B C Berk

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi request reprint Cyclophilin A is an important mediator of platelet function by regulating integrin αIIbβ3 bidirectional signalling
    Lian Wang
    Bradford C Berk, MD, PhD, Aab Cardiovascular Research Institute, University of Rochester, Box CVRI, 601 Elmwood Avenue, Rochester, NY 14642, USA, Tel 1 585 275 3407, Fax 1 585 273 1059, E mail
    Thromb Haemost 111:873-82. 2014
  2. pmc Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms
    Kimio Satoh
    Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Nat Med 15:649-56. 2009
  3. pmc Cyclophilin A is an inflammatory mediator that promotes atherosclerosis in apolipoprotein E-deficient mice
    Patrizia Nigro
    Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Exp Med 208:53-66. 2011
  4. pmc Thioredoxin-interacting protein mediates sustained VEGFR2 signaling in endothelial cells required for angiogenesis
    Shin Young Park
    Aab Cardiovascular Research Institute, University of Rochester, 601 Elmwood Ave, Box CVRI, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 33:737-43. 2013
  5. pmc p62 binding to protein kinase C ζ regulates tumor necrosis factor α-induced apoptotic pathway in endothelial cells
    Geun Young Kim
    Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 32:2974-80. 2012
  6. pmc Thioredoxin-interacting protein mediates nuclear-to-plasma membrane communication: role in vascular endothelial growth factor 2 signaling
    Oded N Spindel
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Aab Cardiovascular Research Institute, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 32:1264-70. 2012
  7. pmc Thioredoxin interacting protein promotes endothelial cell inflammation in response to disturbed flow by increasing leukocyte adhesion and repressing Kruppel-like factor 2
    Xiao Qun Wang
    Aab Cardiovascular Research Institute, 601 Elmwood Avenue, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Circ Res 110:560-8. 2012
  8. pmc Genetic determinants of vascular remodelling
    Bradford C Berk
    Center for Cardiolovascular Research and Department of Medicine, University of Rochester, Rochester, New York 14642, USA
    Can J Cardiol 22:6B-11B. 2006
  9. ncbi request reprint Endothelial atheroprotective and anti-inflammatory mechanisms
    B C Berk
    Department of Medicine, Center for Cardiovascular Research, University of Rochester, New York 14642, USA
    Ann N Y Acad Sci 947:93-109; discussion 109-11. 2001
  10. doi request reprint Atheroprotective signaling mechanisms activated by steady laminar flow in endothelial cells
    Bradford C Berk
    Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Circulation 117:1082-9. 2008

Research Grants

  1. Genetics of Vascular Remodeling
    Bradford C Berk; Fiscal Year: 2010
  2. FLUID SHEAR STRESS SIGNAL TRANSDUCTION IN ENDOTHELIUM
    Bradford Berk; Fiscal Year: 2006
  3. Genetics of Vascular Remodeling
    Bradford Berk; Fiscal Year: 2006
  4. FLUID SHEAR STRESS SIGNAL TRANSDUCTION IN ENDOTHELIUM
    Bradford Berk; Fiscal Year: 2005
  5. OXIDATIVE STRESS AND VASCULAR SMOOTH MUSCLE CELL GROWTH
    Bradford Berk; Fiscal Year: 2006
  6. ANGIOTENSIN II SIGNAL TRANSDUCTION
    Bradford Berk; Fiscal Year: 2006
  7. Genetics of Vascular Remodeling
    Bradford Berk; Fiscal Year: 2005
  8. Genetics of Vascular Remodeling
    Bradford Berk; Fiscal Year: 2004
  9. ANGIOTENSIN II SIGNAL TRANSDUCTION
    Bradford Berk; Fiscal Year: 2007
  10. ANGIOTENSIN II SIGNAL TRANSDUCTION
    Bradford Berk; Fiscal Year: 2006

Collaborators

Detail Information

Publications112 found, 100 shown here

  1. ncbi request reprint Cyclophilin A is an important mediator of platelet function by regulating integrin αIIbβ3 bidirectional signalling
    Lian Wang
    Bradford C Berk, MD, PhD, Aab Cardiovascular Research Institute, University of Rochester, Box CVRI, 601 Elmwood Avenue, Rochester, NY 14642, USA, Tel 1 585 275 3407, Fax 1 585 273 1059, E mail
    Thromb Haemost 111:873-82. 2014
    ..In conclusion, CyPA is an important mediator in platelet function by regulation of αIIbβ3 bidirectionalsignalling through increased ROS production and facilitating interaction between αIIbβ3 and the cell cytoskeleton. ..
  2. pmc Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms
    Kimio Satoh
    Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Nat Med 15:649-56. 2009
    ..These data define a previously undescribed role for CypA in AAA formation and suggest CypA as a new target for treating cardiovascular disease...
  3. pmc Cyclophilin A is an inflammatory mediator that promotes atherosclerosis in apolipoprotein E-deficient mice
    Patrizia Nigro
    Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Exp Med 208:53-66. 2011
    ..These data define a role for CyPA in atherosclerosis and suggest CyPA as a target for cardiovascular therapies...
  4. pmc Thioredoxin-interacting protein mediates sustained VEGFR2 signaling in endothelial cells required for angiogenesis
    Shin Young Park
    Aab Cardiovascular Research Institute, University of Rochester, 601 Elmwood Ave, Box CVRI, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 33:737-43. 2013
    ..Because VEGFR2 is critical for angiogenesis, we explored the role of TXNIP in VEGF-induced angiogenesis...
  5. pmc p62 binding to protein kinase C ζ regulates tumor necrosis factor α-induced apoptotic pathway in endothelial cells
    Geun Young Kim
    Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 32:2974-80. 2012
    ....
  6. pmc Thioredoxin-interacting protein mediates nuclear-to-plasma membrane communication: role in vascular endothelial growth factor 2 signaling
    Oded N Spindel
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Aab Cardiovascular Research Institute, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 32:1264-70. 2012
    ..Because TXNIP is an α-arrestin that regulates VEGFR2 signaling, we hypothesized that PARP1 regulates TXNIP localization and function that might affect HUVEC stress-induced apoptosis...
  7. pmc Thioredoxin interacting protein promotes endothelial cell inflammation in response to disturbed flow by increasing leukocyte adhesion and repressing Kruppel-like factor 2
    Xiao Qun Wang
    Aab Cardiovascular Research Institute, 601 Elmwood Avenue, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Circ Res 110:560-8. 2012
    ..We previously showed that thioredoxin interacting protein (TXNIP) was required for tumor necrosis factor-mediated expression of vascular cell adhesion molecule-1...
  8. pmc Genetic determinants of vascular remodelling
    Bradford C Berk
    Center for Cardiolovascular Research and Department of Medicine, University of Rochester, Rochester, New York 14642, USA
    Can J Cardiol 22:6B-11B. 2006
    ..This model should be useful to identify and characterize the role of genes that mediate vascular remodelling...
