PAUL STEVEN BERNSTEIN

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. pmc Vertebrate and invertebrate carotenoid-binding proteins
    Prakash Bhosale
    Department of Ophthalmology and Visual Sciences, 65 Medical Drive, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Arch Biochem Biophys 458:121-7. 2007
  2. pmc Blue-light reflectance imaging of macular pigment in infants and children
    Paul S Bernstein
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Invest Ophthalmol Vis Sci 54:4034-40. 2013
  3. pmc Macular pigment imaging in AREDS2 participants: an ancillary study of AREDS2 subjects enrolled at the Moran Eye Center
    Paul S Bernstein
    Moran Eye Center, University of Utah School of Medicine, 65 Mario Capecchi Drive, Salt Lake City, UT 84132, USA
    Invest Ophthalmol Vis Sci 53:6178-86. 2012
  4. pmc Macular and serum carotenoid concentrations in patients with malabsorption syndromes
    Matthew S Ward
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, 65 Mario Capecchi Drive, Salt Lake City, Utah 84132 USA
    J Ocul Biol Dis Infor 1:12-8. 2008
  5. ncbi request reprint Discordant retinitis pigmentosa in monozygotic twins
    Paul S Bernstein
    Moran Eye Center, University of Utah School of Medicine, Salt Lake City 84132, USA
    Arch Ophthalmol 121:1059-62. 2003
  6. ncbi request reprint Resonance Raman measurement of macular carotenoids in the living human eye
    Paul S Bernstein
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, USA
    Arch Biochem Biophys 430:163-9. 2004
  7. ncbi request reprint Optical coherence tomography before and after repair of a macular hole induced by an unintentional argon laser burn
    Paul S Bernstein
    Moran Eye Center, University of Utah School of Medicine, Salt Lake City 84132, USA
    Arch Ophthalmol 123:404-5. 2005
  8. doi request reprint Verteporfin photodynamic therapy involving the optic nerve for peripapillary choroidal neovascularization
    Paul S Bernstein
    Moran Eye Center, University of Utah, Salt Lake City, USA
    Retina 28:81-4. 2008
  9. ncbi request reprint Retinal toxicity associated with occupational exposure to the fish anesthetic MS-222
    P S Bernstein
    Moran Eye Center, University of Utah School of Medicine, Salt Lake City 84132, USA
    Am J Ophthalmol 124:843-4. 1997
  10. pmc The value of measurement of macular carotenoid pigment optical densities and distributions in age-related macular degeneration and other retinal disorders
    Paul S Bernstein
    Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT, USA
    Vision Res 50:716-28. 2010

Collaborators

Detail Information

Publications55

  1. pmc Vertebrate and invertebrate carotenoid-binding proteins
    Prakash Bhosale
    Department of Ophthalmology and Visual Sciences, 65 Medical Drive, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Arch Biochem Biophys 458:121-7. 2007
    ....
  2. pmc Blue-light reflectance imaging of macular pigment in infants and children
    Paul S Bernstein
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Invest Ophthalmol Vis Sci 54:4034-40. 2013
    ..We therefore developed a protocol using a digital video fundus camera (RetCam) to measure macular pigment optical density (MPOD) and distributions in premature infants and in children...
  3. pmc Macular pigment imaging in AREDS2 participants: an ancillary study of AREDS2 subjects enrolled at the Moran Eye Center
    Paul S Bernstein
    Moran Eye Center, University of Utah School of Medicine, 65 Mario Capecchi Drive, Salt Lake City, UT 84132, USA
    Invest Ophthalmol Vis Sci 53:6178-86. 2012
    ....
  4. pmc Macular and serum carotenoid concentrations in patients with malabsorption syndromes
    Matthew S Ward
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, 65 Mario Capecchi Drive, Salt Lake City, Utah 84132 USA
    J Ocul Biol Dis Infor 1:12-8. 2008
    ..001). Malabsorption was not associated with decreased serum carotenoid levels. Convincing signs of early maculopathy were not observed. We conclude that intestinal malabsorption results in lower macular carotenoid levels...
