S L Berger

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc H2B ubiquitylation is part of chromatin architecture that marks exon-intron structure in budding yeast
    Grace S Shieh
    Institute of Statistical Sciences, Academia Sinica, Academia Road, Nankang, Taipei 115, Taiwan
    BMC Genomics 12:627. 2011
  2. ncbi request reprint Transgenerational inheritance of longevity: epigenetic mysteries abound
    Shelley L Berger
    Department of Cell and Developmental Biology, 1057 BRB, 421 Curie Boulevard, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell Metab 15:6-7. 2012
  3. doi request reprint Cell signaling and transcriptional regulation via histone phosphorylation
    S L Berger
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Cold Spring Harb Symp Quant Biol 75:23-6. 2010
  4. ncbi request reprint Snf1--a histone kinase that works in concert with the histone acetyltransferase Gcn5 to regulate transcription
    W S Lo
    Molecular Genetics Program, The Wistar Institute, Philadelphia, PA 19104, USA
    Science 293:1142-6. 2001
  5. ncbi request reprint Structure and function of bromodomains in chromatin-regulating complexes
    R Marmorstein
    Structural Biology Program, The Wistar Institute, Philadelphia, PA, USA
    Gene 272:1-9. 2001
  6. pmc Acetylation of histones and transcription-related factors
    D E Sterner
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Microbiol Mol Biol Rev 64:435-59. 2000
  7. ncbi request reprint The acidic transcriptional activation domains of herpes virus VP16 and yeast HAP4 have different co-factor requirements
    L Wang
    Wistar Institute, Philadelphia, PA 19401, USA
    Gene 158:163-70. 1995
  8. ncbi request reprint CREB-binding protein and p300/CBP-associated factor are transcriptional coactivators of the p53 tumor suppressor protein
    D M Scolnick
    Department of Molecular Genetics, The Wistar Institute, University of Pennsylvania, Philadelphia 19104 4268, USA
    Cancer Res 57:3693-6. 1997
  9. ncbi request reprint Chromatin goes global
    S L Berger
    Molecular Genetics Program, The Wistar Institute, Philadelphia, PA 19104, USA
    Mol Cell 8:263-8. 2001
  10. ncbi request reprint Gene activation by histone and factor acetyltransferases
    S L Berger
    Molecular Genetics Program, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Curr Opin Cell Biol 11:336-41. 1999

Collaborators

  • R Marmorstein
  • T D Halazonetis
  • J L Workman
  • C Ying
  • L Liu
  • E Moran
  • P M Lieberman
  • Tom Owen-Hughes
  • R Candau
  • N A Barlev
  • D E Sterner
  • Grace S Shieh
  • W S Lo
  • L Wang
  • R Belotserkovskaya
  • N C T Emre
  • C D Allis
  • D Tsavachidou
  • Wei Chun Hsiao
  • Luh Tung
  • Jia Hong Wu
  • Tien Hsien Chang
  • Chia Yeh Lin
  • Yun Ju Sun
  • L Duggan
  • Chia Chang Wang
  • Alastair B Fleming
  • Yi Chen Lo
  • Cheng Fu Kao
  • Cory Hillyer
  • Mary Ann Osley
  • Chin Hua Pan
  • N H Chehab
  • D M Scolnick
  • N Barlev
  • J Seykora
  • K G Harris
  • R Shiekhattar
  • W S Lane
  • R Belotserkovskya
  • W Podrzucki
  • N C Emre
  • K Mansfield
  • M H Sayre
  • J R Rojas
  • M Deng
  • J Y Hsu
  • R C Trievel
  • L J Duggan
  • L A Pacella
  • P A Grant
  • S M Roberts
  • F Winston
  • V Poltoratsky
  • C Mizzen
  • L Caruso
  • J X Zhou
  • E S Stavridi
  • M C Lien
  • J Brownell
  • C A Rosen
  • P A Moore
  • N Silverman
  • B Turcotte
  • L Guarente
  • P Darpino