  9. ncbi request reprint Endothelial atheroprotective and anti-inflammatory mechanisms
    B C Berk
    Department of Medicine, Center for Cardiovascular Research, University of Rochester, New York 14642, USA
    Ann N Y Acad Sci 947:93-109; discussion 109-11. 2001
    ..In summary, the atheroprotective effects of steady laminar flow on the endothelium involve multiple synergistic mechanisms...
  10. doi request reprint Atheroprotective signaling mechanisms activated by steady laminar flow in endothelial cells
    Bradford C Berk
    Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Circulation 117:1082-9. 2008
  11. ncbi request reprint The International Society on Thrombosis and Haemostasis--XXth Annual Congress
    Bradford Berk
    University of Rochester, Center for Cardiovascular Research, Rochester, NY 14642, USA
    IDrugs 8:904-6. 2005
  12. pmc ECM remodeling in hypertensive heart disease
    Bradford C Berk
    Cardiovascular Research Institute and Department of Medicine, University of Rochester, Rochester, NY 14642, USA
    J Clin Invest 117:568-75. 2007
    ..Recent research suggests that therapies targeting the expression, synthesis, or activation of the enzymes responsible for ECM homeostasis might represent novel opportunities to modify the natural progression of HHD...
  13. ncbi request reprint Angiotensin type 2 receptor (AT2R): a challenging twin
    Bradford C Berk
    Center for Cardiovascular Research and Department of Medicine, University of Rochester, Rochester, NY 14642, USA
    Sci STKE 2003:PE16. 2003
    ..Less is known about signaling through the AT2R, which often antagonizes the effects of signaling through the AT1R, but intriguing data are beginning to emerge concerning the signaling strategies and pathways that the AT2R employs...
  14. pmc Phosphorylation of G protein-coupled receptor kinase 2-interacting protein 1 tyrosine 392 is required for phospholipase C-gamma activation and podosome formation in vascular smooth muscle cells
    Jing Wang
    Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 30:1976-82. 2010
    ..In this study, we identified specific GIT1 tyrosines required for PLCγ activation and podosome formation in vascular smooth muscle cells (VSMC)...
  15. ncbi request reprint Impaired vasorelaxation in inbred mice is associated with alterations in both nitric oxide and super oxide pathways
    Chun Chen
    Cardiovascular Research Institute, Department of Medicine, University of Rochester, Rochester, NY 14642, USA
    J Vasc Res 44:504-12. 2007
    ..In summary, relatively small alterations in redox (SOD-2) and NO pathways (eNOS and PKG) may contribute to significantly impaired vasorelaxation in SJL mice...
  16. ncbi request reprint Redox signals that regulate the vascular response to injury
    B C Berk
    Center for Cardiovascular Research, University of Rochester, NY 14642, USA
    Thromb Haemost 82:810-7. 1999
    ..Although the complexity of ROS-mediated signal transduction is daunting, the diversity offers multiple therapeutic targets for pharmacologic intervention...
  17. ncbi request reprint Angiotensin II signal transduction in vascular smooth muscle: pathways activated by specific tyrosine kinases
    B C Berk
    University of Rochester, Department of Medicine, New York 14642, USA
    J Am Soc Nephrol 10:S62-8. 1999
    ..Thus, understanding AngII-stimulated signaling events, especially those related to tyrosine kinase activity, may form the basis for the development of new therapies for cardiovascular diseases...
  18. ncbi request reprint Angiotensin II mediated signal transduction. Important role of tyrosine kinases
    J Haendeler
    Center for Cardiovascular Research, University of Rochester, Rochester, NY, USA
    Regul Pept 95:1-7. 2000
    ..Understanding the importance of tyrosine phosphorylation in AngII-stimulated signaling events may contribute to new therapies for cardiovascular and renal diseases...
  19. pmc Novel approaches to treat oxidative stress and cardiovascular diseases
    Bradford C Berk
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Trans Am Clin Climatol Assoc 118:209-14. 2007
    ..We suggest that modifying the redox state of the vasculature is an attractive therapeutic approach if we target specific redox dependent pathways such as TXNIP...
  20. ncbi request reprint Transactivation: a novel signaling pathway from angiotensin II to tyrosine kinase receptors
    Y Saito
    Center for Cardiovascular Research, University of Rochester, Rochester, NY, USA
    J Mol Cell Cardiol 33:3-7. 2001
    ..There is accumulating evidence that GPCR take advantage of signaling pathways downstream of RTK to exert its effect on the cells. In this context, RTK may be considered as one of signaling molecules downstream of GPCR...
  21. ncbi request reprint Src and multiple MAP kinase activation in cardiac hypertrophy and congestive heart failure under chronic pressure-overload: comparison with acute mechanical stretch
    Y Takeishi
    Department of Medicine, Case Western Reserve University, Cleveland, OH, 44106-5029, USA
    J Mol Cell Cardiol 33:1637-48. 2001
    ..In addition, the differential inhibition of p90RSK and BMK1 in hearts with congestive heart failure suggests the specific role of these two kinases to maintain cardiac function under chronic pressure-overload...
  22. ncbi request reprint Src family kinase and adenosine differentially regulate multiple MAP kinases in ischemic myocardium: modulation of MAP kinases activation by ischemic preconditioning
    Y Takeishi
    Department of Medicine, Case Western Reserve University, Cleveland, OH 44106-5029, USA
    J Mol Cell Cardiol 33:1989-2005. 2001
    ..These data suggest important roles for Src family kinases and adenosine in mediating preconditioning, and suggest specific roles for individual MAP kinases in preconditioning...
  23. pmc Fluid shear stress inhibits TNF-alpha activation of JNK but not ERK1/2 or p38 in human umbilical vein endothelial cells: Inhibitory crosstalk among MAPK family members
    J Surapisitchat
    Department of Medicine, Center for Cardiovascular Research, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 98:6476-81. 2001
    ..Inhibition of TNF-alpha signal transduction represents a mechanism by which steady laminar flow may exert atheroprotective effects on the endothelium...
  24. pmc Laminar flow inhibits TNF-induced ASK1 activation by preventing dissociation of ASK1 from its inhibitor 14-3-3
    Y Liu
    Center for Cardiovascular Research, University of Rochester Medical Center, Rochester, New York 14641, USA
    J Clin Invest 107:917-23. 2001
    ..These data establish ASK1 as a target for flow-mediated inhibition of cytokine signaling and indicate a novel role for 14-3-3 as an anti-inflammatory mediator in ECs...
  25. ncbi request reprint GIT1 mediates thrombin signaling in endothelial cells: role in turnover of RhoA-type focal adhesions
    Geerten P van Nieuw Amerongen
    Center for Cardiovascular Research and Department of Medicine, Aab Institute for Biomedical Sciences, University of Rochester, Rochester, NY 14642, USA
    Circ Res 94:1041-9. 2004
    ....
