M Bergsneider

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Barrier-limited multimodality closure for reconstruction of wide sellar openings
    Marvin Bergsneider
    Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Neurosurgery 71:68-75; discussion 75-6. 2012
  2. pmc Robust peak recognition in intracranial pressure signals
    Fabien Scalzo
    Department of Neurosurgery, Geffen School of Medicine, Neural Systems and Dynamic Lab, University of California, Los Angeles, CA, USA
    Biomed Eng Online 9:61. 2010
  3. ncbi request reprint Relationship between valve opening pressure, body position, and intracranial pressure in normal pressure hydrocephalus: paradigm for selection of programmable valve pressure setting
    Marvin Bergsneider
    Division of Neurosurgery, David Geffen School of Medicine at University of California at Los Angeles, 90095 6901, USA
    Neurosurgery 55:851-8; discussion 858-9. 2004
  4. doi request reprint Surgical management of adult hydrocephalus
    Marvin Bergsneider
    Division of Neurosurgery, Department of Surgery, University of California Los Angeles, David Geffen School of Medicine, University of California Los Angeles Medical Center, Los Angeles, California 90095 6901, USA
    Neurosurgery 62:643-59; discussion 659-60. 2008
  5. ncbi request reprint Complete microsurgical resection of colloid cysts with a dual-port endoscopic technique
    Marvin Bergsneider
    Division of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095 6901, USA
    Neurosurgery 60:ONS33-42; discussion ONS42-3. 2007
  6. ncbi request reprint Evolving concepts of cerebrospinal fluid physiology
    M Bergsneider
    Division of Neurosurgery, Adult Hydrocephalus Center, University of California, Los Angeles, CA 90095 7039, USA
    Neurosurg Clin N Am 12:631-8, vii. 2001
  7. ncbi request reprint Beneficial effect of siphoning in treatment of adult hydrocephalus
    M Bergsneider
    Division of Neurosurgery, Brain Research Institute, University of California at Los Angeles School of Medicine, 90095 7039, USA
    Arch Neurol 56:1224-9. 1999
  8. ncbi request reprint Management of hydrocephalus with programmable valves after traumatic brain injury and subarachnoid hemorrhage
    M Bergsneider
    UCLA Division of Neurosurgery, Los Angeles, California 90095 7039, USA
    Curr Opin Neurol 13:661-4. 2000
  9. ncbi request reprint Dissociation of cerebral glucose metabolism and level of consciousness during the period of metabolic depression following human traumatic brain injury
    M Bergsneider
    UCLA Division of Neurosurgery, Harbor UCLA Medical Center, UCLA Brain Research Institute, Los Angeles, California 90095 7039, USA
    J Neurotrauma 17:389-401. 2000
  10. ncbi request reprint Endoscopic management of cysticercal cysts within the lateral and third ventricles
    M Bergsneider
    Harbor UCLA Medical Center and Division of Neurosurgery, University of California, Los Angeles 90095 7039, USA
    J Neurosurg 92:14-23. 2000

Research Grants

  1. A HEMODYNAMIC MODEL OF INTRACRANIAL PRESSURE DYNAMICS
    Marvin Bergsneider; Fiscal Year: 2002
  2. In Vivo CSF Shunt Hydrodynamics in Hydrocephalus
    Marvin Bergsneider; Fiscal Year: 2007
  3. In Vivo Imaging of Post-Traumatic Cerebral Amyloid Deposition
    Marvin Bergsneider; Fiscal Year: 2007
  4. In Vivo CSF Shunt Hydrodynamics in Hydrocephalus
    Marvin Bergsneider; Fiscal Year: 2010

Detail Information

Publications72

  1. doi request reprint Barrier-limited multimodality closure for reconstruction of wide sellar openings
    Marvin Bergsneider
    Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Neurosurgery 71:68-75; discussion 75-6. 2012
    ..The alternative, a vascularized pedicle nasoseptal flap, may require several days to heal and still has a > 5% cerebrospinal fluid (CSF) leak rate...
  2. pmc Robust peak recognition in intracranial pressure signals
    Fabien Scalzo
    Department of Neurosurgery, Geffen School of Medicine, Neural Systems and Dynamic Lab, University of California, Los Angeles, CA, USA
    Biomed Eng Online 9:61. 2010
    ..While current ICP pulse analysis frameworks offer satisfying results on most of the pulses, we observed that the performance of several of them deteriorates significantly on abnormal, or simply more challenging pulses...
