Hans Ulrich Bernard

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Gene expression of genital human papillomaviruses and considerations on potential antiviral approaches
    Hans Ulrich Bernard
    Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609
    Antivir Ther 7:219-37. 2002
  2. doi request reprint Regulatory elements in the viral genome
    Hans Ulrich Bernard
    University of California Irvine, Department of Molecular Biology and Biochemistry, and Program in Public Health, Irvine, CA 92617, United States Electronic address
    Virology 445:197-204. 2013
  3. doi request reprint Taxonomy and phylogeny of papillomaviruses: an overview and recent developments
    Hans Ulrich Bernard
    Dept of Molecular Biology and Biochemistry and Program in Public Health, University of California Irvine, Irvine, CA 92617, USA
    Infect Genet Evol 18:357-61. 2013
  4. ncbi request reprint Genome variation of human papillomavirus types: phylogenetic and medical implications
    Hans Ulrich Bernard
    Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA 92697, USA
    Int J Cancer 118:1071-6. 2006
  5. ncbi request reprint Established and potential strategies against papillomavirus infections
    Hans Ulrich Bernard
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697 3900, USA
    J Antimicrob Chemother 53:137-9. 2004
  6. pmc Classification of papillomaviruses (PVs) based on 189 PV types and proposal of taxonomic amendments
    Hans Ulrich Bernard
    Department of Molecular Biology and Biochemistry and Program of Public Health, University of California Irvine, Irvine, CA 92697, USA
    Virology 401:70-9. 2010
  7. ncbi request reprint The clinical importance of the nomenclature, evolution and taxonomy of human papillomaviruses
    Hans Ulrich Bernard
    Department of Molecular Biology and Biochemistry, 114 Sprague Hall, University of California, Irvine, CA 92697 3900, USA
    J Clin Virol 32:S1-6. 2005
  8. ncbi request reprint Methylation of the human papillomavirus-18 L1 gene: a biomarker of neoplastic progression?
    Tolga Turan
    Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA 92697, USA
    Virology 349:175-83. 2006
  9. pmc Papillomavirus subtypes are natural and old taxa: phylogeny of human papillomavirus types 44 and 55 and 68a and -b
    Itzel E Calleja-Macias
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697 3900, USA
    J Virol 79:6565-9. 2005
  10. pmc Conserved methylation patterns of human papillomavirus type 16 DNA in asymptomatic infection and cervical neoplasia
    Mina Kalantari
    Department of Molecular Biology and Biochemistry, 114 Sprague Hall, University of California, Irvine, Irvine, CA 92697 3900, USA
    J Virol 78:12762-72. 2004

Research Grants

  1. Control of Human Papillomavirus-16 Transcription
    Hans Ulrich Bernard; Fiscal Year: 2002
  2. Control of Human Papillomavirus-16 Transcription
    Hans Ulrich Bernard; Fiscal Year: 2003
  3. Control of Human Papillomavirus-16 Transcription
    Hans Ulrich Bernard; Fiscal Year: 2004
  4. Control of Human Papillomavirus-16 Transcription
    Hans Ulrich Bernard; Fiscal Year: 2003
  5. Control of Human Papillomavirus-16 Transcription
    Hans Ulrich Bernard; Fiscal Year: 2005
  6. Control of Human Papillomavirus-16 Transcription
    Hans Ulrich Bernard; Fiscal Year: 2006

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Gene expression of genital human papillomaviruses and considerations on potential antiviral approaches
    Hans Ulrich Bernard
    Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609
    Antivir Ther 7:219-37. 2002
    ..The application of small molecule-based drugs may be restricted to target proteins encoded by the HPV DNA, such as the replication factor E1 and the transcription/replication factor E2...
  2. doi request reprint Regulatory elements in the viral genome
    Hans Ulrich Bernard
    University of California Irvine, Department of Molecular Biology and Biochemistry, and Program in Public Health, Irvine, CA 92617, United States Electronic address
    Virology 445:197-204. 2013
    ..This review summarizes our knowledge of the regulatory elements in several well-studied Alphapapillomavirus types, and indicates some similarities to other papillomavirus genera, whose properties are yet poorly understood. ..
