Leslie Bernstein

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi request reprint Ethnicity-related variation in breast cancer risk factors
    Leslie Bernstein
    Department of Preventive Medicine USC Norris Cancer Center, University of Southern California, Los Angeles, California 90033, USA
    Cancer 97:222-9. 2003
  2. ncbi request reprint Control recruitment in population-based case-control studies
    Leslie Bernstein
    Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA
    Epidemiology 17:255-7. 2006
  3. ncbi request reprint The risk of breast, endometrial and ovarian cancer in users of hormonal preparations
    Leslie Bernstein
    Department of Preventive Medicine, Keck School of Medicine and the Norris Comprehensive Cancer Center, University of Southern California, 90033, USA
    Basic Clin Pharmacol Toxicol 98:288-96. 2006
  4. ncbi request reprint Lifetime recreational exercise activity and breast cancer risk among black women and white women
    Leslie Bernstein
    Department of Preventive Medicine, Keck School of Medicine, USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA
    J Natl Cancer Inst 97:1671-9. 2005
  5. pmc Oral contraceptives and postmenopausal hormones and risk of contralateral breast cancer among BRCA1 and BRCA2 mutation carriers and noncarriers: the WECARE Study
    Jane C Figueiredo
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Harlyne J Norris Cancer Research Tower, 1450 Biggy Street, Los Angeles, CA, 90033, USA
    Breast Cancer Res Treat 120:175-83. 2010
  6. pmc Variations in sex hormone metabolism genes, postmenopausal hormone therapy and risk of endometrial cancer
    Pedram Razavi
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA
    Int J Cancer 130:1629-38. 2012
  7. doi request reprint Effect of reproductive factors and oral contraceptives on breast cancer risk in BRCA1/2 mutation carriers and noncarriers: results from a population-based study
    Eunjung Lee
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Room 4407, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
    Cancer Epidemiol Biomarkers Prev 17:3170-8. 2008
  8. pmc Genetic variation in the progesterone receptor gene and risk of endometrial cancer: a haplotype-based approach
    Eunjung Lee
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90089, USA
    Carcinogenesis 31:1392-9. 2010
  9. pmc Reproductive factors and risk of contralateral breast cancer by BRCA1 and BRCA2 mutation status: results from the WECARE study
    Jenny N Poynter
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA
    Cancer Causes Control 21:839-46. 2010
  10. ncbi request reprint Nonsteroidal anti-inflammatory drug use and breast cancer risk by stage and hormone receptor status
    Sarah F Marshall
    Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    J Natl Cancer Inst 97:805-12. 2005

Research Grants

Collaborators

Detail Information

Publications117 found, 100 shown here

  1. ncbi request reprint Ethnicity-related variation in breast cancer risk factors
    Leslie Bernstein
    Department of Preventive Medicine USC Norris Cancer Center, University of Southern California, Los Angeles, California 90033, USA
    Cancer 97:222-9. 2003
    ..Although risk factors may be similar for African-American and white women, differences in the prevalence of risk factors may explain the differences in patterns of incidence...
  2. ncbi request reprint Control recruitment in population-based case-control studies
    Leslie Bernstein
    Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA
    Epidemiology 17:255-7. 2006
  3. ncbi request reprint The risk of breast, endometrial and ovarian cancer in users of hormonal preparations
    Leslie Bernstein
    Department of Preventive Medicine, Keck School of Medicine and the Norris Comprehensive Cancer Center, University of Southern California, 90033, USA
    Basic Clin Pharmacol Toxicol 98:288-96. 2006
    ..As with oestrogen therapy, the impact of combined therapy on ovarian cancer risk is uncertain...
  4. ncbi request reprint Lifetime recreational exercise activity and breast cancer risk among black women and white women
    Leslie Bernstein
    Department of Preventive Medicine, Keck School of Medicine, USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA
    J Natl Cancer Inst 97:1671-9. 2005
    ....
  5. pmc Oral contraceptives and postmenopausal hormones and risk of contralateral breast cancer among BRCA1 and BRCA2 mutation carriers and noncarriers: the WECARE Study
    Jane C Figueiredo
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Harlyne J Norris Cancer Research Tower, 1450 Biggy Street, Los Angeles, CA, 90033, USA
    Breast Cancer Res Treat 120:175-83. 2010
    ....
  6. pmc Variations in sex hormone metabolism genes, postmenopausal hormone therapy and risk of endometrial cancer
    Pedram Razavi
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA
    Int J Cancer 130:1629-38. 2012
    ..Variations in CYP11A1 may modify the effect of ET use on risk of postmenopausal endometrial cancer; however, larger studies are needed to explore these findings further...
  7. doi request reprint Effect of reproductive factors and oral contraceptives on breast cancer risk in BRCA1/2 mutation carriers and noncarriers: results from a population-based study
    Eunjung Lee
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Room 4407, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
    Cancer Epidemiol Biomarkers Prev 17:3170-8. 2008
    ..However, the effects of these factors in BRCA1 and BRCA2 mutation carriers are less clear...
