ARNOLD BERK

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Activation of RNA polymerase II transcription
    A J Berk
    Molecular Biology Institute, University of California, Los Angeles, 611 Charles E Young Drive East, Box 951570, Los Angeles, CA 90095 1570, USA
    Curr Opin Cell Biol 11:330-5. 1999
  2. ncbi request reprint TBP-like factors come into focus
    A J Berk
    Molecular Biology Institute, University of California, Los Angeles 90095, USA
    Cell 103:5-8. 2000
  3. ncbi request reprint Recent lessons in gene expression, cell cycle control, and cell biology from adenovirus
    Arnold J Berk
    Department of Microbiology, Immunology and Molecular Genetics, Molecular Biology Institute, University of California, Los Angeles UCLA, 90095 1570, USA
    Oncogene 24:7673-85. 2005
  4. ncbi request reprint Effect of regional gene therapy with bone morphogenetic protein-2-producing bone marrow cells on spinal fusion in rats
    Jeffrey C Wang
    Department of Orthopaedic Surgery, University of California at Los Angeles, School of Medicine, 90095 6902, USA
    J Bone Joint Surg Am 85:905-11. 2003
  5. pmc Robust in vivo transduction of a genetically stable Epstein-Barr virus episome to hepatocytes in mice by a hybrid viral vector
    Sean D Gallaher
    Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, California 90095 1570, USA
    J Virol 83:3249-57. 2009
  6. pmc Epigenetic reprogramming by adenovirus e1a
    Roberto Ferrari
    Department of Biological Chemistry, University of California, Los Angeles, CA 90095, USA
    Science 321:1086-8. 2008
  7. pmc Adenovirus small e1a alters global patterns of histone modification
    Gregory A Horwitz
    Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
    Science 321:1084-5. 2008
  8. pmc Adenovirus E1B 55-kilodalton protein is a p53-SUMO1 E3 ligase that represses p53 and stimulates its nuclear export through interactions with promyelocytic leukemia nuclear bodies
    Mario A Pennella
    Molecular Biology Institute and Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, California 90095, USA
    J Virol 84:12210-25. 2010
  9. pmc Development of a novel helper-dependent adenovirus-Epstein-Barr virus hybrid system for the stable transformation of mammalian cells
    Oliver Dorigo
    Molecular Biology Institute, University of California at Los Angeles, 611 Charles E Young Dr East, Los Angeles, CA 90095 1570, USA
    J Virol 78:6556-66. 2004
  10. ncbi request reprint Transcription control by E1A and MAP kinase pathway via Sur2 mediator subunit
    Jennitte L Stevens
    Molecular Biology Institute, University of California, Los Angeles, 611 Charles Young Drive East, Los Angeles, CA 90095, USA
    Science 296:755-8. 2002

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Activation of RNA polymerase II transcription
    A J Berk
    Molecular Biology Institute, University of California, Los Angeles, 611 Charles E Young Drive East, Box 951570, Los Angeles, CA 90095 1570, USA
    Curr Opin Cell Biol 11:330-5. 1999
    ..Mammalian multisubunit coactivator complexes with homologs of the yeast SRB/Mediator subunits have been characterized. Structures of nuclear receptor-coactivator complexes have been determined...
  2. ncbi request reprint TBP-like factors come into focus
    A J Berk
    Molecular Biology Institute, University of California, Los Angeles 90095, USA
    Cell 103:5-8. 2000
  3. ncbi request reprint Recent lessons in gene expression, cell cycle control, and cell biology from adenovirus
    Arnold J Berk
    Department of Microbiology, Immunology and Molecular Genetics, Molecular Biology Institute, University of California, Los Angeles UCLA, 90095 1570, USA
    Oncogene 24:7673-85. 2005
    ..E1A CR4 binds the CtBP corepressor, but the mechanism by which this modulates the frequency of transformation remains to be determined. Clearly, adenovirus has much left to teach us about fundamental cellular processes...
  4. ncbi request reprint Effect of regional gene therapy with bone morphogenetic protein-2-producing bone marrow cells on spinal fusion in rats
    Jeffrey C Wang
    Department of Orthopaedic Surgery, University of California at Los Angeles, School of Medicine, 90095 6902, USA
    J Bone Joint Surg Am 85:905-11. 2003
    ..We used ex vivo adenoviral gene transfer to create BMP-2-producing bone marrow cells, and these autologous cells were found to induce a posterolateral fusion of the spine in syngeneic rats...