  3. doi request reprint Taxonomy and phylogeny of papillomaviruses: an overview and recent developments
    Hans Ulrich Bernard
    Dept of Molecular Biology and Biochemistry and Program in Public Health, University of California Irvine, Irvine, CA 92617, USA
    Infect Genet Evol 18:357-61. 2013
    ....
  4. ncbi request reprint Genome variation of human papillomavirus types: phylogenetic and medical implications
    Hans Ulrich Bernard
    Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA 92697, USA
    Int J Cancer 118:1071-6. 2006
    ....
  5. ncbi request reprint Established and potential strategies against papillomavirus infections
    Hans Ulrich Bernard
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697 3900, USA
    J Antimicrob Chemother 53:137-9. 2004
    ..This article summarizes the research on pharmaceutical and immunological approaches that may find a place in clinical practice to complement or replace surgical treatments...
  6. pmc Classification of papillomaviruses (PVs) based on 189 PV types and proposal of taxonomic amendments
    Hans Ulrich Bernard
    Department of Molecular Biology and Biochemistry and Program of Public Health, University of California Irvine, Irvine, CA 92697, USA
    Virology 401:70-9. 2010
    ..We discuss that based on emerging species concepts derived from genome sequences, PV types could be promoted to the taxonomic level of species, but we do not recommend implementing this change at the current time...
  7. ncbi request reprint The clinical importance of the nomenclature, evolution and taxonomy of human papillomaviruses
    Hans Ulrich Bernard
    Department of Molecular Biology and Biochemistry, 114 Sprague Hall, University of California, Irvine, CA 92697 3900, USA
    J Clin Virol 32:S1-6. 2005
    ..Variants of the same HPV type may have different pathogenicity and may account for part of the worldwide disparities in the occurrence of genital cancers...
  8. ncbi request reprint Methylation of the human papillomavirus-18 L1 gene: a biomarker of neoplastic progression?
    Tolga Turan
    Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA 92697, USA
    Virology 349:175-83. 2006
    ....
  9. pmc Papillomavirus subtypes are natural and old taxa: phylogeny of human papillomavirus types 44 and 55 and 68a and -b
    Itzel E Calleja-Macias
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697 3900, USA
    J Virol 79:6565-9. 2005
    ..We conclude that subtypes of HPV types are natural and old taxa, equivalent to types, which either diverged more recently than types or evolved more slowly...
  10. pmc Conserved methylation patterns of human papillomavirus type 16 DNA in asymptomatic infection and cervical neoplasia
    Mina Kalantari
    Department of Molecular Biology and Biochemistry, 114 Sprague Hall, University of California, Irvine, Irvine, CA 92697 3900, USA
    J Virol 78:12762-72. 2004
    ..Our data document the efficient targeting of HPV genomes by the epithelial methylation machinery, possibly as a cellular defense mechanism, and suggest involvement of methylation in HPV oncogene expression and the early-late switch...
  11. pmc Methylation of human papillomavirus 16, 18, 31, and 45 L2 and L1 genes and the cellular DAPK gene: Considerations for use as biomarkers of the progression of cervical neoplasia
    Mina Kalantari
    Department of Dermatology, University of California Irvine, Irvine, CA 92697, United States
    Virology 448:314-21. 2014
    ..We discuss the problem to develop diagnostic tests based on complex methylation patterns that make it difficult to classify amplicons as "methylated" or "unmethylated"...
  12. pmc Human papillomavirus-16 and -18 in penile carcinomas: DNA methylation, chromosomal recombination and genomic variation
    Mina Kalantari
    Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA 92697, USA
    Int J Cancer 123:1832-40. 2008
    ....
  13. doi request reprint Recombination of human papillomavirus-16 and host DNA in exfoliated cervical cells: a pilot study of L1 gene methylation and chromosomal integration as biomarkers of carcinogenic progression
    Mina Kalantari
    Department of Molecular Biology and Biochemistry, University of California at Irvine, Irvine, California, USA
    J Med Virol 82:311-20. 2010
    ..Since L1 gene methylation indicates integration, it has the potential to be used as a clinical marker of cancer progression...