  26. ncbi request reprint Bcr in vascular smooth muscle cells involvement of Ras and Raf-1 activation by Bcr
    J I Abe
    Center for Cardiovascular Research, University of Rochester, New York 14642, USA
    Ann N Y Acad Sci 947:341-3. 2001
    ..These results demonstrated the importance of Bcr in PDGF-mediated events such as activation of Ras, Raf-1, and ERK1/2 and stimulation of DNA synthesis...
  27. ncbi request reprint Strain-dependent vascular remodeling: the "Glagov phenomenon" is genetically determined
    Vyacheslav A Korshunov
    Center for Cardiovascular Research and Department of Medicine, University of Rochester, Rochester, NY 14642, USA
    Circulation 110:220-6. 2004
    ..Atherosclerosis of the carotid artery, called intima-media thickening (IMT), is a form of vascular remodeling that is an important predictor for cardiovascular events and has a strong genetic component...
  28. ncbi request reprint Cyclosporin A inhibits flow-mediated activation of endothelial nitric-oxide synthase by altering cholesterol content in caveolae
    Andreea O Lungu
    Department of Medicine and Center for Cardiovascular Research, University of Rochester School of Medicine and Dentistry, Aab Institute of Biomedical Sciences, Rochester, New York 14642, USA
    J Biol Chem 279:48794-800. 2004
    ..These data suggest that decreasing cholesterol content in caveolae by CsA is a potentially important pathogenic mechanism for CsA-induced endothelial dysfunction and hypertension...
  29. ncbi request reprint Glutaredoxin mediates Akt and eNOS activation by flow in a glutathione reductase-dependent manner
    Jing Wang
    University of Rochester, Cardiovascular Research Institute and Department of Medicine, 601 Elmwood Ave, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 27:1283-8. 2007
    ..Because steady laminar flow exerts an antioxidant effect, we hypothesized that Grx mediates flow induced Akt and eNOS phosphorylation in a GR dependent manner...
  30. ncbi request reprint Big mitogen-activated protein kinase (BMK1)/ERK5 protects endothelial cells from apoptosis
    Xinchun Pi
    Center for Cardiovascular Research and Department of Medicine, University of Rochester, Rochester, NY, USA
    Circ Res 94:362-9. 2004
    ..These results suggest that BMK1 activation by steady laminar flow is atheroprotective by inhibiting EC apoptosis via phosphorylation of Bad...
  31. ncbi request reprint Transactivation of vascular endothelial growth factor (VEGF) receptor Flk-1/KDR is involved in sphingosine 1-phosphate-stimulated phosphorylation of Akt and endothelial nitric-oxide synthase (eNOS)
    Tatsuo Tanimoto
    Center for Cardiovascular Research, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 277:42997-3001. 2002
    ..These data are the first to establish a critical role of Flk-1/KDR in S1P-stimulated eNOS phosphorylation and activation...
  32. ncbi request reprint GIT1 is a scaffold for ERK1/2 activation in focal adhesions
    Guoyong Yin
    Center for Cardiovascular Research and Department of Medicine, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 280:27705-12. 2005
    ..In summary, the present study further supports a key role for GIT1 (a MEK1-binding protein) as a scaffold for signal transduction in focal adhesions...
  33. ncbi request reprint Sphingosine 1-phosphate transactivates the platelet-derived growth factor beta receptor and epidermal growth factor receptor in vascular smooth muscle cells
    Tatsuo Tanimoto
    Center for Cardiovascular Research, University of Rochester, Rochester, NY 14642, USA
    Circ Res 94:1050-8. 2004
    ..These data establish S1P as an important stimulus for EGFR and PDGFbetaR activation in VSMCs that may have important implications for the vessel response to injury...
  34. ncbi request reprint Fluid shear stress activates proline-rich tyrosine kinase via reactive oxygen species-dependent pathway
    Lung Kuo Tai
    Center for Cardiovascular Research, University of Rochester, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 22:1790-6. 2002
    ..Because flow increases reactive oxygen species (ROS) production in ECs and because H(2)O(2) increases tyrosine phosphorylation of proline-rich tyrosine kinase (PYK2), we hypothesized that flow may activate PYK2 via ROS...
  35. ncbi request reprint Angiotensin II stimulates p21-activated kinase in vascular smooth muscle cells: role in activation of JNK
    U Schmitz
    Department of Medicine, University of Washington, Seattle 98195, USA
    Circ Res 82:1272-8. 1998
    ..Our data provide evidence for alphaPAK as an upstream mediator of JNK in Ang II signaling and extend the role of Ang II as a proinflammatory mediator for VSMCs...
  36. ncbi request reprint p160 Bcr mediates platelet-derived growth factor activation of extracellular signal-regulated kinase in vascular smooth muscle cells
    W Che
    Center for Cardiovascular Research, University of Rochester, Rochester, NY, USA
    Circulation 104:1399-406. 2001
    ..Because Bcr encodes a serine/threonine protein kinase, we studied its kinase activity and determined the role of Bcr in the PDGF signaling pathway to ERK1/2 activation and DNA synthesis in rat aortic smooth muscle cells (RASMCs)...
  37. pmc GIT1 functions as a scaffold for MEK1-extracellular signal-regulated kinase 1 and 2 activation by angiotensin II and epidermal growth factor
    Guoyong Yin
    Center for Cardiovascular Research and Department of Medicine, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Mol Cell Biol 24:875-85. 2004
    ..We propose that GIT1 serves as a scaffold protein to facilitate c-Src-dependent activation of MEK1-ERK1/2 in response to both GPCRs and TKRs...
  38. ncbi request reprint GIT1 mediates Src-dependent activation of phospholipase Cgamma by angiotensin II and epidermal growth factor
    Judith Haendeler
    Center for Cardiovascular Research and Department of Medicine, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 278:49936-44. 2003
    ..We propose that GIT1 is a novel regulator of PLCgamma function that mediates PLCgamma activation by c-Src and integrates signal transduction by GPCRs and TKRs...
  39. pmc Fluid shear stress inhibits vascular inflammation by decreasing thioredoxin-interacting protein in endothelial cells
    Hideyuki Yamawaki
    Center for Cardiovascular Research, University of Rochester, Rochester, New York 14642, USA
    J Clin Invest 115:733-8. 2005
    ..The data suggest that TXNIP and TRX are key components of biomechanical signal transduction and establish them as potentially novel regulators of TNF signaling and inflammation in ECs...
  40. pmc Flow-mediated vascular remodeling in hypertension: relation to hemodyamics
    Jamila Ibrahim
    Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Stroke 40:582-90. 2009
    ..Here, we characterized phenotypic traits related to carotid remodeling in the 2 rat strains that we previously showed the greatest difference in shear stress regulation: Genetically Hypertensive (GH) and Brown Norway (BN) rat strains...
  41. ncbi request reprint Losartan metabolite EXP3179 activates Akt and endothelial nitric oxide synthase via vascular endothelial growth factor receptor-2 in endothelial cells: angiotensin II type 1 receptor-independent effects of EXP3179
    Tetsu Watanabe
    Cardiovascular Research Institute, Department of Medicine, University of Rochester, Rochester, NY 14642, USA
    Circulation 112:1798-805. 2005
    ....
