K A Berg

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. pmc Allosteric interactions between δ and κ opioid receptors in peripheral sensory neurons
    Kelly A Berg
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Mol Pharmacol 81:264-72. 2012
  2. pmc Regulation of κ-opioid receptor signaling in peripheral sensory neurons in vitro and in vivo
    Kelly A Berg
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Pharmacol Exp Ther 338:92-9. 2011
  3. ncbi request reprint A conservative, single-amino acid substitution in the second cytoplasmic domain of the human Serotonin2C receptor alters both ligand-dependent and -independent receptor signaling
    Kelly A Berg
    Department of Pharmacology 7764, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    J Pharmacol Exp Ther 324:1084-92. 2008
  4. ncbi request reprint Differential effects of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxyl]-5-pyridyl]carbamoyl]-6-trifluoromethylindone (SB 243213) on 5-hydroxytryptamine(2C) receptor-mediated responses
    Kelly A Berg
    Department of Pharmacology, University of Texas Health Science Center, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
    J Pharmacol Exp Ther 319:260-8. 2006
  5. ncbi request reprint 5-hydroxytryptamine2C receptor activation inhibits 5-hydroxytryptamine1B-like receptor function via arachidonic acid metabolism
    K A Berg
    Department of Pharmacology, University of Texas Health Science Center at San Antonio 78284 7764, USA
    Mol Pharmacol 50:1017-23. 1996
  6. ncbi request reprint Temporal regulation of agonist efficacy at 5-hydroxytryptamine (5-HT)1A and 5-HT 1B receptors
    Kelly A Berg
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Pharmacol Exp Ther 304:200-5. 2003
  7. ncbi request reprint Regulation of 5-HT(1A) and 5-HT(1B) receptor systems by phospholipid signaling cascades
    K A Berg
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Brain Res Bull 56:471-7. 2001
  8. ncbi request reprint Differences in rapid desensitization of 5-hydroxytryptamine2A and 5-hydroxytryptamine2C receptor-mediated phospholipase C activation
    K A Berg
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Pharmacol Exp Ther 299:593-602. 2001
  9. ncbi request reprint Interactions between effectors linked to serotonin receptors
    K A Berg
    Department of Pharmacology, University of Texas Health Science Center, San Antonio 78284 7764, USA
    Ann N Y Acad Sci 861:111-20. 1998
  10. pmc RNA-editing of the 5-HT(2C) receptor alters agonist-receptor-effector coupling specificity
    K A Berg
    Department of Pharmacology, Mail Code 7764, University of Texas Health Science Center, San Antonio, Texas, TX 78229 3900, USA
    Br J Pharmacol 134:386-92. 2001

