Leslie BergSummaryAffiliation: University of Massachusetts Medical School Country: USA Publications
Research Grants
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Publications
Itk phosphorylation sites are required for functional activity in primary T cellsHeather M Wilcox
Division of Medical Sciences, Harvard University, Cambridge, Massachusetts, USA
J Biol Chem 278:37112-21. 2003..These data provide new insights into the complex regulation of Itk in primary T cells...- Signalling through TEC kinases regulates conventional versus innate CD8(+) T-cell developmentLeslie J Berg
Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655, USA
Nat Rev Immunol 7:479-85. 2007..These findings lead to the hypothesis that altered TCR signalling, together with distinct co-stimulatory signals, is the basis for the development of non-conventional T-cell lineages... - Strength of T cell receptor signaling strikes againLeslie J Berg
University of Massachusetts Medical School, Worcester, MA 01655, USA
Immunity 31:529-31. 2009..2009) demonstrate that signaling via the Itk kinase, a component of the T cell receptor signaling pathway, is required for interleukin-17A but not interleukin-17F expression in T helper 17 cells... - Tec family kinases in T lymphocyte development and functionLeslie J Berg
Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
Annu Rev Immunol 23:549-600. 2005..Although they quantitatively reduce proximal signaling, mutations that eliminate Tec family kinases in T cells nonetheless qualitatively alter T cell development and differentiation... - The Tec family tyrosine kinases Itk and Rlk regulate the development of conventional CD8+ T cellsLuana O Atherly
Department of Pathology, University of Massachusetts Medical School, Worcester, 01655, USA
Immunity 25:79-91. 2006..These data indicate a critical role for Itk and Rlk in conventional CD8(+) T cell development in the thymus... - Tec kinases in T cell and mast cell signalingMartin Felices
Department of Pathology, University of Massachusetts Medical School, Massachusetts, USA
Adv Immunol 93:145-84. 2007..The known functions of Tec kinases in T cell and mast cell signaling will then be described, with a particular focus on T cell receptor and mast cell Fc epsilon RI signaling pathways... - IFN-alpha beta and self-MHC divert CD8 T cells into a distinct differentiation pathway characterized by rapid acquisition of effector functionsHeather D Marshall
Department of Pathology, Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA
J Immunol 185:1419-28. 2010.... - Janus-kinase-3-dependent signals induce chromatin remodeling at the Ifng locus during T helper 1 cell differentiationMin Shi
Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
Immunity 28:763-73. 2008..These data indicate that Jak3 regulates epigenetic modification and chromatin remodeling of the Ifng locus during Th1 cell differentiation... - The Tec kinases Itk and Rlk regulate conventional versus innate T-cell developmentAmanda L Prince
Department of Pathology, University of Massachussets Medical School, Worcester, MA 01655, USA
Immunol Rev 228:115-31. 2009..Here we discuss these two signaling pathways that each contribute to conventional versus innate T-cell lineage commitment... - Tec kinase Itk in gammadeltaT cells is pivotal for controlling IgE production in vivoMartin Felices
Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
Proc Natl Acad Sci U S A 106:8308-13. 2009..Together, these data indicate that Itk signaling regulates gammadelta T cell lineage development and effector function and is required to control IgE production in vivo... - Cutting edge: an alternative pathway of CD4+ T cell differentiation is induced following activation in the absence of gamma-chain-dependent cytokine signalsShane R Mayack
Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
J Immunol 176:2059-63. 2006..We conclude that Jak3 is a critical component of signaling pathways that regulate T cell differentiation into effector vs regulatory lineages... - Tec kinases Itk and Rlk are required for CD8+ T cell responses to virus infection independent of their role in CD4+ T cell helpLuana O Atherly
Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
J Immunol 176:1571-81. 2006..These defects cannot be rescued by providing virus-specific CD4(+) T cell help, thereby substantiating the important role of Tec kinases in CD8(+) T cell signaling... - Itk is not essential for CD28 signaling in naive T cellsCheng Rui Li
Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
J Immunol 174:4475-9. 2005..These findings indicate that Itk is not essential for CD28 signaling in primary naive CD4+ T cells... - New insights into the regulation and functions of Tec family tyrosine kinases in the immune systemAndrew T Miller
Department of Pathology and Program in Immunology and Virology, University of Massachusetts Medical Center, Worcester, MA 01655, USA
