Research Topics
| J R BergerSummaryAffiliation: University of Kentucky Country: USA Publications
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Publications
Paraneoplastic opsoclonus-myoclonus secondary to malignant melanomaJ R Berger
Department of Neurology, University of Kentucky College of Medicine, Lexington, USA
J Neurooncol 41:43-5. 1999..Antineuronal antibodies were not identified despite repeated testing. No therapeutic benefit was observed following corticosteroid administration...- Cerebrovascular changes in the basal ganglia with HIV dementiaJ R Berger
Department of Neurology, University of Kentucky College of Medicine, Lexington 40536 2184, USA
Neurology 54:921-6. 2000..Many investigators have proposed a contribution of a disrupted blood-brain barrier (BBB) to the pathogenesis of HIV dementia... - JC virus detection in bodily fluids: clues to transmissionJoseph R Berger
Department of Neurology, College of Medicine, University of Kentucky, Lexington, KY 40536 0284, USA
Clin Infect Dis 43:e9-12. 2006.... - Familial lipodystrophy associated with neurodegeneration and congenital cataractsJoseph R Berger
Department of Neurology, University of Kentucky College of Medicine, Lexington, USA
Neurology 58:43-7. 2002..The lipodystrophies are characterized by loss of body fat and metabolic disturbances, but the CNS is seldom affected... - Progressive multifocal leukoencephalopathy in acquired immunodeficiency syndrome: explaining the high incidence and disproportionate frequency of the illness relative to other immunosuppressive conditionsJoseph R Berger
Department of Neurology, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0284, USA
J Neurovirol 9:38-41. 2003..g., tat, and by inflammatory byproducts of HIV infection. It is quite likely that multiple diverse mechanisms are at play... 
Low prevalence of varicella zoster virus and herpes simplex virus type 2 in saliva from human immunodeficiency virus-infected persons in the era of highly active antiretroviral therapyChunmei C Wang
Department of Oral Health Practice, University of Kentucky College of Medicine and College of Dentistry, Lexington, Kentucky 40536 0297, USA
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109:232-7. 2010..The aim of this study was to investigate the prevalence and amounts of VZV and HSV-2 in the saliva of HIV-infected orally asymptomatic patients...- Acceleration of HIV dementia with methamphetamine and cocaineA Nath
Department of Neurology, University of Kentucky, Lexington 40526-0284, USA
J Neurovirol 7:66-71. 2001..Careful attention and analysis to histories of remote non-injecting drug abuse may help substantiate our hypothesis... 
A brainstem paraneoplastic syndrome associated with prostate cancerJ R Berger
Department of Neurology, University of Kentucky College of Medicine, Kentucky Clinic L 445, 740 South Limestone Street, Lexington, KY 40536, USA
J Neurol Neurosurg Psychiatry 80:934-5. 2009..A rare paraneoplastic brainstem syndrome associated with prostate cancer is described, and the presence of antineuronal antibodies with this syndrome is demonstrated for the first time...- Acute multifocal placoid pigment epitheliopathy and central nervous system involvement: nine new cases and a review of the literatureH S O'Halloran
Department of Ophthalmology, University of Kentucky, Lexington, KY 40536, USA
Ophthalmology 108:861-8. 2001..The study includes a review of the literature and discussion of evaluation, management, and treatment options... - Optic nerve edema as a consequence of respiratory diseaseH S O'Halloran
Department of Ophthalmology, University of Kentucky, Lexington 40536, USA
Neurology 53:2204-5. 1999..The opening pressure at the time of lumbar puncture was normal, and results of other CSF studies were normal. All abnormalities resolved with home oxygen therapy... - Acute central cord syndrome with bodybuilder signPatricio S Espinosa
Department of Neurology, University of Kentucky College of Medicine, Kentucky Clinic Room L 445, Lexington, KY 40536 0284, United States
Clin Neurol Neurosurg 109:354-6. 2007.... - Alien hand syndromePatricio S Espinosa
Department of Neurology, Kentucky Clinic (Room L-445, Lexington, Kentucky 40536-0284, USA
Neurology 67:E21. 2006 - Progressive multifocal leukoencephalopathyJoseph R Berger
Department of Neurology, University of Kentucky College of Medicine, Kentucky Clinic L 445, 740 S Limestone Street, Lexington, KY 40536 0284, USA
