B C Berk

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Angiotensin II signal transduction in vascular smooth muscle: role of tyrosine kinases
    B C Berk
    University of Washington, Department of Medicine, Seattle 98195, USA
    Circ Res 80:607-16. 1997
  2. ncbi request reprint Angiotensin II signal transduction in vascular smooth muscle cells: role of tyrosine kinases
    M Ishida
    Department of Medicine, University of Washington, Seattle 98195, USA
    Keio J Med 46:61-8. 1997
  3. ncbi request reprint Src and multiple MAP kinase activation in cardiac hypertrophy and congestive heart failure under chronic pressure-overload: comparison with acute mechanical stretch
    Y Takeishi
    Department of Medicine, Case Western Reserve University, Cleveland, OH, 44106-5029, USA
    J Mol Cell Cardiol 33:1637-48. 2001
  4. ncbi request reprint Phosphorylation of endothelial nitric oxide synthase in response to fluid shear stress
    M A Corson
    Cardiology Division, University of Washington School of Medicine, Seattle 98195, USA
    Circ Res 79:984-91. 1996
  5. pmc Fluid shear stress inhibits TNF-alpha activation of JNK but not ERK1/2 or p38 in human umbilical vein endothelial cells: Inhibitory crosstalk among MAPK family members
    J Surapisitchat
    Department of Medicine, Center for Cardiovascular Research, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 98:6476-81. 2001
  6. ncbi request reprint Angiotensin II stimulates p21-activated kinase in vascular smooth muscle cells: role in activation of JNK
    U Schmitz
    Department of Medicine, University of Washington, Seattle 98195, USA
    Circ Res 82:1272-8. 1998
  7. ncbi request reprint Endothelial atheroprotective and anti-inflammatory mechanisms
    B C Berk
    Department of Medicine, Center for Cardiovascular Research, University of Rochester, New York 14642, USA
    Ann N Y Acad Sci 947:93-109; discussion 109-11. 2001
  8. ncbi request reprint Src family kinase and adenosine differentially regulate multiple MAP kinases in ischemic myocardium: modulation of MAP kinases activation by ischemic preconditioning
    Y Takeishi
    Department of Medicine, Case Western Reserve University, Cleveland, OH 44106-5029, USA
    J Mol Cell Cardiol 33:1989-2005. 2001
  9. pmc Agonist-stimulated cytoskeletal reorganization and signal transduction at focal adhesions in vascular smooth muscle cells require c-Src
    T Ishida
    Department of Medicine, Cardiology Division, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Clin Invest 103:789-97. 1999
  10. ncbi request reprint Angiotensin II signal transduction in vascular smooth muscle: pathways activated by specific tyrosine kinases
    B C Berk
    University of Rochester, Department of Medicine, New York 14642, USA
    J Am Soc Nephrol 10:S62-8. 1999

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Angiotensin II signal transduction in vascular smooth muscle: role of tyrosine kinases
    B C Berk
    University of Washington, Department of Medicine, Seattle 98195, USA
    Circ Res 80:607-16. 1997
    ..Thus, understanding angiotensin II-stimulated signaling events, especially those related to tyrosine kinase activity, may form the basis for the development of new therapies for cardiovascular diseases...
  2. ncbi request reprint Angiotensin II signal transduction in vascular smooth muscle cells: role of tyrosine kinases
    M Ishida
    Department of Medicine, University of Washington, Seattle 98195, USA
    Keio J Med 46:61-8. 1997
    ..Thus, it is important to understand angiotensin II-mediated signaling events, especially those related to tyrosine kinase activity, to develop new therapies for cardiovascular diseases...
  3. ncbi request reprint Src and multiple MAP kinase activation in cardiac hypertrophy and congestive heart failure under chronic pressure-overload: comparison with acute mechanical stretch
    Y Takeishi
    Department of Medicine, Case Western Reserve University, Cleveland, OH, 44106-5029, USA
    J Mol Cell Cardiol 33:1637-48. 2001
    ..In addition, the differential inhibition of p90RSK and BMK1 in hearts with congestive heart failure suggests the specific role of these two kinases to maintain cardiac function under chronic pressure-overload...
  4. ncbi request reprint Phosphorylation of endothelial nitric oxide synthase in response to fluid shear stress
    M A Corson
    Cardiology Division, University of Washington School of Medicine, Seattle 98195, USA
    Circ Res 79:984-91. 1996
    ....
  5. pmc Fluid shear stress inhibits TNF-alpha activation of JNK but not ERK1/2 or p38 in human umbilical vein endothelial cells: Inhibitory crosstalk among MAPK family members
    J Surapisitchat
    Department of Medicine, Center for Cardiovascular Research, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 98:6476-81. 2001
    ..Inhibition of TNF-alpha signal transduction represents a mechanism by which steady laminar flow may exert atheroprotective effects on the endothelium...