  5. ncbi request reprint Discordant retinitis pigmentosa in monozygotic twins
    Paul S Bernstein
    Moran Eye Center, University of Utah School of Medicine, Salt Lake City 84132, USA
    Arch Ophthalmol 121:1059-62. 2003
  6. ncbi request reprint Resonance Raman measurement of macular carotenoids in the living human eye
    Paul S Bernstein
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, USA
    Arch Biochem Biophys 430:163-9. 2004
    ..We have recently extended this technology to an imaging mode which will further enhance our understanding of the roles of lutein and zeaxanthin in normal macular function and in the prevention of age-related visual loss...
  7. ncbi request reprint Optical coherence tomography before and after repair of a macular hole induced by an unintentional argon laser burn
    Paul S Bernstein
    Moran Eye Center, University of Utah School of Medicine, Salt Lake City 84132, USA
    Arch Ophthalmol 123:404-5. 2005
  8. doi request reprint Verteporfin photodynamic therapy involving the optic nerve for peripapillary choroidal neovascularization
    Paul S Bernstein
    Moran Eye Center, University of Utah, Salt Lake City, USA
    Retina 28:81-4. 2008
    ..To report the outcome of consecutive patients treated with verteporfin photodynamic therapy in which the treatment zone overlapped the optic nerve...
  9. ncbi request reprint Retinal toxicity associated with occupational exposure to the fish anesthetic MS-222
    P S Bernstein
    Moran Eye Center, University of Utah School of Medicine, Salt Lake City 84132, USA
    Am J Ophthalmol 124:843-4. 1997
    ..To report a case of retinopathy associated with chronic occupational exposure to ethyl-m-aminobenzoic acid methanesulfonate (MS-222), a retinotoxic fish anesthetic...
  10. pmc The value of measurement of macular carotenoid pigment optical densities and distributions in age-related macular degeneration and other retinal disorders
    Paul S Bernstein
    Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT, USA
    Vision Res 50:716-28. 2010
    ....
  11. ncbi request reprint Identification and quantitation of carotenoids and their metabolites in the tissues of the human eye
    P S Bernstein
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Exp Eye Res 72:215-23. 2001
    ..This report lends further support for the critical role of lutein, zeaxanthin, and other ocular carotenoids in protecting the eye from light-induced oxidative damage and aging...
  12. ncbi request reprint Measurement of carotenoids in the living primate eye using resonance Raman spectroscopy
    Paul S Bernstein
    Department of Ophthalmology, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT, USA
    Methods Mol Biol 196:321-9. 2002
  13. ncbi request reprint A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration
    Zhenglin Yang
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Science 314:992-3. 2006
    ..We also found that drusen in the eyes of AMD patients were strongly immunolabeled with HTRA1 antibody. Together, these findings support a key role for HTRA1 in AMD susceptibility and identify a potential new pathway for AMD pathogenesis...
  14. ncbi request reprint HTRA1 variant confers similar risks to geographic atrophy and neovascular age-related macular degeneration
    D Joshua Cameron
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Cell Cycle 6:1122-5. 2007
    ..These findings expand the role of HTRA1 in AMD. Understanding the underlying molecular mechanism will provide an important insight in pathogenesis of AMD...
  15. pmc Identification and metabolic transformations of carotenoids in ocular tissues of the Japanese quail Coturnix japonica
    Prakash Bhosale
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, 65 Medical Drive, Salt Lake City, Utah 84132, USA
    Biochemistry 46:9050-7. 2007
    ..Studies also revealed that the pharmacokinetic patterns of uptake, carotenoid absorption, and transport from serum into ocular tissues were similar to results observed in most human clinical studies...
  16. ncbi request reprint Resonance Raman measurement of macular carotenoids in retinal, choroidal, and macular dystrophies
    Da You Zhao
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City 84132, USA
    Arch Ophthalmol 121:967-72. 2003
    ..It has been hypothesized that the macular carotenoid pigments lutein and zeaxanthin may protect against macular and retinal degenerations and dystrophies...
  17. pmc Macular pigment Raman detector for clinical applications
    Igor Ermakov
    Department of Physics and Dixon Laser Institute, University of Utah, Salt Lake City, UT 84112, USA
    J Biomed Opt 9:139-48. 2004
    ....
