CHRISTOPHER BERNARDS

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Cerebrospinal fluid and spinal cord distribution of baclofen and bupivacaine during slow intrathecal infusion in pigs
    Christopher M Bernards
    Virginia Mason Medical Center, Department of Anesthesiology, Seattle, Washington 98101, USA
    Anesthesiology 105:169-78. 2006
  2. ncbi request reprint Chronic cocaine administration reversibly increases isoflurane minimum alveolar concentration in sheep
    C M Bernards
    Department of Anesthesiology, University of Washington School of Medicine, Seattle 98195 6540, USA
    Anesthesiology 85:91-5. 1996
  3. doi request reprint Respiratory and sleep effects of remifentanil in volunteers with moderate obstructive sleep apnea
    Christopher M Bernards
    Anesthesiology Faculty, Department of Anesthesiology, Virginia Mason Medical Center, Seattle, Washington 98101 2756, USA
    Anesthesiology 110:41-9. 2009
  4. doi request reprint Regional anesthesia in anesthetized or heavily sedated patients
    Christopher M Bernards
    Department of Anesthesiology, Virginia Mason Medical Center, Seattle, WA 98101 2756, USA
    Reg Anesth Pain Med 33:449-60. 2008
  5. ncbi request reprint Epidural, cerebrospinal fluid, and plasma pharmacokinetics of epidural opioids (part 2): effect of epinephrine
    Christopher M Bernards
    Department of Anesthesiology, Box 356540, University of Washington, Seattle, Washington 98195, USA
    Anesthesiology 99:466-75. 2003
  6. ncbi request reprint Epidural, cerebrospinal fluid, and plasma pharmacokinetics of epidural opioids (part 1): differences among opioids
    Christopher M Bernards
    Department of Anesthesiology, Box 356540, University of Washington, Seattle, Washington 98195, USA
    Anesthesiology 99:455-65. 2003
  7. ncbi request reprint Chronic cocaine exposure alters carbon dioxide reactivity but does not affect cerebral blood flow autoregulation in anesthetized dogs
    Christopher M Bernards
    Department of Anesthesiology, University of Washington, Seattle, Washington 98195 6540, USA
    J Trauma 52:912-21. 2002
  8. ncbi request reprint Effect of chronic cocaine administration on the hemodynamic response to acute hemorrhage in awake and anesthetized sheep
    C M Bernards
    Department of Anesthesiology, University of Washington School of Medicine, Seattle 98195 6540, USA
    J Trauma 42:42-8. 1997
  9. ncbi request reprint Chronic cocaine administration does not modify haemodynamic responses to isoflurane anaesthesia in sheep
    C M Bernards
    Department of Anesthesiology, University of Washington School of Medicine, Seattle 98195 6540, USA
    Can J Anaesth 44:202-7. 1997
  10. ncbi request reprint Effect of epinephrine on lidocaine clearance in vivo: a microdialysis study in humans
    C M Bernards
    Department of Anesthesiology, University of Washington, Seattle 98195, USA
    Anesthesiology 91:962-8. 1999

