Jason D Berndt

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. doi request reprint Beta-catenin gets jaded and von Hippel-Lindau is to blame
    Jason D Berndt
    Howard Hughes Medical Institute, Department of Pharmacology and Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Box 357370, Seattle, WA 98109, USA
    Trends Biochem Sci 34:101-4. 2009
  2. doi request reprint Integrative analysis of genome-wide RNA interference screens
    Jason D Berndt
    Howard Hughes Medical Institute, Department of Pharmacology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA
    Sci Signal 2:pt4. 2009
  3. doi request reprint New regulators of Wnt/beta-catenin signaling revealed by integrative molecular screening
    Michael B Major
    Howard Hughes Medical Institute, Department of Pharmacology, Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Box 357370, Seattle, WA 98195, USA
    Sci Signal 1:ra12. 2008
  4. pmc Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling
    Jason D Berndt
    Howard Hughes Medical Institute, Department of Pharmacology, University of Washington School of Medicine, Seattle, WA 98109, USA
    J Cell Biol 194:737-50. 2011
  5. ncbi request reprint Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling
    Michael B Major
    Howard Hughes Medical Institute, University of Washington School of Medicine, Box 357370, Seattle, WA 98195, USA
    Science 316:1043-6. 2007
  6. doi request reprint Crystal structure of a full-length beta-catenin
    Yi Xing
    Department of Biological Structure, University of Washington School of Medicine, Seattle, WA 98195, USA
    Structure 16:478-87. 2008
  7. pmc Wnt/β-catenin signaling promotes differentiation, not self-renewal, of human embryonic stem cells and is repressed by Oct4
    Kathryn C Davidson
    Department of Pharmacology, Howard Hughes Medical Institute, and the Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 109:4485-90. 2012

Collaborators

Detail Information

Publications7

  1. doi request reprint Beta-catenin gets jaded and von Hippel-Lindau is to blame
    Jason D Berndt
    Howard Hughes Medical Institute, Department of Pharmacology and Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Box 357370, Seattle, WA 98109, USA
    Trends Biochem Sci 34:101-4. 2009
    ..Thus, the loss of VHL, as seen in clear cell renal cell carcinoma, could lead to tumor formation through beta-catenin de-repression...
  2. doi request reprint Integrative analysis of genome-wide RNA interference screens
    Jason D Berndt
    Howard Hughes Medical Institute, Department of Pharmacology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA
    Sci Signal 2:pt4. 2009
    ..We present the ongoing evolution and new strategies for the integrative screening approach with respect to understanding and treating human disease...
  3. doi request reprint New regulators of Wnt/beta-catenin signaling revealed by integrative molecular screening
    Michael B Major
    Howard Hughes Medical Institute, Department of Pharmacology, Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Box 357370, Seattle, WA 98195, USA
    Sci Signal 1:ra12. 2008
    ..Using this methodology, we characterized AGGF1 as a nuclear chromatin-associated protein that participates in beta-catenin-mediated transcription in human colon cancer cells...
  4. pmc Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling
    Jason D Berndt
    Howard Hughes Medical Institute, Department of Pharmacology, University of Washington School of Medicine, Seattle, WA 98109, USA
    J Cell Biol 194:737-50. 2011
    ..These findings provide insights into the mechanisms of Wnt/RYK signaling and point to novel targets for the modulation of Wnt signaling...
  5. ncbi request reprint Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling
    Michael B Major
    Howard Hughes Medical Institute, University of Washington School of Medicine, Box 357370, Seattle, WA 98195, USA
    Science 316:1043-6. 2007
    ..These data provide a possible mechanistic explanation for the tumor suppressor activity of WTX...
  6. doi request reprint Crystal structure of a full-length beta-catenin
    Yi Xing
    Department of Biological Structure, University of Washington School of Medicine, Seattle, WA 98195, USA
    Structure 16:478-87. 2008
    ..Our crystallographic and NMR studies also suggest that the unstructured N-terminal and C-terminal tails interact with the ordered armadillo repeat domain in a dynamic and variable manner...
  7. pmc Wnt/β-catenin signaling promotes differentiation, not self-renewal, of human embryonic stem cells and is repressed by Oct4
    Kathryn C Davidson
    Department of Pharmacology, Howard Hughes Medical Institute, and the Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 109:4485-90. 2012
    ..Together these data support a dominant role for Wnt/β-catenin signaling in the differentiation rather than self-renewal of hESCs...