DARWIN BERG

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Ultrastructure of a somatic spine mat for nicotinic signaling in neurons
    Richard D Shoop
    Neurobiology Section, Division of Biology, Department of Neuroscience, University of California, San Diego, La Jolla, California 92093 0357, USA
    J Neurosci 22:748-56. 2002
  2. ncbi request reprint Maturation of postsynaptic nicotinic structures on autonomic neurons requires innervation but not cholinergic transmission
    Sergio Kaiser
    Neurobiology Section, Division of Biology, 0357, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0357, USA
    Eur J Neurosci 16:1-10. 2002
  3. pmc Reversible inhibition of GABAA receptors by alpha7-containing nicotinic receptors on the vertebrate postsynaptic neurons
    Jingming Zhang
    Neurobiology Section, Division of Biological Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    J Physiol 579:753-63. 2007
  4. pmc Timing is everything, even for cholinergic control
    Darwin K Berg
    Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 0357, USA
    Neuron 71:6-8. 2011
  5. ncbi request reprint Nicotinic signal transduction machinery
    D K Berg
    Division of Biological Sciences University of California San Diego, La Jolla, CA 92093 0357, USA
    J Mol Neurosci 30:149-52. 2006
  6. ncbi request reprint Nicotinic alpha 7 receptors: synaptic options and downstream signaling in neurons
    Darwin K Berg
    Neurobiology Section, 9500 Gilman Drive, University of California San Diego, La Jolla, California 92093 0357, USA
    J Neurobiol 53:512-23. 2002
  7. pmc Silent synapses sit and wait for a better day
    Darwin K Berg
    Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 0357, USA
    Neuron 61:157-9. 2009
  8. pmc Multiple cell adhesion molecules shaping a complex nicotinic synapse on neurons
    Gallen B Triana-Baltzer
    Neurobiology Section, Division of Biological Sciences, 0357, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0357, USA
    Mol Cell Neurosci 39:74-82. 2008
  9. ncbi request reprint Sequential interplay of nicotinic and GABAergic signaling guides neuronal development
    Zhaoping Liu
    Division of Biological Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0357, USA
    Science 314:1610-3. 2006
  10. ncbi request reprint Nicotinic alpha 7 receptor clusters on hippocampal GABAergic neurons: regulation by synaptic activity and neurotrophins
    Hideki Kawai
    Neurobiology Section, Biology Division, University of California, San Diego, La Jolla, California 92093 0357, USA
    J Neurosci 22:7903-12. 2002

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Ultrastructure of a somatic spine mat for nicotinic signaling in neurons
    Richard D Shoop
    Neurobiology Section, Division of Biology, Department of Neuroscience, University of California, San Diego, La Jolla, California 92093 0357, USA
    J Neurosci 22:748-56. 2002
    ..The anatomical configuration of spine mats suggests coordinate spine activation by transmitter release into a confined volume while spine morphology is used to control the chemical consequences of synaptic signaling...
  2. ncbi request reprint Maturation of postsynaptic nicotinic structures on autonomic neurons requires innervation but not cholinergic transmission
    Sergio Kaiser
    Neurobiology Section, Division of Biology, 0357, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0357, USA
    Eur J Neurosci 16:1-10. 2002
    ..The results indicate that ciliary neurons are programmed to express postsynaptic components and can initiate clustering of alpha 7-containing receptors but need presynaptic guidance for maturation of the postsynaptic structure...
  3. pmc Reversible inhibition of GABAA receptors by alpha7-containing nicotinic receptors on the vertebrate postsynaptic neurons
    Jingming Zhang
    Neurobiology Section, Division of Biological Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    J Physiol 579:753-63. 2007
    ..The results demonstrate regulation of GABAA receptors by alpha7-nAChRs on the postsynaptic neuron and identify a new mechanism by which nicotinic cholinergic signalling influences nervous system function...