  3. ncbi request reprint Relationship between valve opening pressure, body position, and intracranial pressure in normal pressure hydrocephalus: paradigm for selection of programmable valve pressure setting
    Marvin Bergsneider
    Division of Neurosurgery, David Geffen School of Medicine at University of California at Los Angeles, 90095 6901, USA
    Neurosurgery 55:851-8; discussion 858-9. 2004
    ..We also assessed whether shunt-induced ICP could be predicted on the basis of a simple hydrodynamic equation...
  4. doi request reprint Surgical management of adult hydrocephalus
    Marvin Bergsneider
    Division of Neurosurgery, Department of Surgery, University of California Los Angeles, David Geffen School of Medicine, University of California Los Angeles Medical Center, Los Angeles, California 90095 6901, USA
    Neurosurgery 62:643-59; discussion 659-60. 2008
    ..For the condition of normal pressure hydrocephalus, recommendations are offered regarding the evaluation, surgical treatment, and postoperative management of this disorder...
  5. ncbi request reprint Complete microsurgical resection of colloid cysts with a dual-port endoscopic technique
    Marvin Bergsneider
    Division of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095 6901, USA
    Neurosurgery 60:ONS33-42; discussion ONS42-3. 2007
    ....
  6. ncbi request reprint Evolving concepts of cerebrospinal fluid physiology
    M Bergsneider
    Division of Neurosurgery, Adult Hydrocephalus Center, University of California, Los Angeles, CA 90095 7039, USA
    Neurosurg Clin N Am 12:631-8, vii. 2001
    ..An understanding of a variety of disorders, including hydrocephalus and Chiari malformations, continue to evolve as knowledge of CSF physiology is increased...
  7. ncbi request reprint Beneficial effect of siphoning in treatment of adult hydrocephalus
    M Bergsneider
    Division of Neurosurgery, Brain Research Institute, University of California at Los Angeles School of Medicine, 90095 7039, USA
    Arch Neurol 56:1224-9. 1999
    ..To increase awareness about the treatment of adult patients with shunt-nonresponsive hydrocephalus--a state characterized by marked ventriculomegaly, low intracranial pressure, and a patent cerebrospinal fluid diversionary shunt...
  8. ncbi request reprint Management of hydrocephalus with programmable valves after traumatic brain injury and subarachnoid hemorrhage
    M Bergsneider
    UCLA Division of Neurosurgery, Los Angeles, California 90095 7039, USA
    Curr Opin Neurol 13:661-4. 2000
    ..An improved understanding of the intracranial pressure dynamics occurring both before and after a cerebrospinal fluid diversionary shunt has provided a more scientific basis for the application of these valves...
  9. ncbi request reprint Dissociation of cerebral glucose metabolism and level of consciousness during the period of metabolic depression following human traumatic brain injury
    M Bergsneider
    UCLA Division of Neurosurgery, Harbor UCLA Medical Center, UCLA Brain Research Institute, Los Angeles, California 90095 7039, USA
    J Neurotrauma 17:389-401. 2000
    ....
  10. ncbi request reprint Endoscopic management of cysticercal cysts within the lateral and third ventricles
    M Bergsneider
    Harbor UCLA Medical Center and Division of Neurosurgery, University of California, Los Angeles 90095 7039, USA
    J Neurosurg 92:14-23. 2000
    ..The ultimate goals were to avoid having to place a complication-prone cerebrospinal fluid shunt and to eliminate the risk of complications related to cyst degeneration...
  11. ncbi request reprint Metabolic recovery following human traumatic brain injury based on FDG-PET: time course and relationship to neurological disability
    M Bergsneider
    Department of Surgery, Division of Neurosurgery, UCLA Brain Research Institute, Harbor-University of California at Los Angeles Medical Center, USA
    J Head Trauma Rehabil 16:135-48. 2001
    ..Quantitative FDG-PET cannot be used as a surrogate technique for estimating degree of global functional recovery following traumatic brain injury...
  12. pmc Pulse onset detection using neighbor pulse-based signal enhancement
    Peng Xu
    Neural Systems and Dynamics Laboratory, Department of Neurosurgery, The David Geffen School of Medicine, University of California, Los Angeles, United States
    Med Eng Phys 31:337-45. 2009
    ..These results suggested that the proposed algorithm could help achieve robustness in pulse onset detection and facilitate pulse wave analysis using clinical recordings...