  42. pmc SOXF: redox mediators of vascular smooth muscle cell growth
    Z G Jin
    Center for Cardiovascular Research, University of Rochester, New York 14642, USA
    Heart 90:488-90. 2004
  43. ncbi request reprint Protein kinase C-zeta mediates angiotensin II activation of ERK1/2 in vascular smooth muscle cells
    D F Liao
    Department of Medicine, Division of Cardiology, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 272:6146-50. 1997
    ..These results demonstrate an important difference in signal transduction by angII compared with PDGF and phorbol ester in VSMC, and suggest a critical role for PKC-zeta and Ras in angII stimulation of ERK1/2...
  44. pmc PKCzeta decreases eNOS protein stability via inhibitory phosphorylation of ERK5
    Patrizia Nigro
    Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
    Blood 116:1971-9. 2010
    ..Taken together our results show that PKCζ binds and phosphorylates ERK5, thereby decreasing eNOS protein stability and contributing to early events of atherosclerosis...
  45. pmc Cyclophilin A mediates vascular remodeling by promoting inflammation and vascular smooth muscle cell proliferation
    Kimio Satoh
    Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA
    Circulation 117:3088-98. 2008
    ....
  46. ncbi request reprint Hydrogen peroxide activates the Gas6-Axl pathway in vascular smooth muscle cells
    Atsushi Konishi
    Center for Cardiovascular Research, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Biol Chem 279:28766-70. 2004
    ..In summary, Axl is an important signaling mediator for oxidative stress in cultured vascular smooth muscle cells and intact vessels and may represent an important therapeutic target for vascular remodeling and response to injury...
  47. ncbi request reprint Fluid shear stress attenuates hydrogen peroxide-induced c-Jun NH2-terminal kinase activation via a glutathione reductase-mediated mechanism
    Yukihiro Hojo
    Center for Cardiovascular Research, Cardiology Unit, Department of Medicine, University of Rochester, Rochester, NY 14642, USA
    Circ Res 91:712-8. 2002
    ..These results suggest that flow activates GR, an important regulator of the intracellular redox state of glutathione, and exerts a protective mechanism against oxidative stress in endothelial cells...
  48. pmc Gas6-Axl pathway: the role of redox-dependent association of Axl with nonmuscle myosin IIB
    Megan E Cavet
    Aab Cardiovascular Research Institute, University of Rochester, Box 679, Rochester, NY 14642, USA
    Hypertension 56:105-11. 2010
    ..This interaction provides a direct link between Axl and molecular motors crucial for directed cell migration, which may mediate increased migration in vascular dysfunction...
  49. ncbi request reprint Shear stress is differentially regulated among inbred rat strains
    Jamila Ibrahim
    Center for Cardiovascular Research, Department of Medicine, University of Rochester, 601 Elmwood Ave, Rochester, NY 14642, USA
    Circ Res 92:1001-9. 2003
    ..This study emphasizes the important role of genetic factors in vascular remodeling and suggests that genetic analysis of these strains will provide novel insights into the underlying mechanisms...
  50. ncbi request reprint Angiotensin II signal transduction in vascular smooth muscle: role of tyrosine kinases
    B C Berk
    University of Washington, Department of Medicine, Seattle 98195, USA
    Circ Res 80:607-16. 1997
    ..Thus, understanding angiotensin II-stimulated signaling events, especially those related to tyrosine kinase activity, may form the basis for the development of new therapies for cardiovascular diseases...
  51. ncbi request reprint Molecular cloning of mouse ERK5/BMK1 splice variants and characterization of ERK5 functional domains
    C Yan
    Center for Cardiovascular Research, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 276:10870-8. 2001
    ..Taken together, these observations indicate that ERK5 is regulated by distinct mechanisms determined by its unique structure and presumably the presence of multiple splice variants...
  52. doi request reprint PARP-1 inhibition prevents oxidative and nitrosative stress-induced endothelial cell death via transactivation of the VEGF receptor 2
    Marlene T Mathews
    Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Box 706, Rochester, New York 14642, USA
    Arterioscler Thromb Vasc Biol 28:711-7. 2008
    ....
  53. ncbi request reprint Role of phosphodiesterase 3 in NO/cGMP-mediated antiinflammatory effects in vascular smooth muscle cells
    Toru Aizawa
    University of Rochester, Center for Cardiovascular Research, 601 Elmwood Ave, Box 679, Rochester, NY 14642, USA
    Circ Res 93:406-13. 2003
    ..These results suggest that SNAP and CNP exert inhibitory effects on NF-kappaB-dependent transcription by activation of PKA via cGMP-dependent inhibition of PDE3 activity. Therefore, PDE3 is a novel mediator of inflammation in VSMCs...
  54. ncbi request reprint Flow activates ERK1/2 and endothelial nitric oxide synthase via a pathway involving PECAM1, SHP2, and Tie2
    Lung Kuo Tai
    Cardiovascular Research Institute and Department of Medicine, University of Rochester, New York 14642, USA
    J Biol Chem 280:29620-4. 2005
    ..These results establish Tie2 transactivation via PECAM1 as an early event in flow-mediated mechanotransduction and suggest an important role for a PECAM1-SHP2-Tie2 pathway in flow-mediated signal transduction...
  55. ncbi request reprint Interleukin-18 and macrophage migration inhibitory factor are associated with increased carotid intima-media thickening
    Vyacheslav A Korshunov
    Cardiovascular Research Institute, Department of Medicine, University of Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 26:295-300. 2006
    ..Because the SJL strain is prone to autoimmune diseases, we hypothesized that inflammation contributed to IMT in SJL mice...
  56. ncbi request reprint ERK1/2 associates with the c-Met-binding domain of growth factor receptor-bound protein 2 (Grb2)-associated binder-1 (Gab1): role in ERK1/2 and early growth response factor-1 (Egr-1) nuclear accumulation
    Masaki Osawa
    Center for Cardiovascular Research, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 279:29691-9. 2004
    ..These data suggest that Gab1-ERK1/2 binding and their nuclear translocation play a crucial role in Egr-1 nuclear accumulation...
  57. ncbi request reprint The novel role of the C-terminal region of SHP-2. Involvement of Gab1 and SHP-2 phosphatase activity in Elk-1 activation
    Qunhua Huang
    Center for Cardiovascular Research, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 277:29330-41. 2002
    ..Furthermore, we identified a novel sequence for SHP-2/Gab1 interactions in the C-terminal region of SHP-2...
  58. ncbi request reprint Inhibition of tumor necrosis factor-[alpha]-induced SHP-2 phosphatase activity by shear stress: a mechanism to reduce endothelial inflammation
    Nicole Lerner-Marmarosh
    Center for Cardiovascular Research, University of Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 23:1775-81. 2003
    ....