  18. ncbi request reprint Identification and characterization of a Pi isoform of glutathione S-transferase (GSTP1) as a zeaxanthin-binding protein in the macula of the human eye
    Prakash Bhosale
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    J Biol Chem 279:49447-54. 2004
    ..These results indicate that GSTP1 is a specific XBP in human macula that interacts with (3R,3'S-meso)-zeaxanthin and dietary (3R,3'R)-zeaxanthin in contrast to apparently weaker interactions with (3R,3'R,6'R)-lutein...
  19. ncbi request reprint HPLC measurement of ocular carotenoid levels in human donor eyes in the lutein supplementation era
    Prakash Bhosale
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    Invest Ophthalmol Vis Sci 48:543-9. 2007
    ....
  20. ncbi request reprint Identification of 3-methoxyzeaxanthin as a novel age-related carotenoid metabolite in the human macula
    Prakash Bhosale
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Invest Ophthalmol Vis Sci 48:1435-40. 2007
    ..In addition to these two metabolites, there are still others that have not yet been identified. A highly sensitive HPLC-mass spectral method was used to identify and quantify a new xanthophyll metabolite that increases with age...
  21. doi request reprint 10q26 is associated with increased risk of age-related macular degeneration in the Utah population
    D Joshua Cameron
    Department of Ophthalmology and Visual Sciences, Moran Eye Center and Program in Human Molecular Biology and Genetics, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Adv Exp Med Biol 613:253-8. 2008
  22. ncbi request reprint Microbial xanthophylls
    Prakash Bhosale
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, 75 North Medical Drive, Salt Lake City, UT 84132, USA
    Appl Microbiol Biotechnol 68:445-55. 2005
    ..We also present a critical review of current research and technologies involved in promoting microbes as potential commercial sources for mass production...
  23. ncbi request reprint Retinol-binding protein and retinol analysis in cerebrospinal fluid and serum of patients with and without idiopathic intracranial hypertension
    Judith E A Warner
    Department of Ophthalmology and Visual Sciences, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    J Neuroophthalmol 27:258-62. 2007
    ..The goal of this study was to compare cerebrospinal fluid (CSF) and serum concentrations of retinol and retinol-binding protein (RBP) in subjects with and without IIH...
  24. ncbi request reprint Vitamin A in the cerebrospinal fluid of patients with and without idiopathic intracranial hypertension
    Judith E A Warner
    Department of Ophthalmology and Visual Sciences, John A Moran Eye Center, University of Utah Health Sciences Center, 50 North Medical Drive, Salt Lake City, UT 84132, USA
    Ann Neurol 52:647-50. 2002
    ..There was a significantly higher level of vitamin A in the cerebrospinal fluid of some patients with idiopathic intracranial hypertension. Vitamin A toxicity may play a role in the pathogenesis of idiopathic intracranial hypertension...
  25. ncbi request reprint Dietary modification and moderate antioxidant supplementation differentially affect serum carotenoids, antioxidant levels and markers of oxidative stress in older humans
    Jerusha L Nelson
    Division of Foods and Nutrition, University of Utah, Salt Lake City, UT 84115, USA
    J Nutr 133:3117-23. 2003
    ..The results suggest that both moderate antioxidant supplementation and a diet high in carotenoids elevate serum carotenoids and antioxidant levels in an older adult population, although with different specific effects...
  26. ncbi request reprint In vivo resonant Raman measurement of macular carotenoid pigments in the young and the aging human retina
    Werner Gellermann
    Department of Physics and Dixon Laser Institute, University of Utah, Salt Lake City 84112, USA
    J Opt Soc Am A Opt Image Sci Vis 19:1172-86. 2002
    ....
  27. pmc Resonance Raman measurement of macular carotenoids in normal subjects and in age-related macular degeneration patients
    Paul S Bernstein
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    Ophthalmology 109:1780-7. 2002
    ..We used a novel noninvasive objective method to quantify lutein and zeaxanthin in the human macula using resonance Raman spectroscopy and compared macular pigment levels in AMD and normal subjects...
