Research Topics
Genomes and Genes | Tomas BerlSummaryAffiliation: University of Colorado Health Sciences Center Country: USA Publications
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Publications
American Society of Nephrology Presidential Address 2005Tomas Berl
Health Sciences Center, Division of Renal Diseases and Hypertension, University of Colorado at Denver, 4200 E. 9th Avenue, C-281, Denver, CO 80262, USA
J Am Soc Nephrol 17:926-31. 2006- Preclinical pharmacologic basis for clinical use of rhIL-11 as an effective platelet-support agentT Berl
Department of Medicine, University of Colorado, Health Sciences Center, Denver, USA
Oncology (Williston Park) 14:12-20. 2000.... - Impact of solute intake on urine flow and water excretionTomas Berl
University of Colorado at Denver and Health Sciences Center, 4200 East Ninth Avenue, Box C281, Denver, CO 80262, USA
J Am Soc Nephrol 19:1076-8. 2008..In contrast, an increment in solute intake can be used therapeutically to treat this electrolyte disorder and allow those prone to it to liberalize their water intake... - Impact of achieved blood pressure on cardiovascular outcomes in the Irbesartan Diabetic Nephropathy TrialTomas Berl
University of Colorado Health Sciences Center, 4200 East 9th Avenue, C 281, Denver, CO 80262, USA
J Am Soc Nephrol 16:2170-9. 2005..It is concluded that achieved SBP approaching 120 mmHg and diastolic BP of 85 mmHg are associated with the best protection against CV events in these patients. BP < or =120/85 may be associated with an increase in CV events... - Kidney-heart interactions: epidemiology, pathogenesis, and treatmentTomas Berl
University of Colorado Health Sciences Center, Denver, Colorado, USA
Clin J Am Soc Nephrol 1:8-18. 2006 - Angiotensin-converting enzyme inhibitors versus AT1 receptor antagonist in cardiovascular and renal protection: the case for AT1 receptor antagonistTomas Berl
University of Colorado Health Sciences Center, Department of Medicine, Division of Renal Diseases and Hypertension, Denver, Colorado 80262, USA
J Am Soc Nephrol 15:S71-6. 2004..However, when progression of renal disease is used as an end point, protection has been demonstrated with ACEI only for type 1 but not type 2 diabetes. In this latter group, only ARB have been shown to slow progression to ESRD... - Review: renal protection by inhibition of the renin-angiotensin-aldosterone systemTomas Berl
Division of Renal Diseases and Hypertension, University of Colorado at Denver Health Sciences Center, Denver, Colorado 80262, USA
J Renin Angiotensin Aldosterone Syst 10:1-8. 2009..Future trials should examine higher RAAS inhibitor doses, facilitate differentiation of renoprotective and antihypertensive effects of RAAS blockade, and use end-points that robustly demonstrate renoprotective effects... - The expression of aquaporin-1 in the medulla of the kidney is dependent on the transcription factor associated with hypertonicity, TonEBPMiguel A Lanaspa
Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado, Denver, Colorado 80045, USA
J Biol Chem 285:31694-703. 2010..In conclusion, these data demonstrate that TonEBP is necessary for the regulation of AQP1 expression in the inner medulla of the kidney under hypertonic conditions... - Hypertonic stress increases claudin-4 expression and tight junction integrity in association with MUPP1 in IMCD3 cellsMiguel A Lanaspa
Division of Renal Diseases and Hypertension, School of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Proc Natl Acad Sci U S A 105:15797-802. 2008.... - Cardiovascular outcomes in the Irbesartan Diabetic Nephropathy Trial of patients with type 2 diabetes and overt nephropathyTomas Berl
University of Colorado Medical School, Denver, Colorado, USA
Ann Intern Med 138:542-9. 2003..004). CONCLUSION: The composite cardiovascular event rate did not differ in patients with type 2 diabetes and overt nephropathy treated with irbesartan, amlodipine, or placebo in addition to conventional antihypertensive therapy... - A metabonomic and proteomic analysis of changes in IMCD3 cells chronically adapted to hypertonicityJost Klawitter
