Research Topics
| Rachel Pardes BergerSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Detail Information
Publications
Serum biomarkers after traumatic and hypoxemic brain injuries: insight into the biochemical response of the pediatric brain to inflicted brain injuryRachel Pardes Berger
Department of Pediatrics, Child Advocacy Center, Children s Hospital of Pittsburgh, and Safar Center for Resuscitation Research, University of Pittsburgh, PA 15213, USA
Dev Neurosci 28:327-35. 2006..This may have important implications for the treatment and prognosis of children with iTBI...- Neuron-specific enolase and S100B in cerebrospinal fluid after severe traumatic brain injury in infants and childrenRachel Pardes Berger
Department of Pediatrics, Pittsburgh Child Advocacy Center, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 5213, USA
Pediatrics 109:E31. 2002..In adults, CSF and serum concentrations of NSE and S100B have served as markers of neuronal damage after TBI. Neither NSE nor S100B has previously been studied in CSF after TBI in infants or children... - The use of serum biomarkers to predict outcome after traumatic brain injury in adults and childrenRachel Pardes Berger
Department of Pediatrics, Division of Child Advocacy, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
J Head Trauma Rehabil 21:315-33. 2006.... - Identification of inflicted traumatic brain injury in well-appearing infants using serum and cerebrospinal markers: a possible screening toolRachel Pardes Berger
Department of Pediatrics, Child Advocacy Center, Pittsburgh, Pennsylvania, USA
Pediatrics 117:325-32. 2006..We investigated whether serum and/or cerebrospinal fluid (CSF) concentrations of neuron-specific enolase (NSE), S100B, and myelin-basic protein (MBP) are sensitive and specific for iTBI in high-risk infants... - Serum biomarker concentrations and outcome after pediatric traumatic brain injuryRachel Pardes Berger
Department of Pediatrics, Division of Child Advocacy, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Safar Center for Resuscitation Research, Pittsburgh, Pennsylvania 15213, USA
J Neurotrauma 24:1793-801. 2007..Future studies should focus on assessing the differential benefit of biomarkers compared with clinical variables and in assessing a continuous rather than categorical outcome variable... 
Multiplex assessment of serum biomarker concentrations in well-appearing children with inflicted traumatic brain injuryRachel P Berger
Department of Pediatrics, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Pediatr Res 65:97-102. 2009..The results suggest significant changes in the serum biomarker profile after mild ITBI. Future research is needed to determine whether these biomarkers can screen for brain injury in infants with nonspecific symptoms...- Assessment of the macrophage marker quinolinic acid in cerebrospinal fluid after pediatric traumatic brain injury: insight into the timing and severity of injury in child abuseRachel Pardes Berger
Department of Pediatrics, Children s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
J Neurotrauma 21:1123-30. 2004..Higher initial and peak QUIN concentrations after iTBI may be due to severity of injury, young age, and/or delay in seeking medical care, which allows for increased secondary injury... - Derivation and validation of an equation for adjustment of neuron-specific enolase concentrations in hemolyzed serumRachel Berger
Children s Hospital of Pittsburgh, Pittsburgh, PA, USA
Pediatr Crit Care Med 10:260-3. 2009..To derive and validate a formula to allow for adjustment of serum neuron-specific enolase (NSE) concentrations based on the amount of hemolysis in the sample. To compare the accuracy of qualitative and quantitative assessment of hemolysis... - Serum S100B concentrations are increased after closed head injury in children: a preliminary studyRachel Pardes Berger
Department of Pediatrics, University of Pittsburgh School of Medicine, Graduate School of Public Health, Pittsburgh, Pennsylvania, USA
J Neurotrauma 19:1405-9. 2002..The increase is transient, lasting less than 12 h after injury, except in children with severe injury. Future research will focus on the possibility of using serum S100B as a screening test for inflicted CHI... - Implementation of a program to teach pediatric residents and faculty about domestic violenceRachel P Berger
Department of Pediatrics, Pittsburgh Child Advocacy Center, Children s Hospital of Pittsburgh, PA 15213, USA
Arch Pediatr Adolesc Med 156:804-10. 2002.... - Serum neuron-specific enolase, S100B, and myelin basic protein concentrations after inflicted and noninflicted traumatic brain injury in childrenRachel Pardes Berger
Department of Pediatrics, Child Advocacy Center, Children's Hospital of Pittsburgh, Pennsylvania 15217, USA
J Neurosurg 103:61-8. 2005..Differences in the time course of NSE, S100B, and myelin basic protein after nTBI and iTBI may provide insight into the pathophysiology of iTBI. These serum markers should be prospectively evaluated in a target population of infants... 