  28. ncbi request reprint Noninvasive detection of macular pigments in the human eye
    Werner Gellermann
    Department of Physics and Dixon Laser Institute, University of Utah, Salt Lake City, Utah, USA
    J Biomed Opt 9:75-85. 2004
    ....
  29. ncbi request reprint Genotype-phenotype analysis of ABCR variants in macular degeneration probands and siblings
    Paul S Bernstein
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    Invest Ophthalmol Vis Sci 43:466-73. 2002
    ..This genetically related population provides a cohort of subjects with similar age and ethnic background for genotype-phenotype comparison to the original probands...
  30. ncbi request reprint Resonant Raman quantification of zeaxanthin production from Flavobacterium multivorum
    Prakash Bhosale
    Department of Ophthalmology and Visual Sciences, 50 North Medical Drive, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Biotechnol Lett 25:1007-11. 2003
    ..A striking correlation was observed between the carotenoid level as estimated by HPLC and by resonance Raman spectroscopy...
  31. ncbi request reprint Diagnostic & therapeutic challenges. Tamoxifen toxicity
    Paul S Bernstein
    University of Utah, Department of Ophthalmology, John A Moran Eye Center, Salt Lake City, Utah, USA
    Retina 27:982-8. 2007
  32. pmc Resonance Raman imaging of macular pigment distributions in the human retina
    Mohsen Sharifzadeh
    Department of Physics, University of Utah, Salt Lake City, Utah 84112, USA
    J Opt Soc Am A Opt Image Sci Vis 25:947-57. 2008
    ..RRI imaging can be carried out with undilated pupils and provides a highly molecule-specific diagnostic imaging approach for MP distributions in human subjects...
  33. ncbi request reprint Association of adipose and red blood cell lipids with severity of dominant Stargardt macular dystrophy (STGD3) secondary to an ELOVL4 mutation
    Amy F Hubbard
    Department of Foods and Nutrition, University of Utah, Salt Lake City, USA
    Arch Ophthalmol 124:257-63. 2006
    ..A mutation in the ELOVL4 gene is responsible for the macular dystrophy in this family, and its disease-causing mechanism may be its possible involvement in fatty acid elongation in the retina...
  34. ncbi request reprint Synergistic effects of zeaxanthin and its binding protein in the prevention of lipid membrane oxidation
    Prakash Bhosale
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, 50 North Medical Drive, Salt Lake City, UT 84132, USA
    Biochim Biophys Acta 1740:116-21. 2005
    ..Carotenoid degradation profiles indicated that the zeaxanthin diastereomers in association with GSTP1 were more resistant to degradation which may account for the synergistic antioxidant effects...
  35. pmc Nonmydriatic fluorescence-based quantitative imaging of human macular pigment distributions
    Mohsen Sharifzadeh
    Department of Physics, University of Utah, Salt Lake City, Utah 84112, USA
    J Opt Soc Am A Opt Image Sci Vis 23:2373-87. 2006
    ....
  36. ncbi request reprint Production of deuterated zeaxanthin by Flavobacterium multivorum and its detection by resonance Raman and mass spectrometric methods
    Prakash Bhosale
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, 50 North Medical Drive, Salt Lake City, UT 84132, USA
    Biotechnol Lett 27:1719-23. 2005
    ..HPLC/APCI-MS and HPLC/RRS were specific and sensitive with limits of detection of 2.5 pg and 50 ng, respectively...
  37. ncbi request reprint Quantitative measurement of 3'-oxolutein from human retina by normal-phase high-performance liquid chromatography coupled to atmospheric pressure chemical ionization mass spectrometry
    Prakash Bhosale
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Anal Biochem 345:296-301. 2005
    ..99, p < or = 0.001) linear working range was achieved between 5 and 7200 pg. The 3'-oxolutein contents from 8-mm punches of the central macula and peripheral retina were found to be 375+/-192 and 191+/-95 pg/tissue, respectively...
  38. doi request reprint Purification and partial characterization of a lutein-binding protein from human retina
    Prakash Bhosale
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    Biochemistry 48:4798-807. 2009
    ..Our results suggest that HR-LBP may facilitate lutein's localization to a region of the cell subject to considerable oxidative stress...
