Gabriele Bergers

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Modes of resistance to anti-angiogenic therapy
    Gabriele Bergers
    University of California, San Francisco, Department of Neurological Surgery, Brain Tumour Research Center, San Francisco, California 94143, USA
    Nat Rev Cancer 8:592-603. 2008
  2. pmc Matrix metalloproteinase-2 regulates vascular patterning and growth affecting tumor cell survival and invasion in GBM
    Rose Du
    Department of Neurological Surgery, University of California San Francisco, 513 Parnassus Ave, Box 0520, San Francisco, CA 94143 0520, USA
    Neuro Oncol 10:254-64. 2008
  3. pmc Asymmetry-defective oligodendrocyte progenitors are glioma precursors
    Sista Sugiarto
    Department of Neurological Surgery, University of California San Francisco, USA
    Cancer Cell 20:328-40. 2011
  4. pmc HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion
    Rose Du
    Department of Neurological Surgery, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Cancer Cell 13:206-20. 2008
  5. pmc PDGFRbeta+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival
    Steven Song
    Department of Neurological Surgery, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Nat Cell Biol 7:870-9. 2005
  6. ncbi request reprint The PTEN/Akt pathway dictates the direct alphaVbeta3-dependent growth-inhibitory action of an active fragment of tumstatin in glioma cells in vitro and in vivo
    Tomohiro Kawaguchi
    Brain Tumor Research Center, Department of Neurological Surgery, The University of California San Francisco Comprehensive Cancer Center, CA 94115 0875, USA
    Cancer Res 66:11331-40. 2006
  7. doi request reprint Chapter 3. Bone marrow-derived vascular progenitors and proangiogenic monocytes in tumors
    Kan Lu
    Department of Neurological Surgery, Brain Tumor Research Center, University of California San Francisco, San Francisco, California, USA
    Methods Enzymol 445:53-82. 2008
  8. ncbi request reprint Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
    Oriol Casanovas
    Department of Biochemistry and Biophysics, Comprehensive Cancer Center, and Diabetes Center, University of California, San Francisco, San Francisco, California 94143, USA
    Cancer Cell 8:299-309. 2005
  9. ncbi request reprint The bone marrow constitutes a reservoir of pericyte progenitors
    Chrystelle Lamagna
    Department of Neurological Surgery, University of California San Francisco, CA 94143 0520, USA
    J Leukoc Biol 80:677-81. 2006
  10. pmc Non-stem cell origin for oligodendroglioma
    Anders I Persson
    Department of Neurology, University of California, San Francisco, 94158, USA
    Cancer Cell 18:669-82. 2010

