F G Berger

Summary

Affiliation: University of South Carolina
Country: USA

Publications

  1. ncbi request reprint The interleukin-6 gene: a susceptibility factor that may contribute to racial and ethnic disparities in breast cancer mortality
    Franklin G Berger
    Department of Biological Sciences, Coker Life Sciences Building, University of South Carolina, Columbia, SC, 29208, USA
    Breast Cancer Res Treat 88:281-5. 2004
  2. ncbi request reprint Polyamine metabolism and tumorigenesis in the Apc(Min/+) mouse
    F G Berger
    Department of Biological Sciences and Center for Colon Cancer Research, University of South Carolina, Columbia, SC 29208, USA
    Biochem Soc Trans 35:336-9. 2007
  3. ncbi request reprint Evolution of a mammalian promoter through changes in patterns of transcription factor binding
    N Singh
    Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA
    J Mol Evol 46:639-48. 1998
  4. ncbi request reprint Functional effects of amino acid substitutions at residue 33 of human thymidylate synthase
    R T Reilly
    Department of Biological Sciences, University of South Carolina, Columbia 29208, USA
    Arch Biochem Biophys 342:338-43. 1997
  5. ncbi request reprint Biphasic binding of 5-fluoro-2'-deoxyuridylate to human thymidylate synthase
    R T Reilly
    Department of Chemistry and Biochemistry, School of Medicine, University of South Carolina, Columbia 29208, USA
    Mol Pharmacol 48:72-9. 1995
  6. ncbi request reprint Mechanisms of acquired resistance to thymidylate synthase inhibitors: the role of enzyme stability
    M E Kitchens
    Department of Biological Sciences, University of South Carolina, Columbia 29208, USA
    Mol Pharmacol 56:1063-70. 1999
  7. ncbi request reprint Evolution of transcriptional regulatory elements within the promoter of a mammalian gene
    N Singh
    Department of Biological Sciences, University of South Carolina, Columbia 29208, USA
    Mol Biol Evol 15:312-25. 1998
  8. ncbi request reprint Haptoglobin, inflammation, and tumorigenesis in the MIN mouse
    K W Barbour
    Department of Biological Sciences, University of South Carolina, Columbia 29208, USA
    Redox Rep 6:366-8. 2001
  9. ncbi request reprint Thymidylate synthase as a chemotherapeutic drug target: where are we after fifty years?
    Franklin G Berger
    Department of Biological Sciences, University of South Carolina, Columbia, South Carolina 29208, USA
    Cancer Biol Ther 5:1238-41. 2006
  10. doi request reprint Effect of exercise on biological pathways in ApcMin/+ mouse intestinal polyps
    Kristen A Baltgalvis
    Univ of South Carolina, Dept of Exercise Science, Rm 405A Public Health Research Bldg, 921 Assembly St, Columbia, SC 29208, USA
    J Appl Physiol (1985) 104:1137-43. 2008

Collaborators

Detail Information

Publications43

  1. ncbi request reprint The interleukin-6 gene: a susceptibility factor that may contribute to racial and ethnic disparities in breast cancer mortality
    Franklin G Berger
    Department of Biological Sciences, Coker Life Sciences Building, University of South Carolina, Columbia, SC, 29208, USA
    Breast Cancer Res Treat 88:281-5. 2004
    ..In all, these observations argue for additional studies of the IL-6 gene polymorphism as a predisposing genetic factor that contributes to racial and ethnic differences in breast cancer prognosis...
  2. ncbi request reprint Polyamine metabolism and tumorigenesis in the Apc(Min/+) mouse
    F G Berger
    Department of Biological Sciences and Center for Colon Cancer Research, University of South Carolina, Columbia, SC 29208, USA
    Biochem Soc Trans 35:336-9. 2007
    ..e. the metabolome), is critical to tumour development. The metabolic flux model represents a novel way of thinking about the role of polyamines in cell physiology and the neoplastic process...
  3. ncbi request reprint Evolution of a mammalian promoter through changes in patterns of transcription factor binding
    N Singh
    Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA
    J Mol Evol 46:639-48. 1998
    ..The results are discussed in terms of a model involving a dynamic equilibrium between states of binding site occupancy, the nature of which can be modified during evolution...