  6. ncbi request reprint Angiotensin II stimulates p21-activated kinase in vascular smooth muscle cells: role in activation of JNK
    U Schmitz
    Department of Medicine, University of Washington, Seattle 98195, USA
    Circ Res 82:1272-8. 1998
    ..Our data provide evidence for alphaPAK as an upstream mediator of JNK in Ang II signaling and extend the role of Ang II as a proinflammatory mediator for VSMCs...
  7. ncbi request reprint Endothelial atheroprotective and anti-inflammatory mechanisms
    B C Berk
    Department of Medicine, Center for Cardiovascular Research, University of Rochester, New York 14642, USA
    Ann N Y Acad Sci 947:93-109; discussion 109-11. 2001
    ..In summary, the atheroprotective effects of steady laminar flow on the endothelium involve multiple synergistic mechanisms...
  8. ncbi request reprint Src family kinase and adenosine differentially regulate multiple MAP kinases in ischemic myocardium: modulation of MAP kinases activation by ischemic preconditioning
    Y Takeishi
    Department of Medicine, Case Western Reserve University, Cleveland, OH 44106-5029, USA
    J Mol Cell Cardiol 33:1989-2005. 2001
    ..These data suggest important roles for Src family kinases and adenosine in mediating preconditioning, and suggest specific roles for individual MAP kinases in preconditioning...
  9. pmc Agonist-stimulated cytoskeletal reorganization and signal transduction at focal adhesions in vascular smooth muscle cells require c-Src
    T Ishida
    Department of Medicine, Cardiology Division, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Clin Invest 103:789-97. 1999
    ..c-Src kinase activity is required for the cytoskeletal turnover that occurs in cell spreading, whereas c-Src appears to regulate actin bundling via a kinase-independent mechanism...
  10. ncbi request reprint Angiotensin II signal transduction in vascular smooth muscle: pathways activated by specific tyrosine kinases
    B C Berk
    University of Rochester, Department of Medicine, New York 14642, USA
    J Am Soc Nephrol 10:S62-8. 1999
    ..Thus, understanding AngII-stimulated signaling events, especially those related to tyrosine kinase activity, may form the basis for the development of new therapies for cardiovascular diseases...
  11. ncbi request reprint Protein kinase C-zeta mediates angiotensin II activation of ERK1/2 in vascular smooth muscle cells
    D F Liao
    Department of Medicine, Division of Cardiology, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 272:6146-50. 1997
    ..These results demonstrate an important difference in signal transduction by angII compared with PDGF and phorbol ester in VSMC, and suggest a critical role for PKC-zeta and Ras in angII stimulation of ERK1/2...
  12. ncbi request reprint Angiotensin II stimulates tyrosine phosphorylation of phospholipase C-gamma-associated proteins. Characterization of a c-Src-dependent 97-kD protein in vascular smooth muscle cells
    U Schmitz
    Department of Medicine, University of Washington, Seattle 98195 7710, USA
    Circ Res 81:550-7. 1997
    ..These studies are the first to define a PLC-gamma-associated protein that may be required for Ang II-mediated signal transduction...
  13. ncbi request reprint Identification of flow-dependent endothelial nitric-oxide synthase phosphorylation sites by mass spectrometry and regulation of phosphorylation and nitric oxide production by the phosphatidylinositol 3-kinase inhibitor LY294002
    B Gallis
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 274:30101-8. 1999
    ..Finally, PKB phosphorylated eNOS in vitro at the same site phosphorylated in the cell and increased eNOS enzymatic activity by 15-20-fold...
  14. ncbi request reprint Increased expression of Axl tyrosine kinase after vascular injury and regulation by G protein-coupled receptor agonists in rats
    M G Melaragno
    Department of Medicine, University of Washington, Seattle, WA 98195 7710, USA
    Circ Res 83:697-704. 1998
    ..Our results implicate Axl as a potential mediator of vascular smooth muscle migration and proliferation caused by vascular injury and G protein-coupled receptor agonists...
  15. ncbi request reprint Upregulation of phosphodiesterase 1A1 expression is associated with the development of nitrate tolerance
    D Kim
    Department of Medicine, University of Rochester, Rochester, NY, USA
    Circulation 104:2338-43. 2001
    ..Inhibiting PDE1A1 expression and/or activity could be a novel therapeutic approach to limit nitrate tolerance...
  16. ncbi request reprint Big mitogen-activated protein kinase 1 (BMK1) is a redox-sensitive kinase
    J Abe
    Department of Medicine, Cardiology Division, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 271:16586-90. 1996
    ..These findings demonstrate that activation of BMK1 is different from ERK1/2 and suggest an important role for BMK1 as a redox-sensitive kinase...