  14. pmc Worldwide genomic diversity of the high-risk human papillomavirus types 31, 35, 52, and 58, four close relatives of human papillomavirus type 16
    Itzel E Calleja-Macias
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697 3900, USA
    J Virol 79:13630-40. 2005
    ..Some had one, two, or three amino acid substitutions in these regions, which might indicate biological and pathogenic diversity between the variants of each HPV type...
  15. ncbi request reprint A transcriptional initiator overlaps with a conserved YY1 binding site in the long control region of human papillomavirus type 16
    Shyh Han Tan
    Institute of Molecular and Cell Biology, Singapore 117609, Republic of Singapore
    Virology 305:486-501. 2003
    ..The study of W12 cells complements the examination of YY1-7436 and points to yet undetected promoters upstream of the LCR...
  16. ncbi request reprint Genomic diversity of human papillomavirus-16, 18, 31, and 35 isolates in a Mexican population and relationship to European, African, and Native American variants
    Itzel E Calleja-Macias
    Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA 92697, USA
    Virology 319:315-23. 2004
    ....
  17. doi request reprint Muscarinic cholinergic signaling in cervical cancer cells affects cell motility via ERK1/2 signaling
    Erinn A Parnell
    Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA 92697, USA
    Life Sci 91:1093-8. 2012
    ..In order to comprehensively evaluate the role of cholinergic signaling in cervical cells, we have addressed additional participation of muscarinic acetylcholine receptors (mAChRs)...
  18. pmc High-throughput detection of human papillomavirus-18 L1 gene methylation, a candidate biomarker for the progression of cervical neoplasia
    Tolga Turan
    Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA 92697, USA
    Virology 361:185-93. 2007
    ....
  19. pmc Effects of cellular differentiation, chromosomal integration and 5-aza-2'-deoxycytidine treatment on human papillomavirus-16 DNA methylation in cultured cell lines
    Mina Kalantari
    Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA 92697, USA
    Virology 374:292-303. 2008
    ....
  20. pmc Association of single nucleotide polymorphisms of nicotinic acetylcholine receptor subunits with cervical neoplasia
    Itzel Calleja-Macias
    Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA 92697, USA
    Life Sci 91:1099-102. 2012
    ..Recent literature suggests that single nucleotide polymorphisms (SNPs) of some of these subunits, notably alpha5, are risk factors for developing lung cancer in smokers as well as in non-smokers...
  21. doi request reprint Cholinergic signaling through nicotinic acetylcholine receptors stimulates the proliferation of cervical cancer cells: an explanation for the molecular role of tobacco smoking in cervical carcinogenesis?
    Itzel E Calleja-Macias
    Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA 92697, USA
    Int J Cancer 124:1090-6. 2009
    ....
  22. pmc Laser capture microdissection of cervical human papillomavirus infections: copy number of the virus in cancerous and normal tissue and heterogeneous DNA methylation
    Mina Kalantari
    Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA 92697, USA
    Virology 390:261-7. 2009
    ..LCM is powerful to study molecular parameters of cervical HPV infections like copy number, latency and epigenetics...
  23. ncbi request reprint The human papillomavirus type 11 and 16 E6 proteins modulate the cell-cycle regulator and transcription cofactor TRIP-Br1
    Sanjay Gupta
    Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609
    Virology 317:155-64. 2003
    ....
  24. pmc Reciprocal effects of NNK and SLURP-1 on oncogene expression in target epithelial cells
    Mina Kalantari-Dehaghi
    Department of Dermatology, University of California, Irvine, CA 92697, USA
    Life Sci 91:1122-5. 2012
    ..To elucidate how the nicotinic acetylcholine receptors expressed on bronchial and oral epithelial cells targeted by the tobacco nitrosamine (4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone) (NNK) facilitate carcinogenic transformation...
  25. pmc CpG methylation of human papillomavirus type 16 DNA in cervical cancer cell lines and in clinical specimens: genomic hypomethylation correlates with carcinogenic progression
    Vinay Badal
    Laboratory for DNA Repair and DNA Methylation in Chemical Carcinogenesis, Institute of Molecular Cell Biology, Singapore 117609, Singapore
    J Virol 77:6227-34. 2003
    ....