  8. pmc Genetic variation in the progesterone receptor gene and risk of endometrial cancer: a haplotype-based approach
    Eunjung Lee
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90089, USA
    Carcinogenesis 31:1392-9. 2010
    ..We investigated whether genetic variation in PGR is also associated with endometrial cancer risk using a haplotype-based approach...
  9. pmc Reproductive factors and risk of contralateral breast cancer by BRCA1 and BRCA2 mutation status: results from the WECARE study
    Jenny N Poynter
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA
    Cancer Causes Control 21:839-46. 2010
    ..In this study, we evaluated the association between these factors and CBC risk among BRCA1 and BRCA2 (BRCA1/2) mutation carriers and non-carriers...
  10. ncbi request reprint Nonsteroidal anti-inflammatory drug use and breast cancer risk by stage and hormone receptor status
    Sarah F Marshall
    Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    J Natl Cancer Inst 97:805-12. 2005
    ..We investigated the association of NSAID use with risk of breast cancer in the California Teachers Study cohort, with special attention to risk of specific breast cancer subtypes and to type of NSAID used...
  11. pmc The association of polymorphisms in hormone metabolism pathway genes, menopausal hormone therapy, and breast cancer risk: a nested case-control study in the California Teachers Study cohort
    Eunjung Lee
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
    Breast Cancer Res 13:R37. 2011
    ..It therefore seems plausible that variation in genes involved in metabolism of these hormones may affect breast cancer risk, and that these associations may vary depending on menopausal status and use of hormone therapy...
  12. pmc Type I and II Endometrial Cancers: Have They Different Risk Factors?
    Veronica Wendy Setiawan
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1450 Biggy St, Rm 1517G, Los Angeles, CA 90033
    J Clin Oncol 31:2607-18. 2013
    ..The etiology of type II tumors may, therefore, not be completely estrogen independent, as previously believed. ..
  13. pmc A genome-wide association study of breast cancer in women of African ancestry
    Fang Chen
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA
    Hum Genet 132:39-48. 2013
    ..Identification of novel risk variants for breast cancer in women of African ancestry will demand testing of a substantially larger set of markers from stage 1 in a larger replication sample...
  14. ncbi request reprint Reproductive factors and risk of breast carcinoma in a study of white and African-American women
    Giske Ursin
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
    Cancer 101:353-62. 2004
    ....
  15. ncbi request reprint Germ line variation at 8q24 and endometrial cancer risk
    Veronica Wendy Setiawan
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Harlyne Norris Research Tower, 1450 Biggy Street, Room 1504A, Los Angeles, CA 90033, USA
    Cancer Epidemiol Biomarkers Prev 16:2166-8. 2007
  16. ncbi request reprint Mammographic density and breast cancer in three ethnic groups
    Giske Ursin
    Department of Preventive Medicine, University of California Keck School of Medicine, Los Angeles, California 90089, USA
    Cancer Epidemiol Biomarkers Prev 12:332-8. 2003
    ..Furthermore, our findings suggest that mammographic density is as strong a predictor of risk for African-American and Asian-American women as for white women...
  17. ncbi request reprint Does mammographic density reflect ethnic differences in breast cancer incidence rates?
    Zhengjia Chen
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Am J Epidemiol 159:140-7. 2004
    ..This study suggests that absolute but not percent mammographic density reflects the lower breast cancer incidence rates of Asian Americans in relation to those of African Americans and Whites...
  18. pmc Age-specific effects of hormone therapy use on overall mortality and ischemic heart disease mortality among women in the California Teachers Study
    Daniel O Stram
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Menopause 18:253-61. 2011
    ..The California Teachers Study questionnaire and mortality data were used to examine whether age modified the association between HT and the relative risk of overall mortality and ischemic heart disease deaths...
  19. pmc Risk of contralateral breast cancer associated with common variants in BRCA1 and BRCA2: potential modifying effect of BRCA1/BRCA2 mutation carrier status
    Jane C Figueiredo
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Harlyne J Norris Cancer Research Tower, 1450 Biggy Street Room 1509J, Los Angeles, CA 90033, USA
    Breast Cancer Res Treat 127:819-29. 2011
    ..The association between common variants in BRCA1 and BRCA2 and risk of CBC may differ depending on BRCA1 and BRCA2 mutation carrier status...
  20. doi request reprint Risk factors for arm lymphedema following breast cancer diagnosis in Black women and White women
    Kathleen A Meeske
    Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA
    Breast Cancer Res Treat 113:383-91. 2009
    ....
  21. ncbi request reprint Long-term recreational physical activity and risk of invasive and in situ breast cancer: the California teachers study
    Cher M Dallal
    Keck School of Medicine and USC Norris Cancer Center, University of Southern California, Los Angeles, USA
    Arch Intern Med 167:408-15. 2007
    ..Long-term physical activity may affect breast cancer risk. Few prospective studies have evaluated in situ or invasive breast cancer risk, or breast cancer receptor subtypes, in relation to long-term activity...