  5. pmc Robust in vivo transduction of a genetically stable Epstein-Barr virus episome to hepatocytes in mice by a hybrid viral vector
    Sean D Gallaher
    Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, California 90095 1570, USA
    J Virol 83:3249-57. 2009
    ..Approaches for adapting the HDAd-EBV hybrid to a variety of disease targets and the potential benefits of this approach are discussed...
  6. pmc Epigenetic reprogramming by adenovirus e1a
    Roberto Ferrari
    Department of Biological Chemistry, University of California, Los Angeles, CA 90095, USA
    Science 321:1086-8. 2008
    ..The temporal order of e1a binding requires its interactions with p300/CBP and RB proteins. Our data uncover a defined epigenetic reprogramming leading to cellular transformation...
  7. pmc Adenovirus small e1a alters global patterns of histone modification
    Gregory A Horwitz
    Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
    Science 321:1084-5. 2008
    ..Because global hypoacetylation at this site is observed in prostate carcinomas with poor prognosis, this suggests that processes resulting in global H3K18 hypoacetylation may be linked to oncogenic transformation...
  8. pmc Adenovirus E1B 55-kilodalton protein is a p53-SUMO1 E3 ligase that represses p53 and stimulates its nuclear export through interactions with promyelocytic leukemia nuclear bodies
    Mario A Pennella
    Molecular Biology Institute and Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, California 90095, USA
    J Virol 84:12210-25. 2010
    ..These data indicate that E1B-55K's association with PML nuclear bodies inactivates p53 by first sequestering it in PML nuclear bodies and then greatly facilitating its nuclear export...
  9. pmc Development of a novel helper-dependent adenovirus-Epstein-Barr virus hybrid system for the stable transformation of mammalian cells
    Oliver Dorigo
    Molecular Biology Institute, University of California at Los Angeles, 611 Charles E Young Dr East, Los Angeles, CA 90095 1570, USA
    J Virol 78:6556-66. 2004
    ..This novel gene transfer system has the potential to confer long-term episomal transgene expression and therefore to correct genetic defects with reduced vector-related toxicity and without insertional mutagenesis...
  10. ncbi request reprint Transcription control by E1A and MAP kinase pathway via Sur2 mediator subunit
    Jennitte L Stevens
    Molecular Biology Institute, University of California, Los Angeles, 611 Charles Young Drive East, Los Angeles, CA 90095, USA
    Science 296:755-8. 2002
    ..These results imply that specific activation domains stimulate transcription by binding to distinct Mediator subunits. Activation by E1A and Elk-1 requires recruitment of Mediator to a promoter by binding to its Sur2 subunit...
  11. pmc In vivo association of adenovirus large E1A protein with the human mediator complex in adenovirus-infected and -transformed cells
    Gang Wang
    Molecular Biology Institute and Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, California 90095 1570, USA
    J Virol 76:9186-93. 2002
    ..This stabilization of the interaction between Mediator and RNA polymerase II may contribute to the mechanism of activation by E1A-CR3...
  12. pmc A common site on TBP for transcription by RNA polymerases II and III
    Oliver Schroder
    Division of Biological Sciences, Center for Molecular Genetics, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0634, USA
    EMBO J 22:5115-24. 2003
    ....
  13. pmc Complexity in transcription control at the activation domain-mediator interface
    Michael A Balamotis
    Department of Microbiology, Immunology and Molecular Genetics, Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA 90095, USA
    Sci Signal 2:ra20. 2009
    ..Transcriptome analysis suggests that most genes expressed in both cell types, such as Egr1, are regulated by alternative transcription factors in the two cell types that respond differently to the same signal transduction pathways...
  14. pmc Activation domain-mediator interactions promote transcription preinitiation complex assembly on promoter DNA
    Greg T Cantin
    Molecular Biology Institute and Department of Microbiology, Immunology and Molecular Genetics, 611 Charles E Young Drive East, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 100:12003-8. 2003
    ..These results directly demonstrate that the interaction of activation domains with mediator stimulates preinitiation complex assembly on promoter DNA...