  26. ncbi request reprint The human papillomavirus-18 genome is efficiently targeted by cellular DNA methylation
    Sushma Badal
    Laboratory for DNA Repair and DNA Methylation in Chemical Carcinogenesis, Institute of Molecular and Cell Biology, Singapore
    Virology 324:483-92. 2004
    ..Our data show that epithelial cells efficiently target HPV-18 genomes for DNA methylation, which may affect late and early gene transcription...
  27. ncbi request reprint Human papillomavirus-16 DNA methylation patterns support a causal association of the virus with oral squamous cell carcinomas
    Adriana Balderas-Loaeza
    Facultad de Quimica, Universidad Nacional Autonoma de Mexico, Mexico D F, Mexico
    Int J Cancer 120:2165-9. 2007
    ..These data indicate epigenetic changes of HPV-16 in oral carcinomas similar to those in anogenital carcinomas, suggesting carcinogenic processes under the influence of HPV-16 in most if not all of these oral malignant lesions...
  28. ncbi request reprint Analysis of the regulation of viral transcription
    Bernd Gloss
    Neurotransgenic Laboratory, Duke University Medical Center, Durham, NC, USA
    Methods Mol Med 119:261-78. 2005
    ....
  29. ncbi request reprint Worldwide genomic diversity of the human papillomaviruses-53, 56, and 66, a group of high-risk HPVs unrelated to HPV-16 and HPV-18
    Jose C Prado
    Ludwig Institute for Cancer Research, Sao Paulo, Brazil
    Virology 340:95-104. 2005
    ....
  30. ncbi request reprint Methylation of human papillomavirus genomes in cells of anal epithelia of HIV-infected men
    Dorothy J Wiley
    School of Nursing, University of California Los Angeles, Los Angeles, CA, USA
    J Acquir Immune Defic Syndr 39:143-51. 2005
    ..DNA methylation, taken together with virus load, may be useful to diagnose the emergence of a population of tumor cells...
  31. ncbi request reprint Classification of papillomaviruses
    Ethel Michele de Villiers
    Reference Center for Papillomaviruses, Division for the Characterization of Tumorviruses, Deutsches Krebsforschungszentrum, 69120 Heidelberg, Germany
    Virology 324:17-27. 2004
    ..The taxonomic status of PV types, subtypes, and variants remains unchanged and is based on the traditional criteria that the sequence of their L1 genes should be at least 10%, 2-10%, and maximally 2% dissimilar from one another...
  32. ncbi request reprint NMR and mass spectrometry studies of putative interactions of cell cycle proteins pRb and CDK6 with cell differentiation proteins MyoD and ID-2
    Pawel Smialowski
    Max Planck Institute for Biochemistry, 82152 Martinsried, Germany
    Biochim Biophys Acta 1750:48-60. 2005
    ..Indirect interactions, through additional binding partners in multiprotein complexes or modulation of gene expression levels of these proteins, are therefore their probable mode of action...
  33. ncbi request reprint Past, present, and future of HPV research: highlights from the 19th International Papillomavirus Conference-HPV2001
    Luisa Lina Villa
    Virology Department, Ludwig Institute for Cancer Research, R Professor Antonio Prudente 109, 4th Floor, 01509 010 Sao Paulo, Brazil
    Virus Res 89:163-73. 2002
    ..Highlights derive from the analysis of more than 500 papers presented at the Conference...

Research Grants6

  1. Control of Human Papillomavirus-16 Transcription
    Hans Ulrich Bernard; Fiscal Year: 2002
    ....
  2. Control of Human Papillomavirus-16 Transcription
    Hans Ulrich Bernard; Fiscal Year: 2003
    ....
  3. Control of Human Papillomavirus-16 Transcription
    Hans Ulrich Bernard; Fiscal Year: 2004
    ....
  4. Control of Human Papillomavirus-16 Transcription
    Hans Ulrich Bernard; Fiscal Year: 2003
    ....
  5. Control of Human Papillomavirus-16 Transcription
    Hans Ulrich Bernard; Fiscal Year: 2005
    ....
  6. Control of Human Papillomavirus-16 Transcription
    Hans Ulrich Bernard; Fiscal Year: 2006
    ....