  13. ncbi request reprint PET investigation of post-traumatic cerebral blood volume and blood flow
    N Hattori
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Acta Neurochir Suppl 86:49-52. 2003
    ..In conclusion, regional brain edema is likely to occur in contusion and pericontusion areas, while some of the contusional tissue may show vascular engorgement...
  14. ncbi request reprint Integrative analysis of intracranial pressure and R-R interval signals: a study of ICP B-wave using causal coherence
    Xiao Hu
    Division of Neuroscience, University of California, Los Angeles, USA
    Conf Proc IEEE Eng Med Biol Soc 1:464-7. 2006
    ....
  15. pmc Forecasting ICP elevation based on prescient changes of intracranial pressure waveform morphology
    Xiao Hu
    Neural Systems and Dynamics Laboratory, Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, CA 90024, USA
    IEEE Trans Biomed Eng 57:1070-8. 2010
    ..This paper demonstrated that advanced ICP pulse analysis combined with machine learning could potentially leads to the forecasting of ICP elevation so that a proactive ICP management could be realized based on these accurate forecasts...
  16. doi request reprint Wavelet entropy characterization of elevated intracranial pressure
    Peng Xu
    Neural Systems and Dynamics Laboratory, Department of Neurosurgery, The David Geffen School of Medicine, University of California, Los Angeles, USA
    Conf Proc IEEE Eng Med Biol Soc 2008:2924-7. 2008
    ..Based on these results, we suggest that ICH may be formed by the re-allocation of oscillation energy within brain...
  17. ncbi request reprint Endoscopic removal of cysticercal cysts within the fourth ventricle. Technical note
    M Bergsneider
    Division of Neurosurgery, Harbor UCLA Medical Center, University of California at Los Angeles, 90095 7039, USA
    J Neurosurg 91:340-5. 1999
    ..In properly selected patients, the endoscopic removal of cysticercal cysts located within the fourth ventricle should be considered as the primary treatment for this condition...
  18. ncbi request reprint Morphological changes of intracranial pressure pulses are correlated with acute dilatation of ventricles
    Xiao Hu
    Department of Neurosurgery, The David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Acta Neurochir Suppl 102:131-6. 2008
    ..Potentially useful information may exist in the morphological changes in intracranial pressure pulse therefore their extraction by automated methods is highly desirable...
  19. ncbi request reprint Subcortical white matter metabolic changes remote from focal hemorrhagic lesions suggest diffuse injury after human traumatic brain injury
    Hsiao Ming Wu
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 6901, USA
    Neurosurgery 55:1306-15; discussio 1316-7. 2004
    ..The objective was to determine the nature, extent, and degree of metabolic abnormalities in subcortical brain regions remote from hemorrhagic lesions...
  20. pmc A subspace decomposition approach toward recognizing valid pulsatile signals
    Shadnaz Asgari
    Neural Systems and Dynamics Laboratory, Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Physiol Meas 30:1211-25. 2009
    ..Finally, this SVD-based valid pulse recognition can be potentially applied to process pulsatile signals other than ICP because no proprietary ICP features are incorporated in the algorithm...
  21. pmc Pattern recognition of overnight intracranial pressure slow waves using morphological features of intracranial pressure pulse
    Magdalena Kasprowicz
    Neural Systems and Dynamics Laboratory, Department of Neurosurgery, The David Geffen School of Medicine, University of California, CA 90095, Los Angeles, USA
    J Neurosci Methods 190:310-8. 2010
    ....
  22. ncbi request reprint Delayed increase in extracellular glycerol with post-traumatic electrographic epileptic activity: support for the theory that seizures induce secondary injury
    P Vespa
    UCLA, Department of Neurosurgery, Los Angeles, USA
    Acta Neurochir Suppl 81:355-7. 2002
    ..001). Preliminary evidence suggests that post-traumatic seizures lead to additional membrane injury as reflected by elevated extracellular glycerol levels...
  23. doi request reprint Phase II pilot study of bevacizumab in combination with temozolomide and regional radiation therapy for up-front treatment of patients with newly diagnosed glioblastoma multiforme: interim analysis of safety and tolerability
    Albert Lai
    Department of Neurology, David Geffen School of Medicine at University of California Los Angeles, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Int J Radiat Oncol Biol Phys 71:1372-80. 2008
    ....