  22. pmc An association between a common variant (G972R) in the IRS-1 gene and sex hormone levels in post-menopausal breast cancer survivors
    Jing Fan
    Integrated Substance Abuse Programs, Neuropsychiatric Institute, University of California, 1640 S Sepulveda Boulevard, Suite 200, Los Angeles, CA 90025, USA
    Breast Cancer Res Treat 99:323-31. 2006
    ..02). No association was present for white patients. Our findings provide suggestive evidence that IRS-1 G972R variant may be associated with circulating levels of sex hormones and SHBG in African American breast cancer survivors...
  23. pmc Mitochondrial DNA G10398A variant is not associated with breast cancer in African-American women
    Veronica Wendy Setiawan
    Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA
    Cancer Genet Cytogenet 181:16-9. 2008
    ..18, 95% CI = 0.76-1.82, P = 0.46). Our results do not support the hypothesis that the mtDNA G10398A polymorphism is, as has previously been reported, a marker of breast cancer risk in African Americans...
  24. ncbi request reprint Low-dose medical radiation exposure and breast cancer risk in women under age 50 years overall and by estrogen and progesterone receptor status: results from a case-control and a case-case comparison
    Huiyan Ma
    Institute for Health Promotion and Disease Prevention Research, Keck School of Medicine, University of Southern California, 1000 South Fremont Avenue, Unit 8, Alhambra, CA 91803, USA
    Breast Cancer Res Treat 109:77-90. 2008
    ..We found no effect modification by ER/PR status. In conclusion, our findings support the hypothesis that low-dose ionizing radiation, and particularly exposures during childhood, increase breast cancer risk...
  25. ncbi request reprint Fatigue in breast cancer survivors two to five years post diagnosis: a HEAL Study report
    Kathleen Meeske
    Department of Preventive Medicine, Keck School of Medicine of University of Southern California, USC Norris Comprehensive Cancer Center, 1444 Eastlake Avenue, Room 4449, Los Angeles, CA 90033, USA
    Qual Life Res 16:947-60. 2007
    ....
  26. pmc Adenomyosis and endometriosis in the California Teachers Study
    Claire Templeman
    Department of Obstetrics and Gynecology, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    Fertil Steril 90:415-24. 2008
    ..To evaluate the reproductive and lifestyle correlates of a surgically confirmed diagnosis of endometriosis or adenomyosis in a large prospective cohort...
  27. doi request reprint Oral contraceptives, postmenopausal hormones, and risk of asynchronous bilateral breast cancer: the WECARE Study Group
    Jane C Figueiredo
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    J Clin Oncol 26:1411-8. 2008
    ..To investigate whether oral contraceptive (OC) use and postmenopausal hormones (PMH) are associated with an increased risk of developing asynchronous bilateral breast cancer among women diagnosed with breast cancer younger than 55 years...
  28. pmc Alteration of topoisomerase II-alpha gene in human breast cancer: association with responsiveness to anthracycline-based chemotherapy
    Michael F Press
    Norris Comprehensive Cancer Center, University of Southern California, CA, USA
    J Clin Oncol 29:859-67. 2011
    ..This study was designed to evaluate whether TOP2A gene alterations may predict incremental responsiveness to anthracyclines in some breast cancers...
  29. pmc A genome-wide scan for breast cancer risk haplotypes among African American women
    Chi Song
    Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA
    PLoS ONE 8:e57298. 2013
    ....
  30. pmc The potential for enhancing the power of genetic association studies in African Americans through the reuse of existing genotype data
    Gary K Chen
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, United States of America
    PLoS Genet 6:e1001096. 2010
    ....
  31. pmc Reproductive factors and breast cancer risk according to joint estrogen and progesterone receptor status: a meta-analysis of epidemiological studies
    Huiyan Ma
    Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue 4407, Los Angeles, CA 90089, USA
    Breast Cancer Res 8:R43. 2006
    ..This report presents the first meta-analysis of results from epidemiological studies that have investigated parity, age at first birth, breastfeeding, and age at menarche in relation to ER+PR+ and ER-PR- cancer risk...
  32. ncbi request reprint Validating California teachers study self-reports of recent hospitalization: comparison with California hospital discharge data
    Sarah F Marshall
    Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Am J Epidemiol 158:1012-20. 2003
    ..The combination of self-reports and secondary medical records provides more accurate and complete morbidity data than does use of either source alone...
  33. pmc Evaluation of unclassified variants in the breast cancer susceptibility genes BRCA1 and BRCA2 using five methods: results from a population-based study of young breast cancer patients
    Eunjung Lee
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, USC Norris Comprehensive Cancer Center, Los Angeles, CA 90089 9175, USA
    Breast Cancer Res 10:R19. 2008
    ....
  34. doi request reprint Premature carotid artery disease in pediatric cancer survivors treated with neck irradiation
    Kathleen A Meeske
    Department of Pediatrics, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA
    Pediatr Blood Cancer 53:615-21. 2009
    ..The purpose of this study is to determine if carotid disease is more prevalent among pediatric cancer survivors treated with neck irradiation than among healthy controls...
  35. pmc Long-term postmenopausal hormone therapy and endometrial cancer
    Pedram Razavi
    University of Southern California, Department of Preventive Medicine, Norris Comprehensive Cancer Center, Los Angeles, California, USA
    Cancer Epidemiol Biomarkers Prev 19:475-83. 2010
    ..These findings confirm that long-term use of ET, sequential EPT, or, among normal weight women, continuous-combined EPT is associated with increased risk of endometrial cancer...
