B C Berk

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi request reprint Vascular smooth muscle growth: autocrine growth mechanisms
    B C Berk
    Center for Cardiovascular Research, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642, USA
    Physiol Rev 81:999-1030. 2001
  2. ncbi request reprint Transactivation: a novel signaling pathway from angiotensin II to tyrosine kinase receptors
    Y Saito
    Center for Cardiovascular Research, University of Rochester, Rochester, NY, USA
    J Mol Cell Cardiol 33:3-7. 2001
  3. ncbi request reprint Bcr in vascular smooth muscle cells involvement of Ras and Raf-1 activation by Bcr
    J I Abe
    Center for Cardiovascular Research, University of Rochester, New York 14642, USA
    Ann N Y Acad Sci 947:341-3. 2001
  4. pmc Laminar flow inhibits TNF-induced ASK1 activation by preventing dissociation of ASK1 from its inhibitor 14-3-3
    Y Liu
    Center for Cardiovascular Research, University of Rochester Medical Center, Rochester, New York 14641, USA
    J Clin Invest 107:917-23. 2001
  5. ncbi request reprint Endothelial atheroprotective and anti-inflammatory mechanisms
    B C Berk
    Department of Medicine, Center for Cardiovascular Research, University of Rochester, New York 14642, USA
    Ann N Y Acad Sci 947:93-109; discussion 109-11. 2001
  6. pmc Fluid shear stress inhibits TNF-alpha activation of JNK but not ERK1/2 or p38 in human umbilical vein endothelial cells: Inhibitory crosstalk among MAPK family members
    J Surapisitchat
    Department of Medicine, Center for Cardiovascular Research, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 98:6476-81. 2001
  7. pmc Receptor heterodimerization: essential mechanism for platelet-derived growth factor-induced epidermal growth factor receptor transactivation
    Y Saito
    Center for Cardiovascular Research, University of Rochester, Rochester, New York 14642, USA
    Mol Cell Biol 21:6387-94. 2001
  8. ncbi request reprint Angiotensin II signal transduction in vascular smooth muscle: pathways activated by specific tyrosine kinases
    B C Berk
    University of Rochester, Department of Medicine, New York 14642, USA
    J Am Soc Nephrol 10:S62-8. 1999
  9. ncbi request reprint p160 Bcr mediates platelet-derived growth factor activation of extracellular signal-regulated kinase in vascular smooth muscle cells
    W Che
    Center for Cardiovascular Research, University of Rochester, Rochester, NY, USA
    Circulation 104:1399-406. 2001
  10. ncbi request reprint Angiotensin II mediated signal transduction. Important role of tyrosine kinases
    J Haendeler
    Center for Cardiovascular Research, University of Rochester, Rochester, NY, USA
    Regul Pept 95:1-7. 2000

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Vascular smooth muscle growth: autocrine growth mechanisms
    B C Berk
    Center for Cardiovascular Research, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642, USA
    Physiol Rev 81:999-1030. 2001
    ..Finally, the heterogeneous nature of VSMC developmental origin provides another level of complexity in VSMC growth mechanisms...
  2. ncbi request reprint Transactivation: a novel signaling pathway from angiotensin II to tyrosine kinase receptors
    Y Saito
    Center for Cardiovascular Research, University of Rochester, Rochester, NY, USA
    J Mol Cell Cardiol 33:3-7. 2001
    ..There is accumulating evidence that GPCR take advantage of signaling pathways downstream of RTK to exert its effect on the cells. In this context, RTK may be considered as one of signaling molecules downstream of GPCR...
  3. ncbi request reprint Bcr in vascular smooth muscle cells involvement of Ras and Raf-1 activation by Bcr
    J I Abe
    Center for Cardiovascular Research, University of Rochester, New York 14642, USA
    Ann N Y Acad Sci 947:341-3. 2001
    ..These results demonstrated the importance of Bcr in PDGF-mediated events such as activation of Ras, Raf-1, and ERK1/2 and stimulation of DNA synthesis...
  4. pmc Laminar flow inhibits TNF-induced ASK1 activation by preventing dissociation of ASK1 from its inhibitor 14-3-3
    Y Liu
    Center for Cardiovascular Research, University of Rochester Medical Center, Rochester, New York 14641, USA
    J Clin Invest 107:917-23. 2001
    ..These data establish ASK1 as a target for flow-mediated inhibition of cytokine signaling and indicate a novel role for 14-3-3 as an anti-inflammatory mediator in ECs...
  5. ncbi request reprint Endothelial atheroprotective and anti-inflammatory mechanisms
    B C Berk
    Department of Medicine, Center for Cardiovascular Research, University of Rochester, New York 14642, USA
    Ann N Y Acad Sci 947:93-109; discussion 109-11. 2001
    ..In summary, the atheroprotective effects of steady laminar flow on the endothelium involve multiple synergistic mechanisms...