  24. pmc An algorithm for extracting intracranial pressure latency relative to electrocardiogram R wave
    Xiao Hu
    Neural Systems and Dynamics Laboratory, Department of Neurosurgery, The David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Physiol Meas 29:459-71. 2008
    ..Further investigation is needed to demonstrate the role of ICP latency in characterizing dynamic cerebral vascular pathophysiological changes in clinical states such as subarachnoid hemorrhage and traumatic brain injury...
  25. doi request reprint Waldenström's macroglobulinemia and large B-cell central nervous system lymphoma: a case report
    Jean Philippe Langevin
    Division of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Surg Neurol 69:407-10. 2008
    ..Neurologic symptoms, such as fatigue, dizziness, and blurred vision, are common. The metastatic spread to the CNS, which rarely has been reported, can occur either diffusely or in the form of a mass lesion...
  26. pmc A systematic study of linear dynamic modeling of intracranial pressure dynamics
    Sunghan Kim
    Neural Systems and Dynamics Lab, Department of Neurosurgery, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA
    Physiol Meas 32:319-36. 2011
    ..Our study results show that the fitness of the LDM to data is excellent and the LDM for ICP dynamics is well generalizable, which is of particular interest to adopting our time series data mining framework for noninvasive ICP assessment...
  27. pmc Adaptive computation of approximate entropy and its application in integrative analysis of irregularity of heart rate variability and intracranial pressure signals
    Xiao Hu
    Division of Neurosurgery, Geffen School of Medicine at University of California, Los Angeles, CA 90095, United States
    Med Eng Phys 30:631-9. 2008
    ..In conclusion, the adaptive ApEn algorithm can be used to track nonstationary signal characteristics. Furthermore, interactions between dynamic systems could be studied by using ApEn time series of the direct observations of systems...
  28. pmc Characterization of interdependency between intracranial pressure and heart variability signals: a causal spectral measure and a generalized synchronization measure
    Xiao Hu
    Brain Monitoring and Modelling Laboratory, Division of Neurosurgery, University of California, Los Angeles, CA 90034, USA
    IEEE Trans Biomed Eng 54:1407-17. 2007
    ..This finding regarding the enhanced directional, from ICP to RR interval, coupling between ICP and RR interval was also confirmed by a modified GS measure...
  29. pmc Inferring cerebrovascular changes from latencies of systemic and intracranial pulses: a model-based latency subtraction algorithm
    Xiao Hu
    Neural Systems and Dynamics Laboratory, Department of Neurosurgery, The David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Cereb Blood Flow Metab 29:688-97. 2009
    ..In conclusion, this study suggests that subtraction of systemic ABP latency improves CBFV latency measurements, which in turn improve the characterization of cerebral vascular changes...
  30. doi request reprint MRI compatibility of microfabricated magnetic actuators for implantable catheters: Mechanical evaluations
    HYOWON LEE
    Biomedical Engineering Interdepartmental Program at University of California, Los Angeles, 420 Westwood Plaza, Engineering IV 64 144, USA
    Conf Proc IEEE Eng Med Biol Soc 2010:907-10. 2010
    ..Additional experiments are required to quantify the potential image-artifact size and radio-frequency-induced heating caused by the magnetic microactuators inside an MRI scanner...
  31. pmc A robust approach toward recognizing valid arterial-blood-pressure pulses
    Shadnaz Asgari
    Neural Systems and Dynamics Laboratory, Department of Neurosurgery, University of California, Los Angeles, CA 90024, USA
    IEEE Trans Inf Technol Biomed 14:166-72. 2010
    ..Integration of some of the SAI-value-based abnormality conditions to the validation process of SVD-based method can further improve the performance by reducing the FPR to 3.92%, while keeping the TPR at the high rate of 99.05%...
  32. doi request reprint Thecal shunt placement for treatment of obstructive primary syringomyelia
    Sandi Lam
    Department of Neurosurgery, University of California Los Angeles, California, USA
    J Neurosurg Spine 9:581-8. 2008
    ..The authors report on 7 patients who underwent thecal shunt placement for primary spinal syringomyelia...
  33. doi request reprint A systematic analysis of disease control in acromegaly treated with radiosurgery
    Isaac Yang
    Department of Neurological Surgery, University of California, Los Angeles, California 90095 6901, USA
    Neurosurg Focus 29:E13. 2010
    ..Here, the authors present a systematic analysis of SRS for growth hormone-secreting adenomas to characterize the efficacy of SRS in the treatment of acromegaly...