  36. pmc Serum organochlorines and breast cancer: a case-control study among African-American women
    Nicole M Gatto
    Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, USC Norris Comprehensive Center, 1441 Eastlake Avenue, Room 4449, Los Angeles, CA 90033, USA
    Cancer Causes Control 18:29-39. 2007
    ..This study, the largest study of African-American women to date, does not support a role of DDE and total PCBs in breast cancer risk at the levels measured...
  37. pmc Diabetes and risk of esophageal and gastric adenocarcinomas
    Xuejuan Jiang
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90089 9175, USA
    Int J Cancer 131:1417-22. 2012
    ..Our study further investigated the association between diabetes and adenocarcinomas of the esophagus and distal stomach...
  38. pmc Age at last birth in relation to risk of endometrial cancer: pooled analysis in the epidemiology of endometrial cancer consortium
    Veronica Wendy Setiawan
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Am J Epidemiol 176:269-78. 2012
    ..In this large pooled analysis, late age at last birth was independently associated with a reduced risk of endometrial cancer, and the reduced risk persisted for many years...
  39. pmc Hormone-related risk factors for breast cancer in women under age 50 years by estrogen and progesterone receptor status: results from a case-control and a case-case comparison
    Huiyan Ma
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, USC Norris Comprehensive Cancer Center, Los Angeles, California 90089 9175, USA
    Breast Cancer Res 8:R39. 2006
    ..It has been suggested that hormonal risk factors act predominantly on estrogen receptor and progesterone receptor (ER/PR)-positive breast cancers. However, the data have been inconsistent, especially in younger women...
  40. pmc Lower risk in parous women suggests that hormonal factors are important in bladder cancer etiology
    Carol A Davis-Dao
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Cancer Epidemiol Biomarkers Prev 20:1156-70. 2011
    ..Our objective was to determine whether hormonal and reproductive factors are involved in female bladder cancer...
  41. pmc Risk factors for surgically removed fibroids in a large cohort of teachers
    Claire Templeman
    Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Fertil Steril 92:1436-46. 2009
    ..To describe reproductive and lifestyle correlates of surgically confirmed fibroids...
  42. pmc Breast cancer risk and ovariectomy, hysterectomy, and tubal sterilization in the women's contraceptive and reproductive experiences study
    David J Press
    Department of Preventive Medicine, Keck School of Medicine, and Norris Comprehensive Can cer Center, University of Southern California, Los Angeles, California, USA
    Am J Epidemiol 173:38-47. 2011
    ..No association with breast cancer risk was observed with tubal sterilization only or partial ovariectomy without hysterectomy. Reproductive organ surgeries may alter ovarian hormone levels, thereby affecting breast cancer risk...
  43. doi request reprint The role of established breast cancer susceptibility loci in mammographic density in young women
    Eunjung Lee
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
    Cancer Epidemiol Biomarkers Prev 17:258-60. 2008
  44. pmc Menopausal hormone therapy and subsequent risk of specific invasive breast cancer subtypes in the California Teachers Study
    Tanmai Saxena
    Department of Preventive Medicine, Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    Cancer Epidemiol Biomarkers Prev 19:2366-78. 2010
    ....
  45. ncbi request reprint Cigarette smoking is not associated with breast cancer risk in young women
    Jennifer Prescott
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
    Cancer Epidemiol Biomarkers Prev 16:620-2. 2007
  46. ncbi request reprint A variant in the cytochrome p450 oxidoreductase gene is associated with breast cancer risk in African Americans
    Christopher A Haiman
    Departments of Preventive Medicine and Pathology, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
    Cancer Res 67:3565-8. 2007
    ..03) and stronger in those with advanced disease (411 cases and 877 controls; OR, 2.60; 95% CI, 1.56-4.34; P = 0.0002). These data suggest that African Americans harbor an allele at the POR locus that may increase breast cancer risk...
  47. ncbi request reprint Fiber intake and risk of adenocarcinomas of the esophagus and stomach
    Anna H Wu
    Department of Preventive Medicine, University of Southern California, Keck School of Medicine, 1441 Eastlake Avenue, MS 44, Los Angeles, CA 90089 9175, USA
    Cancer Causes Control 18:713-22. 2007
    ..Since the 1970s, incidence rates for esophageal and gastric cardia adenocarcinomas have risen substantially for reasons that are not well understood. We sought to determine the role of dietary factors in these tumor types...
  48. ncbi request reprint Hiatal hernia, reflux symptoms, body size, and risk of esophageal and gastric adenocarcinoma
    Anna H Wu
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, MC 9175, Los Angeles, CA 90089 9175, USA
    Cancer 98:940-8. 2003
    ..Since the 1970s, incidence rates of esophageal and gastric cardia adenocarcinoma have risen substantially. Reasons for the increasing trends are not well understood...
  49. pmc Physical activity and sex hormone levels in estradiol- and placebo-treated postmenopausal women
    Farzana Choudhury
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Menopause 18:1079-86. 2011
    ..The crucial yet complex relationship between physical activity and physiologic and pharmacologic sex hormone levels in postmenopausal women has not been investigated sufficiently...