Department of Anesthesiology, School of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Nephron Physiol 109:p1-10. 2008..The genomic response to adaptation of IMCD3 cells to hypertonicity results in both upregulation and downregulation of a variety of genes... - The tight junction protein, MUPP1, is up-regulated by hypertonicity and is important in the osmotic stress response in kidney cellsMiguel A Lanaspa
Division of Renal Diseases and Hypertension, School of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Proc Natl Acad Sci U S A 104:13672-7. 2007..These results suggest that MUPP1 specifically, and potentially tight junction complexes in general, are important in the renal osmoadaptive response... - Effects of 2-bromoethanamine on TonEBP expression and its possible role in induction of renal papillary necrosis in miceAna Andres-Hernando
Division of Renal Diseases and Hypertension, School of Medicine, University of Colorado Denver, Aurora, Colorado 80045, USA
Toxicol Sci 118:510-20. 2010..Our data suggest that TonEBP is a potential target for BEA leading to the process of papillary necrosis in the settings of hypertonic stress... - ZAC1 is up-regulated by hypertonicity and decreases sorbitol dehydrogenase expression, allowing accumulation of sorbitol in kidney cellsMiguel A Lanaspa
Department of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
J Biol Chem 284:19974-81. 2009..Taken together, these data strongly suggest that ZAC1 is up-regulated under hypertonic stress and negatively regulates expression of SDH, allowing for accumulation of sorbitol as a compatible organic osmolyte... - Oral tolvaptan is safe and effective in chronic hyponatremiaTomas Berl
University of Colorado Denver, Division of Renal Diseases and Hypertension, Aurora, CO 80045, USA
J Am Soc Nephrol 21:705-12. 2010..In conclusion, prolonged administration of tolvaptan maintains an increased serum sodium with an acceptable margin of safety... - Expression of the calcium-binding protein S100A4 is markedly up-regulated by osmotic stress and is involved in the renal osmoadaptive responseChristopher J Rivard
Division of Renal Diseases and Hypertension, School of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Biol Chem 282:6644-52. 2007..In summary, we describe the heretofore unrecognized up-regulation of a small calcium-binding protein, both in vitro and in vivo, whose absence profoundly delays osmoadaptation and slows cellular growth under hypertonic conditions... - Nucleoporin 88 (Nup88) is regulated by hypertonic stress in kidney cells to retain the transcription factor tonicity enhancer-binding protein (TonEBP) in the nucleusAna Andres-Hernando
Division of Renal Diseases and Hypertension, School of Medicine, University Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Biol Chem 283:25082-90. 2008..Our data, therefore, suggest that Nup88 is up-regulated in response to hypertonic stress and acts to retain TonEBP in the nucleus, activating transcription of critical osmoprotective genes... - Relationship between cystatin C and coronary artery atherosclerosis progression differs by type 1 diabetesDavid M Maahs
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045, USA
Diabetes Technol Ther 12:25-33. 2010..To expand on our previous report, we investigated whether the relationship of cystatin C to progression of coronary artery atherosclerosis (CA) differed between individuals with type 1 diabetes (T1D) and persons without diabetes... - Adaptation of murine inner medullary collecting duct (IMCD3) cell cultures to hypertonicityJuan M Capasso
Department of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
Ann N Y Acad Sci 986:410-5. 2003..Failure to upregulate the expression of the gamma subunit was associated with a marked decrease in cell viability upon stress... - p38 MAP kinase modulates liver cell volume through inhibition of membrane Na+ permeabilityA P Feranchak
Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Clin Invest 108:1495-504. 2001..Thus, functional interactions between p38 MAP kinase and ion channels may represent an important target for modifying volume-sensitive liver functions... - Long-term outcomes after coronary artery bypass grafting: preoperative kidney function is prognosticMichel B Chonchol
