JUDITH ANNE BERLINER

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Role of phospholipid oxidation products in atherosclerosis
    Sangderk Lee
    Department of Pathology, University of California Los Angeles, MRL 4760, 675 Charles E Young Dr S, Los Angeles, CA 90095, USA
    Circ Res 111:778-99. 2012
  2. pmc Metalloproteinase processing of HBEGF is a proximal event in the response of human aortic endothelial cells to oxidized phospholipids
    Sangderk Lee
    Department of Pathology, University of California Los Angeles, Los Angeles, CA, USA
    Arterioscler Thromb Vasc Biol 32:1246-54. 2012
  3. pmc The role of oxidized phospholipids in atherosclerosis
    Judith A Berliner
    Department of Pathology, University of California, Los Angeles, CA, USA
    J Lipid Res 50:S207-12. 2009
  4. pmc Endothelial cell regulation by phospholipid oxidation products
    Judith A Berliner
    Department of Pathology, University of California at Los Angeles 13 229 CHS, Pathology, 650 Charles Young Dr South, Los Angeles, CA 90095, USA
    Free Radic Biol Med 45:119-23. 2008
  5. ncbi request reprint Evidence for a role of phospholipid oxidation products in atherogenesis
    J A Berliner
    Departments of Medicine and Pathology, UCLA School of Medicine, Los Angeles, California, USA
    Trends Cardiovasc Med 11:142-7. 2001
  6. ncbi request reprint Role of the Jak/STAT pathway in the regulation of interleukin-8 transcription by oxidized phospholipids in vitro and in atherosclerosis in vivo
    Nima M Gharavi
    Division of Cardiology, Department of Medicine, Department of Pathology, Molecular Biology Institute, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 282:31460-8. 2007
  7. ncbi request reprint Receptors involved in the oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine-mediated synthesis of interleukin-8. A role for Toll-like receptor 4 and a glycosylphosphatidylinositol-anchored protein
    Kimberly A Walton
    Department of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 278:29661-6. 2003
  8. ncbi request reprint High-density lipoprotein modulates oxidized phospholipid signaling in human endothelial cells from proinflammatory to anti-inflammatory
    Nima M Gharavi
    Department of Medicine, University of California, Los Angeles, Calif, USA
    Arterioscler Thromb Vasc Biol 27:1346-53. 2007
  9. ncbi request reprint The unfolded protein response is an important regulator of inflammatory genes in endothelial cells
    Peter S Gargalovic
    UCLA Department of Medicine, Los Angeles, CA 90095 1679, USA
    Arterioscler Thromb Vasc Biol 26:2490-6. 2006
  10. ncbi request reprint Oxidized phospholipid-induced endothelial cell/monocyte interaction is mediated by a cAMP-dependent R-Ras/PI3-kinase pathway
    Amy L Cole
    David Geffen School of Medicine at University of California Los Angeles, Los Angeles, Calif, USA
    Arterioscler Thromb Vasc Biol 23:1384-90. 2003

Research Grants

  1. Endothelial Activation By An Isoprostane Phospholipid
    Judith Berliner; Fiscal Year: 2007
  2. ENDOTHELIAL ACTIVATION BY AN ISOPROSTANE PHOSPHOLIPID
    Judith Berliner; Fiscal Year: 2003
  3. Endothelial Activation By An Isoprostane Phospholipid
    JUDITH ANNE BERLINER; Fiscal Year: 2010

