W Berrettini

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Pharmacotherapy and pharmacogenetics of nicotine dependence
    Wade H Berrettini
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Clinical Research Bldg, Room 111, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Am J Psychiatry 162:1441-51. 2005
  2. doi request reprint The CHRNA5-A3-B4 gene cluster in nicotine addiction
    W H Berrettini
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Mol Psychiatry 17:856-66. 2012
  3. pmc Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependence
    Jay Jin
    Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    BMC Neurosci 11:33. 2010
  4. pmc Transcriptional profiling of C57 and DBA strains of mice in the absence and presence of morphine
    Dorothy E Grice
    Department of Psychiatry, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ, USA
    BMC Genomics 8:76. 2007
  5. pmc Genetic bases for endophenotypes in psychiatric disorders
    Wade H Berrettini
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania, 415 Curie Boulevard, Room 111, Philadelphia, PA 19107, USA
    Dialogues Clin Neurosci 7:95-101. 2005
  6. ncbi request reprint Catechol-O-methyltransferase (COMT) gene variants predict response to bupropion therapy for tobacco dependence
    Wade H Berrettini
    Department of Psychiatry, Transdisciplinary Tobacco Use Research Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Biol Psychiatry 61:111-8. 2007
  7. ncbi request reprint Bipolar disorder and schizophrenia: convergent molecular data
    Wade Berrettini
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania, PA, USA
    Neuromolecular Med 5:109-17. 2004
  8. pmc Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking
    W Berrettini
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Mol Psychiatry 13:368-73. 2008
  9. ncbi request reprint Evidence for shared susceptibility in bipolar disorder and schizophrenia
    Wade Berrettini
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Med Genet C Semin Med Genet 123:59-64. 2003
  10. ncbi request reprint Molecular linkage studies of bipolar disorders
    W H Berrettini
    Department of Psychiatry and the Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia, PA 19107, USA
    Bipolar Disord 3:276-83. 2001

Research Grants

  1. QUANTITATIVE GENETICS OF OPIATE ADDICTION
    Wade Berrettini; Fiscal Year: 2004
  2. Genetics of Anorexia Nervosa
    Wade Berrettini; Fiscal Year: 2005
  3. A COLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDER
    Wade Berrettini; Fiscal Year: 2007
  4. Genetics of Nicotine Dependence
    Wade Berrettini; Fiscal Year: 2009
  5. A Neuropeptide Gene in Psychiatric Illness
    Wade Berrettini; Fiscal Year: 2004
  6. COLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDER
    Wade Berrettini; Fiscal Year: 2001
  7. Genetics of Nicotine Dependence
    Wade H Berrettini; Fiscal Year: 2010

Detail Information

Publications83

  1. ncbi request reprint Pharmacotherapy and pharmacogenetics of nicotine dependence
    Wade H Berrettini
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Clinical Research Bldg, Room 111, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Am J Psychiatry 162:1441-51. 2005
    ....
  2. doi request reprint The CHRNA5-A3-B4 gene cluster in nicotine addiction
    W H Berrettini
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Mol Psychiatry 17:856-66. 2012
    ..There are other genetic influences on NA in this region, apart from the mis-sense variant, and additional biological experiments must be done to understand them...
  3. pmc Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependence
    Jay Jin
    Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    BMC Neurosci 11:33. 2010
    ..We hypothesize that identifying and characterizing novel MOR interacting proteins (MORIPs) may help to elucidate the underlying mechanisms involved in the development of opioid dependence...
  4. pmc Transcriptional profiling of C57 and DBA strains of mice in the absence and presence of morphine
    Dorothy E Grice
    Department of Psychiatry, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ, USA
    BMC Genomics 8:76. 2007
    ..In the current study, we carried out microarray analysis in C57 and DBA mice in the nucleus accumbens of drug-naïve and morphine-treated animals...
  5. pmc Genetic bases for endophenotypes in psychiatric disorders
    Wade H Berrettini
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania, 415 Curie Boulevard, Room 111, Philadelphia, PA 19107, USA
    Dialogues Clin Neurosci 7:95-101. 2005
    ..Evidence for two useful schizophrenia endophenotypes, the P50 abnormalities and cognitive deficits, is summarized...