  50. ncbi request reprint Interleukin-6-related genotypes, body mass index, and risk of multiple myeloma and plasmacytoma
    Wendy Cozen
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, MC 9175, Los Angeles, CA 90089 9175, USA
    Cancer Epidemiol Biomarkers Prev 15:2285-91. 2006
    ..These results suggest that IL-6 promoter genotypes may be associated with increased risk of plasma cell neoplasms...
  51. ncbi request reprint Risk patterns of multiple myeloma in Los Angeles County, 1972-1999 (United States)
    Mulugeta Gebregziabher
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089 9175, USA
    Cancer Causes Control 17:931-8. 2006
    ..To describe the risk patterns of multiple myeloma in Los Angeles County (LAC)...
  52. pmc A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, USA
    Nat Genet 43:1210-4. 2011
    ..25, P = 1.1 × 10(-9)), particularly in younger women (<50 years of age) (OR = 1.48, P = 1.9 × 10(-9)). Our results identify a genetic locus associated with estrogen receptor negative breast cancer subtypes in multiple populations...
  53. ncbi request reprint A proposed explanation for female predominance in alveolar soft part sarcoma. Noninactivation of X; autosome translocation fusion gene?
    Xiangdong Bu
    Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Cancer 103:1245-53. 2005
    ..Because females have an extra X-chromosome, their likelihood of developing an X;autosome translocation is theoretically double that of males, and thus, this extra X-chromosome is a likely explanation for female predominance of ASPS...
  54. ncbi request reprint Physical activity and breast cancer risk among Asian-American women in Los Angeles: a case-control study
    Dongyun Yang
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
    Cancer 97:2565-75. 2003
    ..To the authors' knowledge, there have been few studies published to date regarding physical activity patterns and breast cancer risk in Asian and Asian-American women...
  55. ncbi request reprint Occupational physical activity and risk of adenocarcinomas of the esophagus and stomach
    Cheryl Vigen
    Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089 9175, USA
    Int J Cancer 118:1004-9. 2006
    ..Future studies with more complete information on occupational and recreational physical activity are needed to confirm and further investigate the suggested protective effect of physical activity on these tumor types...
  56. ncbi request reprint Diagnostic evaluation of HER-2 as a molecular target: an assessment of accuracy and reproducibility of laboratory testing in large, prospective, randomized clinical trials
    Michael F Press
    Women s Cancers Program, Department of Pathology, Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 89195, USA
    Clin Cancer Res 11:6598-607. 2005
    ....
  57. pmc Characteristics of triple-negative breast cancer in patients with a BRCA1 mutation: results from a population-based study of young women
    Eunjung Lee
    Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
    J Clin Oncol 29:4373-80. 2011
    ..These tumors have a poor prognosis, remain a clinical challenge, and are more common among women with BRCA1 mutations. We tested whether there are distinguishing features of TNBC after BRCA1 mutation status has been taken into account...
  58. pmc Epigenetic subgroups of esophageal and gastric adenocarcinoma with differential GATA5 DNA methylation associated with clinical and lifestyle factors
    Xinhui Wang
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 6:e25985. 2011
    ..We used DNA methylation analysis to identify subtype-specific markers and new subgroups of gastroesophageal adenocarcinomas, and studied their association with epidemiological risk factors and clinical outcomes...
  59. ncbi request reprint Medical radiation, family history of cancer, and benign breast disease in relation to breast cancer risk in young women, USA
    Deirdre A Hill
    Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Norris Comprehensive Cancer Center, Los Angeles 90033, USA
    Cancer Causes Control 13:711-8. 2002
    ..Some evidence suggests that such risk may be distinctly elevated among women with a family history of breast or ovarian cancer (probably only carriers of specific gene mutations) and women with benign breast disease (BBD)...
  60. ncbi request reprint Recruitment and retention of African American and Latino preadolescent females into a longitudinal biobehavioral study
    Ahva Shahabi
    Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, California 91803, USA
    Ethn Dis 21:91-8. 2011
    ....
  61. ncbi request reprint Effect of family history, obesity and exercise on breast cancer risk among postmenopausal women
    Catherine L Carpenter
    Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA
    Int J Cancer 106:96-102. 2003
    ..Body-mass index and exercise activity, both modifiable risk factors for breast cancer, seem to have differential effects depending on a woman's family history of breast cancer, and may impact risk through different biological mechanisms...
  62. ncbi request reprint Polymorphism in the androgen receptor and mammographic density in women taking and not taking estrogen and progestin therapy
    Elizabeth Osth Lillie
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089 9175, USA
    Cancer Res 64:1237-41. 2004
    ..4%) than carriers of the more active AR-CAG (25.7%; P = 0.04). Our results raise the question of whether the number of AR-CAG repeats predicts breast cancer risk in estrogen progestin therapy users...