Collaborators

Detail Information

Publications40

  1. pmc Role of phospholipid oxidation products in atherosclerosis
    Sangderk Lee
    Department of Pathology, University of California Los Angeles, MRL 4760, 675 Charles E Young Dr S, Los Angeles, CA 90095, USA
    Circ Res 111:778-99. 2012
    ..With the knowledge we now have of the regulation and effects of Ox-PL in different vascular cell types, it should be possible to design experiments to test the role of specific Ox-PL on the development of atherosclerosis...
  2. pmc Metalloproteinase processing of HBEGF is a proximal event in the response of human aortic endothelial cells to oxidized phospholipids
    Sangderk Lee
    Department of Pathology, University of California Los Angeles, Los Angeles, CA, USA
    Arterioscler Thromb Vasc Biol 32:1246-54. 2012
    ..The goal of this study was to identify the proximal events leading to induction of IL-8 by Ox-PAPC in vascular endothelial cells...
  3. pmc The role of oxidized phospholipids in atherosclerosis
    Judith A Berliner
    Department of Pathology, University of California, Los Angeles, CA, USA
    J Lipid Res 50:S207-12. 2009
    ..Levels of OxPL in plasma have been shown to be correlated with platelet activation. The results of these studies suggest an important role for OxPL in all stages of atherosclerosis...
  4. pmc Endothelial cell regulation by phospholipid oxidation products
    Judith A Berliner
    Department of Pathology, University of California at Los Angeles 13 229 CHS, Pathology, 650 Charles Young Dr South, Los Angeles, CA 90095, USA
    Free Radic Biol Med 45:119-23. 2008
    ..Thus these lipids are potent regulators of endothelial cell function with broad effects comparable in extent but differing from those of cytokines...
  5. ncbi request reprint Evidence for a role of phospholipid oxidation products in atherogenesis
    J A Berliner
    Departments of Medicine and Pathology, UCLA School of Medicine, Los Angeles, California, USA
    Trends Cardiovasc Med 11:142-7. 2001
    ..The mechanism by which these phospholipid oxidation products activate cells has revealed the presence of several different receptors and signal transduction pathways...
  6. ncbi request reprint Role of the Jak/STAT pathway in the regulation of interleukin-8 transcription by oxidized phospholipids in vitro and in atherosclerosis in vivo
    Nima M Gharavi
    Division of Cardiology, Department of Medicine, Department of Pathology, Molecular Biology Institute, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 282:31460-8. 2007
    ..Taken together, these data demonstrate an important role for the JAK2/STAT3 pathway in Ox-PAPC-induced IL-8 transcription in vitro and in atherosclerosis in vivo...
  7. ncbi request reprint Receptors involved in the oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine-mediated synthesis of interleukin-8. A role for Toll-like receptor 4 and a glycosylphosphatidylinositol-anchored protein
    Kimberly A Walton
    Department of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 278:29661-6. 2003
    ..Therefore, these studies suggest that ox-PAPC may initially bind to a 37-kDa GPI-anchored protein, which interacts with TLR4 to induce IL-8 transcription...
  8. ncbi request reprint High-density lipoprotein modulates oxidized phospholipid signaling in human endothelial cells from proinflammatory to anti-inflammatory
    Nima M Gharavi
    Department of Medicine, University of California, Los Angeles, Calif, USA
    Arterioscler Thromb Vasc Biol 27:1346-53. 2007
    ..The goal of the current studies was to determine the role of high-density lipoprotein (HDL) in regulating Ox-PAPC signaling in HAECs...
  9. ncbi request reprint The unfolded protein response is an important regulator of inflammatory genes in endothelial cells
    Peter S Gargalovic
    UCLA Department of Medicine, Los Angeles, CA 90095 1679, USA
    Arterioscler Thromb Vasc Biol 26:2490-6. 2006
    ..The goal of our studies was to identify pathways mediating the induction of inflammatory genes by oxPAPC...
  10. ncbi request reprint Oxidized phospholipid-induced endothelial cell/monocyte interaction is mediated by a cAMP-dependent R-Ras/PI3-kinase pathway
    Amy L Cole
    David Geffen School of Medicine at University of California Los Angeles, Los Angeles, Calif, USA
    Arterioscler Thromb Vasc Biol 23:1384-90. 2003
    ..The present studies identify important signal transduction components regulating this pathway...