Collaborators

Detail Information

Publications28

  1. pmc Allosteric interactions between δ and κ opioid receptors in peripheral sensory neurons
    Kelly A Berg
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Mol Pharmacol 81:264-72. 2012
    ....
  2. pmc Regulation of κ-opioid receptor signaling in peripheral sensory neurons in vitro and in vivo
    Kelly A Berg
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Pharmacol Exp Ther 338:92-9. 2011
    ..Understanding the mechanisms by which peripheral KOR agonist efficacy is regulated may lead to improved pharmacotherapy for the treatment of pain with reduced adverse effects...
  3. ncbi request reprint A conservative, single-amino acid substitution in the second cytoplasmic domain of the human Serotonin2C receptor alters both ligand-dependent and -independent receptor signaling
    Kelly A Berg
    Department of Pharmacology 7764, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    J Pharmacol Exp Ther 324:1084-92. 2008
    ....
  4. ncbi request reprint Differential effects of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxyl]-5-pyridyl]carbamoyl]-6-trifluoromethylindone (SB 243213) on 5-hydroxytryptamine(2C) receptor-mediated responses
    Kelly A Berg
    Department of Pharmacology, University of Texas Health Science Center, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
    J Pharmacol Exp Ther 319:260-8. 2006
    ....
  5. ncbi request reprint 5-hydroxytryptamine2C receptor activation inhibits 5-hydroxytryptamine1B-like receptor function via arachidonic acid metabolism
    K A Berg
    Department of Pharmacology, University of Texas Health Science Center at San Antonio 78284 7764, USA
    Mol Pharmacol 50:1017-23. 1996
    ....
  6. ncbi request reprint Temporal regulation of agonist efficacy at 5-hydroxytryptamine (5-HT)1A and 5-HT 1B receptors
    Kelly A Berg
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Pharmacol Exp Ther 304:200-5. 2003
    ..Moreover, this work underscores the importance of time as a variable in receptor signaling cross talk and serves to further illustrate differences between the 5-HT 1A and 5-HT 1B receptor systems...
  7. ncbi request reprint Regulation of 5-HT(1A) and 5-HT(1B) receptor systems by phospholipid signaling cascades
    K A Berg
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Brain Res Bull 56:471-7. 2001
    ....
  8. ncbi request reprint Differences in rapid desensitization of 5-hydroxytryptamine2A and 5-hydroxytryptamine2C receptor-mediated phospholipase C activation
    K A Berg
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Pharmacol Exp Ther 299:593-602. 2001
    ..Desensitization of the 5-HT2C, but not the 5-HT2A, receptor system was dependent on G protein receptor kinase activity. These data further emphasize the major differences in the signaling systems coupled to 5-HT2A/2C receptors...
  9. ncbi request reprint Interactions between effectors linked to serotonin receptors
    K A Berg
    Department of Pharmacology, University of Texas Health Science Center, San Antonio 78284 7764, USA
    Ann N Y Acad Sci 861:111-20. 1998
    ..Perhaps by exploiting these interactions, new targets for pharmacotherapy may be uncovered which will provide for increased efficacy and specificity of drug action...
  10. pmc RNA-editing of the 5-HT(2C) receptor alters agonist-receptor-effector coupling specificity
    K A Berg
    Department of Pharmacology, Mail Code 7764, University of Texas Health Science Center, San Antonio, Texas, TX 78229 3900, USA
    Br J Pharmacol 134:386-92. 2001
    ..4. These results suggest an important role for the second intracellular loop in transmitting agonist-specific information to signalling molecules...
  11. ncbi request reprint Mechanisms of regulation of agonist efficacy at the 5-HT(1A) receptor by phospholipid-derived signaling components
    K L Evans
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, Texas, USA
    J Pharmacol Exp Ther 297:1025-35. 2001
    ..An understanding of the cellular mechanisms for regulation of 5-HT(1A) function may lead to novel targets for development of psychotherapeutic drugs...
  12. ncbi request reprint Novel actions of inverse agonists on 5-HT2C receptor systems
    K A Berg
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, Texas 78284 7764, USA
    Mol Pharmacol 55:863-72. 1999
    ..These data suggest that actions of inverse agonists may be mediated through effects on receptor systems that are not direct targets for these drugs...
  13. ncbi request reprint Effector pathway-dependent relative efficacy at serotonin type 2A and 2C receptors: evidence for agonist-directed trafficking of receptor stimulus
    K A Berg
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284 7764, USA
    Mol Pharmacol 54:94-104. 1998
    ..Rational drug design that optimizes preferential effector activity within a group of receptor-selective drugs holds the promise of increased selectivity in clinically useful agents...