  63. ncbi request reprint Etiologic clues from the similarity of histology-specific trends in esophageal and lung cancers
    Myles G Cockburn
    Department of Preventive Medicine, USC Keck School of Medicine, Los Angeles, California, USA
    Cancer Causes Control 16:1065-74. 2005
    ..Squamous cell lung cancers, while caused by smoking, are believed to be caused by different constituents of tobacco smoke than lung adenocarcinomas. Smoking is also a risk factor for esophageal cancers...
  64. ncbi request reprint Lifetime recreational exercise activity and risk of breast carcinoma in situ
    Alpa V Patel
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
    Cancer 98:2161-9. 2003
    ..Because of its potential effects on circulating sex hormones, physical activity has been proposed as a modifiable risk factor for invasive breast carcinoma. However, the relation to BCIS risk is poorly understood...
  65. pmc High lifetime incidence of adult acute lymphoblastic leukemia among Hispanics in California
    Sheeja T Pullarkat
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1732, USA
    Cancer Epidemiol Biomarkers Prev 18:611-5. 2009
    ..The higher incidence of acute lymphoblastic leukemia (ALL) among Hispanic children relative to that in other racial/ethnic groups is well-known. We evaluated the incidence patterns of ALL in adults...
  66. ncbi request reprint IL-6 levels and genotype are associated with risk of young adult Hodgkin lymphoma
    Wendy Cozen
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Blood 103:3216-21. 2004
    ..29; P =.03). Risk was decreased for both nodular sclerosis and other subtypes. Persons with genetically determined lower IL-6 levels may be less susceptible to young adult Hodgkin lymphoma...
  67. ncbi request reprint The association between recreational physical activity and mammographic density
    Conchitina Chato Siozon
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
    Int J Cancer 119:1695-701. 2006
    ..07) and percent (p for trend = 0.08) mammographic density after adjustment for BMI. Our results suggest that physical activity is not a strong predictor of mammographic density...
  68. ncbi request reprint High breast cancer incidence rates among California teachers: results from the California Teachers Study (United States)
    Leslie Bernstein
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
    Cancer Causes Control 13:625-35. 2002
    ....
  69. pmc Statistical methods for analysis of radiation effects with tumor and dose location-specific information with application to the WECARE study of asynchronous contralateral breast cancer
    Bryan Langholz
    Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, California 90089, USA
    Biometrics 65:599-608. 2009
    ..The methods are illustrated and compared using the WECARE study of radiation and asynchronous contralateral breast cancer...
  70. ncbi request reprint Impact of reproductive factors and lactation on breast carcinoma in situ risk
    Kathleen Meeske
    Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA
    Int J Cancer 110:102-9. 2004
    ..The results for breast-feeding are contrary to what has been observed in studies of invasive breast cancer...
  71. ncbi request reprint Influence of exercise activity on quality of life in long-term breast cancer survivors
    Adam R Kendall
    Department of Preventive Medicine and Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, USA
    Qual Life Res 14:361-71. 2005
    ..Behavioral and lifestyle factors may influence quality of life (QOL) outcomes in breast cancer survivors...
  72. ncbi request reprint Lifestyle and other risk factors for thyroid cancer in Los Angeles County females
    Wendy J Mack
    University of Southern California, Department of Preventive Medicine, Los Angeles, CA 90089, USA
    Ann Epidemiol 12:395-401. 2002
    ..Cases were 292 women, aged 15-54 when diagnosed between the years 1980 and 1983 (145 diagnosed in 1980-81 and 147 diagnosed in 1982-83). Female neighborhood controls (n = 292) were matched to each case on birth-year and race...
  73. ncbi request reprint Childhood cancer patients' access to cooperative group cancer programs: a population-based study
    Lihua Liu
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
    Cancer 97:1339-45. 2003
    ..To assess the feasibility of developing a nationwide childhood cancer registry, the authors attempted to determine whether COG could serve as a resource for identifying all children with cancer...
  74. pmc The role of androgens and polymorphisms in the androgen receptor in the epidemiology of breast cancer
    Elizabeth O Lillie
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Breast Cancer Res 5:164-73. 2003
    ..We review the quality of this evidence and conclude with a discussion of how the androgen receptor and testosterone results coincide...
  75. ncbi request reprint Urinary 2-hydroxyestrone/16alpha-hydroxyestrone ratio and family history of breast cancer in premenopausal women
    Giske Ursin
    Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles 90089, USA
    Breast Cancer Res Treat 72:139-43. 2002
    ..Our data suggest that among premenopausal women, family history is not associated with higher urinary estrogen levels or a lower ratio of urinary 2-OHE1/16alpha-OHE1...
  76. ncbi request reprint Evaluation of HER-2/neu gene amplification and overexpression: comparison of frequently used assay methods in a molecularly characterized cohort of breast cancer specimens
    Michael F Press
    Breast Cancer Research Program of the Lee Breast Center, Department of Pathology, University of Southern California, Los Angeles, USA
    J Clin Oncol 20:3095-105. 2002
    ..To compare and evaluate HER-2/neu clinical assay methods...
  77. ncbi request reprint Induced abortion, miscarriage, and breast cancer risk of young women
    Maya Mahue-Giangreco
    Department of Preventive Medicine and Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Cancer Epidemiol Biomarkers Prev 12:209-14. 2003
    ..Risk declined as the number of induced abortions increased (P = 0.04). Our results do not support the hypothesis that induced abortion or miscarriage increase the breast cancer risk of young women...