  11. ncbi request reprint Vascular endothelial growth factor receptor 2 plays a role in the activation of aortic endothelial cells by oxidized phospholipids
    Alejandro Zimman
    Departments of Medicine, University of California, Los Angeles, CA, USA
    Arterioscler Thromb Vasc Biol 27:332-8. 2007
    ..The present studies identify vascular endothelial growth factor receptor 2 (VEGFR2) as a major regulator in the activation of SREBP and Erk 1/2 in endothelial cells activated by Ox-PAPC...
  12. ncbi request reprint A role for neutral sphingomyelinase activation in the inhibition of LPS action by phospholipid oxidation products
    Kimberly A Walton
    Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    J Lipid Res 47:1967-74. 2006
    ..Furthermore, we identify specific oxidized phospholipids responsible for this inhibition...
  13. pmc A role for NADPH oxidase 4 in the activation of vascular endothelial cells by oxidized phospholipids
    Sangderk Lee
    Department of Pathology, University of California at Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    Free Radic Biol Med 47:145-51. 2009
    ..In summary, we have identified a VEGFR2/NOX4 regulatory pathway by which Ox-PAPC controls important endothelial functions...
  14. ncbi request reprint Specific phospholipid oxidation products inhibit ligand activation of toll-like receptors 4 and 2
    Kimberly A Walton
    Department of Medicine, University of California, Los Angeles, CA 90095 1732, USA
    Arterioscler Thromb Vasc Biol 23:1197-203. 2003
    ..The current studies identify specific phospholipids that inhibit chemokine induction by Toll-like receptor-4 (TLR4) and -2 (TLR2) ligands inECs and macrophages...
  15. pmc Identification of inflammatory gene modules based on variations of human endothelial cell responses to oxidized lipids
    Peter S Gargalovic
    Department of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 103:12741-6. 2006
    ....
  16. ncbi request reprint OKL38 is an oxidative stress response gene stimulated by oxidized phospholipids
    Rongsong Li
    Department of Pathology and Medicine, University of California, Los Angeles, CA 90095, USA
    J Lipid Res 48:709-15. 2007
    ..Our results suggest that OKL38 is regulated via the Nox/Nrf2 pathway in response to oxidative stress stimuli...
  17. pmc Improved synthesis of the epoxy isoprostane phospholipid PEIPC and its reactivity with amines
    Michael E Jung
    Departments of Chemistry and Biochemistry, Medicine Cardiology, and Pathology, University of California, Los Angeles, California 90095, USA
    Org Lett 10:4207-9. 2008
    ..Opening of an intermediate with pentylamine shows that the allylic epoxide is the position of attack by nucleophiles...
  18. pmc Ox-PAPC activation of PMET system increases expression of heme oxygenase-1 in human aortic endothelial cell
    Sangderk Lee
    Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Lipid Res 50:265-74. 2009
    ..Taken together, we demonstrated that the PMET system in HAEC plays an important role in the regulation of cellular redox status and HO-1 expression by Ox-PAPC...
  19. pmc Systems genetics analysis of gene-by-environment interactions in human cells
    Casey E Romanoski
    Department of Human Genetics, University of California, Los Angeles, CA, 90095, USA
    Am J Hum Genet 86:399-410. 2010
    ....
  20. ncbi request reprint Epoxyisoprostane and epoxycyclopentenone phospholipids regulate monocyte chemotactic protein-1 and interleukin-8 synthesis. Formation of these oxidized phospholipids in response to interleukin-1beta
    Ganesamoorthy Subbanagounder
    Department of Medicine, Center for the Health Sciences, Rm 47 123, UCLA Medical Center, Los Angeles, CA 90095 1679, USA
    J Biol Chem 277:7271-81. 2002
    ..Their accumulation in cells exposed to cytokines and in atherosclerotic lesions suggests that these lipids may play a role in a number of chronic disease processes...
  21. ncbi request reprint Role of endothelial nitric oxide synthase in the regulation of SREBP activation by oxidized phospholipids
    Nima M Gharavi
    Division of Cardiology, Department of Medicine, University of California, Los Angeles, USA
    Circ Res 98:768-76. 2006
    ..Taken together, these findings propose a novel role for eNOS in the activation of SREBP and SREBP-mediated inflammatory processes...
  22. ncbi request reprint Hydroxy alkenal phospholipids regulate inflammatory functions of endothelial cells
    Ganesamoorthy Subbanagounder