  4. pmc Timing is everything, even for cholinergic control
    Darwin K Berg
    Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 0357, USA
    Neuron 71:6-8. 2011
    ..In this issue of Neuron, Gu and Yakel show that the precise timing of a single cholinergic pulse of activity can determine whether plasticity will occur at a glutamatergic synapse and confer long-term potentiation versus depression...
  5. ncbi request reprint Nicotinic signal transduction machinery
    D K Berg
    Division of Biological Sciences University of California San Diego, La Jolla, CA 92093 0357, USA
    J Mol Neurosci 30:149-52. 2006
    ..As a result, the receptors are well equipped to regulate calcium-dependent events in neurons, particularly when depolarization might be occluded...
  6. ncbi request reprint Nicotinic alpha 7 receptors: synaptic options and downstream signaling in neurons
    Darwin K Berg
    Neurobiology Section, 9500 Gilman Drive, University of California San Diego, La Jolla, California 92093 0357, USA
    J Neurobiol 53:512-23. 2002
    ....
  7. pmc Silent synapses sit and wait for a better day
    Darwin K Berg
    Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 0357, USA
    Neuron 61:157-9. 2009
    ..Postsynaptic responses are required, however, for presynaptic terminals to acquire the high-affinity choline transporter necessary for high-frequency transmission...
  8. pmc Multiple cell adhesion molecules shaping a complex nicotinic synapse on neurons
    Gallen B Triana-Baltzer
    Neurobiology Section, Division of Biological Sciences, 0357, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0357, USA
    Mol Cell Neurosci 39:74-82. 2008
    ..SynCAM may affect synaptic maturation rather than synapse formation. The results indicate that individual neurons can express multiple synaptogenic molecules with different effects on the same class of nicotinic synapses...
  9. ncbi request reprint Sequential interplay of nicotinic and GABAergic signaling guides neuronal development
    Zhaoping Liu
    Division of Biological Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0357, USA
    Science 314:1610-3. 2006
    ..Synergistic with nicotinic excitation, GABAergic inhibition constrains neuronal morphology and innervation. The results reveal a multitiered activity-dependent strategy controlling neuronal development...
  10. ncbi request reprint Nicotinic alpha 7 receptor clusters on hippocampal GABAergic neurons: regulation by synaptic activity and neurotrophins
    Hideki Kawai
    Neurobiology Section, Biology Division, University of California, San Diego, La Jolla, California 92093 0357, USA
    J Neurosci 22:7903-12. 2002
    ..The results indicate that both NMDA receptor activation and the neurotrophins BDNF and NGF are necessary to sustain the distribution patterns of alpha7-containing nicotinic receptors on GABAergic hippocampal neurons...
  11. ncbi request reprint Nicotinic activity stabilizes convergence of nicotinic and GABAergic synapses on filopodia of hippocampal interneurons
    Wagner M Zago
    Neurobiology Section, Division of Biology, 0357, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0357, USA
    Mol Cell Neurosci 31:549-59. 2006
    ..The results indicate a convergence of nicotinic and GABAergic input at specific sites on developing hippocampal interneurons and suggest that synaptic activity helps stabilize the nicotinic contribution...
  12. pmc Synchronous and asynchronous transmitter release at nicotinic synapses are differentially regulated by postsynaptic PSD-95 proteins
    Robert A Neff
    Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093 0357, USA
    J Neurosci 29:15770-9. 2009
    ....
  13. pmc Evidence for ectopic neurotransmission at a neuronal synapse
    Jay S Coggan
    Computational Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Science 309:446-51. 2005
    ....
  14. ncbi request reprint Rapid activity-driven SNARE-dependent trafficking of nicotinic receptors on somatic spines
    Zhaoping Liu
    Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093 0357, USA
    J Neurosci 25:1159-68. 2005
    ..Thus, trafficking appears to be essential for maintaining functional coupling between alpha7-receptor responses and downstream signaling...