  39. ncbi request reprint Resonance Raman quantification of nutritionally important carotenoids in fruits, vegetables, and their juices in comparison to high-pressure liquid chromatography analysis
    Prakash Bhosale
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, 50 North Medical Drive, Salt Lake City, Utah 84132, USA
    J Agric Food Chem 52:3281-5. 2004
    ..A strong correlation was observed between the two methods when evaluating juices and when comparing different strains of intact tomatoes at the same stage of ripening...
  40. pmc Studies on the singlet oxygen scavenging mechanism of human macular pigment
    Binxing Li
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Arch Biochem Biophys 504:56-60. 2010
    ....
  41. ncbi request reprint Production of deuterated lutein by Chlorella protothecoides and its detection by mass spectrometric methods
    Prakash Bhosale
    Department of Ophthalmology and Visual Sciences, University of Utah School of Medicine, 50 North Medical Drive, Moran Eye Center, Salt Lake City, UT 84132, USA
    Biotechnol Lett 28:1371-5. 2006
    ..The rapidly growing microalga had much higher levels (58%) of deuterium substitution relative to previously reported (9-15%) natural sources of lutein...
  42. pmc Retinal carotenoids can attenuate formation of A2E in the retinal pigment epithelium
    Prakash Bhosale
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, 65 Mario Capecchi Drive, Salt Lake City, UT 84132, USA
    Arch Biochem Biophys 483:175-81. 2009
    ....
  43. ncbi request reprint Beta-carotene production by Flavobacterium multivorum in the presence of inorganic salts and urea
    Prakash Bhosale
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, 50 North Medical Drive, Salt Lake City, UT, 84132, USA
    J Ind Microbiol Biotechnol 31:565-71. 2004
    ..41 microg ml(-1) h(-1). It is possible that this organism could be an excellent commercial source of either beta-carotene or zeaxanthin, depending on initial culture conditions...
  44. ncbi request reprint Intravitreal injection of triamcinolone acetonide for macular edema due to retinitis pigmentosa and other retinal diseases
    Changguang Wang
    Moran Eye Center, Department of Ophthalmology and Visual Science, University of Utah, Salt Lake City, UT, USA
    Adv Exp Med Biol 572:309-14. 2006
  45. ncbi request reprint Evaluation of 4-methylpyrazole as a potential therapeutic dark adaptation inhibitor
    Cory Jurgensmeier
    Moran Eye Center, University of Utah, Salt Lake City, Utah 84132, USA
    Curr Eye Res 32:911-5. 2007
    ..To investigate whether 4-methylpyrazole (4-MP; fomepizole; Antizol), an alcohol dehydrogenase inhibitor that delays dark adaptation in laboratory animals, is a possible pharmaceutical agent for the treatment of Stargardt disease...
  46. pmc CFH Y402H confers similar risk of soft drusen and both forms of advanced AMD
    Kristinn P Magnusson
    deCODE Genetics, Reykjavik, Iceland
    PLoS Med 3:e5. 2006
    ..However, its impact on soft drusen, GA, or neovascular AMD--or the relationship between them--is unclear...
  47. ncbi request reprint Assessment of the validity of in vivo methods of measuring human macular pigment optical density
    Werner Gellermann
    Optom Vis Sci 83:254-5; author reply 256-9. 2006
  48. ncbi request reprint Photophysical properties of xanthophylls in carotenoproteins from human retinas
    Helena H Billsten
    Department of Chemical Physics, Lund University, Lund, Sweden
    Photochem Photobiol 78:138-45. 2003
    ..This effect is more pronounced for meso-zeaxanthin, suggesting a specific site of binding of this carotenoid to XBP...
  49. ncbi request reprint Transformations of selected carotenoids in plasma, liver, and ocular tissues of humans and in nonprimate animal models
    Frederick Khachik
    Department of Chemistry and Biochemistry, Joint Institute for Food Safety and Applied Nutrition JIFSAN, University of Maryland, College Park, Maryland 20742, USA
    Invest Ophthalmol Vis Sci 43:3383-92. 2002
    ..Similarly, to characterize the carotenoid profiles in the eye tissues, plasma, and liver of quails and frogs to determine whether these can serve as appropriate nonprimate animal models for metabolic studies...