  34. doi request reprint Nonlinear regression for sub-peak detection of intracranial pressure signals
    Fabien Scalzo
    Division of Neurosurgery, Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Conf Proc IEEE Eng Med Biol Soc 2008:5411-4. 2008
    ..They indicate that the use of a regression model significantly increases the peak designation accuracy...
  35. pmc Morphological clustering and analysis of continuous intracranial pressure
    Xiao Hu
    Neural Systems and Dynamics Laboratory, Department of Neurosurgery, University of California, Los Angeles, CA 90024, USA
    IEEE Trans Biomed Eng 56:696-705. 2009
    ..These results show that the proposed algorithm can be reliably applied to process continuous ICP recordings from real clinical environment to extract useful morphological features of ICP pulses...
  36. pmc Intracranial pressure pulse morphological features improved detection of decreased cerebral blood flow
    Xiao Hu
    Department of Neurosurgery, The David Geffen School of Medicine, Neural Systems and Dynamics Laboratory, University of California, Los Angeles, CA, USA
    Physiol Meas 31:679-95. 2010
    ..This study demonstrated that the potential role of ICP monitoring may be extended to provide an indicator of low global cerebral blood perfusion...
  37. pmc Improved noninvasive intracranial pressure assessment with nonlinear kernel regression
    Peng Xu
    Neural Systems and Dynamics Laboratory, Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    IEEE Trans Inf Technol Biomed 14:971-8. 2010
    ..05). The current result confirms the potential of using nonlinear regression to achieve more accurate noninvasive ICP assessment...
  38. doi request reprint Forecasting intracranial pressure elevation using pulse waveform morphology
    Robert Hamilton
    Neural Systems and Dynamics Laboratory, Department of Neurosurgery, University of California, Los Angeles, CA, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:4331-4. 2009
    ..Currently, ICU management of ICP elevations is reactive in nature; we propose a quantitative method to predict potentially harmful elevations in ICP...
  39. ncbi request reprint Endoscope-assisted placement of a multiperforated shunt catheter into the fourth ventricle via a frontal transventricular approach
    Kristen Upchurch
    Division of Neurosurgery, Department of Surgery, UCLA Medical Center and David Geffen School of Medicine at UCLA, Los Angeles, California 90095 7039, USA
    Neurosurg Focus 22:E8. 2007
    ..The authors report on their experience with the treatment of symptomatic adult patients by endoscope-assisted placement of a fourth ventricle shunt catheter via a frontal transventricular approach...
  40. ncbi request reprint Measurement of the global lumped constant for 2-deoxy-2-[18F]fluoro-D-glucose in normal human brain using [15O]water and 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography imaging. A method with validation based on multiple methodologies
    Hsiao Ming Wu
    Department of Molecular and Medical Pharmacology, UCLA DOE Center for Molecular Medicine, Los Angeles, CA 90095, USA
    Mol Imaging Biol 5:32-41. 2003
    ....
  41. ncbi request reprint Persistently low extracellular glucose correlates with poor outcome 6 months after human traumatic brain injury despite a lack of increased lactate: a microdialysis study
    Paul M Vespa
    Division of Neurosurgery, David Geffen School of Medicine at University of California at Los Angeles, CA, USA
    J Cereb Blood Flow Metab 23:865-77. 2003
    ..These results suggest that the level of extracellular glucose is typically reduced after traumatic brain injury and associated with poor outcome, but is not associated with ischemia...
  42. ncbi request reprint Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study
    Paul Vespa
    1David Geffen School of Medicine at UCLA, UCLA Medical Center, University of California, Los Angeles, 90095, USA
    J Cereb Blood Flow Metab 25:763-74. 2005
    ..001), but not with OEF or CvO(2). Traumatic brain injury leads to a state of persistent metabolic crisis as reflected by abnormal cerebral microdialysis LPR that is not related to ischemia...
  43. ncbi request reprint Nonlinear analysis of cerebral hemodynamic and intracranial pressure signals for characterization of autoregulation
    Xiao Hu
    Brain Monitoring and Modeling Laboratory, Division of Neurosurgery, University of California, Los Angeles 90034, USA
    IEEE Trans Biomed Eng 53:195-209. 2006
    ..On the other hand, complex patterns of C measure evolution were observed among 14 cases of propofol data indicating a nontrivial effect of propofol on the dependency of CBFV on ABP...
