Research Topics
Genomes and GenesSpecies | Bryan C BergmanSummaryAffiliation: University of Colorado Health Sciences Center Country: USA Publications
Research Grants
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Detail Information
Publications
Fasting decreases free fatty acid turnover in mice overexpressing skeletal muscle lipoprotein lipaseBryan C Bergman
University of Colorado Health Sciences Center at Fitzsimons, Aurora, CO 80045, USA
Metabolism 55:1481-7. 2006..These data suggest increased skeletal muscle LPL expression decreases dependence on plasma FFA during prolonged fasting in mice...- Effects of fasting on insulin action and glucose kinetics in lean and obese men and womenBryan C Bergman
Division of Endocrinology, Diabetes, and Metabolism, Univ of Colorado Health Sciences Center at Fitzsimons, PO Box 6511, MS 8106, Aurora, CO 80045, USA
Am J Physiol Endocrinol Metab 293:E1103-11. 2007..obese subjects... 
Skeletal muscle munc18c and syntaxin 4 in human obesityBryan C Bergman
Division of Endocrinology, Diabetes, and Metabolism, University of Colorado Denver, Aurora, CO, USA
Nutr Metab (Lond) 5:21. 2008..Animal and cell culture data suggest a critical role for Munc18c and Syntaxin 4 proteins in insulin mediated glucose transport in skeletal muscle, but no studies have been published in humans...- Increased intramuscular lipid synthesis and low saturation relate to insulin sensitivity in endurance-trained athletesBryan C Bergman
Division of Endocrinology, Diabetes, and Metabolism, University of Colorado Denver School of Medicine, PO Box 6511, MS 8106, Aurora, CO 80045, USA
J Appl Physiol 108:1134-41. 2010..Increased synthesis rates are not due to recovery from exercise and are likely adaptations to chronic endurance exercise training... - Features of hepatic and skeletal muscle insulin resistance unique to type 1 diabetesBryan C Bergman
Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Colorado Anschutz Medical Campus, P O Box 6511, MS 8106, Aurora, Colorado 80045, USA
J Clin Endocrinol Metab 97:1663-72. 2012..It is unclear whether insulin resistance is due to glucose toxicity in the post-Diabetes Control and Complications Trial era of tighter glucose control... - The importance of palmitoleic acid to adipocyte insulin resistance and whole-body insulin sensitivity in type 1 diabetesBryan C Bergman
Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Colorado Anschutz Medical Campus, P O Box 6511, MS 8106, Aurora, Colorado 80045
J Clin Endocrinol Metab 98:E40-50. 2013..Our previous report implicated skeletal muscle and liver insulin resistance in people with type 1 diabetes, but this occurred independently of generalized, visceral, or ectopic fat... - Insulin resistance, defective insulin-mediated fatty acid suppression, and coronary artery calcification in subjects with and without type 1 diabetes: The CACTI studyIrene E Schauer
Department of Medicine, University of Colorado Denver, Aurora, USA
Diabetes 60:306-14. 2011..To assess insulin action on peripheral glucose utilization and nonesterified fatty acid (NEFA) suppression as a predictor of coronary artery calcification (CAC) in patients with type 1 diabetes and nondiabetic controls... - Inflexibility in intramuscular triglyceride fractional synthesis distinguishes prediabetes from obesity in humansLeigh Perreault
Department of Medicine, Division of Endocrinology, Metabolism and Diabetes, University of Colorado Denver School of Medicine, Aurora, Colorado, USA
Obesity (Silver Spring) 18:1524-31. 2010..Altogether, higher basal IMTG concentration that is metabolically inflexible distinguishes obese people with PD from those with NGT... - Altered intramuscular lipid metabolism relates to diminished insulin action in men, but not women, in progression to diabetesLeigh Perreault
Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado Denver School of Medicine, Aurora, Colorado, USA
Obesity (Silver Spring) 18:2093-100. 2010..4 µg/mg dry weight, P = 0.03) and FSR being lower (0.23 ± 0.04 vs. 0.42 ± 0.06 %/h, P = 0.02) in women. Alterations in IMTG metabolism relate to diminished insulin action in men, but not women, in the progression toward diabetes... - Fenofibrate administration does not affect muscle triglyceride concentration or insulin sensitivity in humansLeigh Perreault
Division of Endocrinology, Metabolism and Diabetes, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
Metabolism 60:1107-14. 2011..Intramuscular triglyceride saturation, rather than IMTG concentration or FSR, most closely (but not significantly) related to Si and was unchanged by fenofibrate administration... 
