Research Topics
Species | G BergersSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cellsJoachim Silber
Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA
BMC Med 6:14. 2008..In this study, we investigated the role of microRNAs in regulating the differentiation and proliferation of neural stem cells and glioblastoma-multiforme tumor cells...
Extrinsic regulators of epithelial tumor progression: metalloproteinasesG Bergers
Hormone Research Institute, University of California, 1090 HSW Box 0534, San Francisco, California 94143, USA
Curr Opin Genet Dev 10:120-7. 2000....- Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitorsGabriele Bergers
Department of Neurological Surgery, University of California, San Francisco Comprehensive Cancer Center, San Francisco, San Francisco, California 94115, USA
J Clin Invest 111:1287-95. 2003..Thus, combinatorial targeting of receptor tyrosine kinases shows promise for treating multiple stages in tumorigenesis, most notably the often-intractable late-stage solid tumor... - Tumorigenesis and the angiogenic switchGabriele Bergers
University of California San Francisco, Department of Neurological Surgery, Brain Tumor Research Center and Comprehensive Cancer Center, HSE 722, 513 Parnassus Avenue, San Francisco, California 94143 0520, USA
Nat Rev Cancer 3:401-10. 2003.... - Combining antiangiogenic agents with metronomic chemotherapy enhances efficacy against late-stage pancreatic islet carcinomas in miceG Bergers
Department of Neurological Surgery, Cancer Centers, University of California, San Francisco, California 94143, USA
Cold Spring Harb Symp Quant Biol 67:293-300. 2002 - Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesisL M Coussens
Hormone Research Institute, University of California, San Francisco San Francisco, California 94143 0534, USA
Genes Dev 13:1382-97. 1999.... - Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesisG Bergers
Department of Biochemistry and Biophysics, University of California, 513 Parnassus Avenue, San Francisco, California 94143, USA
Nat Cell Biol 2:737-44. 2000..Absence of MMP-2 does not impair induction of angiogenesis, but retards tumour growth, whereas lack of urokinase has no effect. Our results show that MMP-9 is a component of the angiogenic switch... - Loss of vascular endothelial growth factor expression reduces vascularization, but not growth, of tumors lacking the Von Hippel-Lindau tumor suppressor geneB Blouw
Division of Biological Sciences, Molecular Biology Section, University of California, San Diego, La Jolla, California 92093 0377, USA
Oncogene 26:4531-40. 2007.... - The bone marrow constitutes a reservoir of pericyte progenitorsChrystelle Lamagna
Department of Neurological Surgery, University of California San Francisco, CA 94143-0520, USA
J Leukoc Biol 80:677-81. 2006..This review focuses on pericytes in vessel formation and on recent discoveries about their bone marrow origin in the adult... - Malignant progression and blockade of angiogenesis in a murine transgenic model of neuroblastomaLouis Chesler
Department of Pediatrics, Neurology, University of California San Francisco Medical School, San Francisco, California 94143, USA
Cancer Res 67:9435-42. 2007.... - Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targetingKristian Pietras
Department of Biochemistry and Biophysics, Diabetes Center and Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, United States ofAmerica
PLoS Med 5:e19. 2008..We postulated that pharmacological targeting of putative stromal support functions, in particular those of cancer-associated fibroblasts, could have therapeutic utility, and sought to assess the possibility in a pre-clinical setting... - HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasionRose Du
Department of Neurological Surgery, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
Cancer Cell 13:206-20. 2008..VEGF also directly regulates tumor cell invasiveness. When VEGF activity is impaired, tumor cells invade deep into the brain in the perivascular compartment... - Matrix metalloproteinase-2 regulates vascular patterning and growth affecting tumor cell survival and invasion in GBMRose Du
Department of Neurological Surgery, University of California San Francisco, 513 Parnassus Ave, Box 0520, San Francisco, CA 94143 0520, USA
Neuro Oncol 10:254-64. 2008..As a result of impaired and dysfunctional angiogenesis, MMP-2ko GBM became more invasive, predominantly by migrating along blood vessels into the brain parenchyma... - Inhibitors of growth factor receptors, signaling pathways and angiogenesis as therapeutic molecular agentsJocelyn Holash