    Department of Medicine Cardiology, Center for the Health Sciences, Room 47 123, UCLA Medical Center, Los Angeles, CA 90095 1679, USA
    Vascul Pharmacol 38:201-9. 2002
    ..These studies demonstrate the importance of HOOA-PC as a new potential proinflammatory molecule that regulates leukocyte-endothelial interactions...
  23. ncbi request reprint The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL
    Mohamad Navab
    Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    J Lipid Res 45:993-1007. 2004
    ..Apolipoprotein A-I (apoA-I) and apoA-I mimetic peptides may both promote a reduction in oxidized lipids and enhance reverse cholesterol transport and therefore may have therapeutic potential...
  24. pmc Apoptotic cells with oxidation-specific epitopes are immunogenic and proinflammatory
    Mi Kyung Chang
    Division of Endocrinology, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
    J Exp Med 200:1359-70. 2004
    ..These results suggest that apoptotic cell death generates oxidatively modified moieties, which can induce autoimmune responses and a local inflammatory response by recruiting monocytes via monocyte-endothelial cell interaction...
  25. ncbi request reprint Total synthesis of the epoxy isoprostane phospholipids PEIPC and PECPC
    Michael E Jung
    Departments of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA 90095, USA
    Org Lett 7:3933-5. 2005
    ..Final coupling with lyso-PC 16 and silyl group deprotection gave PECPC 2 and PEIPC 1, which showed the same activity as natural PECPC and PEIPC. [reaction: see text]..
  26. ncbi request reprint Oxidized phospholipids increase interleukin 8 (IL-8) synthesis by activation of the c-src/signal transducers and activators of transcription (STAT)3 pathway
    Michael Yeh
    Division of Cardiology, Department of Medicine, University of California, Los Angeles, California 90095, USA
    J Biol Chem 279:30175-81. 2004
    ..Taken together, these data demonstrate the role of the c-src kinase/STAT3 pathway in Ox-PAPC-mediated IL-8 expression in endothelial cells...
  27. ncbi request reprint A role for oxidized phospholipids in atherosclerosis
    Judith A Berliner
    David Geffen School of Medicine, University of California, Los Angeles, USA
    N Engl J Med 353:9-11. 2005
  28. ncbi request reprint Identification of prostaglandin E2 receptor subtype 2 as a receptor activated by OxPAPC
    Rongsong Li
    Department of Pathology, University of California, Los Angeles, CA 90095, USA
    Circ Res 98:642-50. 2006
    ..These results suggest that EP2 functions as a receptor for OxPAPC and PEIPC, either as the phospholipid ester or the released fatty acid, in both endothelial cells and macrophages...
  29. pmc Activation of aortic endothelial cells by oxidized phospholipids: a phosphoproteomic analysis
    Alejandro Zimman
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095 1770, USA
    J Proteome Res 9:2812-24. 2010
    ..Many changes in protein phosphorylation induced by Ox-PAPC are reported here for the first time and provide new insights into the mechanism of activation by oxidized lipids, including phosphorylation-based signal transduction...
  30. pmc Oxidized low-density lipoprotein-activated c-Jun NH2-terminal kinase regulates manganese superoxide dismutase ubiquitination: implication for mitochondrial redox status and apoptosis
    Wakako Takabe
    Department of Biomedical Engineering and Division of Cardiovascular Medicine, School of Medicine and School of Engineering, University of Southern California, 1042 Downey Way, Los Angeles, CA 90089, USA
    Arterioscler Thromb Vasc Biol 30:436-41. 2010
    ..In this study, we investigated the role of manganese superoxide dismutase (Mn-SOD) on oxLDL-induced apoptosis via c-Jun NH2-terminal kinase (JNK)-mediated ubiquitin/proteasome pathway...
  31. ncbi request reprint Minimally oxidized low-density lipoprotein regulates hemostasis factors of brain capillary endothelial cells
    Jeong Ai Kim
    Department of Neurology, University of California, Irvine, College of Medicine, 101 The City Drive South, Building 55, Rm 121, Orange, CA 92868 5120, USA
    J Neurol Sci 217:135-41. 2004
    ..These results suggest that MM-LDL may contribute to thrombus formation in the brain...
  32. ncbi request reprint Glucose regulates monocyte adhesion through endothelial production of interleukin-8
    Suseela Srinivasan
    Division of Cardiology, University of California Los Angeles, Los Angeles, Calif, USA
    Circ Res 92:371-7. 2003