  4. ncbi request reprint Functional effects of amino acid substitutions at residue 33 of human thymidylate synthase
    R T Reilly
    Department of Biological Sciences, University of South Carolina, Columbia 29208, USA
    Arch Biochem Biophys 342:338-43. 1997
    ..Analysis of a number of other amino acid substitutions at residue 33 indicated that maximal enzyme accumulation and function requires a bulky, hydrophobic side chain at this site...
  5. ncbi request reprint Biphasic binding of 5-fluoro-2'-deoxyuridylate to human thymidylate synthase
    R T Reilly
    Department of Chemistry and Biochemistry, School of Medicine, University of South Carolina, Columbia 29208, USA
    Mol Pharmacol 48:72-9. 1995
    ....
  6. ncbi request reprint Mechanisms of acquired resistance to thymidylate synthase inhibitors: the role of enzyme stability
    M E Kitchens
    Department of Biological Sciences, University of South Carolina, Columbia 29208, USA
    Mol Pharmacol 56:1063-70. 1999
    ..The results indicate that changes in the stability of the TS polypeptide accompany, and even contribute to, acquired resistance to TS inhibitors in colon tumor cells...
  7. ncbi request reprint Evolution of transcriptional regulatory elements within the promoter of a mammalian gene
    N Singh
    Department of Biological Sciences, University of South Carolina, Columbia 29208, USA
    Mol Biol Evol 15:312-25. 1998
    ....
  8. ncbi request reprint Haptoglobin, inflammation, and tumorigenesis in the MIN mouse
    K W Barbour
    Department of Biological Sciences, University of South Carolina, Columbia 29208, USA
    Redox Rep 6:366-8. 2001
    ..The MIN mouse is, therefore, a useful model for studying the roles of HP and inflammation in tumorigenesis in vivo...
  9. ncbi request reprint Thymidylate synthase as a chemotherapeutic drug target: where are we after fifty years?
    Franklin G Berger
    Department of Biological Sciences, University of South Carolina, Columbia, South Carolina 29208, USA
    Cancer Biol Ther 5:1238-41. 2006
  10. doi request reprint Effect of exercise on biological pathways in ApcMin/+ mouse intestinal polyps
    Kristen A Baltgalvis
    Univ of South Carolina, Dept of Exercise Science, Rm 405A Public Health Research Bldg, 921 Assembly St, Columbia, SC 29208, USA
    J Appl Physiol (1985) 104:1137-43. 2008
    ..3-fold in polyps from exercised mice. Moderate-intensity exercise training alters cellular pathways in Apc(Min/+) mouse polyps, and these changes may be related to the exercise-induced reduction in polyp formation and growth...
  11. ncbi request reprint Effects of ligand binding and conformational switching on intracellular stability of human thymidylate synthase
    Sondra H Berger
    Center for Colon Cancer Research, University of South Carolina, Columbia, SC 29208, USA
    Biochim Biophys Acta 1696:15-22. 2004
    ....
  12. ncbi request reprint Cell death in response to antimetabolites directed at thymidylate synthase
    Karen W Barbour
    Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA
    Cancer Chemother Pharmacol 61:189-201. 2008
    ..In the present study, we have examined the mode of cell death induced by several TS inhibitors...
  13. ncbi request reprint Structural determinants for the intracellular degradation of human thymidylate synthase
    Antonia M Forsthoefel
    Department of Biological Sciences, University of South Carolina, Columbia, South Carolina 29208, USA
    Biochemistry 43:1972-9. 2004
    ..Finally, we show that TS turnover is carried out by the 26S proteasome in a ubiquitin-independent manner. These findings provide the basis for a mechanistic understanding of TS degradation and its regulation by antimetabolites...
  14. ncbi request reprint Androgen regulation of gene expression in primary epithelial cells of the mouse kidney
    F K Asadi
    Department of Biological Sciences, University of South Carolina, Columbia 29208
    Endocrinology 134:1179-87. 1994
    ....
