Leslie J Berg
Affiliation: University of Massachusetts Medical School
Andreotti A, Joseph R, Conley J, Iwasa J, Berg L. Multidomain Control Over TEC Kinase Activation State Tunes the T Cell Response. Annu Rev Immunol. 2018;36:549-578 pubmed publisher
..This multidomain control over kinase activation state provides a structural mechanism to account for ITK's ability to tune the TCR signal. ..
Cho H, Reboldi A, Hall J, Berg L. The Tec kinase ITK is essential for ILC2 survival and epithelial integrity in the intestine. Nat Commun. 2019;10:784 pubmed publisher
..Reduced Bcl-2 expression in intestinal Itk-/- ILC2 is also restored to WT levels after IL-2 complex treatment, indicating a tissue-specific role for ITK in ILC2 survival in the intestine. ..
Berg L. Strength of T cell receptor signaling strikes again. Immunity. 2009;31:529-31 pubmed publisher
..2009) demonstrate that signaling via the Itk kinase, a component of the T cell receptor signaling pathway, is required for interleukin-17A but not interleukin-17F expression in T helper 17 cells. ..
Nayar R, Schutten E, Bautista B, Daniels K, Prince A, Enos M, et al
. Graded levels of IRF4 regulate CD8+ T cell differentiation and expansion, but not attrition, in response to acute virus infection. J Immunol. 2014;192:5881-93 pubmed publisher
..These data indicate that IRF4 is a key component that translates the strength of TCR signaling into a graded response of virus-specific CD8(+) T cells. ..
Prince A, Watkin L, Yin C, Selin L, Kang J, Schwartzberg P, et al
. Innate PLZF+CD4+ ?? T cells develop and expand in the absence of Itk. J Immunol. 2014;193:673-87 pubmed publisher
..These data support the conclusion that itk(-/-) innate PLZF(+)CD4(+) T cells are a novel subset of innate T cells. ..
Cho H, Shin H, Haberstock Debic H, Xing Y, Owens T, Funk J, et al
. A Small Molecule Inhibitor of ITK and RLK Impairs Th1 Differentiation and Prevents Colitis Disease Progression. J Immunol. 2015;195:4822-31 pubmed publisher
..Taken together, these data indicate that ITK plus RLK inhibition may have therapeutic potential in Th1-mediated inflammatory diseases. ..