Regeneron Pharmaceuticals, Tarrytown, NY, USA
Cancer Metastasis Rev 25:243-52. 2006 - Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumorsOriol Casanovas
Department of Biochemistry and Biophysics, Comprehensive Cancer Center, and Diabetes Center, University of California, San Francisco, San Francisco, California 94143, USA
Cancer Cell 8:299-309. 2005..These other proangiogenic signals are functionally implicated in the revascularization and regrowth of tumors in the evasion phase, as FGF blockade impairs progression in the face of VEGF inhibition... - Antitumor effects in mice of low-dose (metronomic) cyclophosphamide administered continuously through the drinking waterShan Man
Departments of Medical Biophysics, Sunnybrook and Women's College Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5 Canada
Cancer Res 62:2731-5. 2002..o. metronomic chemotherapy regimen, which proved safe, reasonably efficacious, and potentially applicable to chronic treatment. Such a regimen may be particularly well suited for integration with antiangiogenic drugs... - The hypoxic response of tumors is dependent on their microenvironmentBarbara Blouw
Molecular Biology Section, Division of Biological Sciences, University of California at San Diego, Pacific Hall Room 1212, MC-0366, 9500 Gilman Drive, La Jolla, CA 92093, USA
Cancer Cell 4:133-46. 2003..These results demonstrate that HIF-1alpha has differential roles in tumor progression, which are greatly dependent on the extant microenvironment of the tumor... - Stage-specific vascular markers revealed by phage display in a mouse model of pancreatic islet tumorigenesisJohanna A Joyce
Department of Biochemistry and Biophysics, Diabetes and Comprehensive Cancer Centers, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
Cancer Cell 4:393-403. 2003..One peptide is homologous with pro-PDGF-B, which is expressed in endothelial cells, while its receptor is expressed in pericytes... - Integrin beta3 overexpression suppresses tumor growth in a human model of gliomagenesis: implications for the role of beta3 overexpression in glioblastoma multiformeMasayuki Kanamori
Department of Neurological Surgery and The Brain Tumor Research Center, University of California-San Francisco, San Francisco, California, USA
Cancer Res 64:2751-8. 2004..These results show that tumor-specific alphaVbeta3 overexpression has growth-suppressive effects in gliomas, but that these deleterious effects are mitigated by alterations common to alphaVbeta3-overexpressing GBM... - Regulator of G-protein signaling-5 induction in pericytes coincides with active vessel remodeling during neovascularizationMario Berger
Department of Molecular Immunology, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
Blood 105:1094-101. 2005..This further supports the notion that pericytes, like endothelial cells, undergo molecular changes during neovascularization that makes them a novel target for antiangiogenic therapy... - PDGFRbeta+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survivalSteven Song
Department of Neurological Surgery, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
Nat Cell Biol 7:870-9. 2005.... - The role of pericytes in blood-vessel formation and maintenanceGabriele Bergers
Department of Neurological Surgery, Brain Tumor Research Center and UCSF Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143, USA
Neuro Oncol 7:452-64. 2005..This review article describes the current knowledge about the nature of pericytes and their functions during vessel growth, vessel maintenance, and pathological angiogenesis... - Modes of resistance to anti-angiogenic therapyGabriele Bergers
University of California, San Francisco, Department of Neurological Surgery, Brain Tumour Research Center, San Francisco, California 94143, USA
Nat Rev Cancer 8:592-603. 2008.... - The PTEN/Akt pathway dictates the direct alphaVbeta3-dependent growth-inhibitory action of an active fragment of tumstatin in glioma cells in vitro and in vivoTomohiro Kawaguchi
Brain Tumor Research Center, Department of Neurological Surgery, The University of California-San Francisco Comprehensive Cancer Center, CA 94115-0875, USA
Cancer Res 66:11331-40. 2006..These results show that tumstatin, previously considered to be only an endogenous inhibitor of angiogenesis, also directly inhibits the growth of tumors in a manner dependent on Akt/mTOR activation...