol Chem. 2016;291:17569-78 pubmed publisher
Berthoud V, Ngezahayo A. Focus on lens connexins. BMC Cell Biol. 2017;18:6 pubmed publisher
..Dominantly inherited cataracts may result from effects of the connexin mutant on its wild type isotype, the other co-expressed wild type connexin and/or its interaction with other cellular components. ..
Falk M, Kells R, Berthoud V. Degradation of connexins and gap junctions. FEBS Lett. 2014;588:1221-9 pubmed publisher
..In this review, we summarize the current knowledge about connexin and gap junction degradation including the signals and protein-protein interactions that participate in their targeting for degradation. ..
Berthoud V, Minogue P, Snabb J, Dzhashiashvili Y, Novak L, Zoltoski R, et al
. Connexin23 deletion does not affect lens transparency. Exp Eye Res. 2016;146:283-8 pubmed publisher
..These results suggest that although Cx23 expression can influence the abundance of the co-expressed lens fiber connexins, heterozygous or homozygous expression of a Cx23-null allele does not alter lens transparency...