Curr Opin Immunol 14:331-40. 2002..Genetic studies of kinase-knockout mice have emphasized the importance of Tec kinases in lymphocyte development, differentiation and apoptosis... - Signaling through Itk promotes T helper 2 differentiation via negative regulation of T-betAndrew T Miller
Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester 01655, USA
Immunity 21:67-80. 2004..Together, these findings provide a molecular explanation for the essential role of Itk in Th2 differentiation... - The absence of Itk inhibits positive selection without changing lineage commitmentJulie A Lucas
Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
J Immunol 168:6142-51. 2002.... - The role of Tec family kinases in T cell development and functionJulie A Lucas
University of Massachussets Medical School Department of Pathology, Worcester, MA 01655, USA
Immunol Rev 191:119-38. 2003.... - Cell cycle progression following naive T cell activation is independent of Jak3/common gamma-chain cytokine signalsMin Shi
Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
J Immunol 183:4493-501. 2009..Because CD28 signaling has been found to be dispensable for autoreactive T cell responses, these data suggest the potential for interfering with autoimmune T cell responses by inhibition of Jak3 signaling... - Defective Fas ligand expression and activation-induced cell death in the absence of IL-2-inducible T cell kinaseAndrew T Miller
Department of Pathology, Program in Immunology and Virology, University of Massachusetts Medical Center, 55 Lake Avenue North, Worcester, MA 01655, USA
J Immunol 168:2163-72. 2002..Together these studies define an important role for Itk in TCR signaling, leading to cytokine gene expression and activation-induced cell death... - The Tec kinases Itk and Rlk regulate NKT cell maturation, cytokine production, and survivalMartin Felices
Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
J Immunol 180:3007-18. 2008..These data indicate that the Tec kinases Itk and Rlk provide important signals for terminal maturation, efficient cytokine production, and peripheral survival of NKT cells... - Itk and Th2 responses: action but no reactionYoko Kosaka
Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
Trends Immunol 27:453-60. 2006..In this review, we discuss the pathways by which Itk might impact the differentiation of Th cells... - Signals that regulate lymphocyte development and differentiationLeslie J Berg
Curr Opin Immunol 16:163-6. 2004
Research Grants
- Immunobiology of Jak3 Deficient MiceLeslie Berg; Fiscal Year: 2007..Finally, we will determine the role of Stat5 as a downstream mediator of Jak-3 dependent cytokine signals in regulating effector T cell versus regulatory T cell differentiation pathways. ..
- Tec Kinases ltk and RlK in Mast Cell SignalingLeslie Berg; Fiscal Year: 2007..The overall goal of these studies is to further our understanding of signaling pathways that may contribute to the development of allergic diseases, and to suggest mechanisms for the manipulation and/or prevention of allergic responses. ..
- Response to viral infection in immunodeficient miceLeslie Berg; Fiscal Year: 2007..These studies will provide important information for future efforts to modulate T cell immune responses in vivo by manipulating distinct T cell signaling pathways. ..
- Tec family tyrosine kinases in T cell signalingLeslie Berg; Fiscal Year: 2009..These studies will provide important information for future efforts to modulate Th1 vs. Th2 effector responses in vivo by manipulating distinct T cell signaling molecules and pathways. ..
- Tec Kinases ltk and RlK in Mast Cell SignalingLeslie Berg; Fiscal Year: 2009..abstract_text> ..
- Immunobiology of Jak3 Deficient MiceLeslie J Berg; Fiscal Year: 2010..Finally, we will determine the role of StatS as a downstream mediator of Jak-3 dependent cytokine signals in regulating effector T cell versus regulatory T cell differentiation pathways. ..
- IMMUNOBIOLOGY OF JAK3-DEFICIENT MICELeslie Berg; Fiscal Year: 2004..abstract_text> ..
- FASEB Summer Research Conference: Lymphocytes/AntibodiesLeslie Berg; Fiscal Year: 2002..Anatomy of Immune Responses in Vivo, Leo Lefrancois, Discussion Leader 5. Lymphocyte Activation and Signaling, Leslie Berg, Discussion Leader 6. Immune Responses to Pathogens, Rafi Ahmed, Discussion Leader 7...
- T CELL DEVELOPMENT AND THE TYROSINE KINASE, ITK/TSKLeslie Berg; Fiscal Year: 2003....
- THYMIC SELECTION AND T CELL LINEAGE COMMITMENTLeslie Berg; Fiscal Year: 2003..This information could enhance our understanding of T cell recognition and the establishment of self-tolerance. ..
- Regulation of conventional versus innate CD8+ T cell developmentLeslie J Berg; Fiscal Year: 2010..This understanding will aid in efforts to regulate and control the immune system to fight infections and eradicate cancer cells. ..