Curr Neurol Neurosci Rep 7:461-9. 2007..Treatment directed against the JC virus has been unhelpful, but an increased understanding of disease pathogenesis may result in effective therapeutic strategies... - Homonymous hemianopsia complicating treatment of postoperative epistaxisPatricio S Espinosa
Department of Neurology, Kentucky Clinic, Lexington, KY 40536-0284, USA
Neurology 67:1305. 2006 - High prevalence of multiple human herpesviruses in saliva from human immunodeficiency virus-infected persons in the era of highly active antiretroviral therapyCraig S Miller
Department of Microbiology, Immunology and Molecular Genetics, College of Medicine, University of Kentucky, 800 Rose Street, Lexington, KY 40536 0297, USA
J Clin Microbiol 44:2409-15. 2006..These findings suggest that saliva is a potential risk factor for the acquisition of multiple HHVs, and several host factors may function to accelerate HHV reactivation or replication in patients with HIV infection... - Progressive multifocal leukoencephalopathy: lessons from AIDS and natalizumabJoseph R Berger
Department of Neurology, University of Kentucky College of Medicine, Lexington, 40536, USA
Neurol Res 28:299-305. 2006..Studies in these populations will be invaluable in understanding the mechanisms of disease pathogenesis... - Ziconotide infusion for severe chronic pain: case series of patients with neuropathic painDaniel P Wermeling
Department of Pharmacy Practice and Science, College of Pharmacy, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
Pharmacotherapy 26:395-402. 2006..In all three cases, patients achieved considerable pain relief that was long-lasting and persisted well after dose administration or suspension of infusion... - Primary lateral sclerosis with HIV-1 infectionAshok Verma
Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA
Neurology 70:575-7. 2008 - Neurological complications of herpes simplex virus type 2 infectionJoseph R Berger
Department of Neurology, University of Kentucky College of Medicine, Kentucky Clinic, Room L 445, 740 S Limestone St, Lexington, KY 40536 0284, USA
Arch Neurol 65:596-600. 2008..Despite a 50% genetic homology between HSV-1 and HSV-2, there are significant differences in the clinical manifestations of these 2 viruses. We herein review the neurological complications of HSV-2 infection... - Neurologic consequences of autoimmune polyglandular syndrome type 1Joseph R Berger
Department of Neurology, University of Kentucky College of Medicine, Kentucky Clinic L 445, 740 S Limestone Street, Lexington, KY 40536 0284, USA
Neurology 70:2248-51. 2008..The neurologic complications of this disorder have not been well characterized... - Isolated central nervous system histoplasmosis in an immunocompetent patient: 53-month hiatus to diagnosis and treatmentJoseph R Berger
Departments of Neurology, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0281, USA
J Neurovirol 16:472-4. 2010..We report a patient with chronic meningitis due to Histoplasma capsulatum who exhibited a remarkably benign course despite being untreated for the disorder for more than 4 years... - Progressive multifocal leukoencephalopathy and newer biological agentsJoseph R Berger
Department of Neurology, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0284, USA
Drug Saf 33:969-83. 2010..A biologically plausible explanation for the increased risk of PML will be proposed, as well as potential strategies for mitigating disease risk... - A giant MS plaque mimicking PML during natalizumab treatmentCary Twyman
Associates in Neurology, Lexington, KY 40536 0284, USA
J Neurol Sci 291:110-3. 2010..Distinguishing PML from MS may be very difficult in some instances. The frequency with which an aggressive demyelinating disorder due to MS occurs during treatment with natalizumab remains to be determined... - Pearls: neurologic complications of HIV/AIDSJoseph R Berger
Department of Neurology, University of Kentucky College of Medicine, Lexington, Kentucky, USA
Semin Neurol 30:66-70. 2010..Additionally, the complexity of evaluating the HIV-infected person with neurologic disease is increased by the relatively high frequency with which more than one disease concurrently affects the nervous system... - Monoclonal antibodies and progressive multifocal leukoencephalopathyJoseph R Berger