  15. ncbi request reprint PDZ-containing proteins provide a functional postsynaptic scaffold for nicotinic receptors in neurons
    William G Conroy
    Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
    Neuron 38:759-71. 2003
    ..By tethering components to postsynaptic nicotinic receptors, PDZ scaffolds can organize synaptic structure and determine which calcium-dependent processes will be subject to nicotinic modulation...
  16. ncbi request reprint Nicotinic regulation of CREB activation in hippocampal neurons by glutamatergic and nonglutamatergic pathways
    Mei Hu
    Neurobiology Section, Division of Biology, University of California, San Diego, La Jolla, 92093 0357, USA
    Mol Cell Neurosci 21:616-25. 2002
    ..The low levels of sustained nicotinic stimulation required for transcriptional effects are consistent with those likely to be achievable either by the normal septal cholinergic innervation of the hippocampus or by repeated tobacco usage...
  17. pmc EphB receptors co-distribute with a nicotinic receptor subtype and regulate nicotinic downstream signaling in neurons
    Zhaoping Liu
    Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093 0357, USA
    Mol Cell Neurosci 38:236-44. 2008
    ..The enhancement does not appear to result from a change in the alpha7-nAChR current amplitude, suggesting a downstream target. The results demonstrate a role for ephrin/EphB action in nicotinic signaling...
  18. pmc Lateral mobility of nicotinic acetylcholine receptors on neurons is determined by receptor composition, local domain, and cell type
    Catarina C Fernandes
    Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093 0357, USA
    J Neurosci 30:8841-51. 2010
    ..The outcome is a system that could tailor nicotinic signaling capabilities to specific needs of individual locations...
  19. doi request reprint Postsynaptic scaffolds for nicotinic receptors on neurons
    Robert A Neff
    Neurobiology Section, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093 0357, USA
    Acta Pharmacol Sin 30:694-701. 2009
    ..This review summarizes recent results in these areas and raises questions for the future about the mechanism and synaptic role of nAChR trafficking...
  20. pmc BDNF up-regulates alpha7 nicotinic acetylcholine receptor levels on subpopulations of hippocampal interneurons
    Kerri A Massey
    Neurobiology Section, Division of Biological Sciences, 0357, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0357, USA
    Mol Cell Neurosci 33:381-8. 2006
    ..The results suggest that BDNF, acting through glutamatergic transmission, can modulate hippocampal output in part by controlling alpha7-nAChR levels...
  21. ncbi request reprint Alpha-protocadherins are presynaptic and axonal in nicotinic pathways
    Martina Blank
    Neurobiology Section, Division of Biological Sciences, University of California, La Jolla, San Diego, CA 92093 0357, USA
    Mol Cell Neurosci 26:530-43. 2004
    ..The results indicate that pcdh-alphas are widely expressed in nicotinic cholinergic pathways and may engage in heterophilic interactions at synapses and on axons...
  22. ncbi request reprint Postsynaptic neuroligin enhances presynaptic inputs at neuronal nicotinic synapses
    William G Conroy
    Neurobiology Section, Division of Biology, University of California, San Diego, La Jolla, CA 92093 0357, USA
    Dev Biol 307:79-91. 2007
    ..The results indicate that postsynaptic neuroligin is important for functional nicotinic synapses on neurons and that the effects achieved will likely depend on neuroligin levels...
  23. ncbi request reprint Pre- and postsynaptic actions of L1-CAM in nicotinic pathways
    Gallen B Triana-Baltzer
    Neurobiology Section, Division of Biology, 0357, University of California, San Diego, 9500 Gilman Drive, La Jolla, 92093 0357, USA
    Mol Cell Neurosci 33:214-26. 2006
    ..These findings identify new roles for L1 at nicotinic synapses and underscore the multipotency of L1-CAMs...
  24. ncbi request reprint Large clusters of alpha7-containing nicotinic acetylcholine receptors on chick spinal cord neurons
    Adelheid L Roth
    Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093 0357, USA
    J Comp Neurol 465:195-204. 2003
    ..The results demonstrate that CNS neurons can configure alpha7-containing nicotinic receptors into large clusters but also suggest that the clusters are not likely to reflect a common molecular substructure on all neurons...