Incretin action maintains insulin secretion, but not hepatic insulin action, in people with impaired fasting glucoseLeigh Perreault
University of Colorado at Denver School of Medicine, Aurora, CO 80045, USA
Diabetes Res Clin Pract 90:87-94. 2010..To determine whether altered GLP-1 activity contributes to the abnormal endogenous glucose production (EGP) and insulin secretion characteristic of people with impaired fasting glucose (IFG)...- Adiponectin dysregulation and insulin resistance in type 1 diabetesRocio I Pereira
University of Colorado, Anschutz Medical Campus, Division of Endocrinology, MS 8106, Aurora, Colorado 80045 0511, USA
J Clin Endocrinol Metab 97:E642-7. 2012..Whether the expected positive correlation between adiponectin and insulin sensitivity is preserved in a T1D population is unknown... - The effects of short-term overfeeding on insulin action in lean and reduced-obese individualsMarc Andre Cornier
Department of Medicine, Division of Endocrinology, University of Colorado at Denver and Health Sciences Center, Denver, 80045, USA
Metabolism 55:1207-14. 2006..This response may be indirectly involved in the ability of lean women to maintain weight in the face of an obesigenic environment... - Novel and reversible mechanisms of smoking-induced insulin resistance in humansBryan C Bergman
Department of Endocrinology, Diabetes, and Metabolism, University of Colorado Denver, Denver, Colorado, USA
Diabetes 61:3156-66. 2012..Therapeutic agents designed to oppose skeletal muscle mTOR activation may prevent insulin resistance in humans who are unable to stop smoking or are chronically exposed to secondhand smoke... - Impaired fasting glucose with or without impaired glucose tolerance: progressive or parallel states of prediabetes?Leigh Perreault
Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
Am J Physiol Endocrinol Metab 295:E428-35. 2008..Together, these data indicate that IFG/IGT may be a distinct prediabetic syndrome rather than progression from IFG... - Progestin modulates the lipid profile and sensitivity of breast cancer cells to docetaxelIsabel R Schlaepfer
Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
Mol Cell Endocrinol 363:111-21. 2012..Our studies suggest the metabolic adaptations produced by progestin provide novel metabolic targets for future combinatorial therapies for progestin-responsive breast cancers... - Lipoprotein subfraction cholesterol distribution is proatherogenic in women with type 1 diabetes and insulin resistanceDavid M Maahs
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
Diabetes 59:1771-9. 2010..We investigated differences in lipoprotein subfraction cholesterol distribution and insulin resistance between subjects with and without type 1 diabetes to better understand the etiology of increased CVD risk... - Intramuscular lipid metabolism in the insulin resistance of smokingBryan C Bergman
Division of Endocrinology, Diabetes, and Metabolism, University of Colorado Denver School of Medicine, Aurora, Colorado, USA
Diabetes 58:2220-7. 2009..We hypothesized smokers would have increased intramuscular triglyceride (IMTG) and diacylglycerol (DAG) concentration and decreased fractional synthesis rate (FSR) compared with nonsmokers... - Myocardial FFA metabolism during rest and atrial pacing in humansBryan C Bergman
Div of Endocrinology, Diabetes, and Metabolism, Univ of Colorado Denver School of Medicine, P O Box 6511, MS 8106, Aurora, CO 80045, USA
Am J Physiol Endocrinol Metab 296:E358-66. 2009..13). These data suggest that myocardial lipid uptake and oxidation increase with greater heart work during atrial pacing, with a similar relative proportion of fat oxidation to total myocardial energy expenditure... - Gender differences in insulin action after a single bout of exerciseLeigh Perreault
Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Appl Physiol 97:1013-21. 2004..Together, these data imply gender differences in insulin action postexercise exist in peripheral tissues and not in liver... - Pyruvate shuttling during rest and exercise before and after endurance training in menGregory C Henderson
Department of Integrative Biology, University of California, Berkeley, CA 94720-3140, USA
J Appl Physiol 97:317-25. 2004..working muscle also releases alanine, but alanine release is an order of magnitude smaller than lactate or pyruvate release. These results portray the complexity of metabolic integration among diverse tissue beds in vivo...
Research Grants
- Intramuscular Triglyceride Turnover/Insulin SensitivityBryan Bergman; Fiscal Year: 2007..The significance of these studies will be to further the understanding of mechanisms promoting insulin resistance to advance the treatment and prevention of Type II diabetes. ..