Bryan C Bergman

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Fasting decreases free fatty acid turnover in mice overexpressing skeletal muscle lipoprotein lipase
    Bryan C Bergman
    University of Colorado Health Sciences Center at Fitzsimons, Aurora, CO 80045, USA
    Metabolism 55:1481-7. 2006
  2. ncbi request reprint Effects of fasting on insulin action and glucose kinetics in lean and obese men and women
    Bryan C Bergman
    Division of Endocrinology, Diabetes, and Metabolism, Univ of Colorado Health Sciences Center at Fitzsimons, PO Box 6511, MS 8106, Aurora, CO 80045, USA
    Am J Physiol Endocrinol Metab 293:E1103-11. 2007
  3. pmc Skeletal muscle munc18c and syntaxin 4 in human obesity
    Bryan C Bergman
    Division of Endocrinology, Diabetes, and Metabolism, University of Colorado Denver, Aurora, CO, USA
    Nutr Metab (Lond) 5:21. 2008
  4. pmc Increased intramuscular lipid synthesis and low saturation relate to insulin sensitivity in endurance-trained athletes
    Bryan C Bergman
    Division of Endocrinology, Diabetes, and Metabolism, University of Colorado Denver School of Medicine, PO Box 6511, MS 8106, Aurora, CO 80045, USA
    J Appl Physiol (1985) 108:1134-41. 2010
  5. pmc Features of hepatic and skeletal muscle insulin resistance unique to type 1 diabetes
    Bryan C Bergman
    Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Colorado Anschutz Medical Campus, P O Box 6511, MS 8106, Aurora, Colorado 80045, USA
    J Clin Endocrinol Metab 97:1663-72. 2012
  6. pmc The importance of palmitoleic acid to adipocyte insulin resistance and whole-body insulin sensitivity in type 1 diabetes
    Bryan C Bergman
    Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Colorado Anschutz Medical Campus, P O Box 6511, MS 8106, Aurora, Colorado 80045
    J Clin Endocrinol Metab 98:E40-50. 2013
  7. pmc Insulin resistance, defective insulin-mediated fatty acid suppression, and coronary artery calcification in subjects with and without type 1 diabetes: The CACTI study
    Irene E Schauer
    Department of Medicine, University of Colorado Denver, Aurora, USA
    Diabetes 60:306-14. 2011
  8. pmc Inflexibility in intramuscular triglyceride fractional synthesis distinguishes prediabetes from obesity in humans
    Leigh Perreault
    Department of Medicine, Division of Endocrinology, Metabolism and Diabetes, University of Colorado Denver School of Medicine, Aurora, Colorado, USA
    Obesity (Silver Spring) 18:1524-31. 2010
  9. pmc Altered intramuscular lipid metabolism relates to diminished insulin action in men, but not women, in progression to diabetes
    Leigh Perreault
    Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado Denver School of Medicine, Aurora, Colorado, USA
    Obesity (Silver Spring) 18:2093-100. 2010
  10. pmc Fenofibrate administration does not affect muscle triglyceride concentration or insulin sensitivity in humans
    Leigh Perreault
    Division of Endocrinology, Metabolism and Diabetes, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
    Metabolism 60:1107-14. 2011