  15. ncbi request reprint Domains within the mammalian ornithine decarboxylase messenger RNA have evolved independently and episodically
    G J Johannes
    Department of Biological Sciences, University of South Carolina, Columbia 29208
    J Mol Evol 36:555-67. 1993
    ..We suggest that the episodic pattern of ODC mRNA evolution may indicate the existence of selection pressures that were exerted in a time- and domain-specific manner during mammalian speciation...
  16. ncbi request reprint Response to 5-fluorouracil chemotherapy is modified by dietary folic acid deficiency in Apc(Min/+) mice
    Jody M Tucker
    Department of Biological Sciences, University of South Carolina, 700 Sumter Street, Columbia, SC 29208 0001, USA
    Cancer Lett 187:153-62. 2002
    ..Our data indicate that a dietary folic acid deficiency, in promoting tumor regression and inhibiting tumor recovery, may enhance the therapeutic effects of 5-FU...
  17. pmc Replacement of Val3 in human thymidylate synthase affects its kinetic properties and intracellular stability
    Xiao Huang
    Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, USA
    Biochemistry 49:2475-82. 2010
    ..Each of the mechanisms leading to the high K(m,app) values can be exploited to facilitate design of compounds acting as allosteric inhibitors of hTS...
  18. doi request reprint Functional dissection of the N-terminal degron of human thymidylate synthase
    Sandra P Melo
    Department of Biological Sciences, Center for Colon Cancer Research, University of South Carolina, Columbia, 29208, USA
    Biochem J 432:217-26. 2010
    ....
  19. ncbi request reprint Decreased intestinal polyp multiplicity is related to exercise mode and gender in ApcMin/+ mice
    Kristen A Mehl
    Dept of Exercise Science, University of South Carolina, 1300 Wheat Street, Columbia, SC 29208, USA
    J Appl Physiol (1985) 98:2219-25. 2005
    ..Physical activity-induced attenuation of intestinal polyp number and size is dependent on exercise mode and differs between genders. The modulation of systemic and intestinal inflammation may also depend on exercise mode...
  20. ncbi request reprint Interleukin-6 and cachexia in ApcMin/+ mice
    Kristen A Baltgalvis
    Department of Exercise Science, University of South Carolina, Public Health Research Center, 921 Assembly Street, Columbia, SC 29208, USA
    Am J Physiol Regul Integr Comp Physiol 294:R393-401. 2008
    ..These data demonstrate that IL-6 is necessary for the onset of adipose and skeletal muscle wasting in the Apc(Min/+) mouse and that circulating IL-6 can regulate Apc(Min/+) mouse tumor burden...
  21. pmc CD49f and CD61 identify Her2/neu-induced mammary tumor-initiating cells that are potentially derived from luminal progenitors and maintained by the integrin-TGFβ signaling
    P K Lo
    Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA
    Oncogene 31:2614-26. 2012
    ....
  22. ncbi request reprint Drug-resistant variants of Escherichia coli thymidylate synthase: effects of substitutions at Pro-254
    C Fantz
    Department of Chemistry, Columbia, South Carolina, USA
    Mol Pharmacol 57:359-66. 2000
    ..When compared with wild-type TS, the structure shows local conformational changes affecting mostly Asp-253; its carbonyl is rotated approximately 40 degrees, and the side chain forms an ion pair with Arg-225...
  23. ncbi request reprint Assignment of a gene encoding ornithine decarboxylase to the proximal region of chromosome 12 in the mouse
    F G Berger
    Department of Biological Sciences, University of South Carolina, Columbia 29208
    Biochem Genet 27:745-53. 1989
    ..Linkage of Odc to Apob and Ah is conserved in the mouse and human genomes...
  24. ncbi request reprint Potent modulation of intestinal tumorigenesis in Apcmin/+ mice by the polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase
    Jody M Tucker
    Department of Biological Sciences, University of South Carolina, Columbia, South Carolina, USA
    Cancer Res 65:5390-8. 2005
    ..The finding that deletion of SSAT reduces tumorigenesis suggests that small-molecule inhibition of the enzyme may represent a nontoxic prevention and/or treatment strategy for gastrointestinal cancers...