  44. ncbi request reprint Imaging proliferation in brain tumors with 18F-FLT PET: comparison with 18F-FDG
    Wei Chen
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    J Nucl Med 46:945-52. 2005
    ..We characterized (18)F-FLT PET of brain gliomas and compared (18)F-FLT with (18)F-FDG PET in side-by-side studies of the same patients...
  45. ncbi request reprint Acute changes in regional cerebral (18)F-FDG kinetics in patients with traumatic brain injury
    Naoya Hattori
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 6948, USA
    J Nucl Med 45:775-83. 2004
    ..The purpose of this study was to characterize contusional, pericontusional, and remote regions of TBI by estimating glucose transporter and hexokinase activities on the basis of (18)F-FDG kinetic modeling...
  46. ncbi request reprint Accuracy of a method using short inhalation of (15)O-O(2) for measuring cerebral oxygen extraction fraction with PET in healthy humans
    Naoya Hattori
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Nucl Med 45:765-70. 2004
    ..The purpose of this study was to test the accuracy of the short-inhalation technique for estimating OEF in healthy human volunteers...
  47. ncbi request reprint Early and persistent impaired percent alpha variability on continuous electroencephalography monitoring as predictive of poor outcome after traumatic brain injury
    Paul M Vespa
    Department of Neurology, School of Medicine, University of California at Los Angeles, 90095, USA
    J Neurosurg 97:84-92. 2002
    ..The goal of this study was to determine the usefulness of continuous electroencephalography (EEG) monitoring in determining prognosis early after TBI, while the patient is in the intensive care unit...
  48. ncbi request reprint Selective metabolic reduction in gray matter acutely following human traumatic brain injury
    Hsiao Ming Wu
    Department of Molecular and Medical Pharmacology, UCLA Brain Injury Research Center, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Neurotrauma 21:149-61. 2004
    ..There was a selective CMRglc reduction in cortical GM following TBI. The pathophysiological basis for the reduction in GM-to-WM CMRglc ratio seen on FDG-PET imaging following TBI remains to be determined...
  49. pmc A data mining framework for time series estimation
    Xiao Hu
    Neural Systems and Dynamics Lab, Department of Neurosurgery, Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA
    J Biomed Inform 43:190-9. 2010
    ..The performance of the proposed method was superior to that of a simple training-free approach of finding the optimal TTS-RTS pair by a conventional similarity-based search on RTS features...
  50. ncbi request reprint Estimation of hidden state variables of the Intracranial system using constrained nonlinear Kalman filters
    Xiao Hu
    Brain Monitoring and Modeling Laboratory, Division of Neurosurgery, University of California, Los Angeles, CA 90034, USA
    IEEE Trans Biomed Eng 54:597-610. 2007
    ..Finally, the state estimator combined with the I/O configuration that has both ICP and CBFV as outputs can potentially estimate the lumped cerebral arterial radii, which are not measurable in a typical clinical environment...
  51. ncbi request reprint Regional heterogeneity of post-traumatic brain metabolism as studied by microdialysis, magnetic resonance spectroscopy and positron emission tomography
    Paul Vespa
    UCLA Brain Injury Research Center, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, CHS 18 218, Mail code 713909, Los Angeles, CA 90095, USA
    Brain Pathol 14:210-4. 2004
  52. ncbi request reprint Endoscopic removal of cisternal neurocysticercal cysts. Technical note
    Tooraj Gravori
    Harbor UCLA Medical Center, Division of Neurosurgery, University of California, Los Angeles, California, USA
    Neurosurg Focus 12:e7. 2002
    ....
  53. ncbi request reprint Intensive insulin therapy reduces microdialysis glucose values without altering glucose utilization or improving the lactate/pyruvate ratio after traumatic brain injury
    Paul Vespa
    UCLA Division of Neurosurgery, Los Angeles, CA, and Barrows Neurologic Institute, Phoenix, AZ, USA
    Crit Care Med 34:850-6. 2006
    ..To determine that intensive glycemic control does not reduce microdialysis glucose concentration brain metabolism of glucose...