Research Grants

Collaborators

Detail Information

Publications23

  1. pmc Modes of resistance to anti-angiogenic therapy
    Gabriele Bergers
    University of California, San Francisco, Department of Neurological Surgery, Brain Tumour Research Center, San Francisco, California 94143, USA
    Nat Rev Cancer 8:592-603. 2008
    ....
  2. pmc Matrix metalloproteinase-2 regulates vascular patterning and growth affecting tumor cell survival and invasion in GBM
    Rose Du
    Department of Neurological Surgery, University of California San Francisco, 513 Parnassus Ave, Box 0520, San Francisco, CA 94143 0520, USA
    Neuro Oncol 10:254-64. 2008
    ..As a result of impaired and dysfunctional angiogenesis, MMP-2ko GBM became more invasive, predominantly by migrating along blood vessels into the brain parenchyma...
  3. pmc Asymmetry-defective oligodendrocyte progenitors are glioma precursors
    Sista Sugiarto
    Department of Neurological Surgery, University of California San Francisco, USA
    Cancer Cell 20:328-40. 2011
    ..Regulators of asymmetric cell division are misexpressed in low-grade oligodendrogliomas. Our results identify loss of asymmetric division associated with the neoplastic transformation of OPC...
  4. pmc HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion
    Rose Du
    Department of Neurological Surgery, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Cancer Cell 13:206-20. 2008
    ..VEGF also directly regulates tumor cell invasiveness. When VEGF activity is impaired, tumor cells invade deep into the brain in the perivascular compartment...
  5. pmc PDGFRbeta+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival
    Steven Song
    Department of Neurological Surgery, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Nat Cell Biol 7:870-9. 2005
    ....
  6. ncbi request reprint The PTEN/Akt pathway dictates the direct alphaVbeta3-dependent growth-inhibitory action of an active fragment of tumstatin in glioma cells in vitro and in vivo
    Tomohiro Kawaguchi
    Brain Tumor Research Center, Department of Neurological Surgery, The University of California San Francisco Comprehensive Cancer Center, CA 94115 0875, USA
    Cancer Res 66:11331-40. 2006
    ..These results show that tumstatin, previously considered to be only an endogenous inhibitor of angiogenesis, also directly inhibits the growth of tumors in a manner dependent on Akt/mTOR activation...
  7. doi request reprint Chapter 3. Bone marrow-derived vascular progenitors and proangiogenic monocytes in tumors
    Kan Lu
    Department of Neurological Surgery, Brain Tumor Research Center, University of California San Francisco, San Francisco, California, USA
    Methods Enzymol 445:53-82. 2008
    ..Here, we describe specific methods that allow for the identification and functional characterization of these distinct BMDC populations in tumors as exemplified in mouse models of pancreatic neuroendocrine tumors and glioblastomas...
  8. ncbi request reprint Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
    Oriol Casanovas
    Department of Biochemistry and Biophysics, Comprehensive Cancer Center, and Diabetes Center, University of California, San Francisco, San Francisco, California 94143, USA
    Cancer Cell 8:299-309. 2005
    ..These other proangiogenic signals are functionally implicated in the revascularization and regrowth of tumors in the evasion phase, as FGF blockade impairs progression in the face of VEGF inhibition...
  9. ncbi request reprint The bone marrow constitutes a reservoir of pericyte progenitors
    Chrystelle Lamagna
    Department of Neurological Surgery, University of California San Francisco, CA 94143 0520, USA
    J Leukoc Biol 80:677-81. 2006
    ..This review focuses on pericytes in vessel formation and on recent discoveries about their bone marrow origin in the adult...
  10. pmc Non-stem cell origin for oligodendroglioma
    Anders I Persson
    Department of Neurology, University of California, San Francisco, 94158, USA
    Cancer Cell 18:669-82. 2010
    ..Our results suggest that oligodendroglioma cells show hallmarks of OPCs, and that a progenitor rather than a NSC origin underlies improved prognosis in patients with this tumor...
  11. pmc miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells
    Joachim Silber
    Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA
    BMC Med 6:14. 2008
    ..In this study, we investigated the role of microRNAs in regulating the differentiation and proliferation of neural stem cells and glioblastoma-multiforme tumor cells...
  12. pmc The role of pericytes in blood-vessel formation and maintenance
    Gabriele Bergers
    Department of Neurological Surgery, Brain Tumor Research Center and UCSF Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143, USA
    Neuro Oncol 7:452-64. 2005
    ..This review article describes the current knowledge about the nature of pericytes and their functions during vessel growth, vessel maintenance, and pathological angiogenesis...
  13. ncbi request reprint Stage-specific vascular markers revealed by phage display in a mouse model of pancreatic islet tumorigenesis
    Johanna A Joyce
    Department of Biochemistry and Biophysics, Diabetes and Comprehensive Cancer Centers, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Cancer Cell 4:393-403. 2003
    ..One peptide is homologous with pro-PDGF-B, which is expressed in endothelial cells, while its receptor is expressed in pericytes...
  14. doi request reprint VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex
    Kan V Lu
    Department of Neurological Surgery, University of California, Helen Diller Family Cancer Research Center, San Francisco, CA 94143, USA
    Cancer Cell 22:21-35. 2012
    ..Inhibition of MET in GBM mouse models blocks mesenchymal transition and invasion provoked by VEGF ablation, resulting in substantial survival benefit...
  15. pmc Malignant progression and blockade of angiogenesis in a murine transgenic model of neuroblastoma
    Louis Chesler
    Department of Pediatrics, Neurology, University of California San Francisco Medical School, San Francisco, California 94143, USA
    Cancer Res 67:9435-42. 2007
    ....
  16. pmc Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
    Gabriele Bergers
    Department of Neurological Surgery, University of California, San Francisco Comprehensive Cancer Center, San Francisco, San Francisco, California 94115, USA
    J Clin Invest 111:1287-95. 2003
    ..Thus, combinatorial targeting of receptor tyrosine kinases shows promise for treating multiple stages in tumorigenesis, most notably the often-intractable late-stage solid tumor...
  17. ncbi request reprint Tumorigenesis and the angiogenic switch
    Gabriele Bergers
    University of California San Francisco, Department of Neurological Surgery, Brain Tumor Research Center and Comprehensive Cancer Center, HSE 722, 513 Parnassus Avenue, San Francisco, California 94143 0520, USA
    Nat Rev Cancer 3:401-10. 2003
    ....
  18. ncbi request reprint Integrin beta3 overexpression suppresses tumor growth in a human model of gliomagenesis: implications for the role of beta3 overexpression in glioblastoma multiforme
    Masayuki Kanamori
    Department of Neurological Surgery and The Brain Tumor Research Center, University of California San Francisco, San Francisco, California, USA
    Cancer Res 64:2751-8. 2004
    ..These results show that tumor-specific alphaVbeta3 overexpression has growth-suppressive effects in gliomas, but that these deleterious effects are mitigated by alterations common to alphaVbeta3-overexpressing GBM...
  19. ncbi request reprint Regulator of G-protein signaling-5 induction in pericytes coincides with active vessel remodeling during neovascularization
    Mario Berger
    Department of Molecular Immunology, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Blood 105:1094-101. 2005
    ..This further supports the notion that pericytes, like endothelial cells, undergo molecular changes during neovascularization that makes them a novel target for antiangiogenic therapy...
  20. ncbi request reprint The hypoxic response of tumors is dependent on their microenvironment
    Barbara Blouw
    Molecular Biology Section, Division of Biological Sciences, University of California at San Diego, Pacific Hall Room 1212, MC 0366, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Cancer Cell 4:133-46. 2003
    ..These results demonstrate that HIF-1alpha has differential roles in tumor progression, which are greatly dependent on the extant microenvironment of the tumor...
  21. ncbi request reprint Inhibitors of growth factor receptors, signaling pathways and angiogenesis as therapeutic molecular agents
    Jocelyn Holash
    Regeneron Pharmaceuticals, Tarrytown, NY, USA
    Cancer Metastasis Rev 25:243-52. 2006
  22. pmc Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting
    Kristian Pietras
    Department of Biochemistry and Biophysics, Diabetes Center and Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, United States ofAmerica
    PLoS Med 5:e19. 2008
    ..We postulated that pharmacological targeting of putative stromal support functions, in particular those of cancer-associated fibroblasts, could have therapeutic utility, and sought to assess the possibility in a pre-clinical setting...
  23. ncbi request reprint Antitumor effects in mice of low-dose (metronomic) cyclophosphamide administered continuously through the drinking water
    Shan Man
    Departments of Medical Biophysics, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5 Canada
    Cancer Res 62:2731-5. 2002
    ..o. metronomic chemotherapy regimen, which proved safe, reasonably efficacious, and potentially applicable to chronic treatment. Such a regimen may be particularly well suited for integration with antiangiogenic drugs...