Department of Neurology, University of Kentucky College of Medicine, Lexington, Kentucky, USA
MAbs 1:583-9. 2009..Based on our current understanding of the biology of JC virus and the pathogenesis of PML, we propose an explanation for the increased risk for PML that is observed with natalizumab and certain other monoclonal antibodies... - Progressive multifocal leukoencephalopathy and relapsing-remitting multiple sclerosis: a comparative studyAaron Boster
Department of Neurology, Wayne State University School of Medicine, Detroit, MI 48201, USA
Arch Neurol 66:593-9. 2009..To identify clinical and magnetic resonance imaging (MRI) features that distinguish progressive multifocal leukoencephalopathy (PML) from relapsing-remitting multiple sclerosis (RRMS)... - Opportunistic infections and other risks with newer multiple sclerosis therapiesJoseph R Berger
Department of Neurology, University of Kentucky College of Medicine, Lexington, KY, USA
Ann Neurol 65:367-77. 2009..Determining the actual risk frequency for many of these complications will likely require careful postmarketing surveillance... - Cystinosis of the brain and spinal cord with associated vasculopathyJoseph R Berger
Department of Neurology, The University of Kentucky College of Medicine, Lexington, Kentucky 40536 0284, USA
J Neurol Sci 284:182-5. 2009..As more patients with cystinosis experience long term survival, there will likely be an increased frequency of CNS disease... - Cerebrospinal fluid proteomics and human immunodeficiency virus dementia: preliminary observationsJoseph R Berger
Department of Neurology, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0284, USA
J Neurovirol 11:557-62. 2005..In both serum and CSF samples, differences in protein intensity appeared to correlate with degree of dementia. This preliminary study suggests that protein markers of HIV dementia may be detected by MALDI mass spectrometry... - NatalizumabJoseph R Berger
Department of Neurology, University of Kentucky College of Medicine, Kentucky Clinic, Lexington, Kentucky 40536 0284, USA
Drugs Today (Barc) 42:639-55. 2006..Postmarketing surveillance studies should answer this and other questions related to the use of natalizumab... - AIDS and stroke riskJoseph R Berger
Department of Neurology, University of Kentucky College of Medicine, Lexington, Kentucky, USA
Lancet Neurol 3:206-7. 2004 - Understanding pathogenesis and treatment of HIV dementia: a role for magnetic resonance?Malcolm J Avison
Dept of Neurology, University of Kentucky College of Medicine, Lexington, KY 40536 2184, USA
Trends Neurosci 25:468-73. 2002..This could perhaps explain the variability in HIVD development, progression and response to therapy. These findings also suggest that MRI and MRS can identify patients at risk for HIVD and predict response to therapy... - Volitional opsoclonusPatricio S Espinosa
Department of Neurology, Kentucky Clinic, Lexington, Kentucky 40536-0284, USA
Neurology 65:E11. 2005 - Coxsackie B meningoencephalitis in a patient with acquired immunodeficiency syndrome and a multiple sclerosis-like illnessJoseph R Berger
Department of Neurology, University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA
J Neurovirol 15:282-7. 2009..This is the first case report, to the best of our knowledge, of an enteroviral meningoencephalitis complicating human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS)... - Brachial amyotrophic diplegia in a patient with human immunodeficiency virus infection: widening the spectrum of motor neuron diseases occurring with the human immunodeficiency virusJoseph R Berger
Department of Neurology, University of Kentucky College of Medicine, Lexington, KY 40536 0284, USA
Arch Neurol 62:817-23. 2005..This disorder may represent one end of a spectrum of motor neuron diseases occurring with this retrovirus infection... - Intravascular lymphomatosis presenting with sudden hearing lossJoseph R Berger
Department of Neurology, University of Kentucky College of Medicine, Lexington, KY 40536 0284, USA
J Neurol Sci 232:105-9. 2005..We report a patient in whom sudden hearing loss heralded IVL and propose that the hearing loss may have been the consequence of labyrinthine infarction consequent to the aggregation of malignant cells in the internal auditory artery... - The blood brain barrier in HIV infectionJoseph R Berger