University of Colorado Health Sciences Center, Division of Renal Diseases and Hypertension, Denver, Colo 80262, USA
J Thorac Cardiovasc Surg 134:683-9. 2007..The purpose of this study was to assess the impact of kidney function on long-term outcomes in patients undergoing coronary artery bypass grafting... - Silencing and overexpression of the gamma-subunit of Na-K-ATPase directly affect survival of IMCD3 cells in response to hypertonic stressJuan M Capasso
Division of Renal Diseases and Hypertension, Univeristy of Colorado Health Sciences Center, 4200 E 9th Ave, Denver, CO 80262, USA
Am J Physiol Renal Physiol 291:F1142-7. 2006..Taken together, these data demonstrate a direct and critical role of the gamma-subunit on IMCD3 cell survival and/or adaptation in response to ionic hypertonic stress... - Pathogenesis of diabetic nephropathyClaudia van Dijk
University of Colorado Health Sciences Center, Division of Renal Diseases and Hypertension, 4200 E. 9th Ave, C-281, Denver, CO 80262, USA
Rev Endocr Metab Disord 5:237-48. 2004 - Synthesis of the Na-K-ATPase gamma-subunit is regulated at both the transcriptional and translational levels in IMCD3 cellsJuan M Capasso
University of Colorado Health Sciences Center, 4200 E 9th Ave, Mail Stop C 281, Denver, CO 80262, USA
Am J Physiol Renal Physiol 288:F76-81. 2005..There is also posttranscriptional cell specificity in the expression of the gamma -subunit of Na-K-ATPase... - Serum cystatin C predicts progression of subclinical coronary atherosclerosis in individuals with type 1 diabetesDavid M Maahs
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, P O Box 6511, Mail Stop A140, Aurora, CO 80045, USA
Diabetes 56:2774-9. 2007.... - Care of undocumented individuals with ESRD: a national survey of US nephrologistsLaura Hurley
Division of General Internal Medicine, Denver Health, Denver, CO 80204, USA
Am J Kidney Dis 53:940-9. 2009..Although Medicare covers most dialysis therapy for US citizens with end-stage renal disease (ESRD), no national standards for dialysis provision exist for undocumented (ie, immigrant) patients with ESRD... - Tolvaptan, a selective oral vasopressin V2-receptor antagonist, for hyponatremiaRobert W Schrier
University of Colorado, Denver, USA
N Engl J Med 355:2099-112. 2006..We investigated whether tolvaptan, an orally active vasopressin V(2)-receptor antagonist that promotes aquaresis--excretion of electrolyte-free water--might be of benefit in hyponatremia... - Chloride, not sodium, stimulates expression of the gamma subunit of Na/K-ATPase and activates JNK in response to hypertonicity in mouse IMCD3 cellsJuan M Capasso
Department of Medicine, Division of Renal Disease and Hypertension, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver 80262, USA
Proc Natl Acad Sci U S A 100:6428-33. 2003.... - The expression of the gamma subunit of Na-K-ATPase is regulated by osmolality via C-terminal Jun kinase and phosphatidylinositol 3-kinase-dependent mechanismsJ M Capasso
Department of Medicine, Division of Nephrology, University of Colorado School of Medicine, 4200 East 9th Avenue, Denver, CO 80262, USA
Proc Natl Acad Sci U S A 98:13414-9. 2001..This regulation is transcriptionally regulated and involves signaling mediated by phosphatidylinositol 3-kinase and c-Jun N-terminal kinase 2 pathways... - Multiple mitogen-activated protein kinases are regulated by hyperosmolality in mouse IMCD cellsT Berl
Department of Medicine, University of Colorado School of Medicine, Denver 80262, USA
Am J Physiol 272:F305-11. 1997..The roles for JNK and p38 have not been ruled out, and these pathways may represent the initiating event in the subsequent transcription of organic osmolyte transporter genes and adaptation to extracellular hypertonicity... - Mortality and serum sodium in CKD--yet another U?shaped curveAnna Jovanovich
Division of Renal Diseases and Hypertension, University of Colorado, Aurora, CO 80045, USA
Nat Rev Nephrol 8:261-3. 2012.... - The gamma subunit of Na/K-ATPase: an exceptional, small transmembrane proteinChristopher J Rivard
Division of Renal Medicine, University of Colorado Health Sciences Center, School of Medicine, 4200 E. 9th Ave, Denver, CO 80262, USA
