Rachel Pardes Berger

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Serum biomarkers after traumatic and hypoxemic brain injuries: insight into the biochemical response of the pediatric brain to inflicted brain injury
    Rachel Pardes Berger
    Department of Pediatrics, Child Advocacy Center, Children s Hospital of Pittsburgh, and Safar Center for Resuscitation Research, University of Pittsburgh, PA 15213, USA
    Dev Neurosci 28:327-35. 2006
  2. ncbi request reprint Neuron-specific enolase and S100B in cerebrospinal fluid after severe traumatic brain injury in infants and children
    Rachel Pardes Berger
    Department of Pediatrics, Pittsburgh Child Advocacy Center, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 5213, USA
    Pediatrics 109:E31. 2002
  3. ncbi request reprint The use of serum biomarkers to predict outcome after traumatic brain injury in adults and children
    Rachel Pardes Berger
    Department of Pediatrics, Division of Child Advocacy, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    J Head Trauma Rehabil 21:315-33. 2006
  4. ncbi request reprint Identification of inflicted traumatic brain injury in well-appearing infants using serum and cerebrospinal markers: a possible screening tool
    Rachel Pardes Berger
    Department of Pediatrics, Child Advocacy Center, Pittsburgh, Pennsylvania, USA
    Pediatrics 117:325-32. 2006
  5. ncbi request reprint Serum biomarker concentrations and outcome after pediatric traumatic brain injury
    Rachel Pardes Berger
    Department of Pediatrics, Division of Child Advocacy, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Safar Center for Resuscitation Research, Pittsburgh, Pennsylvania 15213, USA
    J Neurotrauma 24:1793-801. 2007
  6. doi request reprint Multiplex assessment of serum biomarker concentrations in well-appearing children with inflicted traumatic brain injury
    Rachel P Berger
    Department of Pediatrics, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Pediatr Res 65:97-102. 2009
  7. ncbi request reprint Assessment of the macrophage marker quinolinic acid in cerebrospinal fluid after pediatric traumatic brain injury: insight into the timing and severity of injury in child abuse
    Rachel Pardes Berger
    Department of Pediatrics, Children s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    J Neurotrauma 21:1123-30. 2004
  8. doi request reprint Derivation and validation of an equation for adjustment of neuron-specific enolase concentrations in hemolyzed serum
    Rachel Berger
    Children s Hospital of Pittsburgh, Pittsburgh, PA, USA
    Pediatr Crit Care Med 10:260-3. 2009
  9. ncbi request reprint Serum S100B concentrations are increased after closed head injury in children: a preliminary study
    Rachel Pardes Berger
    Department of Pediatrics, University of Pittsburgh School of Medicine, Graduate School of Public Health, Pittsburgh, Pennsylvania, USA
    J Neurotrauma 19:1405-9. 2002
  10. ncbi request reprint Implementation of a program to teach pediatric residents and faculty about domestic violence
    Rachel P Berger
    Department of Pediatrics, Pittsburgh Child Advocacy Center, Children s Hospital of Pittsburgh, PA 15213, USA
    Arch Pediatr Adolesc Med 156:804-10. 2002

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Serum biomarkers after traumatic and hypoxemic brain injuries: insight into the biochemical response of the pediatric brain to inflicted brain injury
    Rachel Pardes Berger
    Department of Pediatrics, Child Advocacy Center, Children s Hospital of Pittsburgh, and Safar Center for Resuscitation Research, University of Pittsburgh, PA 15213, USA
    Dev Neurosci 28:327-35. 2006
    ..This may have important implications for the treatment and prognosis of children with iTBI...
  2. ncbi request reprint Neuron-specific enolase and S100B in cerebrospinal fluid after severe traumatic brain injury in infants and children
    Rachel Pardes Berger
    Department of Pediatrics, Pittsburgh Child Advocacy Center, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 5213, USA
    Pediatrics 109:E31. 2002
    ..In adults, CSF and serum concentrations of NSE and S100B have served as markers of neuronal damage after TBI. Neither NSE nor S100B has previously been studied in CSF after TBI in infants or children...
  3. ncbi request reprint The use of serum biomarkers to predict outcome after traumatic brain injury in adults and children
    Rachel Pardes Berger
    Department of Pediatrics, Division of Child Advocacy, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    J Head Trauma Rehabil 21:315-33. 2006
    ....