Research Grants

Detail Information

Publications23

  1. ncbi request reprint Fasting decreases free fatty acid turnover in mice overexpressing skeletal muscle lipoprotein lipase
    Bryan C Bergman
    University of Colorado Health Sciences Center at Fitzsimons, Aurora, CO 80045, USA
    Metabolism 55:1481-7. 2006
    ..These data suggest increased skeletal muscle LPL expression decreases dependence on plasma FFA during prolonged fasting in mice...
  2. ncbi request reprint Effects of fasting on insulin action and glucose kinetics in lean and obese men and women
    Bryan C Bergman
    Division of Endocrinology, Diabetes, and Metabolism, Univ of Colorado Health Sciences Center at Fitzsimons, PO Box 6511, MS 8106, Aurora, CO 80045, USA
    Am J Physiol Endocrinol Metab 293:E1103-11. 2007
    ..obese subjects...
  3. pmc Skeletal muscle munc18c and syntaxin 4 in human obesity
    Bryan C Bergman
    Division of Endocrinology, Diabetes, and Metabolism, University of Colorado Denver, Aurora, CO, USA
    Nutr Metab (Lond) 5:21. 2008
    ..Animal and cell culture data suggest a critical role for Munc18c and Syntaxin 4 proteins in insulin mediated glucose transport in skeletal muscle, but no studies have been published in humans...
  4. pmc Increased intramuscular lipid synthesis and low saturation relate to insulin sensitivity in endurance-trained athletes
    Bryan C Bergman
    Division of Endocrinology, Diabetes, and Metabolism, University of Colorado Denver School of Medicine, PO Box 6511, MS 8106, Aurora, CO 80045, USA
    J Appl Physiol (1985) 108:1134-41. 2010
    ..Increased synthesis rates are not due to recovery from exercise and are likely adaptations to chronic endurance exercise training...
  5. pmc Features of hepatic and skeletal muscle insulin resistance unique to type 1 diabetes
    Bryan C Bergman
    Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Colorado Anschutz Medical Campus, P O Box 6511, MS 8106, Aurora, Colorado 80045, USA
    J Clin Endocrinol Metab 97:1663-72. 2012
    ..It is unclear whether insulin resistance is due to glucose toxicity in the post-Diabetes Control and Complications Trial era of tighter glucose control...
  6. pmc The importance of palmitoleic acid to adipocyte insulin resistance and whole-body insulin sensitivity in type 1 diabetes
    Bryan C Bergman
    Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Colorado Anschutz Medical Campus, P O Box 6511, MS 8106, Aurora, Colorado 80045
    J Clin Endocrinol Metab 98:E40-50. 2013
    ..Our previous report implicated skeletal muscle and liver insulin resistance in people with type 1 diabetes, but this occurred independently of generalized, visceral, or ectopic fat...
  7. pmc Insulin resistance, defective insulin-mediated fatty acid suppression, and coronary artery calcification in subjects with and without type 1 diabetes: The CACTI study
    Irene E Schauer
    Department of Medicine, University of Colorado Denver, Aurora, USA
    Diabetes 60:306-14. 2011
    ..To assess insulin action on peripheral glucose utilization and nonesterified fatty acid (NEFA) suppression as a predictor of coronary artery calcification (CAC) in patients with type 1 diabetes and nondiabetic controls...
  8. pmc Inflexibility in intramuscular triglyceride fractional synthesis distinguishes prediabetes from obesity in humans
    Leigh Perreault
    Department of Medicine, Division of Endocrinology, Metabolism and Diabetes, University of Colorado Denver School of Medicine, Aurora, Colorado, USA
    Obesity (Silver Spring) 18:1524-31. 2010
    ..Altogether, higher basal IMTG concentration that is metabolically inflexible distinguishes obese people with PD from those with NGT...
  9. pmc Altered intramuscular lipid metabolism relates to diminished insulin action in men, but not women, in progression to diabetes
    Leigh Perreault
    Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado Denver School of Medicine, Aurora, Colorado, USA
    Obesity (Silver Spring) 18:2093-100. 2010
    ..4 µg/mg dry weight, P = 0.03) and FSR being lower (0.23 ± 0.04 vs. 0.42 ± 0.06 %/h, P = 0.02) in women. Alterations in IMTG metabolism relate to diminished insulin action in men, but not women, in the progression toward diabetes...
  10. pmc Fenofibrate administration does not affect muscle triglyceride concentration or insulin sensitivity in humans
    Leigh Perreault
    Division of Endocrinology, Metabolism and Diabetes, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
    Metabolism 60:1107-14. 2011
    ..Intramuscular triglyceride saturation, rather than IMTG concentration or FSR, most closely (but not significantly) related to Si and was unchanged by fenofibrate administration...
  11. doi request reprint Incretin action maintains insulin secretion, but not hepatic insulin action, in people with impaired fasting glucose
    Leigh Perreault
    University of Colorado at Denver School of Medicine, Aurora, CO 80045, USA
    Diabetes Res Clin Pract 90:87-94. 2010
    ..To determine whether altered GLP-1 activity contributes to the abnormal endogenous glucose production (EGP) and insulin secretion characteristic of people with impaired fasting glucose (IFG)...
  12. pmc Adiponectin dysregulation and insulin resistance in type 1 diabetes
    Rocio I Pereira
    University of Colorado, Anschutz Medical Campus, Division of Endocrinology, MS 8106, Aurora, Colorado 80045 0511, USA
    J Clin Endocrinol Metab 97:E642-7. 2012
