E N Benveniste
Affiliation: University of Alabama at Birmingham
- Cytokine actions in the central nervous systemE N Benveniste
Department of Cell Biology, University of Alabama at Birmingham, 35294 0005, USA
Cytokine Growth Factor Rev 9:259-75. 1998..The significance of these cytokines to neurological diseases with an immunological component will be discussed...
- Immunological aspects of microglia: relevance to Alzheimer's diseaseE N Benveniste
Department of Cell Biology, The University of Alabama at Birmingham, 1918 University Boulevard, MCLM 395, Birmingham, AL 35294 0005, USA
Neurochem Int 39:381-91. 2001..Inflammation mediated by activated microglia is an important component of AD pathophysiology, and strategies to control this response could provide new therapeutic approaches for the treatment of AD...
- The transcription factors Sp1, Sp3, and AP-2 are required for constitutive matrix metalloproteinase-2 gene expression in astroglioma cellsH Qin
Department of Cell Biology, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
J Biol Chem 274:29130-7. 1999..Delineation of MMP-2 regulation may have implications for development of new therapeutic strategies to arrest glioma invasion...
- IFN-gamma regulation of class II transactivator promoter IV in macrophages and microglia: involvement of the suppressors of cytokine signaling-1 proteinV T Nguyen
Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
J Immunol 166:2260-9. 2001..As well, IFN-gamma-induced expression of IRF-1 and its binding to the IRF element is inhibited. These results indicate that SOCS-1 may be responsible for attenuating IFN-gamma-induced CIITA and class II MHC expression in macrophages...
- CXC chemokine receptor 4 expression and function in human astroglioma cellsJ W Oh
Department of Cell Biology, University of Alabama, Birmingham, AL 35294, USA
J Immunol 166:2695-704. 2001..Collectively, these data suggest that CXCR4-mediated signaling pathways in astroglioma cells may be another mechanism for these cells to express chemokines involved in angiogenesis and inflammation...
- Attachment of primary neonatal rat astrocytes to vitronectin is mediated by integrins alphavbeta5 and alpha8beta1: modulation by the type 1 plasminogen activator inhibitorC L Gladson
Department of Pathology, Division of Neuropathology, University of Alabama at Birmingham, 35294, USA
Neurosci Lett 283:157-61. 2000..Our data demonstrate that unstimulated primary neonatal rat astrocytes attach to vitronectin, utilizing integrins alphavbeta5 and alpha8beta1, and that this attachment is regulated by PAI-1...
- Immune function of astrocytesY Dong
Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294-0005, USA
Glia 36:180-90. 2001..The significance of astrocytic antigen presentation and chemokine/cytokine production to neurological diseases with an immunological component is described...
- The prolyl isomerase Pin1 regulates the NF-kappaB signaling pathway and interleukin-8 expression in glioblastomaG P Atkinson
Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294 0006, USA
Oncogene 28:3735-45. 2009..Taken together, these data suggest that Pin1 is an important regulator of NF-kappaB in GBM, and support the notion of using Pin1 as a therapeutic target in the future...