  78. ncbi request reprint Epidemiology of endocrine-related risk factors for breast cancer
    Leslie Bernstein
    Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles 90033, USA
    J Mammary Gland Biol Neoplasia 7:3-15. 2002
    ..Improved understanding of these exposures and their potential interactions with breast cancer susceptibility genes may, in the future, improve our prospects for breast cancer prevention...
  79. ncbi request reprint Rapidly rising breast cancer incidence rates among Asian-American women
    Dennis Deapen
    Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA
    Int J Cancer 99:747-50. 2002
    ..Japanese-American rates in Los Angeles County may have already surpassed those of non-Hispanic whites if recent trends have continued unabated...
  80. ncbi request reprint Role of Helicobacter pylori CagA+ strains and risk of adenocarcinoma of the stomach and esophagus
    Anna H Wu
    Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, CA 90089 9175, USA
    Int J Cancer 103:815-21. 2003
    ..pylori reduces risk of esophageal and gastric cardia adenocarcinoma in this population. Our findings confirm the positive association between risk of distal gastric cancer and infection with H. pylori infection, especially CagA+ strains...
  81. ncbi request reprint Prevalence and correlates of fatigue in long-term survivors of childhood leukemia
    Kathleen A Meeske
    Department of Preventive Medicine and USC Norris Comprehensive Cancer Center, Los Angeles, CA, USA
    J Clin Oncol 23:5501-10. 2005
    ..To estimate the prevalence of fatigue, identify the factors associated with fatigue, and to explore the relationship between fatigue and quality of life (QOL) in long-term survivors of childhood acute lymphoblastic leukemia (ALL)...
  82. ncbi request reprint Premature carotid artery disease in long-term survivors of childhood cancer treated with neck irradiation: a series of 5 cases
    Kathleen A Meeske
    Department of Pediatrics, Division of Hematology Oncology, Children s Hospital Los Angeles, Los Angeles, CA 90027, USA
    J Pediatr Hematol Oncol 29:480-4. 2007
    ..These radiation-related late effects are now being detected in young adult survivors of childhood cancer...
  83. pmc Genetic determinants of mammographic density
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
    Breast Cancer Res 4:R5. 2002
    ..Changes in breast density are highly correlated with steroid hormone exposure...
  84. ncbi request reprint Projecting individualized absolute invasive breast cancer risk in African American women
    Mitchell H Gail
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Executive Plaza South Rm 8032, Bethesda, MD 20892 7244, USA
    J Natl Cancer Inst 99:1782-92. 2007
    ..We developed a model for projecting absolute risk of invasive breast cancer in African American women and compared its projections with those from the Breast Cancer Risk Assessment Tool...
  85. ncbi request reprint Do thyroid disorders increase the risk of breast cancer?
    Michael S Simon
    Division of Hematology and Oncology, Karmanos Cancer Institute at Wayne State University, Detroit, Michigan, USA
    Cancer Epidemiol Biomarkers Prev 11:1574-8. 2002
    ..There was no statistical interaction between thyroid disorders, thyroid treatments, and race, menopausal status, or parity. We found no association between thyroid disorders or their associated treatments and the risk of breast cancer...
  86. ncbi request reprint Hormone replacement therapy regimens and breast cancer risk(1)
    Linda K Weiss
    Population Studies and Prevention Program, Karmanos Cancer Institute at Wayne State University, Detroit, Michigan, USA
    Obstet Gynecol 100:1148-58. 2002
    ..Progestin administered in an uninterrupted regimen may be a contributing factor. Risk dissipates once use is discontinued...
  87. ncbi request reprint Relation of regimens of combined hormone replacement therapy to lobular, ductal, and other histologic types of breast carcinoma
    Janet R Daling
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer 95:2455-64. 2002
    ..However, the use of combined (estrogen and progestin) hormone replacement therapy (CHRT) also has increased during the last decade and may account in part for the increase in invasive lobular breast carcinoma...
  88. ncbi request reprint Recreational physical activity and risk of postmenopausal breast cancer in a large cohort of US women
    Alpa V Patel
    Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA 30329 4251, USA
    Cancer Causes Control 14:519-29. 2003
    ..Our findings are consistent with other studies that show lower risk of postmenopausal breast cancer associated with regular physical activity...
  89. pmc Physical activity, long-term symptoms, and physical health-related quality of life among breast cancer survivors: a prospective analysis
    Catherine M Alfano
    Comprehensive Cancer Center and School of Public Health, The Ohio State University, Columbus, OH, USA
    J Cancer Surviv 1:116-28. 2007
    ..This prospective study investigated physical activity (PA), occurrence of physical symptoms, and HRQOL in a large, ethnically-diverse cohort of breast cancer survivors...
  90. pmc Possible socioeconomic and ethnic disparities in quality of life in a cohort of breast cancer survivors
    Deborah J Bowen
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, M4 B402, Seattle, WA 98109, USA
    Breast Cancer Res Treat 106:85-95. 2007
    ..This paper describes the ethnic and socioeconomic correlates of functioning in a cohort of long-term nonrecurring breast cancer survivors...