Detail Information

Publications23

  1. pmc H2B ubiquitylation is part of chromatin architecture that marks exon-intron structure in budding yeast
    Grace S Shieh
    Institute of Statistical Sciences, Academia Sinica, Academia Road, Nankang, Taipei 115, Taiwan
    BMC Genomics 12:627. 2011
    ..The packaging of DNA into chromatin regulates transcription from initiation through 3' end processing. One aspect of transcription in which chromatin plays a poorly understood role is the co-transcriptional splicing of pre-mRNA...
  2. ncbi request reprint Transgenerational inheritance of longevity: epigenetic mysteries abound
    Shelley L Berger
    Department of Cell and Developmental Biology, 1057 BRB, 421 Curie Boulevard, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell Metab 15:6-7. 2012
    ..A recent report by Anne Brunet and colleagues describes a fascinating example of persistence across generations of extended life span in worm and explores whether epigenetic mechanisms account for the longevity...
  3. doi request reprint Cell signaling and transcriptional regulation via histone phosphorylation
    S L Berger
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Cold Spring Harb Symp Quant Biol 75:23-6. 2010
    ..These results lead to a gathering appreciation of the potential role of signal transduction kinase-mediated direct histone phosphorylation in regulating transcription...
  4. ncbi request reprint Snf1--a histone kinase that works in concert with the histone acetyltransferase Gcn5 to regulate transcription
    W S Lo
    Molecular Genetics Program, The Wistar Institute, Philadelphia, PA 19104, USA
    Science 293:1142-6. 2001
    ....
  5. ncbi request reprint Structure and function of bromodomains in chromatin-regulating complexes
    R Marmorstein
    Structural Biology Program, The Wistar Institute, Philadelphia, PA, USA
    Gene 272:1-9. 2001
    ..Interactions between bromodomains and modified histones may be an important mechanism underlying chromatin structural changes and gene regulation...
  6. pmc Acetylation of histones and transcription-related factors
    D E Sterner
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Microbiol Mol Biol Rev 64:435-59. 2000
    ..Thus, we also detail these known factor acetyltransferase (FAT) substrates and the demonstrated or potential roles of their acetylation in transcriptional processes...
  7. ncbi request reprint The acidic transcriptional activation domains of herpes virus VP16 and yeast HAP4 have different co-factor requirements
    L Wang
    Wistar Institute, Philadelphia, PA 19401, USA
    Gene 158:163-70. 1995
    ..These results strongly suggest that HAP4 and VP16 have distinct cofactor requirements, although they are both acidic activators...
  8. ncbi request reprint CREB-binding protein and p300/CBP-associated factor are transcriptional coactivators of the p53 tumor suppressor protein
    D M Scolnick
    Department of Molecular Genetics, The Wistar Institute, University of Pennsylvania, Philadelphia 19104 4268, USA
    Cancer Res 57:3693-6. 1997
    ..These studies link two tumor suppressor families and provide a framework for understanding the molecular mechanism by which p53 activates transcription...
  9. ncbi request reprint Chromatin goes global
    S L Berger
    Molecular Genetics Program, The Wistar Institute, Philadelphia, PA 19104, USA
    Mol Cell 8:263-8. 2001
    ..The latest findings on the structure of chromatin, its organization in the nucleus, and its involvement in regulating gene expression were presented at a recent meeting at the Juan March Foundation in Madrid, Spain...
  10. ncbi request reprint Gene activation by histone and factor acetyltransferases
    S L Berger
    Molecular Genetics Program, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Curr Opin Cell Biol 11:336-41. 1999
    ..Finally, enzymatic acetyltransferase activities are themselves regulated by phosphorylation and interaction with other proteins...
  11. ncbi request reprint Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases
    N A Barlev
    Molecular Genetics Program, The Wistar Institute, Philadelphia, PA 19104, USA
    Mol Cell 8:1243-54. 2001
    ..Therefore, we propose that an acetylation cascade consisting of p53 acetylation-dependent recruitment of coactivators/HATs is crucial for p53 function...