  25. pmc Developmental abnormalities in multiple proliferative tissues of Apc(Min/+) mice
    Shaojin You
    Center for Colon Cancer Research, Dorn Research Institute, WJB Dorn Veterans Affairs Medical Center 151, Columbia, SC 29209, USA
    Int J Exp Pathol 87:227-36. 2006
    ....
  26. pmc The interaction of a high-fat diet and regular moderate intensity exercise on intestinal polyp development in Apc Min/+ mice
    Kristen A Baltgalvis
    Department of Exercise Science, University of South Carolina, 921 Assembly Street, Columbia, SC 29208, USA
    Cancer Prev Res (Phila) 2:641-9. 2009
    ..These data suggest that the induction of adiposity, inflammation, and immunosuppression by the Western-style diet may compromise the beneficial effect of moderate-intensity exercise on the intestinal polyp burden in Apc(Min/+) mice...
  27. ncbi request reprint Beta-catenin induces beta-TrCP-mediated PER2 degradation altering circadian clock gene expression in intestinal mucosa of ApcMin/+ mice
    Xiaoming Yang
    Medical Chronobiology Laboratory, Dorn Research Institute, WJB Dorn Veterans Affairs Medical Center, University of South Carolina, Columbia, SC, USA
    J Biochem 145:289-97. 2009
    ..These findings suggest that disruption of the peripheral intestinal circadian clock may be intimately involved in beta-catenin induced intestinal epithelial neoplastic transformation in both mouse and man...
  28. ncbi request reprint Alterations in mRNA translation as a mechanism for the modification of enzyme synthesis during evolution. The ornithine decarboxylase model
    G Johannes
    Department of Biological Sciences, University of South Carolina, Columbia 29208
    J Biol Chem 267:10108-15. 1992
    ..We conclude that during evolution, modifications that alter the biosynthesis of specific proteins can occur at the translational level; these modifications exert their effects on translation in a transcript- and tissue-specific manner...
  29. pmc The intrinsically disordered N-terminal domain of thymidylate synthase targets the enzyme to the ubiquitin-independent proteasomal degradation pathway
    Maria Marjorette O Pena
    Department of Biological Sciences, University of South Carolina, Columbia, South Carolina 29208, USA
    J Biol Chem 284:31597-607. 2009
    ..The implications of these findings to the proteasome-targeting function of the N-terminal domain, particularly with regard to its intrinsic flexibility, are discussed...
  30. pmc Muscle wasting and interleukin-6-induced atrogin-I expression in the cachectic Apc ( Min/+ ) mouse
    Kristen A Baltgalvis
    Exercise Science Department, University of South Carolina, Columbia, USA
    Pflugers Arch 457:989-1001. 2009
    ..These data suggest that high circulating IL-6 levels induce type IIB fiber CSA loss in Apc ( Min/+ ) mice, and circulating IL-6 is sufficient to regulate Atrogin-I gene expression in cachectic mice...
  31. ncbi request reprint Myofiber degeneration/regeneration is induced in the cachectic ApcMin/+ mouse
    Kristen A Mehl
    Division of Applied Physiology, Dept of Exercise Science, University of South Carolina, Columbia, SC 29208, USA
    J Appl Physiol 99:2379-87. 2005
    ..These data demonstrate that the Apc(Min/+) mouse becomes cachectic by 6 mo of age and that skeletal muscle degeneration and regeneration may be related to the muscle loss...
  32. pmc Role of N-terminal residues in the ubiquitin-independent degradation of human thymidylate synthase
    Maria Marjorette O Pena
    Department of Biological Sciences, University of South Carolina, 715 Sumter Street, Columbia, SC 29208, USA
    Biochem J 394:355-63. 2006
    ..The implications of these findings for the control of TS expression, and for the regulation of protein degradation in general, are discussed...
  33. pmc Oncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathway
    Xinna Zhang
    Department of Biological Sciences and Center for Colon Cancer Research, University of South Carolina, Columbia, SC 29208, USA
    Cancer Res 70:7176-86. 2010
    ..Together, our results suggest an important role of miR-16 in the regulation of Wip1 phosphatase in the DNA damage response and mammary tumorigenesis...