  54. ncbi request reprint Reduction of compartment compliance increases venous flow pulsatility and lowers apparent vascular compliance: implications for cerebral blood flow hemodynamics
    Xiao Hu
    Division of Neurosurgery, The David Geffen School of Medicine at UCLA, University of California, 10833 LeConte Ave, 74 134 CHS Mail Code 956901, Los Angeles, CA 90095 6901, USA
    Med Eng Phys 28:304-14. 2006
    ..These experimental results support the concept that the vessel compliance of vascular systems enclosed within a rigid compartment is a function of the global compartment compliance...
  55. ncbi request reprint Guidelines for management of idiopathic normal pressure hydrocephalus: progress to date
    A Marmarou
    Department of Neurosurgery, Virginia Commonwealth University Medical Center, Richmond, VA 23219, USA
    Acta Neurochir Suppl 95:237-40. 2005
    ..It became clear that more prospective randomized studies are needed to resolve some of the controversial issues such as iNPH classification and sensitivity of diagnostic tests for identifying shunt responsive iNPH...
  56. ncbi request reprint Mahaley Clinical Research Award: extent of glioma resection using low-field (0.2 T) versus high-field (1.5 T) intraoperative MRI and image-guided frameless neuronavigation
    Marvin Bergsneider
    Division of Neurosurgery, The David Geffen School of Medicine at UCLA, University of California, Los Angeles, USA
    Clin Neurosurg 52:389-99. 2005
  57. ncbi request reprint Success and complication rates of endoscopic third ventriculostomy for adult hydrocephalus: a series of 108 patients
    Joshua R Dusick
    Division of Neurosurgery, University of California at Los Angeles David Geffen School of Medicine, UCLA Medical Center, Los Angeles, CA 90095 6901, USA
    Surg Neurol 69:5-15. 2008
    ..We sought to determine which factors might predict clinical success and failure...
  58. ncbi request reprint Correlation of regional metabolic rates of glucose with glasgow coma scale after traumatic brain injury
    Naoya Hattori
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Nucl Med 44:1709-16. 2003
    ..Therefore, thalamic and brain stem CMRglc may have a closer correlation than does the cerebral cortex with depth of coma after TBI...
  59. ncbi request reprint Surgical management of idiopathic normal-pressure hydrocephalus
    Marvin Bergsneider
    Division of Neurosurgery, University of California at Los Angeles Medical Center, Los Angeles, California, USA
    Neurosurgery 57:S29-39; discussion ii-v. 2005
    ..Many earlier studies predated our current understanding of the hydrodynamics of cerebrospinal fluid shunts, and therefore, the conclusions drawn may no longer be valid...
  60. ncbi request reprint Hydrocephalus: new theories and new shunts?
    Marvin Bergsneider
    Division of Neurosurgery, The David Geffen School of Medicine at UCLA, University of California, Los Angeles, USA
    Clin Neurosurg 52:120-6. 2005
  61. pmc Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma
    Tim F Cloughesy
    Department of Neurology, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS Med 5:e8. 2008
    ..Small, molecularly focused clinical studies offer the promise of the early definition of optimal biologic dose and patient population...
  62. ncbi request reprint Why valve opening pressure plays a relatively minor role in the postural ICP response to ventricular shunts in normal pressure hydrocephalus: modeling and implications
    S W Cook
    UCLA Division of Neurosurgery, Los Angeles, CA, USA
    Acta Neurochir Suppl 81:15-7. 2002
    ..In this study, the objective was to determine whether the relationship between valve opening pressure and post-operative postural ICP changes was predictable...
  63. ncbi request reprint Magnetic microactuators for MEMS-enabled ventricular catheters for hydrocephalus
    SELENE A LEE
    NeuroEng Training Program, School of Medicine, Electrical Engineering Department, Univ of CA, Los Angeles, CA 90095, USA
    Conf Proc IEEE Eng Med Biol Soc 1:2494-7. 2006
    ..By integrating the microactuators into the catheters, we hope to produce an improved catheter with the ability to actively combat the health-threatening occlusion process...
  64. doi request reprint Functional evaluation of magnetic microactuators for removing biological accumulation: an in vitro study
    SELENE A LEE
    NeuroEngineering Training Program, University of California, Los Angeles, Los Angeles, CA 90095 USA
    Conf Proc IEEE Eng Med Biol Soc 2008:947-50. 2008
    ..On average, microactuators removed 37.4% of the adherent cells. The results also revealed that the cell-clearing capability of the microactuator increased as a function of the actuation duration and angle of deflection...
