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Genomes and GenesSpecies | Leslie BernsteinSummaryAffiliation: University of Southern California Country: USA Publications
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The risk of breast, endometrial and ovarian cancer in users of hormonal preparationsLeslie Bernstein
Department of Preventive Medicine, Keck School of Medicine and the Norris Comprehensive Cancer Center, University of Southern California, 90033, USA
Basic Clin Pharmacol Toxicol 98:288-96. 2006..As with oestrogen therapy, the impact of combined therapy on ovarian cancer risk is uncertain...- Ethnicity-related variation in breast cancer risk factorsLeslie Bernstein
Department of Preventive Medicine USC Norris Cancer Center, University of Southern California, Los Angeles, California 90033, USA
Cancer 97:222-9. 2003..Although risk factors may be similar for African-American and white women, differences in the prevalence of risk factors may explain the differences in patterns of incidence... - Lifetime recreational exercise activity and breast cancer risk among black women and white womenLeslie Bernstein
Department of Preventive Medicine, Keck School of Medicine, USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA
J Natl Cancer Inst 97:1671-9. 2005.... - Control recruitment in population-based case-control studiesLeslie Bernstein
Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA
Epidemiology 17:255-7. 2006 
Variations in sex hormone metabolism genes, postmenopausal hormone therapy and risk of endometrial cancerPedram Razavi
Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA
Int J Cancer 130:1629-38. 2012..Variations in CYP11A1 may modify the effect of ET use on risk of postmenopausal endometrial cancer; however, larger studies are needed to explore these findings further...- Oral contraceptives and postmenopausal hormones and risk of contralateral breast cancer among BRCA1 and BRCA2 mutation carriers and noncarriers: the WECARE StudyJane C Figueiredo
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Harlyne J Norris Cancer Research Tower, 1450 Biggy Street, Los Angeles, CA, 90033, USA
Breast Cancer Res Treat 120:175-83. 2010.... 
Effect of reproductive factors and oral contraceptives on breast cancer risk in BRCA1/2 mutation carriers and noncarriers: results from a population-based studyEunjung Lee
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Room 4407, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
Cancer Epidemiol Biomarkers Prev 17:3170-8. 2008..However, the effects of these factors in BRCA1 and BRCA2 mutation carriers are less clear...- Genetic variation in the progesterone receptor gene and risk of endometrial cancer: a haplotype-based approachEunjung Lee
Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90089, USA
Carcinogenesis 31:1392-9. 2010..We investigated whether genetic variation in PGR is also associated with endometrial cancer risk using a haplotype-based approach... - Reproductive factors and risk of contralateral breast cancer by BRCA1 and BRCA2 mutation status: results from the WECARE studyJenny N Poynter
Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA
Cancer Causes Control 21:839-46. 2010..In this study, we evaluated the association between these factors and CBC risk among BRCA1 and BRCA2 (BRCA1/2) mutation carriers and non-carriers... - Nonsteroidal anti-inflammatory drug use and breast cancer risk by stage and hormone receptor statusSarah F Marshall
Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
J Natl Cancer Inst 97:805-12. 2005..We investigated the association of NSAID use with risk of breast cancer in the California Teachers Study cohort, with special attention to risk of specific breast cancer subtypes and to type of NSAID used... - The association of polymorphisms in hormone metabolism pathway genes, menopausal hormone therapy, and breast cancer risk: a nested case-control study in the California Teachers Study cohortEunjung Lee
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
Breast Cancer Res 13:R37. 2011..It therefore seems plausible that variation in genes involved in metabolism of these hormones may affect breast cancer risk, and that these associations may vary depending on menopausal status and use of hormone therapy... - A genome-wide association study of breast cancer in women of African ancestryFang Chen
Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA
Hum Genet 132:39-48. 2013..Identification of novel risk variants for breast cancer in women of African ancestry will demand testing of a substantially larger set of markers from stage 1 in a larger replication sample... - Reproductive factors and risk of breast carcinoma in a study of white and African-American womenGiske Ursin
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
Cancer 101:353-62. 2004.... - Mammographic density and breast cancer in three ethnic groupsGiske Ursin
Department of Preventive Medicine, University of California Keck School of Medicine, Los Angeles, California 90089, USA