  34. ncbi request reprint Raltitrexed increases tumorigenesis as a single agent yet exhibits anti-tumor synergy with 5-fluorouracil in ApcMin/+ mice
    John T Murphy
    Department of Biological Sciences and the Center for Colon Cancer Research, University of South Carolina, Columbia, South Carolina 29208, USA
    Cancer Biol Ther 3:1169-76. 2004
    ..This is the first illustration of in vivo synergy of RTX and FUra in a genetically predisposed animal model. Possible mechanisms underlying the current observations are discussed...
  35. ncbi request reprint The murine alpha(1)-proteinase inhibitor gene family: polymorphism, chromosomal location, and structure
    Karen W Barbour
    Department of Biological Sciences, University of South Carolina, Columbia, South Carolina, 29208, USA
    Genomics 80:515-22. 2002
    ..Finally, we present the complete sequence of an 84-kb region of Serpina1 containing a tandem repeat of two alpha(1)-PI genes...
  36. ncbi request reprint Functional diversification during evolution of the murine alpha(1)-proteinase inhibitor family: role of the hypervariable reactive center loop
    Karen W Barbour
    Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA
    Mol Biol Evol 19:718-27. 2002
    ..The possible physiological benefits of alpha(1)-PI diversity are discussed...
  37. ncbi request reprint Enhanced splenomegaly and severe liver inflammation in haptoglobin/hemopexin double-null mice after acute hemolysis
    Emanuela Tolosano
    Department of Genetics, Biology and Biochemistry, University of Turin and the San Giovanni Battista Hospital, Turin, Italy
    Blood 100:4201-8. 2002
    ..These data demonstrate that haptoglobin and hemopexin together are essential for protection from splenomegaly and liver fibrosis resulting from intravascular hemolysis...
  38. doi request reprint Tissue-specific shRNA delivery: a novel approach for gene therapy in cancer
    Shilenath Ghatak
    Department of Cell Biology and Anatomy, MUSC, Charleston, South Carolina 29425, USA
    Connect Tissue Res 49:265-9. 2008
    ..This system has strong potential in cancer therapy...
  39. pmc Hyaluronan constitutively regulates activation of COX-2-mediated cell survival activity in intestinal epithelial and colon carcinoma cells
    Suniti Misra
    Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, SC 29425, USA
    J Biol Chem 283:14335-44. 2008
    ..Defining hyaluronan-dependent cyclooxygenase-2/prostaglandin E(2)-associated signaling pathways will provide a platform for developing novel therapeutic approaches for colon cancer...
  40. ncbi request reprint Haptoglobin genotype determines myocardial infarct size in diabetic mice
    Shany Blum
    Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    J Am Coll Cardiol 49:82-7. 2007
    ..We sought to understand the importance of oxidative stress in explaining why the haptoglobin (Hp) genotype determines myocardial infarction (MI) size in diabetes mellitus (DM)...
  41. ncbi request reprint Increased renal hypertrophy in diabetic mice genetically modified at the haptoglobin locus
    Rachel Miller-Lotan
    Technion Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Diabetes Metab Res Rev 21:332-7. 2005
    ..These studies have presented a compelling argument that diabetic individuals homozygous for the Hp 1 allele are at decreased risk of vascular complications as compared to diabetic individuals with the Hp 2 allele...
  42. ncbi request reprint Alpha(1)-acid glycoprotein: an acute phase protein with inflammatory and immunomodulating properties
    Tino Hochepied
    Department for Molecular Biomedical Research, Flanders Interuniversity Institute for Biotechnology, Ghent University, KL Ledeganckstraat 35, Belgium
    Cytokine Growth Factor Rev 14:25-34. 2003
    ..In vivo, AGP clearly has protective effects in several models of inflammation. Here we review the data supporting an anti-inflammatory and immunomodulating role of AGP...
  43. doi request reprint Expression of cyclic guanosine monophosphate-dependent protein kinase in metastatic colon carcinoma cells blocks tumor angiogenesis
    In Kiu Kwon
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia 30912, USA
    Cancer 112:1462-70. 2008
    ..Type 1 cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG) reportedly has exhibited antitumor properties, and its expression is down-regulated in many tumors...