  6. ncbi request reprint Catechol-O-methyltransferase (COMT) gene variants predict response to bupropion therapy for tobacco dependence
    Wade H Berrettini
    Department of Psychiatry, Transdisciplinary Tobacco Use Research Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Biol Psychiatry 61:111-8. 2007
    ..We investigated variants in the catechol-O-methyltransferase (COMT) gene in a smoking cessation trial of bupropion...
  7. ncbi request reprint Bipolar disorder and schizophrenia: convergent molecular data
    Wade Berrettini
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania, PA, USA
    Neuromolecular Med 5:109-17. 2004
    ..As the genes underlying these confirmed linkages are identified, the current nosology must be changed to reflect the new knowledge concerning the shared etiologies of BPD and SZ...
  8. pmc Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking
    W Berrettini
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Mol Psychiatry 13:368-73. 2008
    ..These results (in three independent populations of European origin, totaling approximately 15 000 individuals) suggest that a common haplotype in the CHRNA5/CHRNA3 gene cluster on chromosome 15 contains alleles, which predispose to ND...
  9. ncbi request reprint Evidence for shared susceptibility in bipolar disorder and schizophrenia
    Wade Berrettini
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Med Genet C Semin Med Genet 123:59-64. 2003
    ..It is suggested that nosology must be changed to reflect the genetic origins of the multiple disorders that are collectively described by the terms BPD and SZ...
  10. ncbi request reprint Molecular linkage studies of bipolar disorders
    W H Berrettini
    Department of Psychiatry and the Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia, PA 19107, USA
    Bipolar Disord 3:276-83. 2001
    ..To review the reports of linkage findings for bipolar disorder...
  11. ncbi request reprint Progress and pitfalls: bipolar molecular linkage studies
    W Berrettini
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia 19104, USA
    J Affect Disord 50:287-97. 1998
    ..The issue of anticipation and expanding triplet repeats is discussed. Finally, there is a brief section on recommendations for future genetic linkage studies of bipolar disorder...
  12. ncbi request reprint Review of bipolar molecular linkage and association studies
    Wade Berrettini
    Department of Psychiatry and Center for Neurobiology and Behavior, University of Pennsylvania, 415 Curie Blvd, Room 111, Philadelphia, PA 19104, USA
    Curr Psychiatry Rep 4:124-9. 2002
    ..The history of BPD LD studies is reviewed, using monoamine oxidase as as an example. Some suggestions of improving these BPD LD are offered...
  13. ncbi request reprint Human G(olf) gene polymorphisms and vulnerability to bipolar disorder
    W H Berrettini
    Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA
    Psychiatr Genet 8:235-8. 1998
    ....
  14. ncbi request reprint Genetics of psychiatric disease
    W H Berrettini
    Department of Psychiatry, University of Pennsylvania, Philadelphia 19107, USA
    Annu Rev Med 51:465-79. 2000
    ..Thus, both family and molecular studies of these disorders suggest shared genetic susceptibility. These two group of disorders may not be so distinct as current nosology suggests...
  15. ncbi request reprint Identification of three mouse mu-opioid receptor (MOR) gene (Oprm1) splice variants containing a newly identified alternatively spliced exon
    Glenn A Doyle
    The Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States
    Gene 388:135-47. 2007
    ..In summary, we have identified three brain expressed, alternatively spliced mouse MOR splice variants containing a novel exon and encoding new putative MOR isoforms, MOR-1V and MOR-1W...
  16. ncbi request reprint Identification and functional significance of polymorphisms in the mu-opioid receptor gene (Oprm) promoter of C57BL/6 and DBA/2 mice
    Glenn A Doyle
    The Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States
    Neurosci Res 55:244-54. 2006
    ..No significant differences in construct activity were found between untreated and morphine-treated BE(2)-C or Neuro-2a cells, suggesting that morphine does not regulate transcription of Oprm...
  17. ncbi request reprint A genetic association study of the mu opioid receptor and severe opioid dependence
    James J Crowley
    Department of Pharmacology, University of Pennsylvania, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    Psychiatr Genet 13:169-73. 2003
    ..A recent report (Hoehe et al., 2000) found a significant association between a specific combination of OPRM1 single nucleotide polymorphisms (SNPs) and substance dependence...
  18. ncbi request reprint Analysis of variations in the tryptophan hydroxylase-2 (TPH2) gene in cocaine dependence
    John P Dahl
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, USA
    Addict Biol 11:76-83. 2006
    ..This work suggests that variations in the TPH2 gene are not a risk factor for the development of cocaine dependence, but these findings require confirmation in larger, independent samples of cocaine-dependent and control subjects...
