Research Topics
Genomes and Genes | Gabriele BergersSummaryAffiliation: University of California Country: USA Publications
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Publications
Modes of resistance to anti-angiogenic therapyGabriele Bergers
University of California, San Francisco, Department of Neurological Surgery, Brain Tumour Research Center, San Francisco, California 94143, USA
Nat Rev Cancer 8:592-603. 2008....- Matrix metalloproteinase-2 regulates vascular patterning and growth affecting tumor cell survival and invasion in GBMRose Du
Department of Neurological Surgery, University of California San Francisco, 513 Parnassus Ave, Box 0520, San Francisco, CA 94143 0520, USA
Neuro Oncol 10:254-64. 2008..As a result of impaired and dysfunctional angiogenesis, MMP-2ko GBM became more invasive, predominantly by migrating along blood vessels into the brain parenchyma... - Asymmetry-defective oligodendrocyte progenitors are glioma precursorsSista Sugiarto
Department of Neurological Surgery, University of California San Francisco, USA
Cancer Cell 20:328-40. 2011..Regulators of asymmetric cell division are misexpressed in low-grade oligodendrogliomas. Our results identify loss of asymmetric division associated with the neoplastic transformation of OPC... - HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasionRose Du
Department of Neurological Surgery, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
Cancer Cell 13:206-20. 2008..VEGF also directly regulates tumor cell invasiveness. When VEGF activity is impaired, tumor cells invade deep into the brain in the perivascular compartment... - PDGFRbeta+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survivalSteven Song
Department of Neurological Surgery, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
Nat Cell Biol 7:870-9. 2005.... 
The PTEN/Akt pathway dictates the direct alphaVbeta3-dependent growth-inhibitory action of an active fragment of tumstatin in glioma cells in vitro and in vivoTomohiro Kawaguchi
Brain Tumor Research Center, Department of Neurological Surgery, The University of California-San Francisco Comprehensive Cancer Center, CA 94115-0875, USA
Cancer Res 66:11331-40. 2006..These results show that tumstatin, previously considered to be only an endogenous inhibitor of angiogenesis, also directly inhibits the growth of tumors in a manner dependent on Akt/mTOR activation...
Chapter 3. Bone marrow-derived vascular progenitors and proangiogenic monocytes in tumorsKan Lu
Department of Neurological Surgery, Brain Tumor Research Center, University of California San Francisco, San Francisco, California, USA
Methods Enzymol 445:53-82. 2008..Here, we describe specific methods that allow for the identification and functional characterization of these distinct BMDC populations in tumors as exemplified in mouse models of pancreatic neuroendocrine tumors and glioblastomas...- Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumorsOriol Casanovas
Department of Biochemistry and Biophysics, Comprehensive Cancer Center, and Diabetes Center, University of California, San Francisco, San Francisco, California 94143, USA
Cancer Cell 8:299-309. 2005..These other proangiogenic signals are functionally implicated in the revascularization and regrowth of tumors in the evasion phase, as FGF blockade impairs progression in the face of VEGF inhibition... - The bone marrow constitutes a reservoir of pericyte progenitorsChrystelle Lamagna
Department of Neurological Surgery, University of California San Francisco, CA 94143-0520, USA
J Leukoc Biol 80:677-81. 2006..This review focuses on pericytes in vessel formation and on recent discoveries about their bone marrow origin in the adult... - Non-stem cell origin for oligodendrogliomaAnders I Persson
Department of Neurology, University of California, San Francisco, 94158, USA
Cancer Cell 18:669-82. 2010..Our results suggest that oligodendroglioma cells show hallmarks of OPCs, and that a progenitor rather than a NSC origin underlies improved prognosis in patients with this tumor... - miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cellsJoachim Silber
Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA
BMC Med 6:14. 2008..In this study, we investigated the role of microRNAs in regulating the differentiation and proliferation of neural stem cells and glioblastoma-multiforme tumor cells... - The role of pericytes in blood-vessel formation and maintenanceGabriele Bergers
Department of Neurological Surgery, Brain Tumor Research Center and UCSF Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143, USA
Neuro Oncol 7:452-64. 2005..This review article describes the current knowledge about the nature of pericytes and their functions during vessel growth, vessel maintenance, and pathological angiogenesis... - Stage-specific vascular markers revealed by phage display in a mouse model of pancreatic islet tumorigenesisJohanna A Joyce
Department of Biochemistry and Biophysics, Diabetes and Comprehensive Cancer Centers, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
Cancer Cell 4:393-403. 2003..One peptide is homologous with pro-PDGF-B, which is expressed in endothelial cells, while its receptor is expressed in pericytes... - VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complexKan V Lu