  15. ncbi request reprint Mediator requirement for both recruitment and postrecruitment steps in transcription initiation
    Gang Wang
    Molecular Biology Institute and Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, 611 Young Drive East, Los Angeles, California 90095, USA
    Mol Cell 17:683-94. 2005
    ..These results indicate that an interaction with MED23 stimulates initiation by promoter bound Pol II in addition to Pol II and GTF recruitment...
  16. pmc Analysis of the adenovirus E1B-55K-anchored proteome reveals its link to ubiquitination machinery
    Josephine N Harada
    Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California 90095 1570, USA
    J Virol 76:9194-206. 2002
    ..Lastly, we describe the identification and characterization of two novel E1B-55K interacting factors, importin-alpha 1 and pp32, that may also participate in the functions previously ascribed to E1B-55K and E4-orf6...
  17. pmc Adenovirus ubiquitin-protein ligase stimulates viral late mRNA nuclear export
    Jennifer L Woo
    Molecular Biology Institute, Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, California, USA
    J Virol 81:575-87. 2007
    ..We conclude that the stimulation of adenovirus late mRNA nuclear export by E1B-55K and E4orf6 results from the ubiquitin-protein ligase activity of the adenovirus ubiquitin-protein ligase complex...
  18. pmc Evidence that TAF-TATA box-binding protein interactions are required for activated transcription in mammalian cells
    Lisa S Martel
    Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, California, USA
    Mol Cell Biol 22:2788-98. 2002
    ....
  19. ncbi request reprint Enhanced expression of hypersensitive alpha4* nAChR in adult mice increases the loss of midbrain dopaminergic neurons
    Johannes Schwarz
    Department of Neurology, University of Leipzig, Leipzig, Germany
    FASEB J 20:935-46. 2006
    ..This produced increased L9'S mutant nAChR expression, which in turn led to nicotinic cholinergic excitotoxicity in dopaminergic neurons...
  20. pmc Adenovirus exploits the cellular aggresome response to accelerate inactivation of the MRN complex
    Yue Liu
    Molecular Biology Institute and Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, California 90095 1570, USA
    J Virol 79:14004-16. 2005
    ....
  21. ncbi request reprint PTEN deletion in Bergmann glia leads to premature differentiation and affects laminar organization
    Qing Yue
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA
    Development 132:3281-91. 2005
    ..These results uncover an unexpected role for PTEN in regulating Bergmann glia differentiation, as well as the importance of time-dependent Bergmann glia differentiation during cerebellar development...
  22. ncbi request reprint A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II
    Henri Marc Bourbon
    Mol Cell 14:553-7. 2004
  23. pmc Requirement of Sur2 for efficient replication of mouse adenovirus type 1
    Lei Fang
    Department of Microbiology and Immunology, University of Michigan Medical School, 1150 W Medical Center Dr, 6723 Medical Science Bldg II, Ann Arbor, MI 48109 0620, USA
    J Virol 78:12888-900. 2004
    ..The viral replication defects in Sur2(-/-) MEFs appeared to be due at least in part to a defect in viral early gene transcription...

Research Grants14

  1. MECHANISM OF P53 SILENCING BY ADENOVIRUS E1B 55K PROTEIN
    ARNOLD BERK; Fiscal Year: 2007
    ..We will study how ATM activation inhibits viral mRNA nuclear export and translation. Our findings may allow us to genetically characterize tumors to determine which ones might be effectively treated with dl1520. ..
  2. BIOSYNTHESIS OF ADENOVIRUS EARLY RNA'S
    ARNOLD BERK; Fiscal Year: 2007
    ..abstract_text> ..
  3. MECHANISM OF P53 SILENCING BY ADENOVIRUS E1B 55K PROTEIN
    ARNOLD BERK; Fiscal Year: 2004
    ..abstract_text> ..
  4. MECHANISM OF P53 SILENCING BY ADENOVIRUS E1B 55K PROTEIN
    ARNOLD BERK; Fiscal Year: 1999
    ..Understanding the mechanism of transcriptional activation by p53 and its inhibition by adenovirus E1B 55K may allow the design of therapies which reactivate p53 in human tumors, leading to cell-cycle arrest and apoptosis of tumor cells. ..
  5. MECHANISM OF P53 SILENCING BY ADENOVIRUS E1B 55K PROTEIN
    Arnold J Berk; Fiscal Year: 2010
    ..We will study how ATM activation inhibits viral mRNA nuclear export and translation. Our findings may allow us to genetically characterize tumors to determine which ones might be effectively treated with dl1520. ..