Cancer Epidemiol Biomarkers Prev 12:332-8. 2003..Furthermore, our findings suggest that mammographic density is as strong a predictor of risk for African-American and Asian-American women as for white women... - Does mammographic density reflect ethnic differences in breast cancer incidence rates?Zhengjia Chen
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
Am J Epidemiol 159:140-7. 2004..This study suggests that absolute but not percent mammographic density reflects the lower breast cancer incidence rates of Asian Americans in relation to those of African Americans and Whites... - Germ line variation at 8q24 and endometrial cancer riskVeronica Wendy Setiawan
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Harlyne Norris Research Tower, 1450 Biggy Street, Room 1504A, Los Angeles, CA 90033, USA
Cancer Epidemiol Biomarkers Prev 16:2166-8. 2007 - Risk factors for arm lymphedema following breast cancer diagnosis in Black women and White womenKathleen A Meeske
Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA
Breast Cancer Res Treat 113:383-91. 2009.... - Risk of contralateral breast cancer associated with common variants in BRCA1 and BRCA2: potential modifying effect of BRCA1/BRCA2 mutation carrier statusJane C Figueiredo
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Harlyne J Norris Cancer Research Tower, 1450 Biggy Street Room 1509J, Los Angeles, CA 90033, USA
Breast Cancer Res Treat 127:819-29. 2011..The association between common variants in BRCA1 and BRCA2 and risk of CBC may differ depending on BRCA1 and BRCA2 mutation carrier status... - Low-dose medical radiation exposure and breast cancer risk in women under age 50 years overall and by estrogen and progesterone receptor status: results from a case-control and a case-case comparisonHuiyan Ma
Institute for Health Promotion and Disease Prevention Research, Keck School of Medicine, University of Southern California, 1000 South Fremont Avenue, Unit 8, Alhambra, CA 91803, USA
Breast Cancer Res Treat 109:77-90. 2008..We found no effect modification by ER/PR status. In conclusion, our findings support the hypothesis that low-dose ionizing radiation, and particularly exposures during childhood, increase breast cancer risk... - Mitochondrial DNA G10398A variant is not associated with breast cancer in African-American womenVeronica Wendy Setiawan
Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA
Cancer Genet Cytogenet 181:16-9. 2008..18, 95% CI = 0.76-1.82, P = 0.46). Our results do not support the hypothesis that the mtDNA G10398A polymorphism is, as has previously been reported, a marker of breast cancer risk in African Americans... - An association between a common variant (G972R) in the IRS-1 gene and sex hormone levels in post-menopausal breast cancer survivorsJing Fan
Integrated Substance Abuse Programs, Neuropsychiatric Institute, University of California, 1640 S Sepulveda Boulevard, Suite 200, Los Angeles, CA 90025, USA
Breast Cancer Res Treat 99:323-31. 2006..02). No association was present for white patients. Our findings provide suggestive evidence that IRS-1 G972R variant may be associated with circulating levels of sex hormones and SHBG in African American breast cancer survivors... - Long-term recreational physical activity and risk of invasive and in situ breast cancer: the California teachers studyCher M Dallal
Keck School of Medicine and USC Norris Cancer Center, University of Southern California, Los Angeles, USA
Arch Intern Med 167:408-15. 2007..Long-term physical activity may affect breast cancer risk. Few prospective studies have evaluated in situ or invasive breast cancer risk, or breast cancer receptor subtypes, in relation to long-term activity... - Oral contraceptives, postmenopausal hormones, and risk of asynchronous bilateral breast cancer: the WECARE Study GroupJane C Figueiredo
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
J Clin Oncol 26:1411-8. 2008..To investigate whether oral contraceptive (OC) use and postmenopausal hormones (PMH) are associated with an increased risk of developing asynchronous bilateral breast cancer among women diagnosed with breast cancer younger than 55 years... - Adenomyosis and endometriosis in the California Teachers StudyClaire Templeman
Department of Obstetrics and Gynecology, University of Southern California Keck School of Medicine, Los Angeles, California, USA
Fertil Steril 90:415-24. 2008..To evaluate the reproductive and lifestyle correlates of a surgically confirmed diagnosis of endometriosis or adenomyosis in a large prospective cohort... - Age-specific effects of hormone therapy use on overall mortality and ischemic heart disease mortality among women in the California Teachers StudyDaniel O Stram
Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA
Menopause 18:253-61. 2011..The California Teachers Study questionnaire and mortality data were used to examine whether age modified the association between HT and the relative risk of overall mortality and ischemic heart disease deaths... - Reproductive factors and breast cancer risk according to joint estrogen and progesterone receptor status: a meta-analysis of epidemiological studiesHuiyan Ma
Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue 4407, Los Angeles, CA 90089, USA
Breast Cancer Res 8:R43. 2006..This report presents the first meta-analysis of results from epidemiological studies that have investigated parity, age at first birth, breastfeeding, and age at menarche in relation to ER+PR+ and ER-PR- cancer risk... - Fatigue in breast cancer survivors two to five years post diagnosis: a HEAL Study reportKathleen Meeske
Department of Preventive Medicine, Keck School of Medicine of University of Southern California, USC Norris Comprehensive Cancer Center, 1444 Eastlake Avenue, Room 4449, Los Angeles, CA 90033, USA
Qual Life Res 16:947-60. 2007.... - Premature carotid artery disease in pediatric cancer survivors treated with neck irradiationKathleen A Meeske
Department of Pediatrics, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA
Pediatr Blood Cancer 53:615-21. 2009..The purpose of this study is to determine if carotid disease is more prevalent among pediatric cancer survivors treated with neck irradiation than among healthy controls... - Long-term postmenopausal hormone therapy and endometrial cancerPedram Razavi
University of Southern California, Department of Preventive Medicine, Norris Comprehensive Cancer Center, Los Angeles, California, USA
Cancer Epidemiol Biomarkers Prev 19:475-83. 2010..These findings confirm that long-term use of ET, sequential EPT, or, among normal weight women, continuous-combined EPT is associated with increased risk of endometrial cancer... - Evaluation of unclassified variants in the breast cancer susceptibility genes BRCA1 and BRCA2 using five methods: results from a population-based study of young breast cancer patientsEunjung Lee
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, USC Norris Comprehensive Cancer Center, Los Angeles, CA 90089 9175, USA
Breast Cancer Res 10:R19. 2008.... - Serum organochlorines and breast cancer: a case-control study among African-American womenNicole M Gatto
Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, USC Norris Comprehensive Center, 1441 Eastlake Avenue, Room 4449, Los Angeles, CA 90033, USA
Cancer Causes Control 18:29-39. 2007..This study, the largest study of African-American women to date, does not support a role of DDE and total PCBs in breast cancer risk at the levels measured... - Validating California teachers study self-reports of recent hospitalization: comparison with California hospital discharge dataSarah F Marshall
Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Am J Epidemiol 158:1012-20. 2003..The combination of self-reports and secondary medical records provides more accurate and complete morbidity data than does use of either source alone... - Diabetes and risk of esophageal and gastric adenocarcinomasXuejuan Jiang
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90089 9175, USA
Int J Cancer 131:1417-22. 2012..Our study further investigated the association between diabetes and adenocarcinomas of the esophagus and distal stomach... - Age at last birth in relation to risk of endometrial cancer: pooled analysis in the epidemiology of endometrial cancer consortiumVeronica Wendy Setiawan
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Am J Epidemiol 176:269-78. 2012..In this large pooled analysis, late age at last birth was independently associated with a reduced risk of endometrial cancer, and the reduced risk persisted for many years... - Hormone-related risk factors for breast cancer in women under age 50 years by estrogen and progesterone receptor status: results from a case-control and a case-case comparisonHuiyan Ma
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, USC Norris Comprehensive Cancer Center, Los Angeles, California 90089 9175, USA
Breast Cancer Res 8:R39. 2006..It has been suggested that hormonal risk factors act predominantly on estrogen receptor and progesterone receptor (ER/PR)-positive breast cancers. However, the data have been inconsistent, especially in younger women... - Diagnostic evaluation of HER-2 as a molecular target: an assessment of accuracy and reproducibility of laboratory testing in large, prospective, randomized clinical trialsMichael F Press
Women's Cancers Program, Department of Pathology, Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 89195, USA
Clin Cancer Res 11:6598-607. 2005.... - The role of established breast cancer susceptibility loci in mammographic density in young womenEunjung Lee
Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
Cancer Epidemiol Biomarkers Prev 17:258-60. 2008 - Breast cancer risk and ovariectomy, hysterectomy, and tubal sterilization in the women's contraceptive and reproductive experiences studyDavid J Press
Department of Preventive Medicine, Keck School of Medicine, and Norris Comprehensive Can cer Center, University of Southern California, Los Angeles, California, USA