  59. ncbi request reprint Chronic physiological shear stress inhibits tumor necrosis factor-induced proinflammatory responses in rabbit aorta perfused ex vivo
    Hideyuki Yamawaki
    Center for Cardiovascular Research, Box 679, 601 Elmwood Ave, University of Rochester, Rochester, NY 14642, USA
    Circulation 108:1619-25. 2003
    ..Therefore, we examined the effects of chronic shear stress on TNF-alpha-induced inflammatory responses using an ex vivo perfusion organ culture system...
  60. ncbi request reprint Flow-induced vascular remodeling in the mouse: a model for carotid intima-media thickening
    Vyacheslav A Korshunov
    Center for Cardiovascular Research, University of Rochester, 601 Elmwood Ave, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 23:2185-91. 2003
    ..Vascular remodeling of the carotid artery with intima-media thickness (IMT) is an important predictive factor for human cardiovascular disease. We characterized a mouse model of vascular remodeling...
  61. ncbi request reprint Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells: role of Gab1 and MEKK3 in TNF-alpha-induced c-Jun and NF-kappaB activation and adhesion molecule expression
    Wenyi Che
    Center for Cardiovascular Research, University of Rochester, Rochester, NY, USA
    Circ Res 90:1222-30. 2002
    ..Furthermore, the IGF-1-mediated downregulation of Gab1 expression represents a novel mechanism to promote vascular inflammation and atherosclerosis...
  62. pmc Receptor heterodimerization: essential mechanism for platelet-derived growth factor-induced epidermal growth factor receptor transactivation
    Y Saito
    Center for Cardiovascular Research, University of Rochester, Rochester, New York 14642, USA
    Mol Cell Biol 21:6387-94. 2001
    ..In conclusion, our data demonstrate that the PDGFbetaR and the EGFR form PDGFbetaR-EGFR heterodimers basally, and we suggest that heterodimers represent a novel signaling complex which plays an important role in PDGF signal transduction...
  63. pmc Agonist-stimulated cytoskeletal reorganization and signal transduction at focal adhesions in vascular smooth muscle cells require c-Src
    T Ishida
    Department of Medicine, Cardiology Division, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Clin Invest 103:789-97. 1999
    ..c-Src kinase activity is required for the cytoskeletal turnover that occurs in cell spreading, whereas c-Src appears to regulate actin bundling via a kinase-independent mechanism...
  64. pmc GIT1 mediates VEGF-induced podosome formation in endothelial cells: critical role for PLCgamma
    Jing Wang
    Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 29:202-8. 2009
    ..Because GIT1 is a substrate of c-Src, and podosome formation is c-Src dependent, we hypothesized that GIT1 plays an important role in VEGF-induced EC podosome formation and cell migration...
  65. ncbi request reprint Gas6 inhibits apoptosis in vascular smooth muscle: role of Axl kinase and Akt
    Matthew G Melaragno
    Center for Cardiovascular Research, Department of Medicine, Aab Institute for Biomedical Sciences, University of Rochester, Box MED, Rochester, NY 14642, USA
    J Mol Cell Cardiol 37:881-7. 2004
    ..These findings establish the Gas6-Axl-PI3K-Akt pathway as an anti-apoptotic mechanism for VSMC that may be important in the response to vascular injury...
  66. ncbi request reprint Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor
    Yuji Saito
    Center for Cardiovascular Research, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 277:23216-22. 2002
    ..Because PDGF-mediated ERK activation is enhanced in Chinese hamster ovary cells that overexpress Gab1, Gab1 serves as an important link between PKC and ERK activation by PDGFbeta receptors in VSMC...
  67. ncbi request reprint Angiotensin II stimulates tyrosine phosphorylation of phospholipase C-gamma-associated proteins. Characterization of a c-Src-dependent 97-kD protein in vascular smooth muscle cells
    U Schmitz
    Department of Medicine, University of Washington, Seattle 98195 7710, USA
    Circ Res 81:550-7. 1997
    ..These studies are the first to define a PLC-gamma-associated protein that may be required for Ang II-mediated signal transduction...
  68. ncbi request reprint Role of secreted oxidative stress-induced factors (SOXFs) in the pathogenesis of atherosclerosis
    Z G Jin
    Center for Cardiovascular Research and Department of Medicine, University of Rochester Medical Center, New York, NY, USA
    Arch Mal Coeur Vaiss 97:1256-9. 2004
    ....
  69. ncbi request reprint Upregulation of phosphodiesterase 1A1 expression is associated with the development of nitrate tolerance
    D Kim
    Department of Medicine, University of Rochester, Rochester, NY, USA
    Circulation 104:2338-43. 2001
    ..Inhibiting PDE1A1 expression and/or activity could be a novel therapeutic approach to limit nitrate tolerance...
  70. ncbi request reprint Identification of flow-dependent endothelial nitric-oxide synthase phosphorylation sites by mass spectrometry and regulation of phosphorylation and nitric oxide production by the phosphatidylinositol 3-kinase inhibitor LY294002
    B Gallis
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 274:30101-8. 1999
    ..Finally, PKB phosphorylated eNOS in vitro at the same site phosphorylated in the cell and increased eNOS enzymatic activity by 15-20-fold...
  71. pmc GPCR kinase 2 interacting protein 1 (GIT1) regulates osteoclast function and bone mass
    Prashanthi Menon
    Department of Medicine and Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Cell Physiol 225:777-85. 2010
    ..These data show that GIT1 is a key regulator of bone mass in vivo by regulating osteoclast function and suggest GIT1 as a potential target for osteoporosis therapy...
  72. pmc Cyclophilin A: promising new target in cardiovascular therapy
    Kimio Satoh
    Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry
    Circ J 74:2249-56. 2010
    ....
  73. doi request reprint Glucose 6-phosphate dehydrogenase is regulated through c-Src-mediated tyrosine phosphorylation in endothelial cells
    Shi Pan
    Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Arterioscler Thromb Vasc Biol 29:895-901. 2009
    ..Because tyrosine phosphorylation is a key regulatory pathway for VEGF-mediated endothelial cell (EC) responses, we investigated tyrosine phosphorylation of G6PD and the role of the nonreceptor tyrosine kinase Src...
  74. pmc Fluid shear stress inhibits TNF-mediated JNK activation via MEK5-BMK1 in endothelial cells
    Lingli Li
    Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, Box 706, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Biochem Biophys Res Commun 370:159-63. 2008
    ..These results support a key role for the MEK5-BMK1 signaling pathway in the atheroprotective effects of blood flow...
  75. ncbi request reprint Epidermal growth factor receptor transactivation is regulated by glucose in vascular smooth muscle cells
    Atsushi Konishi
    Center for Cardiovascular Research, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 278:35049-56. 2003
    ..These results establish a novel mechanism by which glucose-dependent EGFR N-glycosylation modulates AngII signal transduction and suggest a potential mechanism for pathogenic effects of AngII in diabetic vasculopathy...
  76. ncbi request reprint Cyclophilin A is secreted by a vesicular pathway in vascular smooth muscle cells
    Jun Suzuki
    Cardiovascular Research Institute, Department of Medicine, University of Rochester, NY 14642, USA
    Circ Res 98:811-7. 2006
    ..Our findings define a novel VSMC vesicular secretory pathway for CyPA that involves actin remodeling and myosin II activation via RhoA-, Cdc42-, and Rho kinase-dependent signaling events...