Research Grants18

  1. Perivascular Invasion of GBMs
    Gabriele Bergers; Fiscal Year: 2010
    ..1: Identify the exact cell sources of MMP-9 production in GBM. AIM2.2: Reveal function of host cell-produced MMP-9 in angiogenesis and invasion. AIM2.3: Elicit function of tumor cell-produced MMP-9 in angiogenesis and invasion. ..
  2. Mechanism and therapeutic targeting of evasive resistance to antiangiogenic drugs
    Douglas Hanahan; Fiscal Year: 2009
    ..Targeting such resistance mechanisms holds promise to produce more enduring anti-angiogenic therapies for human cancers. ..
  3. Perivascular Invasion of GBMs
    Gabriele Bergers; Fiscal Year: 2007
    ..AIM2.1: Identify the exact cell sources of MMP-9 production in GBM. AIM2.2: Reveal function of host cell-produced MMP-9 in angiogenesis and invasion. AIM2.3: Elicit function of tumor cell-produced MMP-9 in angiogenesis and invasion. ..
  4. PDGFRbeta+-Perivascular Cells In Tumor Angiogenesis
    Gabriele Bergers; Fiscal Year: 2007
    ....
  5. Stage- & cell-specific targeting of RTK in tumorigenesis
    Douglas Hanahan; Fiscal Year: 2007
    ....
  6. Mechanism and therapeutic targeting of evasive resistance to antiangiogenic drugs
    Douglas Hanahan; Fiscal Year: 2010
    ..Targeting such resistance mechanisms holds promise to produce more enduring anti-angiogenic therapies for human cancers. ..