Am J Epidemiol 173:38-47. 2011..No association with breast cancer risk was observed with tubal sterilization only or partial ovariectomy without hysterectomy. Reproductive organ surgeries may alter ovarian hormone levels, thereby affecting breast cancer risk... - Risk factors for surgically removed fibroids in a large cohort of teachersClaire Templeman
Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
Fertil Steril 92:1436-46. 2009..To describe reproductive and lifestyle correlates of surgically confirmed fibroids... - Menopausal hormone therapy and subsequent risk of specific invasive breast cancer subtypes in the California Teachers StudyTanmai Saxena
Department of Preventive Medicine, Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California, USA
Cancer Epidemiol Biomarkers Prev 19:2366-78. 2010.... - Lower risk in parous women suggests that hormonal factors are important in bladder cancer etiologyCarol A Davis-Dao
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Cancer Epidemiol Biomarkers Prev 20:1156-70. 2011..Our objective was to determine whether hormonal and reproductive factors are involved in female bladder cancer... - Cigarette smoking is not associated with breast cancer risk in young womenJennifer Prescott
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
Cancer Epidemiol Biomarkers Prev 16:620-2. 2007 - Hiatal hernia, reflux symptoms, body size, and risk of esophageal and gastric adenocarcinomaAnna H Wu
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, MC 9175, Los Angeles, CA 90089 9175, USA
Cancer 98:940-8. 2003..Since the 1970s, incidence rates of esophageal and gastric cardia adenocarcinoma have risen substantially. Reasons for the increasing trends are not well understood... - A variant in the cytochrome p450 oxidoreductase gene is associated with breast cancer risk in African AmericansChristopher A Haiman
Departments of Preventive Medicine and Pathology, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
Cancer Res 67:3565-8. 2007..03) and stronger in those with advanced disease (411 cases and 877 controls; OR, 2.60; 95% CI, 1.56-4.34; P = 0.0002). These data suggest that African Americans harbor an allele at the POR locus that may increase breast cancer risk... - Fiber intake and risk of adenocarcinomas of the esophagus and stomachAnna H Wu
Department of Preventive Medicine, University of Southern California, Keck School of Medicine, 1441 Eastlake Avenue, MS 44, Los Angeles, CA 90089 9175, USA
Cancer Causes Control 18:713-22. 2007..Since the 1970s, incidence rates for esophageal and gastric cardia adenocarcinomas have risen substantially for reasons that are not well understood. We sought to determine the role of dietary factors in these tumor types... - Physical activity and sex hormone levels in estradiol- and placebo-treated postmenopausal womenFarzana Choudhury
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Menopause 18:1079-86. 2011..The crucial yet complex relationship between physical activity and physiologic and pharmacologic sex hormone levels in postmenopausal women has not been investigated sufficiently... - Interleukin-6-related genotypes, body mass index, and risk of multiple myeloma and plasmacytomaWendy Cozen
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, MC 9175, Los Angeles, CA 90089 9175, USA
Cancer Epidemiol Biomarkers Prev 15:2285-91. 2006..These results suggest that IL-6 promoter genotypes may be associated with increased risk of plasma cell neoplasms... - Risk patterns of multiple myeloma in Los Angeles County, 1972-1999 (United States)Mulugeta Gebregziabher
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089-9175, USA
Cancer Causes Control 17:931-8. 2006..86, 95% confidence interval [CI] = 0.74-0.99]. Jews had an 11% higher risk compared to Protestants (OR = 1.11; 95% CI = 0.99-1.24). CONCLUSION: Risk patterns suggest a role for both environmental and genetic factors... - Physical activity and breast cancer risk among Asian-American women in Los Angeles: a case-control studyDongyun Yang
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
Cancer 97:2565-75. 2003..CONCLUSIONS: The findings of the current study provide further support for the finding that physical activity has a protective role in breast cancer... - A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancerChristopher A Haiman
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, USA
Nat Genet 43:1210-4. 2011..25, P = 1.1 × 10(-9)), particularly in younger women (<50 years of age) (OR = 1.48, P = 1.9 × 10(-9)). Our results identify a genetic locus associated with estrogen receptor negative breast cancer subtypes in multiple populations... - Alteration of topoisomerase II-alpha gene in human breast cancer: association with responsiveness to anthracycline-based chemotherapyMichael F Press
Norris Comprehensive Cancer Center, University of Southern California, CA, USA