  77. pmc G-protein-coupled receptor kinase interacting protein-1 is required for pulmonary vascular development
    Jinjiang Pang
    Aab Cardiovascular Research Institute and the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Circulation 119:1524-32. 2009
    ..However, there have been no in vivo studies of GIT1 function to date...
  78. pmc The hinge-helix 1 region of peroxisome proliferator-activated receptor gamma1 (PPARgamma1) mediates interaction with extracellular signal-regulated kinase 5 and PPARgamma1 transcriptional activation: involvement in flow-induced PPARgamma activation in end
    Masashi Akaike
    Center for Cardiovascular Research, 601 Elmwood Ave, Box 679, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Mol Cell Biol 24:8691-704. 2004
    ..These data suggest that ERK5 mediates flow- and ligand-induced PPARgamma activation via the interaction of ERK5 with the hinge-helix 1 region of PPARgamma...
  79. ncbi request reprint Plasminogen activator expression correlates with genetic differences in vascular remodeling
    Vyacheslav A Korshunov
    Center for Cardiovascular Research, Aab Institute of Biomedical Sciences and Department of Medicine, University of Rochester, 601 Elmwood Ave, Rochester, NY 14642, USA
    J Vasc Res 41:481-90. 2004
    ..In summary, flow-induced IMT of the carotid is genetically determined and correlates with t-PA and u-PA expression in 2 inbred mouse strains...
  80. ncbi request reprint Vascular smooth muscle growth: autocrine growth mechanisms
    B C Berk
    Center for Cardiovascular Research, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642, USA
    Physiol Rev 81:999-1030. 2001
    ..Finally, the heterogeneous nature of VSMC developmental origin provides another level of complexity in VSMC growth mechanisms...
  81. ncbi request reprint Increased expression of Axl tyrosine kinase after vascular injury and regulation by G protein-coupled receptor agonists in rats
    M G Melaragno
    Department of Medicine, University of Washington, Seattle, WA 98195 7710, USA
    Circ Res 83:697-704. 1998
    ..Our results implicate Axl as a potential mediator of vascular smooth muscle migration and proliferation caused by vascular injury and G protein-coupled receptor agonists...
  82. ncbi request reprint Big mitogen-activated protein kinase 1 (BMK1) is a redox-sensitive kinase
    J Abe
    Department of Medicine, Cardiology Division, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 271:16586-90. 1996
    ..These findings demonstrate that activation of BMK1 is different from ERK1/2 and suggest an important role for BMK1 as a redox-sensitive kinase...
  83. ncbi request reprint Interleukin-18 and interleukin-18 binding protein levels before and after percutaneous coronary intervention in patients with and without recent myocardial infarction
    Craig R Narins
    Cardiology Unit, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Am J Cardiol 94:1285-7. 2004
    ....
  84. pmc Oxidative stress and vascular smooth muscle cell growth: a mechanistic linkage by cyclophilin A
    Kimio Satoh
    Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, New York 14642, USA
    Antioxid Redox Signal 12:675-82. 2010
    ..CyPA plays a crucial role in VSMC proliferation/migration and inflammatory cell recruitment, resulting in cardiovascular diseases in vivo...
  85. ncbi request reprint Cyclophilin A is a proinflammatory cytokine that activates endothelial cells
    Zheng Gen Jin
    Department of Medicine and Center for Cardiovascular Research, University of Rochester School of Medicine and Dentistry, Aab Institute of Biomedical Sciences, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 24:1186-91. 2004
    ..We therefore studied the proinflammatory effects of CyPA on vascular endothelium...
  86. pmc Bcr kinase activation by angiotensin II inhibits peroxisome-proliferator-activated receptor gamma transcriptional activity in vascular smooth muscle cells
    Jeffrey D Alexis
    Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Circ Res 104:69-78. 2009
    ....
  87. ncbi request reprint Ligand-independent activation of vascular endothelial growth factor receptor 2 by fluid shear stress regulates activation of endothelial nitric oxide synthase
    Zheng Gen Jin
    Center for Cardiovascular Research and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Circ Res 93:354-63. 2003
    ..Finally, we show that inhibiting VEGFR2 kinase significantly reduces flow-mediated NO-dependent arteriolar dilation in vivo. These data identify VEGFR2 as a key mechanotransducer that activates eNOS in response to blood flow...
  88. ncbi request reprint Strain-dependent differences in responses to exercise training in inbred and hybrid mice
    Michael P Massett
    Center for Cardiovascular Research, Aab Institute of Biomedical Sciences, University of Rochester, 601 Elmwood Ave, Box 679, Rochester, NY 14642, USA
    Am J Physiol Regul Integr Comp Physiol 288:R1006-13. 2005
    ..Furthermore, the contrasting responses in B6F and FB6 F(1) strains show that a maternal component strongly influences strain-dependent differences in training responses...
  89. ncbi request reprint Flow shear stress stimulates Gab1 tyrosine phosphorylation to mediate protein kinase B and endothelial nitric-oxide synthase activation in endothelial cells
    Zheng Gen Jin
    Center for Cardiovascular Research and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 280:12305-9. 2005
    ..Finally, knockdown of endogenous Gab1 by small interference RNA abrogated flow activation of Akt and eNOS. These data demonstrate a critical role of Gab1 in flow-stimulated PI3K/Akt/eNOS signal pathway in endothelial cells...
  90. pmc GIT1 mediates HDAC5 activation by angiotensin II in vascular smooth muscle cells
    Jinjiang Pang
    Aab Cardiovascular Research Institute and the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Arterioscler Thromb Vasc Biol 28:892-8. 2008
    ..Here we investigated the hypothesis that Ang II-mediated vascular smooth muscle cell (VSMC) gene transcription involves GIT1-CamK II-dependent phosphorylation of HDAC5...
  91. ncbi request reprint Comparison of simultaneous measurements of blood pressure by tail-cuff and carotid arterial methods in conscious spontaneously hypertensive and Wistar-Kyoto rats
    Jamila Ibrahim
    Clinical Pharmacology, NHLI Division, Faculty of Medicine, Imperial College of Medicine, London, UK
    Clin Exp Hypertens 28:57-72. 2006
    ..Telemetered SBP measurements in conscious rats were highly variable in a strain-dependent manner...
  92. ncbi request reprint Vascular remodeling: hemodynamic and biochemical mechanisms underlying Glagov's phenomenon
    Vyacheslav A Korshunov
    Cardiovascular Research Institute and Department of Medicine, University of Rochester, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 27:1722-8. 2007
    ..More comprehensive analyses of the specific molecular pathways in the vessels that determine constant flow may provide new therapeutic approaches to regulate vascular remodeling...