  4. ncbi request reprint Identification of inflicted traumatic brain injury in well-appearing infants using serum and cerebrospinal markers: a possible screening tool
    Rachel Pardes Berger
    Department of Pediatrics, Child Advocacy Center, Pittsburgh, Pennsylvania, USA
    Pediatrics 117:325-32. 2006
    ..We investigated whether serum and/or cerebrospinal fluid (CSF) concentrations of neuron-specific enolase (NSE), S100B, and myelin-basic protein (MBP) are sensitive and specific for iTBI in high-risk infants...
  5. ncbi request reprint Serum biomarker concentrations and outcome after pediatric traumatic brain injury
    Rachel Pardes Berger
    Department of Pediatrics, Division of Child Advocacy, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Safar Center for Resuscitation Research, Pittsburgh, Pennsylvania 15213, USA
    J Neurotrauma 24:1793-801. 2007
    ..Future studies should focus on assessing the differential benefit of biomarkers compared with clinical variables and in assessing a continuous rather than categorical outcome variable...
  6. doi request reprint Multiplex assessment of serum biomarker concentrations in well-appearing children with inflicted traumatic brain injury
    Rachel P Berger
    Department of Pediatrics, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Pediatr Res 65:97-102. 2009
    ..The results suggest significant changes in the serum biomarker profile after mild ITBI. Future research is needed to determine whether these biomarkers can screen for brain injury in infants with nonspecific symptoms...
  7. ncbi request reprint Assessment of the macrophage marker quinolinic acid in cerebrospinal fluid after pediatric traumatic brain injury: insight into the timing and severity of injury in child abuse
    Rachel Pardes Berger
    Department of Pediatrics, Children s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    J Neurotrauma 21:1123-30. 2004
    ..Higher initial and peak QUIN concentrations after iTBI may be due to severity of injury, young age, and/or delay in seeking medical care, which allows for increased secondary injury...
  8. doi request reprint Derivation and validation of an equation for adjustment of neuron-specific enolase concentrations in hemolyzed serum
    Rachel Berger
    Children s Hospital of Pittsburgh, Pittsburgh, PA, USA
    Pediatr Crit Care Med 10:260-3. 2009
    ..To derive and validate a formula to allow for adjustment of serum neuron-specific enolase (NSE) concentrations based on the amount of hemolysis in the sample. To compare the accuracy of qualitative and quantitative assessment of hemolysis...
  9. ncbi request reprint Serum S100B concentrations are increased after closed head injury in children: a preliminary study
    Rachel Pardes Berger
    Department of Pediatrics, University of Pittsburgh School of Medicine, Graduate School of Public Health, Pittsburgh, Pennsylvania, USA
    J Neurotrauma 19:1405-9. 2002
    ..The increase is transient, lasting less than 12 h after injury, except in children with severe injury. Future research will focus on the possibility of using serum S100B as a screening test for inflicted CHI...
  10. ncbi request reprint Implementation of a program to teach pediatric residents and faculty about domestic violence
    Rachel P Berger
    Department of Pediatrics, Pittsburgh Child Advocacy Center, Children s Hospital of Pittsburgh, PA 15213, USA
    Arch Pediatr Adolesc Med 156:804-10. 2002
    ....
  11. ncbi request reprint Serum neuron-specific enolase, S100B, and myelin basic protein concentrations after inflicted and noninflicted traumatic brain injury in children
    Rachel Pardes Berger
    Department of Pediatrics, Child Advocacy Center, Children s Hospital of Pittsburgh, Pennsylvania 15217, USA
    J Neurosurg 103:61-8. 2005
    ..The authors investigated whether serum concentrations of biomarkers were increased after noninflicted (n)TBI and iTBI in pediatric cases of varying severity...
  12. pmc Trajectory analysis of serum biomarker concentrations facilitates outcome prediction after pediatric traumatic and hypoxemic brain injury
    Rachel Pardes Berger
    Department of Pediatrics, Children s Hospital of Pittsburgh of UPMC, Safar Center for Resuscitation Research, Pittsburgh, PA 15227, USA
    Dev Neurosci 32:396-405. 2010
    ..These data suggest that trajectory analysis of biomarker data may provide a useful approach for predicting outcome after pediatric brain injury...
  13. ncbi request reprint Urinary S100B concentrations are increased after brain injury in children: A preliminary study
    Rachel Pardes Berger
    Department of Pediatrics, Child Advocacy Center, Children s Hospital of Pittsburgh, Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA, USA
    Pediatr Crit Care Med 7:557-61. 2006
    ..However, increases in serum are rapid and transient and therefore may be of limited use in certain patients. Urinary S100B concentrations may be able to provide information about brain injury in this subgroup of patients...