  50. pmc Toll-like receptor 3 and geographic atrophy in age-related macular degeneration
    Zhenglin Yang
    Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Chengdu, China
    N Engl J Med 359:1456-63. 2008
    ..Advanced age-related macular degeneration consists of geographic atrophy and choroidal neovascularization. The specific genetic variants that predispose patients to geographic atrophy are largely unknown...
  51. pmc Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complications
    Zongzhong Tong
    Department of Ophthalmology and Visual Sciences, Eccles Institute of Human Genetics
    Proc Natl Acad Sci U S A 105:6998-7003. 2008
    ..These results suggest that rs1617640 in the EPO promoter is significantly associated with PDR and ESRD. This study identifies a disease risk-associated gene and potential pathway mediating severe diabetic microvascular complications...
  52. doi request reprint Macular carotenoid levels of normal subjects and age-related maculopathy patients in a Japanese population
    Akira Obana
    Department of Ophthalmology, Seirei Hamamatsu General Hospital, Hamamatsu, Japan
    Ophthalmology 115:147-57. 2008
    ..Macular carotenoid pigments composed of lutein and zeaxanthin are thought to affect the development of age-related maculopathy (ARM). Macular carotenoid levels were measured in normal Japanese subjects and Japanese patients with ARM...
  53. doi request reprint Transport and retinal capture of lutein and zeaxanthin with reference to age-related macular degeneration
    Edward Loane
    Macular Pigment Research Group, Waterford Institute of Technology, Waterford, Ireland
    Surv Ophthalmol 53:68-81. 2008
    ..This article reviews the literature germane to the mechanisms involved in the capture, accumulation and stabilization of lutein and zeaxanthin by the retina, and the processes involved in their transport in serum...
  54. doi request reprint Diagnostic and therapeutic challenges
    Michael J Davis
    Retina 28:520-4. 2008
  55. ncbi request reprint Chemistry, distribution, and metabolism of tomato carotenoids and their impact on human health
    Frederick Khachik
    Department of Chemistry and Biochemistry, Joint Institute for Food Safety and Applied Nutrition JIFSAN, University of Maryland, College Park, MD 20742, USA
    Exp Biol Med (Maywood) 227:845-51. 2002
    ..The possible role of lycopene and other dietary carotenoids in the prevention of age-related macular degeneration and other eye diseases is discussed...

Research Grants7

  1. BIOCHEMISTRY AND PHARMACOLOGY OF THE MACULAR CAROTENOIDS
    Paul Bernstein; Fiscal Year: 2004
    ..abstract_text> ..
  2. BIOCHEMISTRY AND PHARMACOLOGY OF THE MACULAR CAROTENOIDS
    Paul Bernstein; Fiscal Year: 2005
    ..abstract_text> ..
  3. BIOCHEMISTRY AND PHARMACOLOGY OF THE MACULAR CAROTENOIDS
    Paul Bernstein; Fiscal Year: 2006
    ..abstract_text> ..
  4. BIOCHEMISTRY AND PHARMACOLOGY OF THE MACULAR CAROTENOIDS
    Paul Bernstein; Fiscal Year: 2007
    ..This grant proposal will provide valuable insights into the physiology of the macular carotenoid pigments in the normal eye and a greater understanding of the alterations that may occur with aging and degenerative processes. ..
  5. BIOCHEMISTRY AND PHARMACOLOGY OF THE MACULAR CAROTENOIDS
    Paul Bernstein; Fiscal Year: 2009
    ..This grant proposal will provide valuable insights into the physiology of the macular carotenoid pigments in the normal eye and a greater understanding of the alterations that may occur with aging and degenerative processes. ..
  6. BIOCHEMISTRY AND PHARMACOLOGY OF THE MACULAR CAROTENOIDS
    PAUL STEVEN BERNSTEIN; Fiscal Year: 2010
    ..This grant proposal will provide valuable insights into the physiology of the macular carotenoid pigments in the normal eye and a greater understanding of the alterations that may occur with aging and degenerative processes. ..