J Clin Oncol 29:859-67. 2011..This study was designed to evaluate whether TOP2A gene alterations may predict incremental responsiveness to anthracyclines in some breast cancers... - Occupational physical activity and risk of adenocarcinomas of the esophagus and stomachCheryl Vigen
Department of Preventive Medicine, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089-9175, USA
Int J Cancer 118:1004-9. 2006..Future studies with more complete information on occupational and recreational physical activity are needed to confirm and further investigate the suggested protective effect of physical activity on these tumor types... - A proposed explanation for female predominance in alveolar soft part sarcoma. Noninactivation of X; autosome translocation fusion gene?Xiangdong Bu
Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Cancer 103:1245-53. 2005..Because females have an extra X-chromosome, their likelihood of developing an X;autosome translocation is theoretically double that of males, and thus, this extra X-chromosome is a likely explanation for female predominance of ASPS... - A genome-wide scan for breast cancer risk haplotypes among African American womenChi Song
Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA
PLoS ONE 8:e57298. 2013.... - Characteristics of triple-negative breast cancer in patients with a BRCA1 mutation: results from a population-based study of young womenEunjung Lee
Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
J Clin Oncol 29:4373-80. 2011..These tumors have a poor prognosis, remain a clinical challenge, and are more common among women with BRCA1 mutations. We tested whether there are distinguishing features of TNBC after BRCA1 mutation status has been taken into account... - Epigenetic subgroups of esophageal and gastric adenocarcinoma with differential GATA5 DNA methylation associated with clinical and lifestyle factorsXinhui Wang
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
PLoS ONE 6:e25985. 2011..We used DNA methylation analysis to identify subtype-specific markers and new subgroups of gastroesophageal adenocarcinomas, and studied their association with epidemiological risk factors and clinical outcomes... - Recruitment and retention of African American and Latino preadolescent females into a longitudinal biobehavioral studyAhva Shahabi
Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, California 91803, USA
Ethn Dis 21:91-8. 2011.... - Medical radiation, family history of cancer, and benign breast disease in relation to breast cancer risk in young women, USADeirdre A Hill
Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Norris Comprehensive Cancer Center, Los Angeles 90033, USA
Cancer Causes Control 13:711-8. 2002..Some evidence suggests that such risk may be distinctly elevated among women with a family history of breast or ovarian cancer (probably only carriers of specific gene mutations) and women with benign breast disease (BBD)... - Effect of family history, obesity and exercise on breast cancer risk among postmenopausal womenCatherine L Carpenter
Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA
Int J Cancer 106:96-102. 2003..Body-mass index and exercise activity, both modifiable risk factors for breast cancer, seem to have differential effects depending on a woman's family history of breast cancer, and may impact risk through different biological mechanisms... - Polymorphism in the androgen receptor and mammographic density in women taking and not taking estrogen and progestin therapyElizabeth Osth Lillie
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089 9175, USA
Cancer Res 64:1237-41. 2004..4%) than carriers of the more active AR-CAG (25.7%; P = 0.04). Our results raise the question of whether the number of AR-CAG repeats predicts breast cancer risk in estrogen progestin therapy users... - Lifetime recreational exercise activity and risk of breast carcinoma in situAlpa V Patel
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
Cancer 98:2161-9. 2003..02). CONCLUSIONS: The findings of the current study suggest that exercise activity may modify the risk of BCIS, particularly among women without a family history of breast carcinoma... - Etiologic clues from the similarity of histology-specific trends in esophageal and lung cancersMyles G Cockburn
Department of Preventive Medicine, USC Keck School of Medicine, Los Angeles, California, USA
Cancer Causes Control 16:1065-74. 2005..Squamous cell lung cancers, while caused by smoking, are believed to be caused by different constituents of tobacco smoke than lung adenocarcinomas. Smoking is also a risk factor for esophageal cancers... - High lifetime incidence of adult acute lymphoblastic leukemia among Hispanics in CaliforniaSheeja T Pullarkat
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1732, USA
Cancer Epidemiol Biomarkers Prev 18:611-5. 2009..The higher incidence of acute lymphoblastic leukemia (ALL) among Hispanic children relative to that in other racial/ethnic groups is well-known. We evaluated the incidence patterns of ALL in adults... - Influence of exercise activity on quality of life in long-term breast cancer survivorsAdam R Kendall
