Research Topics
Species | KENT BERRIDGESummaryAffiliation: University of Michigan Country: USA Publications
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Publications
Contributions of Philip Teitelbaum to affective neuroscienceKent C Berridge
Department of Psychology, 530 Church Street, University of Michigan, Ann Arbor, MI 48109 1043, USA
Behav Brain Res 231:396-403. 2012..In short, Philip Teitelbaum can be seen to have made remarkable contributions to several domains of psychology and neuroscience, including affective neuroscience...- From prediction error to incentive salience: mesolimbic computation of reward motivationKent C Berridge
Department of Psychology, University of Michigan, Ann Arbor, MI 48109 1043, USA
Eur J Neurosci 35:1124-43. 2012..To understand these phenomena, future models of mesocorticolimbic reward function should address the neurobiological state factors that participate to control generation of incentive salience... - Nucleus accumbens corticotropin-releasing factor increases cue-triggered motivation for sucrose reward: paradoxical positive incentive effects in stress?Susana Pecina
Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA
BMC Biol 4:8. 2006..On test days, rats received microinjections of vehicle, CRF (250 or 500 ng/0.2 microl) or amphetamine (20 microg/0.2 microl). Lever pressing was assessed in the presence or absence of the Pavlovian cues during a half-hour test... - Sequential super-stereotypy of an instinctive fixed action pattern in hyper-dopaminergic mutant mice: a model of obsessive compulsive disorder and Tourette'sKent C Berridge
Department of Psychology, University of Michigan, Ann Arbor, USA
BMC Biol 3:4. 2005..Knockdown mutation of the dopamine transporter gene (DAT) causes extracellular dopamine levels in the neostriatum of these adult mutant mice to rise to 170% of wild-type control levels... 
Espresso reward learning, hold the dopamine: theoretical comment on Robinson et al. (2005)Kent C Berridge
University of Michigan, Ann Arbor, MI 48109 1109, USA
Behav Neurosci 119:336-41. 2005....- Dissecting components of reward: 'liking', 'wanting', and learningKent C Berridge
Department of Psychology, University of Michigan, Ann Arbor, 48109 1043, USA
Curr Opin Pharmacol 9:65-73. 2009.... - The debate over dopamine's role in reward: the case for incentive salienceKent C Berridge
Department of Psychology, University of Michigan, 530 Church Street East Hall, Ann Arbor, MI 48109, USA
Psychopharmacology (Berl) 191:391-431. 2007..Results from studies that exploited those opportunities are described here. CONCLUSION: In short, dopamine's contribution appears to be chiefly to cause 'wanting' for hedonic rewards, more than 'liking' or learning for those rewards... - Affective neuroscience of pleasure: reward in humans and animalsKent C Berridge
Department of Psychology, University of Michigan, Ann Arbor, MI, USA
Psychopharmacology (Berl) 199:457-80. 2008..Pleasure and reward are generated by brain circuits that are largely shared between humans and other animals... - 'Liking' and 'wanting' food rewards: brain substrates and roles in eating disordersKent C Berridge
Department of Psychology, University of Michigan, Ann Arbor, USA
Physiol Behav 97:537-50. 2009..Finally, it considers some potential ways in which 'wanting' and 'liking' might relate to eating disorders... - The tempted brain eats: pleasure and desire circuits in obesity and eating disordersKent C Berridge
Department of Psychology, University of Michigan, Ann Arbor, MI, USA
Brain Res 1350:43-64. 2010..We focus on ways in which these brain reward circuits might participate in obesity or in eating disorders... - Motivation concepts in behavioral neuroscienceKent C Berridge
Department of Psychology, University of Michigan, 525 E University Street, Ann Arbor, MI 48109 1109, USA
Physiol Behav 81:179-209. 2004.... - Super-stereotypy I: enhancement of a complex movement sequence by systemic dopamine D1 agonistsK C Berridge
Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109 1109, USA
Synapse 37:194-204. 2000..Thus, dopamine D1 receptor activation appears to contribute to a kind of sequential super-stereotypy in which a complex, stereotyped behavioral sequence is initiated more frequently and more often goes to completion... - Measuring hedonic impact in animals and infants: microstructure of affective taste reactivity patternsK C Berridge
Department of Psychology, University of Michigan, Ann Arbor, MI 48109 1109, USA
Neurosci Biobehav Rev 24:173-98. 2000..It considers the neural bases of incentive 'wanting' versus 'liking'. Finally, it notes the difference between human subjective affective ratings of pleasure and 'core hedonic processes' reflected by behavioral affective reactions... - Super-stereotypy II: enhancement of a complex movement sequence by intraventricular dopamine D1 agonistsK C Berridge