  91. pmc Adiposity and sex hormones in postmenopausal breast cancer survivors
    Anne McTiernan
    Cancer Prevention Research Program, MP 900, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    J Clin Oncol 21:1961-6. 2003
    ..This study examined the association between adiposity and concentrations of estrogens, androgens, and sex hormone-binding globulin (SHBG) in a population-based sample of postmenopausal women with breast cancer...
  92. ncbi request reprint Active smoking, household passive smoking, and breast cancer: evidence from the California Teachers Study
    Peggy Reynolds
    California Department of Health Services, Environmental Health Investigations Branch, Oakland, CA 94612, USA
    J Natl Cancer Inst 96:29-37. 2004
    ..To date, literature addressing this question has been mixed, and the question has seldom been examined in large prospective study designs...
  93. pmc Influence of pre- and postdiagnosis physical activity on mortality in breast cancer survivors: the health, eating, activity, and lifestyle study
    Melinda L Irwin
    Department of Epidemiology and Public Health, Yale School of Medicine, P O Box 208034, New Haven, CT 06520 8034, USA
    J Clin Oncol 26:3958-64. 2008
    ..To investigate the association between pre- and postdiagnosis physical activity (as well as change in prediagnosis to postdiagnosis physical activity) and mortality among women with breast cancer...
  94. ncbi request reprint Stroke risk and tamoxifen therapy for breast cancer
    Ann M Geiger
    Research and Evaluation Department, Kaiser Permanente Southern California, 100 S Los Robles, Pasadena, CA 91188, USA
    J Natl Cancer Inst 96:1528-36. 2004
    ..We assessed the impact of tamoxifen treatment for breast cancer on the risk of stroke, considering dose, duration, and recency of use of tamoxifen and known stroke risk factors...
  95. ncbi request reprint Ovarian cysts and breast cancer: results from the Women's Contraceptive and Reproductive Experiences Study
    Julia A Knight
    Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 60 Murray Street, Box 18, Toronto, ON, Canada, M5T 3L9
    Breast Cancer Res Treat 109:157-64. 2008
    ..Additional studies are required to determine the specific cyst type(s) responsible for the observed relationship...
  96. ncbi request reprint Benefit of screening mammography in reducing the rate of late-stage breast cancer diagnoses (United States)
    Sandra A Norman
    Center for Clinical Epidemiology and Biostatistics and Department of Biostatistics and Epidemiology, University of Pennsylvania, 801 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    Cancer Causes Control 17:921-9. 2006
    ..We studied the benefit of modern mammography screening in community settings, evaluating age-related differences in rates of late-stage breast cancer detection...
  97. ncbi request reprint Alcohol exposure and breast cancer: results of the women's contraceptive and reproductive experiences study
    Jill A McDonald
    National Center for Chronic Disease Prevention and Health Promotion, Division of Reproductive Health, 4770 Buford Highway Northeast, MS K22, Atlanta, GA 30341 3724, USA
    Cancer Epidemiol Biomarkers Prev 13:2106-16. 2004
    ..To explore associated biological outcomes and clarify the role of timing of exposure in the alcohol-breast cancer relationship...
  98. ncbi request reprint Reproductive history and risk of second primary breast cancer: the WECARE study
    Joan A Largent
    Epidemiology Division, Department of Medicine, University of California, Irvine, Irvine, CA 92697 7555, USA
    Cancer Epidemiol Biomarkers Prev 16:906-11. 2007
    ..Women with an initial breast cancer diagnosis are at elevated risk of developing subsequent cancer in the contralateral breast. Studies of reproductive factors and contralateral breast cancer (CBC) have provided inconsistent results...
  99. ncbi request reprint Racial differences in the familial aggregation of breast cancer and other female cancers
    Michael S Simon
    Division of Haematology and Oncology, Barbara Ann Karmanos Cancer Institute, 4100 John R, 4221 Hudson, Weber Cancer Research Building, Detroit, M1 48201, USA
    Breast Cancer Res Treat 89:227-35. 2005
    ..17 (1.22-3.85). In conclusion, these racially distinct aggregation patterns may reflect different modes of inheritance and/or environmental factors that impact cancer risk...
  100. ncbi request reprint Multi-center screening of mutations in the ATM gene among women with breast cancer - the WECARE Study
    Jonine L Berstein
    Radiat Res 163:698-9. 2005
  101. ncbi request reprint Physical activity, body mass index, and mammographic density in postmenopausal breast cancer survivors
    Melinda L Irwin
    Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT 06520 8034, USA
    J Clin Oncol 25:1061-6. 2007
    ....

Research Grants3

  1. Physical Activity, Ovarian and Endometrial Cancer Risk
    Leslie Bernstein; Fiscal Year: 2003
    ..abstract_text> ..
  2. GENES AND THE ESTROGEN EFFECT ON ENDOMETRIAL CANCER
    Giske Ursin; Fiscal Year: 2006
    ..We will also examine in detail the possible impact of phytoestrogens on endometrial cancer risk reduction in conjunction with HRT, obesity and the eight candidate genes under evaluation. ..