  19. ncbi request reprint No association between polymorphisms in the serotonin transporter gene and susceptibility to cocaine dependence among African-American individuals
    Ashwin A Patkar
    Division of Substance Abuse Programs, Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Psychiatr Genet 12:161-4. 2002
    ..8%, 10 = 36.6%, 9 = 0.6%). Our findings do not seem to support a relationship between VNTR polymorphisms and cocaine dependence among African-American patients. Further studies involving larger samples are required to confirm our results...
  20. ncbi request reprint Relationship between serotonin transporter gene polymorphisms and platelet serotonin transporter sites among African-American cocaine-dependent individuals and healthy volunteers
    Ashwin A Patkar
    Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Psychiatr Genet 14:25-32. 2004
    ....
  21. ncbi request reprint Polymorphism in the serotonin transporter gene and response to treatment in African American cocaine and alcohol-abusing individuals
    Paolo Mannelli
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27704, USA
    Addict Biol 10:261-8. 2005
    ..Further investigations are required to determine the role of the 5-HTTLPR polymorphism in influencing treatment - outcome among substance abusers...
  22. doi request reprint Family-based association of YWHAH in psychotic bipolar disorder
    Deepak Grover
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    Am J Med Genet B Neuropsychiatr Genet 150:977-83. 2009
    ....
  23. ncbi request reprint The genetic determinants of smoking
    Vikas Batra
    Department of Medicine, Division of Critical Care, Pulmonary, Allergic and Immunologic Diseases, Thomas Jefferson University, Philadelphia, USA
    Chest 123:1730-9. 2003
    ..Insights into the genetic contributions to smoking can potentially lead to more effective strategies to reduce smoking...
  24. ncbi request reprint Pharmacogenomic evaluation of the antidepressant citalopram in the mouse tail suspension test
    James J Crowley
    Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 31:2433-42. 2006
    ..The present quantitative trait study suggests possible candidate genes for human pharmacogenetic studies of therapeutic responses to SSRIs such as citalopram...
  25. doi request reprint A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa
    K Wang
    Center for Applied Genomics, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Mol Psychiatry 16:949-59. 2011
    ..In conclusion, our study suggests that both common SNPs and rare CNVs may confer genetic risk to AN. These results point to intriguing genes that await further validation in independent cohorts for confirmatory roles in AN...
  26. ncbi request reprint A functional prodynorphin promoter polymorphism and opioid dependence
    Riju Ray
    Department of Pharmacology, University of Pennsylvania, Philadelphia, 19104, USA
    Psychiatr Genet 15:295-8. 2005
    ..We examined this polymorphism for association in our sample of 168 opioid-dependent patients and 122 ethnically and geographically matched controls...
  27. ncbi request reprint Association of a polymorphism in the Homer1 gene with cocaine dependence in an African American population
    John P Dahl
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Clinical Research Building, Philadelphia, 19104, USA
    Psychiatr Genet 15:277-83. 2005
    ..The purpose of this study is to determine whether single-nucleotide polymorphisms in the Homer1 and Homer2 genes associate with the cocaine-dependent phenotype in an African American population...
  28. ncbi request reprint Lack of association between variations in the melanocortin 5 receptor gene and bipolar disorder
    Falk W Lohoff
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, 19104 6140, USA
    Psychiatr Genet 15:255-8. 2005
    ..We tested the hypothesis that the potential functional variation Phe209Leu confers susceptibility to bipolar disorder in a case-control study...
  29. ncbi request reprint Confirmation of the association between a polymorphism in the promoter region of the prodynorphin gene and cocaine dependence
    John P Dahl
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Clinical Research Building, Philadelphia, PA 19104, USA
    Am J Med Genet B Neuropsychiatr Genet 139:106-8. 2005
    ....
  30. pmc Association between the catechol-O-methyltransferase Val158Met polymorphism and cocaine dependence
    Falk W Lohoff
    Department of Psychiatry, Translational Research Laboratories, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 33:3078-84. 2008
    ..Additional studies are required to elucidate the role of COMT in the pathophysiology of substance use disorders...
  31. pmc Variations in the vesicular monoamine transporter 1 gene (VMAT1/SLC18A1) are associated with bipolar i disorder
    Falk W Lohoff
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 31:2739-47. 2006
    ..Additional studies are necessary to confirm this effect and to elucidate the role of VMAT1 in central nervous system physiology...