Department of Neurology, University of Kentucky College of Medicine, Kentucky Clinic L 445, Lexington, KY 40536 0284, USA
Front Biosci 9:2680-5. 2004..Additionally, BBB disruption has implications with respect to antiretroviral therapy. This review will address these issues... - Neuroimaging correlates of HIV-associated BBB compromiseMalcolm J Avison
Department of Neurology, University of Kentucky Medical Center, Lexington, KY, USA
J Neuroimmunol 157:140-6. 2004..Additionally, they suggest a salutary effect of HAART on the incidence and severity of HAD, which may, in part, be due to protection of BBB integrity... - Infectious myelopathiesJoseph R Berger
Department of Neurology, University of Kentucky College of Medicine, Lexington 40536, USA
Semin Neurol 22:133-42. 2002..This review addresses the infectious myelopathies by microorganism... - Inflammatory changes and breakdown of microvascular integrity in early human immunodeficiency virus dementiaMalcolm J Avison
Department of Neurology, University of Kentucky Medical Center, Lexington, USA
J Neurovirol 10:223-32. 2004..These results suggest that early CNS inflammation may underlie the microvascular changes observed, and may be a factor in the development of HIV dementia... - Paradoxically aggressive multiple sclerosis in the face of natalizumab therapyJ R Berger
Department of Neurology, University of Kentucky College of Medicine, 740 S Limestone Street, Lexington, KY 40536, USA
Mult Scler 14:708-10. 2008..Neutralizing antibodies to natalizumab were not detected. She subsequently responded to combination therapy of pulsed methylprednisolone and daily glatiramer acetate... - Molecular targets of opiate drug abuse in neuroAIDSK F Hauser
Department of Anatomy and Neurobiology, University of Kentucky Medical Center, Lexington, KY 40536, USA
Neurotox Res 8:63-80. 2005.... - ALS syndrome in patients with HIV-1 infectionAshok Verma
Department of Neurology, Kessenich Family MDA ALS Center, University of Miami Miller School of Medicine, 1150 NW 14 Street, Suite 701, Miami, FL 33136, USA
J Neurol Sci 240:59-64. 2006..During the last 20 years, at least 19 cases of ALS or ALS-like disease have been reported in HIV-1 (HIV) seropositive individuals... - Monofocal acute inflammatory Demyelination (MAID): a unique disorder simulating brain neoplasmJosé A Gutrecht
Department of Neurology, Lahey Clinic Medical Center, Burlington, Mass, USA
South Med J 95:1180-6. 2002..Monofocal acute inflammatory demyelinating (MAID) lesions present as large masses that mimic brain tumors. The natural history and nosologic classification are not well defined... - HIV and the central nervous systemMeriem K Bensalem
Department of Neurology, University of Kentucky College of Medicine, Kentucky Clinic, L-445, Lexington, KY 40536-0284, USA
Compr Ther 28:23-33. 2002..The spectrum of neurological disease is broad. This article highlights the common disorders of the central nervous system associated with HIV/AIDS... - Persistent Coxsackie B encephalitis: Report of a case and review of the literatureJoseph R Berger
Department of Neurology, Internal Medicine, University of Kentucky College of Medicine, Lexington, Kentucky 40536-0284, USA
J Neurovirol 12:511-6. 2006..It also emphasizes the importance of performing brain biopsy on individuals with neurological disease of obscure nature... - Oxidative stress in HIV demented patients and protection ex vivo with novel antioxidantsJ Turchan
Department of Neurology, Pharmaceutical Sciences, University of Kentucky, Lexington, USA
Neurology 60:307-14. 2003..The authors have identified several novel compounds that are capable of blocking the CSF-induced toxicity, the therapeutic potential of which is worthy of further exploration... - Natalizumab and progressive multifocal leucoencephalopathyJ R Berger
Department of Neurology, University of Kentucky College of Medicine, Kentucky Clinic L 445, 740 S Limestone Street, Lexington, KY 40536 0284, USA
Ann Rheum Dis 65:iii48-53. 2006..It is likely that use of drugs which cause specific perturbations of the immune system will be accompanied by similar rare infections. Thus researchers should be on the alert when using such agents in clinical trials... - The HIV Dementia Scale: predictive power in mild dementia and HAARTKara Anne Bottiggi
Graduate Center for Gerontology, College of Public Health, University of Kentucky, KY, USA