    ..These data indicate that glucose regulates monocyte:endothelial interactions through stimulation of IL-8 and ROS production and activation of the alpha5beta1 integrin complex on HAECs...
  33. ncbi request reprint Future of toxicology--lipidomics, an important emerging area for toxicologists: focus on lipid oxidation products
    Judith A Berliner
    Department of Pathology and Laboratory Medicine, University of California, Los Angeles, 13 229 CHS, 650 Charles Young South, Los Angeles, California 90095 1732, USA jberliner mednet ucla edu
    Chem Res Toxicol 20:849-53. 2007
  34. ncbi request reprint Oxidative stress as a regulator of murine atherosclerosis
    Tzung Hsiai
    Biomedical Engineering and Cardiovascular Medicine, University of Southern California, Los Angeles, CA 90089, USA
    Curr Drug Targets 8:1222-9. 2007
    ..Reactive species from a variety of sources further play an important role in plaque disruption partly through lipid oxidation, low-density lipoprotein oxidation nitration, and signaling [3-6]...
  35. ncbi request reprint Combined blockade of the chemokine receptors CCR1 and CCR5 attenuates chronic rejection
    James J Yun
    Department of Surgery, Division of Cardiothoracic Surgery, University of California at Los Angeles, Los Angeles, Calif, USA
    Circulation 109:932-7. 2004
    ..In this study, we sought to determine whether blockade of chemokine receptors CCR1 and CCR5 with Met-RANTES affects the development of CAV in a murine model...
  36. ncbi request reprint Identification of a biologically active component in minimally oxidized low density lipoprotein (MM-LDL) responsible for aortic smooth muscle cell proliferation
    Subroto Chatterjee
    Department of Pediatrics, Lipid Signaling and Vascular Biology Laboratory, Lipid Research Atherosclerosis Division, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Glycoconj J 20:331-8. 2004
    ....
  37. ncbi request reprint Role for sterol regulatory element-binding protein in activation of endothelial cells by phospholipid oxidation products
    Michael Yeh
    Department of Medicine, Geffen School of Medicine at University of California Los Angeles, USA
    Circ Res 95:780-8. 2004
    ..The current studies suggest a novel role for endothelial cholesterol depletion and subsequent SREBP activation in inflammatory processes in which phospholipid oxidation products accumulate...
  38. ncbi request reprint Specific monocyte adhesion to endothelial cells induced by oxidized phospholipids involves activation of cPLA2 and lipoxygenase
    Joakim Huber
    Department of Vascular Biology and Thrombosis Research, Medical University of Vienna, Austria
    J Lipid Res 47:1054-62. 2006
    ..Further analysis of signaling pathways induced by oxidized phospholipids that lead to specific monocyte adhesion should ultimately lead to the development of novel therapeutic approaches against chronic inflammatory diseases...
  39. ncbi request reprint Altered activities of anti-atherogenic enzymes LCAT, paraoxonase, and platelet-activating factor acetylhydrolase in atherosclerosis-susceptible mice
    Trudy M Forte
    Life Sciences Division MS 1 222, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    J Lipid Res 43:477-85. 2002
    ..We conclude that impairment of LCAT activity and accumulation of oxidized phospholipids are part of an early atherogenic phenotype in these models...
  40. ncbi request reprint Overexpression of interleukin-10 by activated T lymphocytes inhibits atherosclerosis in LDL receptor-deficient Mice by altering lymphocyte and macrophage phenotypes
    Laura J Pinderski
    Department of Medicine, University of California Los Angeles, USA
    Circ Res 90:1064-71. 2002
    ..These studies demonstrate that T lymphocyte IL-10 can influence the function of other immune cells to reduce the development of advanced atherosclerotic lesions in mice...

Research Grants11

  1. Endothelial Activation By An Isoprostane Phospholipid
    Judith Berliner; Fiscal Year: 2007
    ..abstract_text> ..
  2. ENDOTHELIAL ACTIVATION BY AN ISOPROSTANE PHOSPHOLIPID
    Judith Berliner; Fiscal Year: 2003
    ..In summary, this interdisciplinary proposal will provide important information about the receptor interactions of the novel epoxy isoprostane phospholipid PEIPC. ..
  3. Endothelial Activation By An Isoprostane Phospholipid
    JUDITH ANNE BERLINER; Fiscal Year: 2010
    ..These studies thus may provide a new drug target for atherosclerosis and other chronic inflammatory diseases. ..