  32. doi request reprint Association between polymorphisms in the vesicle-associated membrane protein-associated protein A (VAPA) gene on chromosome 18p and bipolar disorder
    Falk W Lohoff
    Department of Psychiatry, Translational Research Laboratories, University of Pennsylvania School of Medicine, Center for Neurobiology and Behavior, 125 South 31st Street, Room 2213, Philadelphia, PA 19104, USA
    J Neural Transm 115:1339-45. 2008
    ..Additional studies are necessary to confirm and elucidate the role of VAPA as a susceptibility gene for BPD on chromosome 18p...
  33. doi request reprint Association between polymorphisms in the vesicular monoamine transporter 1 gene (VMAT1/SLC18A1) on chromosome 8p and schizophrenia
    Falk W Lohoff
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychobiology 57:55-60. 2008
    ..Further studies are necessary to confirm this effect, and to elucidate the role of VMAT1 in central nervous system physiology and possible involvement in the genetic origins of SZ...
  34. doi request reprint Association analysis of the pituitary adenylate cyclase-activating polypeptide (PACAP/ADCYAP1) gene in bipolar disorder
    Falk W Lohoff
    Department of Psychiatry, Translational Research Laboratory, Center for Neurobiology and Behavior, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104 USA
    Psychiatr Genet 18:53-8. 2008
    ..Animal models of PACAP mutations show remarkable behavioral defects, including hyperactivity and increased exploratory behavior...
  35. doi request reprint Fine mapping of a major QTL influencing morphine preference in C57BL/6 and DBA/2 mice using congenic strains
    Glenn A Doyle
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 33:2801-9. 2008
    ..10 (which harbors Oprm1) between the acromere and Stxbp5, as well as on distal Chr. 6 between marker D6Mit10 and the telomere...
  36. pmc Association analysis between polymorphisms in the conserved dopamine neurotrophic factor (CDNF) gene and cocaine dependence
    Falk W Lohoff
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Neurosci Lett 453:199-203. 2009
    ..However, additional studies using larger sample sizes, comprehensive SNP coverage, and clinically homogenous populations are necessary before confidently excluding CDNF as a significant genetic risk factor for cocaine dependence...
  37. ncbi request reprint Quantitative trait locus for seizure susceptibility on mouse chromosome 5 confirmed with reciprocal congenic strains
    Thomas N Ferraro
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104 3404, USA
    Physiol Genomics 31:458-62. 2007
    ....
  38. pmc Identification of five mouse mu-opioid receptor (MOR) gene (Oprm1) splice variants containing a newly identified alternatively spliced exon
    Glenn A Doyle
    The Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States
    Gene 395:98-107. 2007
    ..These exon 19-containing splice variants add to the growing complexity of the mouse Oprm1 gene...
  39. ncbi request reprint Analysis of a quantitative trait locus for seizure susceptibility in mice using bacterial artificial chromosome-mediated gene transfer
    Thomas N Ferraro
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104 3404, USA
    Epilepsia 48:1667-77. 2007
    ....
  40. ncbi request reprint No association between polymorphisms in the prostate apoptosis factor-4 gene and cocaine dependence
    Andrew E Weller
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Psychiatr Genet 16:193-6. 2006
    ..The aim of this study is to investigate whether polymorphisms in the human Par-4 gene contribute to the etiology of cocaine dependence...
  41. ncbi request reprint Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia
    Chang Gyu Hahn
    Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Med 12:824-8. 2006
    ..Therefore, these findings suggest that enhanced NRG1 signaling may contribute to NMDA hypofunction in schizophrenia...
  42. ncbi request reprint Lack of association between single nucleotide polymorphisms in the corticotropin releasing hormone receptor 1 (CRHR1) gene and alcohol dependence
    John P Dahl
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Psychiatr Res 39:475-9. 2005
    ..The results of this study suggest that polymorphisms in the CRHR 1 gene are not major risk factors for the development of alcohol dependence in persons of European ancestry...
  43. ncbi request reprint Mouse strain variation in maximal electroshock seizure threshold
    Thomas N Ferraro
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, 415 Curie Blvd, Philadelphia, PA 19104 6140, USA
    Brain Res 936:82-6. 2002
    ..We conclude that MEST represents a useful tool for dissecting the multifactorial nature of seizure sensitivity in mice...