  93. ncbi request reprint 14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform 1-binding protein that negatively regulates RSK kinase activity
    Megan E Cavet
    Center for Cardiovascular Research and Department of Medicine, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 278:18376-83. 2003
    ..These data suggest that 14-3-3beta binding negatively regulates RSK1 activity to maintain signal specificity and that association/dissociation of the 14-3-3beta-RSK1 complex is likely to be important for mitogen-mediated RSK1 activation...
  94. ncbi request reprint Axl, a receptor tyrosine kinase, mediates flow-induced vascular remodeling
    Vyacheslav A Korshunov
    Cardiovascular Research Institute, Department of Medicine, University of Rochester, NY, USA
    Circ Res 98:1446-52. 2006
    ..These data demonstrate an important role for Axl in flow-dependent remodeling by regulating vascular apoptosis and vascular inflammation...
  95. ncbi request reprint 14-3-3 Binding to Na+/H+ exchanger isoform-1 is associated with serum-dependent activation of Na+/H+ exchange
    S Lehoux
    Center for Cardiovascular Research and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 276:15794-800. 2001
    ..13 +/- 0.02 versus 0.48 +/- 0.06 mmol of H(+)/min/liter, p < 0.01). These data suggest that 14-3-3 binding to NHE1 participates in serum-stimulated exchanger activation, a new function for 14-3-3...
  96. ncbi request reprint Purification and identification of secreted oxidative stress-induced factors from vascular smooth muscle cells
    D F Liao
    Center for Cardiovascular Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 275:189-96. 2000
    ..These results show that brief oxidative stress causes sustained release of protein factors from VSMC that can stimulate ERK1/2. These factors may be important mediators for the effects of reactive oxygen species on vascular function...
  97. ncbi request reprint Retinoic acid-induced tissue transglutaminase and apoptosis in vascular smooth muscle cells
    H Ou
    Center for Cardiovascular Research, University of Rochester Medical Center, Rochester, NY, USA
    Circ Res 87:881-7. 2000
    ..atRA-mediated apoptosis in SMCs seems to require the participation of active tTG, suggesting a potential mechanistic link between this retinoid-inducible gene and programmed cell death...
  98. ncbi request reprint Angiotensin II signal transduction in vascular smooth muscle cells: role of tyrosine kinases
    M Ishida
    Department of Medicine, University of Washington, Seattle 98195, USA
    Keio J Med 46:61-8. 1997
    ..Thus, it is important to understand angiotensin II-mediated signaling events, especially those related to tyrosine kinase activity, to develop new therapies for cardiovascular diseases...
  99. doi request reprint Thioredoxin-interacting protein mediates TRX1 translocation to the plasma membrane in response to tumor necrosis factor-α: a key mechanism for vascular endothelial growth factor receptor-2 transactivation by reactive oxygen species
    Cameron World
    Department of Medicine, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    Arterioscler Thromb Vasc Biol 31:1890-7. 2011
    ..Because TXNIP is an α-arrestin with numerous protein-protein interacting domains, we hypothesized that TXNIP-TRX1 trafficking should alter function of EC exposed to reactive oxygen species (ROS)...
  100. pmc Cyclophilin A promotes cardiac hypertrophy in apolipoprotein E-deficient mice
    Kimio Satoh
    Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Box CVRI, 601 Elmwood Ave, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 31:1116-23. 2011
    ..In this study, we sought to evaluate the role of CyPA in Ang II-induced cardiac hypertrophy...
  101. ncbi request reprint 14-3-3beta binds to big mitogen-activated protein kinase 1 (BMK1/ERK5) and regulates BMK1 function
    Qinlei Zheng
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Aab Institute of Biomedical Sciences, Rochester, New York 14642, USA
    J Biol Chem 279:8787-91. 2004
    ..These data demonstrate an inhibitory function for 14-3-3beta binding to BMK1 and show that serine 486 phosphorylation represents a novel regulatory mechanism for BMK1...

Research Grants48

  1. Genetics of Vascular Remodeling
    Bradford C Berk; Fiscal Year: 2010
    ..Elucidating the tissue- and cell-specific pathways by which vessels remodel in response to low flow should provide insights for therapies to improve vascular function in atherosclerosis, hypertension, and stroke. ..
  2. FLUID SHEAR STRESS SIGNAL TRANSDUCTION IN ENDOTHELIUM
    Bradford Berk; Fiscal Year: 2006
    ..These studies should provide insight into mechanisms by which flow inhibits vascular inflammation and facilitate development of new therapeutic approaches to limit atherosclerosis. ..
  3. Genetics of Vascular Remodeling
    Bradford Berk; Fiscal Year: 2006
    ..This proposal represents the first step in elucidating the genetics of vascular remodeling which may yield new therapeutic approaches to diseases such as carotid and coronary atherosclerosis. ..
  4. FLUID SHEAR STRESS SIGNAL TRANSDUCTION IN ENDOTHELIUM
    Bradford Berk; Fiscal Year: 2005
    ..These studies should provide insight into mechanisms by which flow inhibits vascular inflammation and facilitate development of new therapeutic approaches to limit atherosclerosis. ..
  5. OXIDATIVE STRESS AND VASCULAR SMOOTH MUSCLE CELL GROWTH
    Bradford Berk; Fiscal Year: 2006
    ..These studies will provide new insight into the mechanisms by which ROS regulate vascular function and the specific role of CyPA in atherosclerosis. ..
  6. ANGIOTENSIN II SIGNAL TRANSDUCTION
    Bradford Berk; Fiscal Year: 2006
    ..The proposed studies will provide insight into a novel scaffold protein that should be important both for AII signal transduction and MAP kinase function. ..
  7. Genetics of Vascular Remodeling
    Bradford Berk; Fiscal Year: 2005
    ..This proposal represents the first step in elucidating the genetics of vascular remodeling which may yield new therapeutic approaches to diseases such as carotid and coronary atherosclerosis. ..
  8. Genetics of Vascular Remodeling
    Bradford Berk; Fiscal Year: 2004
    ..This proposal represents the first step in elucidating the genetics of vascular remodeling which may yield new therapeutic approaches to diseases such as carotid and coronary atherosclerosis. ..
  9. ANGIOTENSIN II SIGNAL TRANSDUCTION
    Bradford Berk; Fiscal Year: 2007
    ..The proposed studies will provide insight into a novel scaffold protein that should be important both for AII signal transduction and MAP kinase function. ..
  10. ANGIOTENSIN II SIGNAL TRANSDUCTION
    Bradford Berk; Fiscal Year: 2006
    ..The proposed studies will provide insight into a novel scaffold protein that should be important both for AII signal transduction and MAP kinase function. ..
  11. ANGIOTENSIN II SIGNAL TRANSDUCTION
    Bradford C Berk; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: The healing of tissues after surgery or trauma is critical for long-term survival. The proposed work will study novel mechanisms by which blood vessels grow in response to tissue injury. ..
  12. Oxidative Stress and Vascular Smoth Muscle Cell Growth
    Bradford C Berk; Fiscal Year: 2010
    ..Elucidating the tissue- and cell-specific pathways by which cyclophilin A modulates atherogenesis would provide insights for therapies to improve vascular function in this disease. ..