Research Grants

  1. SPINAL CORD INJURY, METHYLPREDNISOLONE & P GLYCOPROTEIN
    CHRISTOPHER BERNARDS; Fiscal Year: 2002

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Cerebrospinal fluid and spinal cord distribution of baclofen and bupivacaine during slow intrathecal infusion in pigs
    Christopher M Bernards
    Virginia Mason Medical Center, Department of Anesthesiology, Seattle, Washington 98101, USA
    Anesthesiology 105:169-78. 2006
    ..However, to date, there have been no studies aimed at characterizing drug distribution within cerebrospinal fluid (CSF) and spinal cord during these slow infusion rates. Therefore, this study was designed to address this knowledge gap...
  2. ncbi request reprint Chronic cocaine administration reversibly increases isoflurane minimum alveolar concentration in sheep
    C M Bernards
    Department of Anesthesiology, University of Washington School of Medicine, Seattle 98195 6540, USA
    Anesthesiology 85:91-5. 1996
    ..The purpose of this study was to investigate the effect of chronic cocaine exposure on the minimum alveolar concentration (MAC) of isoflurane in sheep...
  3. doi request reprint Respiratory and sleep effects of remifentanil in volunteers with moderate obstructive sleep apnea
    Christopher M Bernards
    Anesthesiology Faculty, Department of Anesthesiology, Virginia Mason Medical Center, Seattle, Washington 98101 2756, USA
    Anesthesiology 110:41-9. 2009
    ..Consequently, the authors designed this study as the first prospective, double-blind, placebo-controlled investigation of opioid pharmacology in patients with documented OSA...
  4. doi request reprint Regional anesthesia in anesthetized or heavily sedated patients
    Christopher M Bernards
    Department of Anesthesiology, Virginia Mason Medical Center, Seattle, WA 98101 2756, USA
    Reg Anesth Pain Med 33:449-60. 2008
    ..The advisory contains recommendations pertaining to both adult and pediatric patients...
  5. ncbi request reprint Epidural, cerebrospinal fluid, and plasma pharmacokinetics of epidural opioids (part 2): effect of epinephrine
    Christopher M Bernards
    Department of Anesthesiology, Box 356540, University of Washington, Seattle, Washington 98195, USA
    Anesthesiology 99:466-75. 2003
    ..This study was designed to characterize the effect of epinephrine on the epidural, cerebrospinal fluid, and plasma pharmacokinetics of epidurally administered opioids...
  6. ncbi request reprint Epidural, cerebrospinal fluid, and plasma pharmacokinetics of epidural opioids (part 1): differences among opioids
    Christopher M Bernards
    Department of Anesthesiology, Box 356540, University of Washington, Seattle, Washington 98195, USA
    Anesthesiology 99:455-65. 2003
    ....
  7. ncbi request reprint Chronic cocaine exposure alters carbon dioxide reactivity but does not affect cerebral blood flow autoregulation in anesthetized dogs
    Christopher M Bernards
    Department of Anesthesiology, University of Washington, Seattle, Washington 98195 6540, USA
    J Trauma 52:912-21. 2002
    ..Consequently, understanding how cocaine alters normal physiology is important to providing appropriate medical care for these patients. This study was designed to identify how chronic cocaine exposure alters cerebrovascular physiology...
  8. ncbi request reprint Effect of chronic cocaine administration on the hemodynamic response to acute hemorrhage in awake and anesthetized sheep
    C M Bernards
    Department of Anesthesiology, University of Washington School of Medicine, Seattle 98195 6540, USA
    J Trauma 42:42-8. 1997
    ..This study determined the effect of chronic cocaine use on the cardiovascular response to hemorrhage in awake and anesthetized sheep...
  9. ncbi request reprint Chronic cocaine administration does not modify haemodynamic responses to isoflurane anaesthesia in sheep
    C M Bernards
    Department of Anesthesiology, University of Washington School of Medicine, Seattle 98195 6540, USA
    Can J Anaesth 44:202-7. 1997
    ..The purpose of this study was to determine the effect of chronic cocaine exposure on the cardiovascular response to isoflurane general anaesthesia...
  10. ncbi request reprint Effect of epinephrine on lidocaine clearance in vivo: a microdialysis study in humans
    C M Bernards
    Department of Anesthesiology, University of Washington, Seattle 98195, USA
    Anesthesiology 91:962-8. 1999
    ..This study was designed to address this issue...
  11. ncbi request reprint Effect of chronic cocaine exposure on the hemodynamic response to vasopressors in sheep
    C M Bernards
    Department of Anesthesiology, University of Washington, Seattle 98195 6540, USA
    J Trauma 43:680-6. 1997
    ..The purpose of this study was to determine how chronic cocaine exposure affects the hemodynamic response to epinephrine, dopamine, phenylephrine, and ephedrine in awake sheep...
  12. doi request reprint Morphine distribution in the spinal cord after chronic infusion in pigs
    Sean H Flack
    Department of Anesthesiology and Pain Medicine, University of Washington, and Seattle Children s Hospital, USA
    Anesth Analg 112:460-4. 2011
    ..We designed this study to determine whether the limited drug distribution observed in our acute studies occurs with chronic administration as well...
  13. ncbi request reprint Sophistry in medicine: lessons from the epidural space
    Christopher M Bernards
    Department of Anesthesiology, University of Washington, Seattle, WA 98195, USA
    Reg Anesth Pain Med 30:56-66. 2005
  14. ncbi request reprint Understanding the physiology and pharmacology of epidural and intrathecal opioids
    Christopher M Bernards
    University of Washington, Box 356540, Seattle, WA 98195, USA
    Best Pract Res Clin Anaesthesiol 16:489-505. 2002
    ..This chapter presents the basic science and clinical data available to assist clinicians in identifying which opioids are appropriate for spinal use and which are not...
  15. ncbi request reprint Pharmacokinetics of intrathecal oligodeoxynucleotides
    Jennifer L Krupp
    Department of Anesthesiology, University of Washington, Seattle, Washington, USA
    Anesthesiology 100:315-22. 2004
    ..To date, there have been no systematic studies of the pharmacokinetics of intrathecal oligonucleotides. This study was designed to fill that knowledge gap...
  16. ncbi request reprint A model to evaluate the pharmacokinetic and pharmacodynamic variables of extended-release products using in vivo tissue microdialysis in humans: bupivacaine-loaded microcapsules
    Dan J Kopacz
    Department of Anesthesiology, Virginia Mason Clinic, Seattle, Washington 98111, USA
    Anesth Analg 97:124-31, table of contents. 2003
    ..Systemic absorption of bupivacaine produces higher peak plasma levels after aqueous injection than after microcapsule injection, despite the injection of a threefold larger load of bupivacaine in the latter...
  17. ncbi request reprint An unusual cause of airway obstruction during general anesthesia with a laryngeal mask airway
    Christopher M Bernards
    Department of Anesthesiology, University of Washington, Seattle, Washington 98195, USA
    Anesthesiology 100:1017-8. 2004
  18. ncbi request reprint Exploring the epidural trail
    Spencer S Liu
    Reg Anesth Pain Med 27:122-4. 2002
  19. ncbi request reprint Does the hole in the dura mater really matter: what's the evidence?
    Christopher M Bernards
    Anesthesiology 101:556; author reply 556-8. 2004

Research Grants4

  1. SPINAL CORD INJURY, METHYLPREDNISOLONE & P GLYCOPROTEIN
    CHRISTOPHER BERNARDS; Fiscal Year: 2002
    ..4. To determine whether increased spinal cord bioavailability of methylprednisolone decreases secondary damage following spinal cord injury. ..