J Neurol Sci 260:11-5. 2007..With the advent of highly active antiretroviral therapy (HAART), the use of sensitive and efficient screening tests for HIV-D continue to be needed for identifying individuals who develop this disorder... - Stroke in HIV infection and AIDSMichael R Dobbs
Department of Neurology, University of Kentucky College of Medicine, Lexington, KY, USA
Expert Rev Cardiovasc Ther 7:1263-71. 2009..Selecting the appropriate therapy for treating stroke in the HIV-infected patient is dependent on diagnostic rigor in identifying its underlying etiology... - The neurological complications of bariatric surgeryJoseph R Berger
Department of Neurology, University of Kentucky College of Medicine, Lexington 40536-0284, USA
Arch Neurol 61:1185-9. 2004 - Cervical myelopathy secondary to violent tics of Tourette's syndromeMichael Dobbs
Department of Neurology, University of Kentucky College of Medicine, Lexington, KY 40536-0284, USA
Neurology 60:1862-3. 2003 - Frequency and phenotype of JC virus-specific CD8+ T lymphocytes in the peripheral blood of patients with progressive multifocal leukoencephalopathyMarco A Lima
Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
J Virol 81:3361-8. 2007..Immunotherapies aiming at increasing the cellular immune response against JCV may be valuable in the treatment of HIV+ individuals with PML... - Hereditary hemorrhagic telangectasia and spinal cord infarct: case report with a review of the neurological complications of HHTPatricio S Espinosa
Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
Clin Neurol Neurosurg 110:484-91. 2008..While myelopathy secondary to arteriovenous malformation with HHT has been previously reported, this is the first instance of spinal cord infarction due to paradoxical embolization in this disorder... - The "bedsheet" BabinskiJoseph R Berger
Department of Neurology, University of Kentucky College of Medicine, Kentucky Clinic, Lexington 40536-0284, USA
South Med J 95:1178-9. 2002.... - JCV-specific CD4 T cell response: another piece of the puzzle in explaining some aspects of AIDS associated PMLJoseph R Berger
AIDS 17:1557-9. 2003 - Progressive multifocal leukoencephalopathy and natalizumab--unforeseen consequencesJoseph R Berger
N Engl J Med 353:414-6. 2005 - A placebo-controlled study of memantine for the treatment of human immunodeficiency virus-associated sensory neuropathyGiovanni Schifitto
University of Rochester, Rochester, New York 14620, USA
J Neurovirol 12:328-31. 2006..Results were similar to those of other pilot studies of memantine for neuropathic pain unrelated to HIV, suggesting that memantine is ineffective for the symptomatic treatment of HIV-associated SDSP... - Reply to "'Thinking without thinking' about natalizumab and PML"Sidney Houff
J Neurol Sci 264:198-9; author reply 199. 2008 - Parinaud syndrome heralding MSWilliam B Lee
University of California, Davis Medical Center, 4860 Y Street, Suite 2400, Sacramento, CA 95817, USA
Neurology 60:322. 2003 - Identification of potential antibody markers in HIV-associated dementiaSteven E Schutzer
Department of Medicine, UMDNJ New Jersey Medical School, 185 South Orange Ave, Newark, NJ 07103, USA
J Neuroimmunol 157:120-5. 2004..All 11 non-HIV-1 controls were negative. These and published data suggest antibrain antibodies and IC may serve as markers of HAD... - Proceedings of the 10th International Conference on Neuroscience of HIV Infection: emerging issuesHans Jürgen von Giesen
Neurologische Klinik der Heinrich Heine Universität Düsseldorf, Dusseldorf, Germany
J Neurovirol 8:3-7. 2002..Viral opportunistic infections (e.g., JCV infection resulting in progressive multifocal leukoencephalopathy) as well as coinfection with hepatitis C represented a further topic... - Mass lesions of the brain in AIDS: the dilemmas of distinguishing toxoplasmosis from primary CNS lymphomaJoseph R Berger
AJNR Am J Neuroradiol 24:554-5. 2003 - Autoimmune markers in HIV-associated dementiaSteven E Schutzer
Department of Medicine, UMDNJ New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
J Neuroimmunol 138:156-61. 2003..Reactivity against control tissue was negative. Though the etiopathogenetic relation of these antibrain antibodies remains to be delineated, the data suggest that they may be a marker of HAD... - An international screening tool for HIV dementiaJoseph R Berger
AIDS 19:2165-6. 2005