Departments of Psychology, University of Michigan, Ann Arbor, Michigan 48109 1109, USA
Synapse 37:205-15. 2000..Our results highlight a role for dopamine D1 receptors, probably within the basal ganglia, in the production of sequential super-stereotypy of complex behavioral patterns... - Parsing rewardKent C Berridge
Department of Psychology, Biopsychology Program, University of Michigan, Ann Arbor, MI 48109 1109, USA
Trends Neurosci 26:507-13. 2003..The challenge is to identify how different brain circuits mediate different psychological components of reward, and how these components interact... - Pleasures of the brainKent C Berridge
Department of Psychology, University of Michigan, Ann Arbor, MI 48109 1109, USA
Brain Cogn 52:106-28. 2003..The same subcortical 'liking' network, via connection to brain systems involved in explicit cognitive representations, may also in turn cause conscious experiences of sensory pleasure... - Opioid site in nucleus accumbens shell mediates eating and hedonic 'liking' for food: map based on microinjection Fos plumesS Pecina
Department of Psychology, University of Michigan, 525 E University, Ann Arbor, MI, USA
Brain Res 863:71-86. 2000..Opioid receptors within this site thus are capable of mediating morphine-induced increases in eating, in part by enhancing the hedonic reward properties of food... - Which cue to "want?" Central amygdala opioid activation enhances and focuses incentive salience on a prepotent reward cueStephen V Mahler
Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109, USA
J Neurosci 29:6500-13. 2009..We conclude that opioid neurotransmission in CeA helps determine which environmental stimuli become most "wanted," and how "wanted" they become. This may powerfully guide reward-seeking behavior... - Ventral pallidal neurons code incentive motivation: amplification by mesolimbic sensitization and amphetamineAmy J Tindell
Department of Psychology, University of Michigan, Ann Arbor, MI 48109-0607, USA
Eur J Neurosci 22:2617-34. 2005..Our results support incentive-sensitization predictions and suggest why cues temporally proximal to drug presentation may precipitate cue-triggered relapse in human addicts... - A neural computational model of incentive salienceJun Zhang
Department of Psychology, University of Michigan, Ann Arbor, Michigan, USA
PLoS Comput Biol 5:e1000437. 2009..Computational models can adequately capture fluctuations in cue-triggered 'wanting' only by incorporating modulation of previously learned values by natural appetite and addiction-related states... - Ventral pallidal representation of pavlovian cues and reward: population and rate codesAmy J Tindell
Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109-0489, USA
J Neurosci 24:1058-69. 2004..Thus, the VP makes use of dynamic CS population and rate codes to encode pavlovian reward cues in reward learning and uses stable UCS population and firing codes to encode sucrose reward itself... - Ventral pallidum firing codes hedonic reward: when a bad taste turns goodAmy J Tindell
Department of Psychology, University of Michigan Medical School, 1150 West Medical Center Drive, Medical Science Bldg I, Room 3317, Ann Arbor, MI 48109 0607, USA
J Neurophysiol 96:2399-409. 2006..Our data provide the strongest evidence yet for neural hedonic coding of natural sensory pleasures and suggest, by extension, how abnormalities in VP firing patterns might contribute to clinical hedonic dysfunctions... - Endogenous opioids are necessary for benzodiazepine palatability enhancement: naltrexone blocks diazepam-induced increase of sucrose-'liking'Derek K Richardson
Department of Psychology, University of Michigan, 525 E University, Ann Arbor, MI 48109 1109, USA
Pharmacol Biochem Behav 81:657-63. 2005..These results indicate that endogenous opioid neurotransmission may be crucial to benzodiazepine enhancement of hedonic 'liking' for natural taste reward... - Review. The incentive sensitization theory of addiction: some current issuesTerry E Robinson
Department of Psychology, Biopsychology Program, The University of Michigan, East Hall, 530 Church Street, Ann Arbor, MI 48109 1109, USA
Philos Trans R Soc Lond B Biol Sci 363:3137-46. 2008..the development of addiction-like behaviour in animals associated with sensitization? What is the best way to model addiction symptoms using animal models? And, finally, what are the roles of affective pleasure or withdrawal in addiction?.. - Mesolimbic dopamine in desire and dread: enabling motivation to be generated by localized glutamate disruptions in nucleus accumbensAlexis Faure
Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109 1109, USA
J Neurosci 28:7184-92. 2008..Thus, dopamine interacts with localization of valence-biased glutamate circuits in medial shell to facilitate keyboard stimulation of both appetitive and fearful motivations... - Hyperdopaminergic mutant mice have higher "wanting" but not "liking" for sweet rewardsSusana Pecina
Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109 1109, USA
J Neurosci 23:9395-402. 2003.... - Dynamic computation of incentive salience: "wanting" what was never "liked"Amy J Tindell
Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109 1043, USA
J Neurosci 29:12220-8. 2009.... - Hedonic hot spots in the brainSusana Pecina
Department of Psychology, University of Michigan, Ann Arbor, MI 48109 1109, USA
Neuroscientist 12:500-11. 2006..Better understanding of how brain hedonic hot spots increase the positive affective impact of natural sensory pleasures will help characterize the neural mechanisms potentially involved in 'liking' for many rewards... - Desire and dread from the nucleus accumbens: cortical glutamate and subcortical GABA differentially generate motivation and hedonic impact in the ratAlexis Faure
Department of Psychology, University of Michigan, Ann Arbor, Michigan, United States of America
PLoS ONE 5:e11223. 2010..However, GABA and glutamate signals in NAc differ in important ways, despite the similarity of their rostrocaudal motivation gradients... - Metabotropic glutamate receptor blockade in nucleus accumbens shell shifts affective valence towards fear and disgustJocelyn M Richard
Department of Psychology, University of Michigan, Ann Arbor, MI, USA
Eur J Neurosci 33:736-47. 2011..These results are discussed in terms of implications for clinical disorders and the influence of corticolimbic glutamate inputs to NAc in the generation of motivation and affect... - Emotional environments retune the valence of appetitive versus fearful functions in nucleus accumbensSheila M Reynolds
Department of Psychology, 525 E University Avenue, University of Michigan, Ann Arbor, Michigan 48109 1109, USA
Nat Neurosci 11:423-5. 2008..Thus, the emotional environments retuned the generation of motivation in corticolimbic circuits... - Hedonic hot spot in nucleus accumbens shell: where do mu-opioids cause increased hedonic impact of sweetness?Susana Pecina
Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109, USA
J Neurosci 25:11777-86. 2005..Opioid circuits for stimulating food intake are widely distributed, whereas hedonic "liking" circuits are more tightly localized in the rostromedial shell of the nucleus accumbens... - Glutamate motivational ensembles in nucleus accumbens: rostrocaudal shell gradients of fear and feedingSheila M Reynolds
Department of Psychology, University of Michigan, Ann Arbor, MI 48109 1109, USA
Eur J Neurosci 17:2187-200. 2003..Hyperpolarization of local shell ensembles by AMPA/kainate glutamate receptor blockade elicits fear and feeding behaviours mapped along distinct positive-to-negative rostrocaudal gradients... - Basal ganglia neural mechanisms of natural movement sequencesJ Wayne Aldridge
Department of Neurology, University of Michigan, 1150 West Medical Center, 1150 West Medical Center Drive, Medical Science Building I, Room 3317, Ann Arbor, MI 49109, USA
Can J Physiol Pharmacol 82:732-9. 2004..The basal ganglia are modulated by the context of the sequence and may play an executive function in the complex natural patterns of sequenced behaviour... - AddictionTerry E Robinson
Department of Psychology Biopsychology Program, University of Michigan, Ann Arbor, Michigan 48109 1109, USA
Annu Rev Psychol 54:25-53. 2003.... - Positive and negative motivation in nucleus accumbens shell: bivalent rostrocaudal gradients for GABA-elicited eating, taste "liking"/"disliking" reactions, place preference/avoidance, and fearSheila M Reynolds
Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109 1109, USA
J Neurosci 22:7308-20. 2002..These results indicate that GABAergic neurotransmission in local microcircuits in nucleus accumbens mediates motivated/affective behavior that is bivalently organized along rostrocaudal gradients... - Dopamine receptor modulation of repetitive grooming actions in the rat: potential relevance for Tourette syndromeJennifer L Taylor
Department of Psychology, University of Michigan, Ann Arbor, MI48109 1043, USA
Brain Res 1322:92-101. 2010..Together, these results have implications for understanding how dopamine receptors facilitate particular stereotypies manifest in animal models of Tourette syndrome and obsessive compulsive disorder... - Opioid limbic circuit for reward: interaction between hedonic hotspots of nucleus accumbens and ventral pallidumKyle S Smith
Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109, USA
J Neurosci 27:1594-605. 2007..This pattern reveals differences between limbic opioid circuits that control reward "liking" and "wanting" functions... - Endocannabinoid hedonic hotspot for sensory pleasure: anandamide in nucleus accumbens shell enhances 'liking' of a sweet rewardStephen V Mahler
Department of Psychology, The University of Michigan, Ann Arbor, MI 48109, USA
Neuropsychopharmacology 32:2267-78. 2007..Identification of an endocannabinoid hotspot for sensory pleasure gives insight into brain mechanisms of natural reward, and may be relevant to understanding the neural effects of cannabinoid drugs of abuse and therapeutic agents... - The ventral pallidum and hedonic reward: neurochemical maps of sucrose "liking" and food intakeKyle S Smith
Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109, USA
J Neurosci 25:8637-49. 2005..Hedonic "liking" and eating are systematically mapped in a neuroanatomically and neurochemically interactive manner in the VP... - Unconscious affective reactions to masked happy versus angry faces influence consumption behavior and judgments of valuePiotr Winkielman
Department of Psychology, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
Pers Soc Psychol Bull 31:121-35. 2005..The results suggest that basic affective reactions can be unconscious and interact with incentive motivation to influence assessment of value and behavior toward valenced objects... - Neural correlates of social and nonsocial emotions: An fMRI studyJennifer C Britton
Neuroscience Program, University of Michigan, Ann Arbor, MI 48109
Neuroimage 31:397-409. 2006..Overall, these findings highlight that sociality has a key role in processing emotional valence, which may have implications for patient populations with social and emotional deficits... - Differential subjective and psychophysiological responses to socially and nonsocially generated emotional stimuliJennifer C Britton
Neuroscience Program, University of Michigan, USA
Emotion 6:150-5. 2006..Heart rate deceleration was more responsive to nonsocially generated emotions. Taken together, these findings suggest that sociality affects the physiological profile of responses to emotional valence... - Substantia nigra pars reticulata neurons code initiation of a serial pattern: implications for natural action sequences and sequential disordersMelanie Meyer-Luehmann
Department of Neuropathology, University of Basel, Switzerland
Eur J Neurosci 16:1599-608. 2002..We conclude that the context of sequential pattern may be more important than the elemental motor parameters in determining SNpr neuronal activation... - The neuroscience of natural rewards: relevance to addictive drugsAnn E Kelley
Department of Psychiatry, University of Wisconsin-Madison Medical School, Madison, Wisconsin 53719, USA
J Neurosci 22:3306-11. 2002 - Dopamine D1 activation shortens the duration of phases in stereotyped grooming sequencesMatthew S Matell
Department of Neurology, University of Michigan Medical School, USA
Behav Processes 71:241-9. 2006..By this model, SKF 81297 increases the speed of the clock used for the temporal control of grooming actions, and thus shortens phase durations...
Research Grants
- Affective neuroscience of taste reactivityKent C Berridge; Fiscal Year: 2010....
- Cue-triggered reward seekingKENT BERRIDGE; Fiscal Year: 2009..The studies proposed here will help reveal those brain mechanisms underlying cue-triggered relapse, and will shed light on how compulsive 'wants' are produced in addiction and in eating disorders. ..
- Affective neuroscience of taste reactivityKENT BERRIDGE; Fiscal Year: 2009....
- Cue-triggered reward seekingKENT BERRIDGE; Fiscal Year: 2007..These studies will clarify basic mechanisms of natural cue-triggered 'wanting', and will be useful in understanding mechanisms of cue-triggered relapse in human drug addiction. ..
- Affective neuroscience of taste reactivityKENT BERRIDGE; Fiscal Year: 2006..This will begin to clarify the neural circuits underlying generation of positive affective reactions, which may be involved in human affective disorders that involve specific deficits of positive affect. ..
- SENSITIZATION AND CONDITIONING WITH ETHANOLKENT BERRIDGE; Fiscal Year: 2006..abstract_text> ..
- Cue-triggered reward seekingKent C Berridge; Fiscal Year: 2010..The studies proposed here will help reveal those brain mechanisms underlying cue-triggered relapse, and will shed light on how compulsive 'wants'are produced in addiction and in eating disorders. ..