Department of Preventive Medicine and Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, USA
Qual Life Res 14:361-71. 2005..These findings suggest a potential role for exercise activity in maintaining well-being after a cancer diagnosis... - IL-6 levels and genotype are associated with risk of young adult Hodgkin lymphomaWendy Cozen
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
Blood 103:3216-21. 2004..29; P =.03). Risk was decreased for both nodular sclerosis and other subtypes. Persons with genetically determined lower IL-6 levels may be less susceptible to young adult Hodgkin lymphoma... - Statistical methods for analysis of radiation effects with tumor and dose location-specific information with application to the WECARE study of asynchronous contralateral breast cancerBryan Langholz
Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, California 90089, USA
Biometrics 65:599-608. 2009..The methods are illustrated and compared using the WECARE study of radiation and asynchronous contralateral breast cancer... - High breast cancer incidence rates among California teachers: results from the California Teachers Study (United States)Leslie Bernstein
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
Cancer Causes Control 13:625-35. 2002.... - The association between recreational physical activity and mammographic densityConchitina Chato Siozon
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
Int J Cancer 119:1695-701. 2006..07) and percent (p for trend = 0.08) mammographic density after adjustment for BMI. Our results suggest that physical activity is not a strong predictor of mammographic density... - Impact of reproductive factors and lactation on breast carcinoma in situ riskKathleen Meeske
Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA
Int J Cancer 110:102-9. 2004..The results for breast-feeding are contrary to what has been observed in studies of invasive breast cancer... - Lifestyle and other risk factors for thyroid cancer in Los Angeles County femalesWendy J Mack
University of Southern California, Department of Preventive Medicine, Los Angeles, CA 90089, USA
Ann Epidemiol 12:395-401. 2002..Smoking and body mass were not associated with thyroid cancer risk. CONCLUSIONS: These results suggest a role of family history of thyroid disease and certain dietary variables in the etiology of thyroid cancer in adult females... - Childhood cancer patients' access to cooperative group cancer programs: a population-based studyLihua Liu
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
Cancer 97:1339-45. 2003.... - Induced abortion, miscarriage, and breast cancer risk of young womenMaya Mahue-Giangreco
Department of Preventive Medicine and Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
Cancer Epidemiol Biomarkers Prev 12:209-14. 2003..Risk declined as the number of induced abortions increased (P = 0.04). Our results do not support the hypothesis that induced abortion or miscarriage increase the breast cancer risk of young women... - The role of androgens and polymorphisms in the androgen receptor in the epidemiology of breast cancerElizabeth O Lillie
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Breast Cancer Res 5:164-73. 2003..We review the quality of this evidence and conclude with a discussion of how the androgen receptor and testosterone results coincide... - Role of Helicobacter pylori CagA+ strains and risk of adenocarcinoma of the stomach and esophagusAnna H Wu
Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, CA 90089 9175, USA
Int J Cancer 103:815-21. 2003..pylori reduces risk of esophageal and gastric cardia adenocarcinoma in this population. Our findings confirm the positive association between risk of distal gastric cancer and infection with H. pylori infection, especially CagA+ strains... - Prevalence and correlates of fatigue in long-term survivors of childhood leukemiaKathleen A Meeske
Department of Preventive Medicine and USC Norris Comprehensive Cancer Center, Los Angeles, CA, USA
J Clin Oncol 23:5501-10. 2005..To estimate the prevalence of fatigue, identify the factors associated with fatigue, and to explore the relationship between fatigue and quality of life (QOL) in long-term survivors of childhood acute lymphoblastic leukemia (ALL)... - Urinary 2-hydroxyestrone/16alpha-hydroxyestrone ratio and family history of breast cancer in premenopausal womenGiske Ursin
Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles 90089, USA
Breast Cancer Res Treat 72:139-43. 2002..Our data suggest that among premenopausal women, family history is not associated with higher urinary estrogen levels or a lower ratio of urinary 2-OHE1/16alpha-OHE1... - Epidemiology of endocrine-related risk factors for breast cancerLeslie Bernstein
Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles 90033, USA