    ..Whether the expected positive correlation between adiponectin and insulin sensitivity is preserved in a T1D population is unknown...
  13. ncbi request reprint The effects of short-term overfeeding on insulin action in lean and reduced-obese individuals
    Marc Andre Cornier
    Department of Medicine, Division of Endocrinology, University of Colorado at Denver and Health Sciences Center, Denver, 80045, USA
    Metabolism 55:1207-14. 2006
    ..This response may be indirectly involved in the ability of lean women to maintain weight in the face of an obesigenic environment...
  14. pmc Novel and reversible mechanisms of smoking-induced insulin resistance in humans
    Bryan C Bergman
    Department of Endocrinology, Diabetes, and Metabolism, University of Colorado Denver, Denver, Colorado, USA
    Diabetes 61:3156-66. 2012
    ..Therapeutic agents designed to oppose skeletal muscle mTOR activation may prevent insulin resistance in humans who are unable to stop smoking or are chronically exposed to secondhand smoke...
  15. pmc Impaired fasting glucose with or without impaired glucose tolerance: progressive or parallel states of prediabetes?
    Leigh Perreault
    Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Am J Physiol Endocrinol Metab 295:E428-35. 2008
    ..Together, these data indicate that IFG/IGT may be a distinct prediabetic syndrome rather than progression from IFG...
  16. doi request reprint Progestin modulates the lipid profile and sensitivity of breast cancer cells to docetaxel
    Isabel R Schlaepfer
    Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
    Mol Cell Endocrinol 363:111-21. 2012
    ..Our studies suggest the metabolic adaptations produced by progestin provide novel metabolic targets for future combinatorial therapies for progestin-responsive breast cancers...
  17. pmc Lipoprotein subfraction cholesterol distribution is proatherogenic in women with type 1 diabetes and insulin resistance
    David M Maahs
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes 59:1771-9. 2010
    ..We investigated differences in lipoprotein subfraction cholesterol distribution and insulin resistance between subjects with and without type 1 diabetes to better understand the etiology of increased CVD risk...
  18. pmc Myocardial FFA metabolism during rest and atrial pacing in humans
    Bryan C Bergman
    Div of Endocrinology, Diabetes, and Metabolism, Univ of Colorado Denver School of Medicine, P O Box 6511, MS 8106, Aurora, CO 80045, USA
    Am J Physiol Endocrinol Metab 296:E358-66. 2009
    ..13). These data suggest that myocardial lipid uptake and oxidation increase with greater heart work during atrial pacing, with a similar relative proportion of fat oxidation to total myocardial energy expenditure...
  19. pmc Intramuscular lipid metabolism in the insulin resistance of smoking
    Bryan C Bergman
    Division of Endocrinology, Diabetes, and Metabolism, University of Colorado Denver School of Medicine, Aurora, Colorado, USA
    Diabetes 58:2220-7. 2009
    ..We hypothesized smokers would have increased intramuscular triglyceride (IMTG) and diacylglycerol (DAG) concentration and decreased fractional synthesis rate (FSR) compared with nonsmokers...
  20. pmc Hepatic glucose sensing is impaired, but can be normalized, in people with impaired fasting glucose
    Leigh Perreault
    Division of Endocrinology, Metabolism, and Diabetes L P, A A K, S D B, B C B, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045 and Steno Diabetes Center K F, DK 2820 Gentofte, Denmark
    J Clin Endocrinol Metab 99:E1154-62. 2014
    ..24). Conclusions: In summary, glucose sensing is impaired in IFG but can be experimentally restored with low-dose fructose. Glucokinase activation may prove to be a novel strategy for the prevention of diabetes in this high-risk group. ..
  21. pmc Bisphenol A impairs hepatic glucose sensing in C57BL/6 male mice
    Leigh Perreault
    Division of Endocrinology, Metabolism and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America
    PLoS ONE 8:e69991. 2013
    ..Estrogen can stimulate glucokinase activity, whereas the pervasive environmental pollutant bisphenol A (BPA) can inhibit estrogen action, hence we aimed to determine the effect of BPA on glucokinase activity directly...
  22. ncbi request reprint Gender differences in insulin action after a single bout of exercise
    Leigh Perreault
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Appl Physiol (1985) 97:1013-21. 2004
    ..Together, these data imply gender differences in insulin action postexercise exist in peripheral tissues and not in liver...
  23. ncbi request reprint Pyruvate shuttling during rest and exercise before and after endurance training in men
    Gregory C Henderson
    Department of Integrative Biology, University of California, Berkeley, CA 94720 3140, USA
    J Appl Physiol 97:317-25. 2004
    ..working muscle also releases alanine, but alanine release is an order of magnitude smaller than lactate or pyruvate release. These results portray the complexity of metabolic integration among diverse tissue beds in vivo...

Research Grants2

  1. Intramuscular Triglyceride Turnover/Insulin Sensitivity
    Bryan Bergman; Fiscal Year: 2007
    ..The significance of these studies will be to further the understanding of mechanisms promoting insulin resistance to advance the treatment and prevention of Type II diabetes. ..