  13. FLUID SHEAR STRESS SIGNAL TRANSDUCTION IN ENDOTHELIUM
    Keigi Fujiwara; Fiscal Year: 2010
    ..Elucidating the specific pathways by which protein kinase C-zeta modulates vessel function would provide the basis to develop new therapies to prevent atherosclerosis. ..
  14. ANGIOTENSIN II SIGNAL TRANSDUCTION
    Bradford Berk; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: The healing of tissues after surgery or trauma is critical for long-term survival. The proposed work will study novel mechanisms by which blood vessels grow in response to tissue injury. ..
  15. Oxidative Stress and Vascular Smoth Muscle Cell Growth
    Bradford Berk; Fiscal Year: 2009
    ..Elucidating the tissue- and cell-specific pathways by which cyclophilin A modulates atherogenesis would provide insights for therapies to improve vascular function in this disease. ..
  16. 2007 Vascular Cell Biology Gordon Research Conference
    Bradford Berk; Fiscal Year: 2007
    ..We believe this will be an excellent Gordon Research conference based on the timeliness of the subject matter, the excellence of the organization and program content, the excellence of the proposed speakers, and the meeting facilities. ..
  17. FLUID SHEAR STRESS SIGNAL TRANSDUCTION IN ENDOTHELIUM
    Bradford Berk; Fiscal Year: 2007
    ..These studies should provide insight into mechanisms by which flow inhibits vascular inflammation and facilitate development of new therapeutic approaches to limit atherosclerosis. ..
  18. Genetics of Vascular Remodeling
    Bradford Berk; Fiscal Year: 2007
    ..This proposal represents the first step in elucidating the genetics of vascular remodeling which may yield new therapeutic approaches to diseases such as carotid and coronary atherosclerosis. ..
  19. CARDIOVASCULAR RESEARCH TRAINING
    Bradford Berk; Fiscal Year: 2004
    ..The University of Rochester is a research-intensive institution with a long tradition and commitment to training investigators which should facilitate the success of this program in cardiovascular research. ..
  20. GENETICS OF VASCULAR REMODELING IN HYPERTENSION
    Bradford Berk; Fiscal Year: 2001
    ..Aim 4. Create a congenic strain of GH rats containing genes associated with high remodeling ability. ..
  21. OXIDATIVE STRESS AND VASCULAR SMOOTH MUSCLE CELL GROWTH
    Bradford Berk; Fiscal Year: 2001
    ..these studies should provide insight into the mechanisms by which ROS regulate remodeling and aid development of new therapeutic approaches to limit restenosis and atherogenesis. ..
  22. ANGIOTENSIN II SIGNAL TRANSDUCTION
    Bradford Berk; Fiscal Year: 2001
    ..Aim 3: Study the role of PDGF receptor tyrosine phosphorylation in fine domains of the AT I R required knowledge of the mechanisms by which AII exerts physiologic and pathologic effects on the cardiovascular system. ..
  23. FLUID SHEAR STRESS SIGNAL TRANSDUCTION IN ENDOTHELIUM
    Bradford Berk; Fiscal Year: 2001
    ..These studies should provide insight into the mechanisms by which flow generates an atheroprotective signal and facilitate development of new therapeutic approaches to limit atherosclerosis. ..
  24. GENETICS OF VASCULAR REMODELING IN HYPERTENSION
    Bradford Berk; Fiscal Year: 2000
    ..Aim 4. Create a congenic strain of GH rats containing genes associated with high remodeling ability. ..
  25. OXIDATIVE STRESS AND VASCULAR SMOOTH MUSCLE CELL GROWTH
    Bradford Berk; Fiscal Year: 2000
    ..these studies should provide insight into the mechanisms by which ROS regulate remodeling and aid development of new therapeutic approaches to limit restenosis and atherogenesis. ..
  26. ANGIOTENSIN II SIGNAL TRANSDUCTION
    Bradford Berk; Fiscal Year: 2000
    ..Aim 3: Study the role of PDGF receptor tyrosine phosphorylation in fine domains of the AT I R required knowledge of the mechanisms by which AII exerts physiologic and pathologic effects on the cardiovascular system. ..
  27. REGULATION OF NA+/H+ EXCHANGE IN VASCULAR SMOOTH MUSCLE
    Bradford Berk; Fiscal Year: 1999
    ....
  28. OXIDATIVE STRESS AND VASCULAR SMOOTH MUSCLE CELL GROWTH
    Bradford Berk; Fiscal Year: 1999
    ..these studies should provide insight into the mechanisms by which ROS regulate remodeling and aid development of new therapeutic approaches to limit restenosis and atherogenesis. ..
  29. ANGIOTENSIN II SIGNAL TRANSDUCTION
    Bradford Berk; Fiscal Year: 2002
    ..Aim 3: Study the role of PDGF receptor tyrosine phosphorylation in fine domains of the AT I R required knowledge of the mechanisms by which AII exerts physiologic and pathologic effects on the cardiovascular system. ..
  30. FLUID SHEAR STRESS SIGNAL TRANSDUCTION IN ENDOTHELIUM
    Bradford Berk; Fiscal Year: 2004
    ..These studies should provide insight into the mechanisms by which flow generates an atheroprotective signal and facilitate development of new therapeutic approaches to limit atherosclerosis. ..
  31. FLUID SHEAR STRESS SIGNAL TRANSDUCTION IN ENDOTHELIUM
    Bradford Berk; Fiscal Year: 2003
    ..These studies should provide insight into the mechanisms by which flow generates an atheroprotective signal and facilitate development of new therapeutic approaches to limit atherosclerosis. ..
  32. OXIDATIVE STRESS AND VASCULAR SMOOTH MUSCLE CELL GROWTH
    Bradford Berk; Fiscal Year: 2003
    ..These studies will provide new insight into the mechanisms by which ROS regulate vascular function and the specific role of CyPA in atherosclerosis. ..
  33. ANGIOTENSIN II SIGNAL TRANSDUCTION
    Bradford Berk; Fiscal Year: 2003
    ..The proposed studies will provide insight into a novel scaffold protein that should be important both for AII signal transduction and MAP kinase function. ..
  34. GENETICS OF VASCULAR REMODELING IN HYPERTENSION
    Bradford Berk; Fiscal Year: 2002
    ..Aim 4. Create a congenic strain of GH rats containing genes associated with high remodeling ability. ..
  35. FLUID SHEAR STRESS SIGNAL TRANSDUCTION IN ENDOTHELIUM
    Bradford Berk; Fiscal Year: 2002
    ..These studies should provide insight into the mechanisms by which flow generates an atheroprotective signal and facilitate development of new therapeutic approaches to limit atherosclerosis. ..
  36. GENETICS OF VASCULAR REMODELING IN HYPERTENSION
    Bradford Berk; Fiscal Year: 1999
    ..Aim 4. Create a congenic strain of GH rats containing genes associated with high remodeling ability. ..