  44. ncbi request reprint Fine mapping of a seizure susceptibility locus on mouse Chromosome 1: nomination of Kcnj10 as a causative gene
    Thomas N Ferraro
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Mamm Genome 15:239-51. 2004
    ..The critical interval contains several candidate genes, one of which, Kcnj10, exhibits a potentially important polymorphism with regard to fundamental aspects of seizure susceptibility...
  45. ncbi request reprint Confirmation of a major QTL influencing oral morphine intake in C57 and DBA mice using reciprocal congenic strains
    Thomas N Ferraro
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia, PA 19104 6140, USA
    Neuropsychopharmacology 30:742-6. 2005
    ..B6-Mop2 mice. Overall, these data confirm the existence of a gene(s) on chromosome 10 proximal to D10Mit124 that has a strong influence on the difference in morphine drinking behavior between B6 and D2 mice...
  46. ncbi request reprint Novel exonic mu-opioid receptor gene (OPRM1) polymorphisms not associated with opioid dependence
    Rachel J Smith
    Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Med Genet B Neuropsychiatr Genet 133:105-9. 2005
    ..The results indicate that polymorphisms in the novel splice variant are not associated with opioid dependence, but are in LD with other polymorphisms in OPRM1...
  47. ncbi request reprint Serotonin transporter polymorphisms and measures of impulsivity, aggression, and sensation seeking among African-American cocaine-dependent individuals
    Ashwin A Patkar
    Division of Substance Abuse Programs, Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Psychiatry Res 110:103-15. 2002
    ..The findings do not seem to support an association between these polymorphisms in the 5HTT gene and impulsive-aggressive traits among cocaine-dependent African-American individuals...
  48. ncbi request reprint No association between common variations in the human alpha 2 subunit gene (ATP1A2) of the sodium-potassium-transporting ATPase and idiopathic generalized epilepsy
    Falk W Lohoff
    Department of Psychiatry, University of Pennsylvania School of Medicine, Center for Neurobiology and Behavior, 3535 Market Street, 2nd Floor, R2070, Philadelphia, PA 19104, USA
    Neurosci Lett 382:33-8. 2005
    ..Linkage disequilibrium was demonstrated throughout the gene. Results suggest that the polymorphisms we studied in the ATP1A2 gene do not represent major susceptibility factors for common forms of IGE...
  49. pmc Genetic variants in the cocaine- and amphetamine-regulated transcript gene (CARTPT) and cocaine dependence
    Falk W Lohoff
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neurosci Lett 440:280-3. 2008
    ....
  50. ncbi request reprint Relationship between platelet serotonin uptake sites and measures of impulsivity, aggression, and craving among African-American cocaine abusers
    Ashwin A Patkar
    Division of Substance Abuse Programs, Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Am J Addict 12:432-47. 2003
    ..Our findings indicate that densities of serotonin uptake sites may be reduced among cocaine abusers and related to impulsive-aggressive behavioral dimensions...
  51. ncbi request reprint No association between common variations in the neuronal nicotinic acetylcholine receptor alpha2 subunit gene (CHRNA2) and bipolar I disorder
    Falk W Lohoff
    School of Medicine Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Clinical Research Building, Room 135a, 415 Curie Boulevard, Philadelphia, PA 19104 6140, USA
    Psychiatry Res 135:171-7. 2005
    ..Our results suggest that common variations in the CHRNA2 gene are unlikely to confer susceptibility to BPD in this sample. Further studies are required to elucidate the susceptibility locus for BPD on chromosome 8p21-22...
  52. ncbi request reprint Differences in platelet serotonin transporter sites between African-American tobacco smokers and non-smokers
    Ashwin A Patkar
    Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Psychopharmacology (Berl) 166:221-7. 2003
    ..Although nicotine and other constituents of tobacco smoke may influence serotonin turnover among animals, few studies have examined whether smoking is associated with alteration in 5HTT in humans...
  53. ncbi request reprint Lack of association between variations in the brain-derived neurotrophic factor (BDNF) gene and temporal lobe epilepsy
    Falk W Lohoff
    Department of Psychiatry, Center for Neurobiology and Behaviour, University of Pennsylvania School of Medicine, 3535 Market Street, 2nd Floor, R2070, Philadelphia, PA 19104, USA
    Epilepsy Res 66:59-62. 2005
    ..Results suggest that neither of the studied polymorphisms are strong susceptibility factors for TLE in this sample of individuals of European ancestry...