  65. ncbi request reprint Energy dysfunction as a predictor of outcome after moderate or severe head injury: indices of oxygen, glucose, and lactate metabolism
    Thomas C Glenn
    UCLA Cerebral Blood Flow Laboratory, California, USA
    J Cereb Blood Flow Metab 23:1239-50. 2003
    ..Future studies are needed to determine to what degree nonglycolytic energy production from alternative fuels such as lactate occurs after TBI and whether alternative fuel administration is a viable therapy for TBI patients...
  66. ncbi request reprint Impaired percent alpha variability on continuous electroencephalography is associated with thalamic injury and predicts poor long-term outcome after human traumatic brain injury
    Matthew O Hebb
    Brain Repair Centre, Division of Neurosurgery, Dalhousie University, Halifax, Nova Scotia, Canada
    J Neurotrauma 24:579-90. 2007
    ..PAV appears best utilized as a functional adjunct to traditional clinical and anatomical predictors...
  67. ncbi request reprint Improved parametric image generation using spatial-temporal analysis of dynamic PET studies
    Yun Zhou
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Neuroimage 15:697-707. 2002
    ..NLRRSC provided a reliable estimate of glucose metabolite uptake rate with a comparable image quality compared to Patlak analysis. In conclusion, NLRRSC is a reliable and robust parametric imaging algorithm for dynamic PET studies...
  68. ncbi request reprint The value of supplemental prognostic tests for the preoperative assessment of idiopathic normal-pressure hydrocephalus
    Anthony Marmarou
    Department of Neurosurgery, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0508, USA
    Neurosurgery 57:S17-28; discussion ii-v. 2005
    ..This report develops evidence-based guidelines for the use of supplementary tests as an aid in prognosis...
  69. ncbi request reprint Outcome of shunting in idiopathic normal-pressure hydrocephalus and the value of outcome assessment in shunted patients
    Petra Klinge
    Neurosurgical Department, Medical School Hannover, Hannover, Germany
    Neurosurgery 57:S40-52; discussion ii-v. 2005
    ..Because specific criteria for defining clinical improvement are seldom reported, conclusions drawn about shunt outcome may be subjective...
  70. ncbi request reprint Diagnosing idiopathic normal-pressure hydrocephalus
    Norman Relkin
    Department of Neurology and Neuroscience, The New York Presbyterian Weill Cornell Medical College, New York, New York, USA
    Neurosurgery 57:S4-16; discussion ii-v. 2005
    ..This report contains evidence-based guidelines for clinical diagnosis of INPH that are intended to facilitate future epidemiological studies of INPH, promote earlier and more accurate diagnosis, and ultimately improve treatment outcome...
  71. ncbi request reprint What we don't (but should) know about hydrocephalus
    Marvin Bergsneider
    Department of Neurosurgery, University of California at Los Angeles, California, USA
    J Neurosurg 104:157-9. 2006
    ....
  72. ncbi request reprint Development of guidelines for idiopathic normal-pressure hydrocephalus: introduction
    Anthony Marmarou
    Department of Neurosurgery, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0508, USA
    Neurosurgery 57:S1-3; discussion ii-v. 2005
    ..The guidelines were to encompass value of clinical presentation, value of supplementary diagnostic tests, surgical management, and outcome assessment...

Research Grants8

  1. A HEMODYNAMIC MODEL OF INTRACRANIAL PRESSURE DYNAMICS
    Marvin Bergsneider; Fiscal Year: 2002
    ..An improved understanding of these disorders will offer new and better treatment modalities for millions of affected patients. ..
  2. In Vivo CSF Shunt Hydrodynamics in Hydrocephalus
    Marvin Bergsneider; Fiscal Year: 2007
    ..Documenting definitive evidence of the tuned-dynamic absorber model could have fundamental implications to all ICP disorders. ..
  3. In Vivo Imaging of Post-Traumatic Cerebral Amyloid Deposition
    Marvin Bergsneider; Fiscal Year: 2007
    ..The results may have important public health implications in that improved understanding of the pathological consequences of cerebral amyloid deposition may lead to medical treatments that will improve outcome following TBI. ..
  4. In Vivo CSF Shunt Hydrodynamics in Hydrocephalus
    Marvin Bergsneider; Fiscal Year: 2010
    ..Documenting definitive evidence of the tuned-dynamic absorber model could have fundamental implications to all ICP disorders. ..