  14. ncbi request reprint Biochemical markers of brain injury: could they be used as diagnostic adjuncts in cases of inflicted traumatic brain injury?
    Rachel Pardes Berger
    Department of Pediatrics, Pittsburgh Child Advocacy Center, Children s Hospital of Pittsburgh, Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Child Abuse Negl 28:739-54. 2004
    ..1998; Jenny, Hymel, Pitzen, Reinert, & Hay, 1999). Unlike CF for which there are several well established screening tests, there are currently no diagnostic adjuncts to help physicians screen for possible iTBI...
  15. ncbi request reprint Neurocognitive outcome and serum biomarkers in inflicted versus non-inflicted traumatic brain injury in young children
    Sue R Beers
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
    J Neurotrauma 24:97-105. 2007
    ..Outcome may be due to the mechanism of iTBI, cumulative effects of unreported TBI, and/or other unidentified risk factors...
  16. pmc Quantification of poly(ADP-ribose)-modified proteins in cerebrospinal fluid from infants and children after traumatic brain injury
    Ericka L Fink
    Department of Critical Care Medicine, Safar Center for Resuscitation Research and Brain Trauma Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Cereb Blood Flow Metab 28:1523-9. 2008
    ..As PAR-modified protein concentration correlated with age and male sex, developmental and sex-dependent roles for PARP after TBI are implicated...
  17. doi request reprint Biomarkers of primary and evolving damage in traumatic and ischemic brain injury: diagnosis, prognosis, probing mechanisms, and therapeutic decision making
    Patrick M Kochanek
    Safar Center for Resuscitation Research, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA
    Curr Opin Crit Care 14:135-41. 2008
    ..Novel proteomic, multiplex, and lipidomic methods are also being applied...
  18. ncbi request reprint Cytochrome c, a biomarker of apoptosis, is increased in cerebrospinal fluid from infants with inflicted brain injury from child abuse
    Margaret A Satchell
    Department of Critical Care Medicine, The Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Cereb Blood Flow Metab 25:919-27. 2005
    ..The degree of apoptosis after TBI also appears to be gender-dependent. Development of strategies targeting apoptosis after TBI, particularly in victims of child abuse and in girls, appears justified...
  19. ncbi request reprint Cerebrospinal fluid biomarkers versus glasgow coma scale and glasgow outcome scale in pediatric traumatic brain injury: the role of young age and inflicted injury
    Paul M Shore
    Department of Pediatrics, University of Texas Southwestern Medical Center, Division of Critical Care Services, Children s Medical Center of Dallas, 1935 Motor Street, Dallas, TX 73235, USA
    J Neurotrauma 24:75-86. 2007
    ..Although further, prospective study is warranted, these findings suggest important limitations in our current ability to assess injury severity in this important population...
  20. ncbi request reprint Multiplex assessment of cytokine and chemokine levels in cerebrospinal fluid following severe pediatric traumatic brain injury: effects of moderate hypothermia
    Sandra D W Buttram
    Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA
    J Neurotrauma 24:1707-17. 2007
    ..Moderate therapeutic hypothermia did not attenuate the increase in CSF cytokine levels in children after TBI...
  21. ncbi request reprint Cost-effectiveness of head computed tomography in infants with possible inflicted traumatic brain injury
    Kristine A Campbell
    Division of Safe and Healthy Families, Department of Pediatrics, University of Utah, 295 Chipeta Way, Box 581289, Salt Lake City, UT 84158, USA
    Pediatrics 120:295-304. 2007
    ..We undertook this study to estimate the cost-effectiveness of a policy of head computed tomography (CT) for inflicted traumatic brain injury in selected infants seen in an emergency department...
  22. ncbi request reprint Abusive head trauma in young children: characteristics and medical charges in a hospitalized population
    Lorraine Ettaro
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Child Abuse Negl 28:1099-111. 2004
    ....
  23. pmc A gel-based proteomic comparison of human cerebrospinal fluid between inflicted and non-inflicted pediatric traumatic brain injury
    Wei Min Gao
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
    J Neurotrauma 24:43-53. 2007
    ..These initial results with conventional gel-based proteomics show new protein changes that may ultimately help to understand pathophysiological differences between iTBI and nTBI...