  6. pmc Fluid shear stress inhibits TNF-alpha activation of JNK but not ERK1/2 or p38 in human umbilical vein endothelial cells: Inhibitory crosstalk among MAPK family members
    J Surapisitchat
    Department of Medicine, Center for Cardiovascular Research, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 98:6476-81. 2001
    ..Inhibition of TNF-alpha signal transduction represents a mechanism by which steady laminar flow may exert atheroprotective effects on the endothelium...
  7. pmc Receptor heterodimerization: essential mechanism for platelet-derived growth factor-induced epidermal growth factor receptor transactivation
    Y Saito
    Center for Cardiovascular Research, University of Rochester, Rochester, New York 14642, USA
    Mol Cell Biol 21:6387-94. 2001
    ..In conclusion, our data demonstrate that the PDGFbetaR and the EGFR form PDGFbetaR-EGFR heterodimers basally, and we suggest that heterodimers represent a novel signaling complex which plays an important role in PDGF signal transduction...
  8. ncbi request reprint Angiotensin II signal transduction in vascular smooth muscle: pathways activated by specific tyrosine kinases
    B C Berk
    University of Rochester, Department of Medicine, New York 14642, USA
    J Am Soc Nephrol 10:S62-8. 1999
    ..Thus, understanding AngII-stimulated signaling events, especially those related to tyrosine kinase activity, may form the basis for the development of new therapies for cardiovascular diseases...
  9. ncbi request reprint p160 Bcr mediates platelet-derived growth factor activation of extracellular signal-regulated kinase in vascular smooth muscle cells
    W Che
    Center for Cardiovascular Research, University of Rochester, Rochester, NY, USA
    Circulation 104:1399-406. 2001
    ..Because Bcr encodes a serine/threonine protein kinase, we studied its kinase activity and determined the role of Bcr in the PDGF signaling pathway to ERK1/2 activation and DNA synthesis in rat aortic smooth muscle cells (RASMCs)...
  10. ncbi request reprint Angiotensin II mediated signal transduction. Important role of tyrosine kinases
    J Haendeler
    Center for Cardiovascular Research, University of Rochester, Rochester, NY, USA
    Regul Pept 95:1-7. 2000
    ..Understanding the importance of tyrosine phosphorylation in AngII-stimulated signaling events may contribute to new therapies for cardiovascular and renal diseases...
  11. ncbi request reprint Redox signals that regulate the vascular response to injury
    B C Berk
    Center for Cardiovascular Research, University of Rochester, NY 14642, USA
    Thromb Haemost 82:810-7. 1999
    ..Although the complexity of ROS-mediated signal transduction is daunting, the diversity offers multiple therapeutic targets for pharmacologic intervention...
  12. ncbi request reprint Upregulation of phosphodiesterase 1A1 expression is associated with the development of nitrate tolerance
    D Kim
    Department of Medicine, University of Rochester, Rochester, NY, USA
    Circulation 104:2338-43. 2001
    ..Inhibiting PDE1A1 expression and/or activity could be a novel therapeutic approach to limit nitrate tolerance...
  13. ncbi request reprint 14-3-3 Binding to Na+/H+ exchanger isoform-1 is associated with serum-dependent activation of Na+/H+ exchange
    S Lehoux
    Center for Cardiovascular Research and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 276:15794-800. 2001
    ..13 +/- 0.02 versus 0.48 +/- 0.06 mmol of H(+)/min/liter, p < 0.01). These data suggest that 14-3-3 binding to NHE1 participates in serum-stimulated exchanger activation, a new function for 14-3-3...
  14. ncbi request reprint Molecular cloning of mouse ERK5/BMK1 splice variants and characterization of ERK5 functional domains
    C Yan
    Center for Cardiovascular Research, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 276:10870-8. 2001
    ..Taken together, these observations indicate that ERK5 is regulated by distinct mechanisms determined by its unique structure and presumably the presence of multiple splice variants...
  15. ncbi request reprint Retinoic acid-induced tissue transglutaminase and apoptosis in vascular smooth muscle cells
    H Ou
    Center for Cardiovascular Research, University of Rochester Medical Center, Rochester, NY, USA
    Circ Res 87:881-7. 2000
    ..atRA-mediated apoptosis in SMCs seems to require the participation of active tTG, suggesting a potential mechanistic link between this retinoid-inducible gene and programmed cell death...
  16. pmc SOXF: redox mediators of vascular smooth muscle cell growth
    Z G Jin
    Center for Cardiovascular Research, University of Rochester, New York 14642, USA
    Heart 90:488-90. 2004