  25. pmc Endogenous signaling through alpha7-containing nicotinic receptors promotes maturation and integration of adult-born neurons in the hippocampus
    Nolan R Campbell
    Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093 0357, USA
    J Neurosci 30:8734-44. 2010
    ....
  26. pmc Role of endogenous nicotinic signaling in guiding neuronal development
    Zhaoping Liu
    Neurobiology Section, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093 0357, USA
    Biochem Pharmacol 74:1112-9. 2007
    ..The results reveal a multi-layered pattern of activity-dependent controls in development and indicate the significance of nicotinic signaling in shaping these events...
  27. ncbi request reprint Potentiation of alpha7-containing nicotinic acetylcholine receptors by select albumins
    William G Conroy
    Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093, USA
    Mol Pharmacol 63:419-28. 2003
    ....

Research Grants49

  1. Neuronal Nicotinic Receptors- Expression and Regulation
    DARWIN BERG; Fiscal Year: 2006
    ..These results will provide new insight into regulatory mechanisms that shape nicotinic signaling, important because the signaling is pervasive and has profound biomedical consequences. ..
  2. Signal Transduction at Neuronal Nicotinic Synapses
    DARWIN BERG; Fiscal Year: 2009
    ..The findings should also have biomedical relevance in revealing the consequences of nicotine exposure during these formative periods. ..
  3. NEURONAL NICOTINIC RECEPTORS-EXPRESSION AND REGULATION
    DARWIN BERG; Fiscal Year: 2004
    ....
  4. NEURONAL DEVELOPMENT AND SYNAPSE FORMATION IN VITRO
    DARWIN BERG; Fiscal Year: 2001
    ..More broadly, they may provide new insight into fundamental aspects of synaptic function and lay groundwork for considering therapeutic strategies involving nicotinic receptors. ..
  5. Nicotinic Synapse Formation on Neurons
    DARWIN BERG; Fiscal Year: 2005
    ..The biomedical relevance stems in part from the role of nicotinic signaling in fundamental brain function such as learning and memory, and in related disorders such as Alzheimers disease and nicotine addiction. ..
  6. Nicotinic Control of Non-Nicotinic Synapses in the Hippocampus
    Darwin K Berg; Fiscal Year: 2010
    ....
  7. Signal Transduction at Neuronal Nicotinic Synapses
    Darwin K Berg; Fiscal Year: 2010
    ..The findings should also have biomedical relevance in revealing the consequences of nicotine exposure during these formative periods. ..
  8. Nicotinic Control of Non-Nicotinic Synapses in the Hippocampus
    DARWIN BERG; Fiscal Year: 2009
    ....
  9. Signal Transduction at Neuronal Nicotinic Synapses
    DARWIN BERG; Fiscal Year: 2007
    ..The findings should also have biomedical relevance in revealing the consequences of nicotine exposure during these formative periods. ..
  10. Neuronal Nicotinic Receptors- Expression and Regulation
    DARWIN BERG; Fiscal Year: 2007
    ..These results will provide new insight into regulatory mechanisms that shape nicotinic signaling, important because the signaling is pervasive and has profound biomedical consequences. ..
  11. NEURONAL NICOTINIC RECEPTORS--EXPRESSION AND REGULATION
    DARWIN BERG; Fiscal Year: 2000
    ..These studies should reveal important aspects of the cell and molecular biology of neuronal nicotinic receptors and are relevant to the role of nicotinic AChRs in nicotine addiction. ..
  12. NEURONAL DEVELOPMENT AND SYNAPSE FORMATION IN VITRO
    DARWIN BERG; Fiscal Year: 1980
    ..Fluorescent- and radiolabeled-toxins together with iontophoretic application of ACh will be used for the receptor analysis. ..
  13. NEURONAL DEVELOPMENT AND SYNAPSE FORMATION IN VITRO
    DARWIN BERG; Fiscal Year: 1993
    ..1 treatment...