Front Biosci 10:2604-10. 2005..Alternative roles have been established for the gamma subunit in embryonic development and quite possibly additional functions in cell signaling as yet unrecognized may be possible... - Long-term adaptation of renal cells to hypertonicity: role of MAP kinases and Na-K-ATPaseJ M Capasso
Division of Nephrology, Department of Medicine, University of Colorado School of Medicine, Denver, CO 80262, USA
Am J Physiol Renal Physiol 280:F768-76. 2001..Rather, in this setting there is upregulation of other osmoprotective proteins, among which Na-K-ATPase appears to be an important component of the adaptive process... - Clinically unrecognized Q-wave myocardial infarction in patients with diabetes mellitus, systemic hypertension, and nephropathyDavid Aguilar
Division of Cardiology, University of Texas Health Science Center, Houston, 77030, USA
Am J Cardiol 94:337-9. 2004..During a mean follow-up of 2.5 years, 14 of 99 first nonfatal MIs in this group were clinically unrecognized, accounting for 14% of all first nonfatal MIs... - Effects of sulodexide in patients with type 2 diabetes and persistent albuminuriaHiddo Lambers Heerspink
Department of Clinical Pharmacology University Medical Center Groningen, University of Groningen, A Deusinglaan, 19713 AV Groningen, The Netherlands
Nephrol Dial Transplant 23:1946-54. 2008..We have conducted a multi-center randomized double-blind pilot study in order to determine the effect of 6 months' therapy with sulodexide on urinary albumin excretion and to address logistical issues for a full-scale trial... - A multicenter, randomized, double-blind, placebo-controlled, dose-ranging study of AST-120 (Kremezin) in patients with moderate to severe CKDGerald Schulman
Nephrology, Vanderbilt University Medical Center, Nashville, TN, USA
Am J Kidney Dis 47:565-77. 2006..AST-120 is approved in Japan for prolonging time to hemodialysis therapy and improving uremic symptoms in patients with CKD... - Clinical practice. The syndrome of inappropriate antidiuresisDavid H Ellison
Division of Nephrology and Hypertension and the Department of Physiology and Pharmacology, Oregon Health and Science University and Veterans Affairs Medical Center, Portland, OR 97239, USA
N Engl J Med 356:2064-72. 2007 - Lower progression rate of end-stage renal disease in patients with peripheral arterial disease using statins or Angiotensin-converting enzyme inhibitorsHarm H H Feringa
Department of Cardiology, Erasmus Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
J Am Soc Nephrol 18:1872-9. 2007..68 to 0.96], respectively). In patients with PAD, low ABI values independently predict the onset of ESRD. Less progression toward ESRD and improved cardiovascular outcome was observed among patients who were on long-term statins and ACEI... - The gamma-subunit of Na-K-ATPase is incorporated into plasma membranes of mouse IMCD3 cells in response to hypertonicityKaarina Pihakaski-Maunsbach
The Water and Salt Research Ctr, Dept of Cell Biology, Institute of Anatomy, Univ of Aarhus, DK 8000 Aarhus C, Denmark
Am J Physiol Renal Physiol 288:F650-7. 2005..We conclude that the gamma-subunit has an important role in the function of Na-K-ATPase to sustain the cellular cation balance over the plasma membrane in a hypertonic environment... - The Adrogue-Madias formula revisitedTomas Berl
Clin J Am Soc Nephrol 2:1098-9. 2007
Research Grants
- Osmoregulated Proteins in the Inner MedullaTomas Berl; Fiscal Year: 2005..These experiments should define genes and proteins involved in osmoregulation and particularly unveil the role of the y subunit as a vital component in the adaption to the hypertonic environment of the mammalian inner medulla. ..
- Osmoregulated Proteins in the Inner MedullaTomas Berl; Fiscal Year: 2007..These experiments should define genes and proteins involved in osmoregulation and particularly unveil the role of the subunit as a vital component in the adaption to the hypertonic environment of the mammalian inner medulla. ..
- RENAL AND ELECTROLYTE DISEASE AND HYPERTENSIONTomas Berl; Fiscal Year: 2007..This ensures that the individual is ready for his or her initial clinical training, which is then followed by their research training. ..