Trajectory analysis of serum biomarker concentrations facilitates outcome prediction after pediatric traumatic and hypoxemic brain injuryRachel Pardes Berger
Department of Pediatrics, Children s Hospital of Pittsburgh of UPMC, Safar Center for Resuscitation Research, Pittsburgh, PA 15227, USA
Dev Neurosci 32:396-405. 2010..These data suggest that trajectory analysis of biomarker data may provide a useful approach for predicting outcome after pediatric brain injury...- Urinary S100B concentrations are increased after brain injury in children: A preliminary studyRachel Pardes Berger
Department of Pediatrics, Child Advocacy Center, Children's Hospital of Pittsburgh, Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA, USA
Pediatr Crit Care Med 7:557-61. 2006..Urinary and/or serum S100B concentrations may be useful to assist in the prediction of outcome after pediatric brain injury... - Biochemical markers of brain injury: could they be used as diagnostic adjuncts in cases of inflicted traumatic brain injury?Rachel Pardes Berger
Department of Pediatrics, Pittsburgh Child Advocacy Center, Children s Hospital of Pittsburgh, Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Child Abuse Negl 28:739-54. 2004..1998; Jenny, Hymel, Pitzen, Reinert, & Hay, 1999). Unlike CF for which there are several well established screening tests, there are currently no diagnostic adjuncts to help physicians screen for possible iTBI... - Neurocognitive outcome and serum biomarkers in inflicted versus non-inflicted traumatic brain injury in young childrenSue R Beers
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
J Neurotrauma 24:97-105. 2007..Outcome may be due to the mechanism of iTBI, cumulative effects of unreported TBI, and/or other unidentified risk factors... - Quantification of poly(ADP-ribose)-modified proteins in cerebrospinal fluid from infants and children after traumatic brain injuryEricka L Fink
Department of Critical Care Medicine, Safar Center for Resuscitation Research and Brain Trauma Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
J Cereb Blood Flow Metab 28:1523-9. 2008..As PAR-modified protein concentration correlated with age and male sex, developmental and sex-dependent roles for PARP after TBI are implicated... - Biomarkers of primary and evolving damage in traumatic and ischemic brain injury: diagnosis, prognosis, probing mechanisms, and therapeutic decision makingPatrick M Kochanek
Safar Center for Resuscitation Research, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA
Curr Opin Crit Care 14:135-41. 2008..Novel proteomic, multiplex, and lipidomic methods are also being applied... - Cytochrome c, a biomarker of apoptosis, is increased in cerebrospinal fluid from infants with inflicted brain injury from child abuseMargaret A Satchell
Department of Critical Care Medicine, The Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
J Cereb Blood Flow Metab 25:919-27. 2005..The degree of apoptosis after TBI also appears to be gender-dependent. Development of strategies targeting apoptosis after TBI, particularly in victims of child abuse and in girls, appears justified... - Cerebrospinal fluid biomarkers versus glasgow coma scale and glasgow outcome scale in pediatric traumatic brain injury: the role of young age and inflicted injuryPaul M Shore
Department of Pediatrics, University of Texas Southwestern Medical Center, Division of Critical Care Services, Children s Medical Center of Dallas, 1935 Motor Street, Dallas, TX 73235, USA
J Neurotrauma 24:75-86. 2007..Although further, prospective study is warranted, these findings suggest important limitations in our current ability to assess injury severity in this important population... - Multiplex assessment of cytokine and chemokine levels in cerebrospinal fluid following severe pediatric traumatic brain injury: effects of moderate hypothermiaSandra D W Buttram
Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA
J Neurotrauma 24:1707-17. 2007..Moderate therapeutic hypothermia did not attenuate the increase in CSF cytokine levels in children after TBI... - Cost-effectiveness of head computed tomography in infants with possible inflicted traumatic brain injuryKristine A Campbell
Division of Safe and Healthy Families, Department of Pediatrics, University of Utah, 295 Chipeta Way, Box 581289, Salt Lake City, UT 84158, USA
Pediatrics 120:295-304. 2007..We undertook this study to estimate the cost-effectiveness of a policy of head computed tomography (CT) for inflicted traumatic brain injury in selected infants seen in an emergency department... - Abusive head trauma in young children: characteristics and medical charges in a hospitalized populationLorraine Ettaro
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
Child Abuse Negl 28:1099-111. 2004..CONCLUSIONS: These results highlight the differences in the demographics, presenting characteristics and economic impact of abusive head injuries compared to non-abusive head injuries... - A gel-based proteomic comparison of human cerebrospinal fluid between inflicted and non-inflicted pediatric traumatic brain injuryWei Min Gao
Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
J Neurotrauma 24:43-53. 2007..These initial results with conventional gel-based proteomics show new protein changes that may ultimately help to understand pathophysiological differences between iTBI and nTBI...