  54. ncbi request reprint Relationship of serum prolactin with severity of drug use and treatment outcome in cocaine dependence
    Ashwin A Patkar
    Department of Psychiatry and Human Behavior, Jefferson Medical College and Thomas Jefferson University Hospital, 33 South 9th Street, Suite 210E, Philadelphia, PA 19107, USA
    Psychopharmacology (Berl) 176:74-81. 2004
    ..Therefore, serum PRL may have a potential role as a biological marker of drug severity and treatment outcome in cocaine dependence...
  55. pmc Rare structural variants found in attention-deficit hyperactivity disorder are preferentially associated with neurodevelopmental genes
    J Elia
    Department of Child and Adolescent Psychiatry, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Mol Psychiatry 15:637-46. 2010
    ..Together, these results suggest that rare inherited structural variations play an important role in ADHD development and indicate a set of putative candidate genes for further study in the etiology of ADHD...
  56. ncbi request reprint Predicting treatment-outcome in cocaine dependence from admission urine drug screen and peripheral serotonergic measures
    Ashwin A Patkar
    Division of Substance Abuse Programs, Department of Psychiatry and Human Behavior, Thomas Jefferson University, 833 Chestnut Street East, Suite 210E, Philadelphia, PA 19107, USA
    J Subst Abuse Treat 23:33-40. 2002
    ..Although both admission UDS and paroxetine binding seem to contribute individually in predicting outcome of cocaine patients, a combination of the two variables seems to have a stronger effect in terms of predicting treatment-outcome...
  57. ncbi request reprint Seasonal variations in the binding of [3H]paroxetine to the platelet serotonin transporter sites in African-American cocaine-dependent patients and healthy volunteers
    Ashwin A Patkar
    Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Hum Psychopharmacol 18:103-11. 2003
    ..Biological studies that employ platelet serotonin transporter sites as a marker of serotonin function should consider seasonal variations in these markers as a potential source of variance...
  58. doi request reprint Variation in the genes encoding vesicular monoamine transporter 2 and beta-1 adrenergic receptor and antidepressant treatment outcome
    James J Crowley
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Psychiatr Genet 18:248-51. 2008
    ..These data do not rule out the possible involvement of SLC18A2 or ADRB1 in antidepressant treatment response as these genes may contribute a small effect size or interact epistatically with other genes...
  59. ncbi request reprint Alcohol use disorder comorbidity in eating disorders: a multicenter study
    Cynthia M Bulik
    Department of Psychiatry, University of North Carolina at Chapel Hill, 27599 7160, USA
    J Clin Psychiatry 65:1000-6. 2004
    ..Our aim was to explore the nature of the co-morbid relation between AUDs and eating disorders in a large and phenotypically well-characterized group of individuals...
  60. pmc Association study of 182 candidate genes in anorexia nervosa
    Andrea Poyastro Pinheiro
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7160, USA
    Am J Med Genet B Neuropsychiatr Genet 153:1070-80. 2010
    ....
  61. ncbi request reprint Serum prolactin and response to treatment among cocaine-dependent individuals
    Ashwin A Patkar
    Division of Substance Abuse Programs, Department of Psychiatry and Human Behavior, Jefferson Medical College and Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
    Addict Biol 7:45-53. 2002
    ..Moreover, higher prolactin seems to be related negatively with certain measures of response to treatment among cocaine patients...
  62. pmc Selection of eating-disorder phenotypes for linkage analysis
    Cynthia M Bulik
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Am J Med Genet B Neuropsychiatr Genet 139:81-7. 2005
    ..Linkage results appear in a subsequent report. Our report lays out a systematic roadmap for utilizing a rich set of phenotypes for genetic analyses, including the selection of linkage methods paired to those phenotypes...
  63. ncbi request reprint Targeting treatments for alcohol dependence: the pharmacogenetics of naltrexone
    David W Oslin
    University of Pennsylvania, Geriartric and Addiction Psychiatry, Philadelphia, PA 19104, USA
    Addict Biol 11:397-403. 2006
    ..This article reviews the biological correlates and outlines a scientific agenda for better understanding the role of opioid neurotransmission in the etiology, maintenance and treatment of alcohol dependence...
  64. ncbi request reprint Association analysis of CHMP1.5 genetic variation and bipolar disorder
    Leilah D McNabb
    Department of Pharmacology, University of Pennsylvania, Philadelphia, USA
    Psychiatr Genet 15:211-4. 2005
    ..We hypothesized that the linkage in this region might be due to a gene in close physical proximity to G-olf, and we examined variations in the CHMP1.5 gene within intron 5 of G-olf for association with bipolar disorder...