  14. ncbi request reprint Rapid desensitization of the serotonin(2C) receptor system: effector pathway and agonist dependence
    Brian D Stout
    Department of Pharmacology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Pharmacol Exp Ther 302:957-62. 2002
    ....
  15. doi request reprint Physiological and therapeutic relevance of constitutive activity of 5-HT 2A and 5-HT 2C receptors for the treatment of depression
    Kelly A Berg
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Prog Brain Res 172:287-305. 2008
    ..Consequently, drugs with inverse agonist properties may have more activity in vivo to regulate DA neurotransmission than that afforded by simple competitive antagonism...
  16. pmc Integrins regulate opioid receptor signaling in trigeminal ganglion neurons
    K A Berg
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Neuroscience 144:889-97. 2007
    ..g. Galphai vs. Galphas). Collectively, these data provide the first evidence that specific integrins regulate opioid receptor signaling in sensory neurons...
  17. ncbi request reprint Rapid modulation of micro-opioid receptor signaling in primary sensory neurons
    Kelly A Berg
    Department of Pharmacology, MS 7764, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Pharmacol Exp Ther 321:839-47. 2007
    ..The results indicate that micro-opioid receptor signaling in primary sensory TG neurons is enhanced by activation of phospholipase C-coupled receptors via a cyclooxygenase-dependent AA metabolite that is downstream of PKC...
  18. ncbi request reprint Physiological relevance of constitutive activity of 5-HT2A and 5-HT2C receptors
    Kelly A Berg
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Trends Pharmacol Sci 26:625-30. 2005
    ....
  19. pmc Signalling profile differences: paliperidone versus risperidone
    W P Clarke
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX, USA
    Br J Pharmacol 170:532-45. 2013
    ..Because paliperidone differs from risperidone by only a single hydroxyl group, questions have been raised as to whether there are significant differences in the effects elicited between these two drugs...
  20. ncbi request reprint Bradykinin-induced functional competence and trafficking of the delta-opioid receptor in trigeminal nociceptors
    Amol M Patwardhan
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    J Neurosci 25:8825-32. 2005
    ..These findings indicate that exposure to certain inflammatory mediators rapidly alters the signaling properties and neuronal localization of DOR, possibly contributing to peripheral opioid analgesia...
  21. ncbi request reprint Intracellular Ca2+ regulates amphetamine-induced dopamine efflux and currents mediated by the human dopamine transporter
    Margaret E Gnegy
    Department of Pharmacology, 2220E MSRB III, University of Michigan Medical School, Ann Arbor, MI 48109 0632, USA
    Mol Pharmacol 66:137-43. 2004
    ....
  22. pmc Peripheral delta opioid receptors require priming for functional competence in vivo
    Matthew P Rowan
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX 78229 3900 USA
    Eur J Pharmacol 602:283-7. 2009
    ....
  23. ncbi request reprint Modulation of bradykinin signaling by EP24.15 and EP24.16 in cultured trigeminal ganglia
    Nathaniel A Jeske
    Department of Pharmacology, UTHSCSA, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    J Neurochem 97:13-21. 2006
    ..Taken together, these data demonstrate that EP24.15/16 modulate intracellular, peptidergic signaling cascades through B2R in a physiologically relevant nociceptive system...
  24. pmc Fine-tuning serotonin2c receptor function in the brain: molecular and functional implications
    Kelly A Berg
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Neuropharmacology 55:969-76. 2008
    ....
  25. ncbi request reprint Constitutive activity of the serotonin2C receptor inhibits in vivo dopamine release in the rat striatum and nucleus accumbens
    Philippe De Deurwaerdère
    Unité Mixte de Recherche Centre National de la Recherche Scientifique 5541 Université Victor Segalen Bordeaux 2, Boîte Postale 31, 33076 Bordeaux Cedex, France
    J Neurosci 24:3235-41. 2004
    ....
  26. ncbi request reprint Functional selectivity of hallucinogenic phenethylamine and phenylisopropylamine derivatives at human 5-hydroxytryptamine (5-HT)2A and 5-HT2C receptors
    Pablo R Moya
    Department of Chemistry, Faculty of Sciences, University of Chile, Santiago, Chile
    J Pharmacol Exp Ther 321:1054-61. 2007
    ..Our results support the concept of functional selectivity and indicate that subtle changes in ligand structure can result in significant differences in the cellular signaling profile...
  27. ncbi request reprint Calcium-sensing receptor-mediated ERK1/2 activation requires Galphai2 coupling and dynamin-independent receptor internalization
    Deborah M Holstein
    Department of Biochemistry, University of Texas Health Science Center at San Antonio, 78229 3900, USA
    J Biol Chem 279:10060-9. 2004
    ....