J Mammary Gland Biol Neoplasia 7:3-15. 2002..Improved understanding of these exposures and their potential interactions with breast cancer susceptibility genes may, in the future, improve our prospects for breast cancer prevention... - Evaluation of HER-2/neu gene amplification and overexpression: comparison of frequently used assay methods in a molecularly characterized cohort of breast cancer specimensMichael F Press
Breast Cancer Research Program of the Lee Breast Center, Department of Pathology, University of Southern California, Los Angeles, USA
J Clin Oncol 20:3095-105. 2002..To compare and evaluate HER-2/neu clinical assay methods... - Rapidly rising breast cancer incidence rates among Asian-American womenDennis Deapen
Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA
Int J Cancer 99:747-50. 2002..Japanese-American rates in Los Angeles County may have already surpassed those of non-Hispanic whites if recent trends have continued unabated... - Premature carotid artery disease in long-term survivors of childhood cancer treated with neck irradiation: a series of 5 casesKathleen A Meeske
Department of Pediatrics, Division of Hematology Oncology, Children s Hospital Los Angeles, Los Angeles, CA 90027, USA
J Pediatr Hematol Oncol 29:480-4. 2007..These radiation-related late effects are now being detected in young adult survivors of childhood cancer... - Genetic determinants of mammographic densityChristopher A Haiman
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
Breast Cancer Res 4:R5. 2002..Changes in breast density are highly correlated with steroid hormone exposure... - Correlates of active and passive smoking in the California Teachers Study cohortPeggy Reynolds
California Department of Health Services, Environmental Health Investigations Branch, Environmental Epidemiology Section, Oakland, California 94612, USA
J Womens Health (Larchmt) 13:778-90. 2004..These analyses were designed to describe characteristics associated with active and passive smoking in a large cohort of women in order to identify possible confounders of the relationship between smoking exposures and breast cancer risk... - Serum high-density lipoprotein cholesterol, metabolic profile, and breast cancer riskAnne Sofie Furberg
Section of Epidemiology and Medical Statistics, Institute of Community Medicine, Faculty of Medicine, University of Tromsø, Tromsø, Norway
J Natl Cancer Inst 96:1152-60. 2004..HDL-C represents an important aspect of the syndrome, yet its role in breast cancer is still undefined... - Study design: evaluating gene-environment interactions in the etiology of breast cancer - the WECARE studyJonine L Bernstein
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY, USA
Breast Cancer Res 6:R199-214. 2004..Three genes (ATM, BRCA1, and BRCA2) encode products that are essential for the normal cellular response to DSBs, but predispose to breast cancer when mutated... - Oral contraceptive use and risk of breast carcinoma in situ (United States)Jasmeet K Gill
Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI, USA
Cancer Causes Control 17:1155-62. 2006..CONCLUSIONS: Our results are consistent with recent results on invasive breast cancer reported for the Women's Contraceptive and Reproductive Experiences Study and show no association between oral contraceptive use and risk of BCIS... - Residential proximity to agricultural pesticide use and incidence of breast cancer in the California Teachers Study cohortPeggy Reynolds
Environmental Health Investigations Branch, California Department of Health Services, 1515 Clay Street, Suite 1700, Oakland, CA 94612, USA
Environ Res 96:206-18. 2004..Our analyses suggest that breast cancer incidence is not elevated in areas of recent, high agricultural pesticide use in California... - Active smoking, household passive smoking, and breast cancer: evidence from the California Teachers StudyPeggy Reynolds
California Department of Health Services, Environmental Health Investigations Branch, Oakland, CA 94612, USA
J Natl Cancer Inst 96:29-37. 2004..To date, literature addressing this question has been mixed, and the question has seldom been examined in large prospective study designs... - Recreational physical activity and risk of postmenopausal breast cancer in a large cohort of US womenAlpa V Patel
Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA 30329 4251, USA
Cancer Causes Control 14:519-29. 2003..Our findings are consistent with other studies that show lower risk of postmenopausal breast cancer associated with regular physical activity... - Vitamin D insufficiency in a multiethnic cohort of breast cancer survivorsMarian L Neuhouser
Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Am J Clin Nutr 88:133-9. 2008..Little is known about vitamin D status in breast cancer survivors. This issue is important because vitamin D influences pathways related to carcinogenesis... - Adiposity and sex hormones in postmenopausal breast cancer survivorsAnne McTiernan
Cancer Prevention Research Program, MP 900, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