Department of Neurological Surgery, University of California, Helen Diller Family Cancer Research Center, San Francisco, CA 94143, USA
Cancer Cell 22:21-35. 2012..Inhibition of MET in GBM mouse models blocks mesenchymal transition and invasion provoked by VEGF ablation, resulting in substantial survival benefit... - Malignant progression and blockade of angiogenesis in a murine transgenic model of neuroblastomaLouis Chesler
Department of Pediatrics, Neurology, University of California San Francisco Medical School, San Francisco, California 94143, USA
Cancer Res 67:9435-42. 2007.... - Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitorsGabriele Bergers
Department of Neurological Surgery, University of California, San Francisco Comprehensive Cancer Center, San Francisco, San Francisco, California 94115, USA
J Clin Invest 111:1287-95. 2003..Thus, combinatorial targeting of receptor tyrosine kinases shows promise for treating multiple stages in tumorigenesis, most notably the often-intractable late-stage solid tumor... - Tumorigenesis and the angiogenic switchGabriele Bergers
University of California San Francisco, Department of Neurological Surgery, Brain Tumor Research Center and Comprehensive Cancer Center, HSE 722, 513 Parnassus Avenue, San Francisco, California 94143 0520, USA
Nat Rev Cancer 3:401-10. 2003.... - Integrin beta3 overexpression suppresses tumor growth in a human model of gliomagenesis: implications for the role of beta3 overexpression in glioblastoma multiformeMasayuki Kanamori
Department of Neurological Surgery and The Brain Tumor Research Center, University of California-San Francisco, San Francisco, California, USA
Cancer Res 64:2751-8. 2004..These results show that tumor-specific alphaVbeta3 overexpression has growth-suppressive effects in gliomas, but that these deleterious effects are mitigated by alterations common to alphaVbeta3-overexpressing GBM... - Regulator of G-protein signaling-5 induction in pericytes coincides with active vessel remodeling during neovascularizationMario Berger
Department of Molecular Immunology, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
Blood 105:1094-101. 2005..This further supports the notion that pericytes, like endothelial cells, undergo molecular changes during neovascularization that makes them a novel target for antiangiogenic therapy... - The hypoxic response of tumors is dependent on their microenvironmentBarbara Blouw
Molecular Biology Section, Division of Biological Sciences, University of California at San Diego, Pacific Hall Room 1212, MC-0366, 9500 Gilman Drive, La Jolla, CA 92093, USA
Cancer Cell 4:133-46. 2003..These results demonstrate that HIF-1alpha has differential roles in tumor progression, which are greatly dependent on the extant microenvironment of the tumor... - Inhibitors of growth factor receptors, signaling pathways and angiogenesis as therapeutic molecular agentsJocelyn Holash
Regeneron Pharmaceuticals, Tarrytown, NY, USA
Cancer Metastasis Rev 25:243-52. 2006 - Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targetingKristian Pietras
Department of Biochemistry and Biophysics, Diabetes Center and Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, United States ofAmerica
PLoS Med 5:e19. 2008..We postulated that pharmacological targeting of putative stromal support functions, in particular those of cancer-associated fibroblasts, could have therapeutic utility, and sought to assess the possibility in a pre-clinical setting... - Antitumor effects in mice of low-dose (metronomic) cyclophosphamide administered continuously through the drinking waterShan Man
Departments of Medical Biophysics, Sunnybrook and Women's College Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5 Canada
Cancer Res 62:2731-5. 2002..o. metronomic chemotherapy regimen, which proved safe, reasonably efficacious, and potentially applicable to chronic treatment. Such a regimen may be particularly well suited for integration with antiangiogenic drugs...
Research Grants
- Perivascular Invasion of GBMsGabriele Bergers; Fiscal Year: 2010..1: Identify the exact cell sources of MMP-9 production in GBM. AIM2.2: Reveal function of host cell-produced MMP-9 in angiogenesis and invasion. AIM2.3: Elicit function of tumor cell-produced MMP-9 in angiogenesis and invasion. ..
- Mechanism and therapeutic targeting of evasive resistance to antiangiogenic drugsDouglas Hanahan; Fiscal Year: 2009..Targeting such resistance mechanisms holds promise to produce more enduring anti-angiogenic therapies for human cancers. ..
- Perivascular Invasion of GBMsGabriele Bergers; Fiscal Year: 2007..AIM2.1: Identify the exact cell sources of MMP-9 production in GBM. AIM2.2: Reveal function of host cell-produced MMP-9 in angiogenesis and invasion. AIM2.3: Elicit function of tumor cell-produced MMP-9 in angiogenesis and invasion. ..
- PDGFRbeta+-Perivascular Cells In Tumor AngiogenesisGabriele Bergers; Fiscal Year: 2007....
- Stage- & cell-specific targeting of RTK in tumorigenesisDouglas Hanahan; Fiscal Year: 2007....
- Mechanism and therapeutic targeting of evasive resistance to antiangiogenic drugsDouglas Hanahan; Fiscal Year: 2010..Targeting such resistance mechanisms holds promise to produce more enduring anti-angiogenic therapies for human cancers. ..