  12. ncbi request reprint Histone H2B ubiquitylation and deubiquitylation in genomic regulation
    N C T Emre
    Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Cold Spring Harb Symp Quant Biol 69:289-99. 2004
  13. pmc Histone acetyltransferase activity is conserved between yeast and human GCN5 and is required for complementation of growth and transcriptional activation
    L Wang
    Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 17:519-27. 1997
    ..These findings directly link enzymatic histone acetylation and transcriptional activation and show evolutionary conservation of this potentially crucial pathway in gene regulation...
  14. pmc Functional organization of the yeast SAGA complex: distinct components involved in structural integrity, nucleosome acetylation, and TATA-binding protein interaction
    D E Sterner
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 19:86-98. 1999
    ..Loss of either of these causes slight impairment in vivo, but loss of both is highly detrimental to growth and transcription...
  15. pmc Histone acetyltransferase activity and interaction with ADA2 are critical for GCN5 function in vivo
    R Candau
    The Wistar Institute, Philadelphia, PA 19104, USA
    EMBO J 16:555-65. 1997
    ..These results suggest that both functions of GCN5, HAT activity and interaction with ADA2, are necessary for targeting and acetylation of nucleosomal histones...
  16. ncbi request reprint Phosphorylation of serine 10 in histone H3 is functionally linked in vitro and in vivo to Gcn5-mediated acetylation at lysine 14
    W S Lo
    Molecular Genetics Program, Wistar Institute, Philadelphia, Pennsylvania 19024, USA
    Mol Cell 5:917-26. 2000
    ..These observations suggest that transcriptional regulation occurs by multiple mechanistically linked covalent modifications of histones...
  17. pmc Gene array analysis reveals changes in peripheral nervous system gene expression following stimuli that result in reactivation of latent herpes simplex virus type 1: induction of transcription factor Bcl-3
    D Tsavachidou
    The Wistar Institute, Philadelphia, Pennsylvania 19104-4268, USA
    J Virol 75:9909-17. 2001
    ..We discuss a potential role for this factor in upregulating ICP0 transcription, which is an important viral event for initiation of HSV-1 reactivation...
  18. pmc Inhibition of TATA-binding protein function by SAGA subunits Spt3 and Spt8 at Gcn4-activated promoters
    R Belotserkovskaya
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 20:634-47. 2000
    ..These results suggest that the composition of SAGA may be dynamic in vivo and may be regulated through dissociable inhibitory subunits...
  19. pmc p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage
    L Liu
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 19:1202-9. 1999
    ..These data indicate that site-specific acetylation of p53 increases under physiological conditions that activate p53 and identify CBP/p300 and PCAF as the probable enzymes that modify p53 in vivo...
  20. pmc Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5
    R Candau
    Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 16:593-602. 1996
    ..These data indicated that the human proteins correspond to functional homologs of the yeast adaptors, suggesting that these cofactors play a key role in transcriptional activation...
  21. ncbi request reprint Characterization of physical interactions of the putative transcriptional adaptor, ADA2, with acidic activation domains and TATA-binding protein
    N A Barlev
    Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 270:19337-44. 1995
    ..In addition, ADA2 physically associated with TBP, but not with TFIIB. These results suggest that the role of ADA2 in transcriptional activation is to promote physical interaction between activation domains and TBP...
  22. ncbi request reprint Structural and functional analysis of yeast putative adaptors. Evidence for an adaptor complex in vivo
    R Candau
    Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 271:5237-45. 1996
    ....
  23. pmc Repression of GCN5 histone acetyltransferase activity via bromodomain-mediated binding and phosphorylation by the Ku-DNA-dependent protein kinase complex
    N A Barlev
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 18:1349-58. 1998
    ..These findings suggest a possible regulatory mechanism of HAT activity...