  65. ncbi request reprint Analysis of variations in the NAPG gene on chromosome 18p11 in bipolar disorder
    Andrew E Weller
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Psychiatr Genet 16:3-8. 2006
    ..The purpose of this study is to investigate whether polymorphisms in the human NAPG gene contribute to the etiology of bipolar disorder...
  66. ncbi request reprint Relationship between platelet serotonin uptake sites and treatment outcome among African-American cocaine dependent individuals
    Ashwin A Patkar
    Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Addict Dis 22:79-92. 2003
    ..The findings indicate that serotonergic mechanisms may be involved in cocaine dependence and may influence treatment-outcome among cocaine patients...
  67. doi request reprint Assessment of circadian function in fibroblasts of patients with bipolar disorder
    S Yang
    Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104 6141, USA
    Mol Psychiatry 14:143-55. 2009
    ....
  68. pmc Significant linkage on chromosome 10p in families with bulimia nervosa
    Cynthia M Bulik
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Am J Hum Genet 72:200-7. 2003
    ..92 and 3.39, meet the widely accepted criterion for genomewide significance. Another region on 14q meets the criterion for genomewide suggestive linkage, with MLSs of 1.97 (full sample) and 1.75 (subset) at 62 centimorgans from p-ter...
  69. ncbi request reprint Linkage analysis of anorexia nervosa incorporating behavioral covariates
    Bernie Devlin
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213 2593, USA
    Hum Mol Genet 11:689-96. 2002
    ..50, P = 0.00035). By comparing our results to those implemented using more standard linkage methods, we find the covariates convey substantial information for the linkage analysis...
  70. ncbi request reprint Patterns of menstrual disturbance in eating disorders
    Andréa Poyastro Pinheiro
    Department of Psychiatry, University of North Carolina at Chapel Hill, North Carolina 27599 7160, USA
    Int J Eat Disord 40:424-34. 2007
    ..To describe menstrual disturbance in eating disorders (ED)...
  71. doi request reprint Familial aggregation of postpartum mood symptoms in bipolar disorder pedigrees
    Jennifer L Payne
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Bipolar Disord 10:38-44. 2008
    ..We sought to determine if postpartum mood symptoms and depressive episodes exhibit familial aggregation in bipolar I pedigrees...
  72. doi request reprint Suicide attempts in anorexia nervosa
    Cynthia M Bulik
    Department of Psychiatry, University of North Carolina at Chapel Hill, 101 Manning Drive, CB 7160, Chapel Hill, NC 27599 7160, USA
    Psychosom Med 70:378-83. 2008
    ..To explore prevalence and patterns of suicidal attempts in persons with anorexia nervosa (AN)...
  73. ncbi request reprint Genetic analysis of bulimia nervosa: methods and sample description
    Walter H Kaye
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Int J Eat Disord 35:556-70. 2004
    ..The current study presents the clinical characteristics of this sample as well as a description of the study methodology...
  74. ncbi request reprint Symptom fluctuation in eating disorders: correlates of diagnostic crossover
    Federica Tozzi
    Department of Psychiatry, CB 7160, University of North Carolina at Chapel Hill, Neurosciences Hospital, Chapel Hill, NC 27599 7160l, USA
    Am J Psychiatry 162:732-40. 2005
    ..The authors identified factors that are associated with crossover from anorexia nervosa to bulimia nervosa and from bulimia nervosa to anorexia nervosa...
  75. pmc Linkage analysis of anorexia and bulimia nervosa cohorts using selected behavioral phenotypes as quantitative traits or covariates
    Silviu Alin Bacanu
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213 2593, USA
    Am J Med Genet B Neuropsychiatr Genet 139:61-8. 2005
    ..3); for covariate-based linkage analysis, five suggestive signals (for BMI at 4q13.1, for CM at 11p11.2 and 17q25.1, and for OBF at 17q25.1 and 15q26.2). Overlap between the two cohorts was minimal for substantial linkage signals...
  76. ncbi request reprint No evidence for a major role of polymorphisms during bupropion treatment
    Jianfang Hu
    Department of Biostatistics, Section on Statistical Genetics, Ryals Public Health Building, Suite 327, University of Alabama at Birmingham, 1665 University Boulevard, Birmingham, AL 35294, USA
    Obesity (Silver Spring) 14:1863-7. 2006
    ..Overall, our results do not support a major role for these five candidate genes in weight gain after smoking cessation...