J Clin Oncol 21:1961-6. 2003..This study examined the association between adiposity and concentrations of estrogens, androgens, and sex hormone-binding globulin (SHBG) in a population-based sample of postmenopausal women with breast cancer... - Do thyroid disorders increase the risk of breast cancer?Michael S Simon
Division of Hematology and Oncology, Karmanos Cancer Institute at Wayne State University, Detroit, Michigan, USA
Cancer Epidemiol Biomarkers Prev 11:1574-8. 2002..There was no statistical interaction between thyroid disorders, thyroid treatments, and race, menopausal status, or parity. We found no association between thyroid disorders or their associated treatments and the risk of breast cancer... - Hormone replacement therapy regimens and breast cancer risk(1)Linda K Weiss
Population Studies and Prevention Program, Karmanos Cancer Institute at Wayne State University, Detroit, Michigan, USA
Obstet Gynecol 100:1148-58. 2002..Progestin administered in an uninterrupted regimen may be a contributing factor. Risk dissipates once use is discontinued... - Relation of regimens of combined hormone replacement therapy to lobular, ductal, and other histologic types of breast carcinomaJanet R Daling
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Cancer 95:2455-64. 2002..However, the use of combined (estrogen and progestin) hormone replacement therapy (CHRT) also has increased during the last decade and may account in part for the increase in invasive lobular breast carcinoma... - Regional variations in breast cancer among california teachersPeggy Reynolds
California Department of Health Services, Environmental Health Investigations Branch, Oakland, California 94612, USA
Epidemiology 15:746-54. 2004..This large cohort study has followed female professional school employees for cancer incidence since 1995 and has collected extensive information on breast cancer risk factors... - Stroke risk and tamoxifen therapy for breast cancerAnn M Geiger
Research and Evaluation Department, Kaiser Permanente Southern California, 100 S Los Robles, Pasadena, CA 91188, USA
J Natl Cancer Inst 96:1528-36. 2004..We assessed the impact of tamoxifen treatment for breast cancer on the risk of stroke, considering dose, duration, and recency of use of tamoxifen and known stroke risk factors... - Alcohol exposure and breast cancer: results of the women's contraceptive and reproductive experiences studyJill A McDonald
National Center for Chronic Disease Prevention and Health Promotion, Division of Reproductive Health, 4770 Buford Highway Northeast, MS-K22, Atlanta, GA 30341-3724, USA
Cancer Epidemiol Biomarkers Prev 13:2106-16. 2004..Further work is needed to explain how alcohol exposure, sex hormones, and tumor receptor status interact... - Physical activity, body mass index, and mammographic density in postmenopausal breast cancer survivorsMelinda L Irwin
Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT 06520 8034, USA
J Clin Oncol 25:1061-6. 2007.... - Reproductive history and risk of second primary breast cancer: the WECARE studyJoan A Largent
Epidemiology Division, Department of Medicine, University of California, Irvine, Irvine, CA 92697 7555, USA
Cancer Epidemiol Biomarkers Prev 16:906-11. 2007..Women with an initial breast cancer diagnosis are at elevated risk of developing subsequent cancer in the contralateral breast. Studies of reproductive factors and contralateral breast cancer (CBC) have provided inconsistent results... - Nonsteroidal anti-inflammatory drugs and risk of esophageal and gastric adenocarcinomas in Los Angeles CountyLei Duan
Division of Population Sciences, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA
Cancer Epidemiol Biomarkers Prev 17:126-34. 2008..Yet, data on potential confounding effects by upper gastrointestinal tract (UGI) disorders on adenocarcinomas of the UGI are limited... - Vitamin D receptor polymorphisms and breast cancer risk in a large population-based case-control study of Caucasian and African-American womenBritton Trabert
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Fairview Ave N, Seattle, Washington 98109 1024, USA
Breast Cancer Res 9:R84. 2007..The involvement of vitamin D receptor (VDR), which is a key mediator in the vitamin D pathway, in breast cancer etiology has long been of interest... - Projecting individualized absolute invasive breast cancer risk in African American womenMitchell H Gail
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Executive Plaza South Rm 8032, Bethesda, MD 20892 7244, USA
J Natl Cancer Inst 99:1782-92. 2007..We developed a model for projecting absolute risk of invasive breast cancer in African American women and compared its projections with those from the Breast Cancer Risk Assessment Tool...
Research Grants
- Physical Activity, Ovarian and Endometrial Cancer RiskLeslie Bernstein; Fiscal Year: 2003..abstract_text> ..
- GENES AND THE ESTROGEN EFFECT ON ENDOMETRIAL CANCERGiske Ursin; Fiscal Year: 2006..We will also examine in detail the possible impact of phytoestrogens on endometrial cancer risk reduction in conjunction with HRT, obesity and the eight candidate genes under evaluation. ..