  77. ncbi request reprint Pharmacogenetics and nicotine addiction treatment
    Marcus R Munafo
    University of Bristol, Department of Experimental Psychology, Bristol BS8 ITN, UK
    Pharmacogenomics 6:211-23. 2005
    ....
  78. ncbi request reprint Association of multiple DRD2 polymorphisms with anorexia nervosa
    Andrew W Bergen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7236, USA
    Neuropsychopharmacology 30:1703-10. 2005
    ..Genetically transmitted variation in D2 dopamine receptor expression mediated by functional polymorphisms affecting transcription and translation efficiency may play a role in vulnerability to AN...
  79. ncbi request reprint Polymorphism in the serotonin transporter gene and moderators of prolactin response to meta-chlorophenylpiperazine in African-American cocaine abusers and controls
    Paolo Mannelli
    Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA
    Psychiatry Res 144:99-108. 2006
    ....
  80. ncbi request reprint Loci on chromosomes 6q and 6p interact to increase susceptibility to bipolar affective disorder in the national institute of mental health genetics initiative pedigrees
    Thomas G Schulze
    Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, Bethesda, USA
    Biol Psychiatry 56:18-23. 2004
    ....
  81. ncbi request reprint Mood-incongruent psychotic features in bipolar disorder: familial aggregation and suggestive linkage to 2p11-q14 and 13q21-33
    Fernando S Goes
    Johns Hopkins Hospital, 600 North Wolfe St, Meyer 4 119, Baltimore, MD 21287 7419, USA
    Am J Psychiatry 164:236-47. 2007
    ..This study attempts to characterize clinical correlates, familial aggregation, and genetic linkage in subjects with these features...
  82. ncbi request reprint Application of a latent class analysis to empirically define eating disorder phenotypes
    Pamela K Keel
    Department of Psychology, Harvard University, Cambridge, MA, USA
    Arch Gen Psychiatry 61:192-200. 2004
    ..Diagnostic criteria for eating disorders influence how we recognize, research, and treat eating disorders, and empirically valid phenotypes are required for revealing their genetic bases...
  83. ncbi request reprint Personality, perfectionism, and attitudes toward eating in parents of individuals with eating disorders
    D Blake Woodside
    Department of Psychiatry, Toronto General Hospital, Toronto, Ontario, Canada
    Int J Eat Disord 31:290-9. 2002
    ..This study compares personality and eating-related traits in parents of probands with eating disorders, with age-band matched healthy normal controls...

Research Grants21

  1. QUANTITATIVE GENETICS OF OPIATE ADDICTION
    Wade Berrettini; Fiscal Year: 2004
    ..This may enhance our knowledge of genetic susceptibility to opioid dependence in human populations. ..
  2. Genetics of Anorexia Nervosa
    Wade Berrettini; Fiscal Year: 2005
    ..The diagnostic and genetic data and lymphoblastoid cell lines (derived from blood samples) will become part of a national archival resource for genetic studies of AN through the NIMH Genetics Initiative. ..
  3. A COLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDER
    Wade Berrettini; Fiscal Year: 2007
    ..Analysis of the existing sib pair families plus this large set of cases and controls should permit the confirmation of several vulnerability genes during this grant period. ..
  4. Genetics of Nicotine Dependence
    Wade Berrettini; Fiscal Year: 2009
    ..These binding proteins are involved in the development of nicotine addiction. Understanding the function consequences of these DNA variations will provide direction in developing new medications for nicotine addiction. ..
  5. A Neuropeptide Gene in Psychiatric Illness
    Wade Berrettini; Fiscal Year: 2004
    ..We have assembled sets (n>600) of parent-child trios for both SZ and BPD to test the hypothesis that variation in this gene increases risks for these disorders. These studies may identify a susceptibility gene for SZ and/or BPD. ..
  6. COLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDER
    Wade Berrettini; Fiscal Year: 2001
    ..Genotypes will be shared with a consortium of investigators studying linkage in bipolar illness. Cell lines and interview data will be made freely available to the scientific community. ..
  7. Genetics of Nicotine Dependence
    Wade H Berrettini; Fiscal Year: 2010
    ..These binding proteins are involved in the development of nicotine addiction. Understanding the function consequences of these DNA variations will provide direction in developing new medications for nicotine addiction. ..