Christopher Benson

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc Acid-sensing ion channels (ASICs) in mouse skeletal muscle afferents are heteromers composed of ASIC1a, ASIC2, and ASIC3 subunits
    Mamta Gautam
    Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University ofIowa, Iowa City, Iowa 52242, USA
    FASEB J 27:793-802. 2013
  2. pmc Acid-sensing ion channels (ASICs) are differentially modulated by anions dependent on their subunit composition
    Nobuyoshi Kusama
    Dept of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Am J Physiol Cell Physiol 304:C89-101. 2013
  3. ncbi request reprint Toward an understanding of the molecules that sense myocardial ischemia
    C J Benson
    Department of Medicine, University of Iowa College of Medicine, 371 EMRB, Iowa City, IA 52242, USA
    Ann N Y Acad Sci 940:96-109. 2001
  4. pmc Heteromultimers of DEG/ENaC subunits form H+-gated channels in mouse sensory neurons
    Christopher J Benson
    Department of Internal Medicine and Psychiatry, and Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 99:2338-43. 2002
  5. pmc DEG/ENaC ion channels involved in sensory transduction are modulated by cold temperature
    C C Askwith
    Department of Internal Medicine and Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 98:6459-63. 2001
  6. pmc The ion channel ASIC2 is required for baroreceptor and autonomic control of the circulation
    Yongjun Lu
    Department of Internal Medicine and Cardiovascular Research Center, University of Iowa, Iowa City, IA 52242, USA
    Neuron 64:885-97. 2009
  7. ncbi request reprint The mammalian sodium channel BNC1 is required for normal touch sensation
    M P Price
    Howard Hughes Medical Institute, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242, USA
    Nature 407:1007-11. 2000
  8. ncbi request reprint Acid-sensing ion channels contribute to transduction of extracellular acidosis in rat carotid body glomus cells
    Zhi Yong Tan
    Cardiovascular Center and Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    Circ Res 101:1009-19. 2007
  9. pmc Acid-sensing ion channel 3 (ASIC3) cell surface expression is modulated by PSD-95 within lipid rafts
    Jayasheel O Eshcol
    Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Physiol Cell Physiol 295:C732-9. 2008
  10. ncbi request reprint Stomatin modulates gating of acid-sensing ion channels
    Margaret P Price
    Department of Internal Medicine, University of Iowa College of Medicine, 200 Hawkins Dr, Iowa City, IA 52242, USA
    J Biol Chem 279:53886-91. 2004

Research Grants

  1. Acid-Sensing Ion Channels in Cardiac Ischemia
    Christopher Benson; Fiscal Year: 2009
  2. Acid-Sensing Ion Channels in Cardiac Ischemia
    Christopher Benson; Fiscal Year: 2009

Collaborators

Detail Information

Publications12

  1. pmc Acid-sensing ion channels (ASICs) in mouse skeletal muscle afferents are heteromers composed of ASIC1a, ASIC2, and ASIC3 subunits
    Mamta Gautam
    Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University ofIowa, Iowa City, Iowa 52242, USA
    FASEB J 27:793-802. 2013
    ..These results will help us understand the role of ASICs in exercise physiology and provide a molecular target for potential drug therapies to treat muscle pain...
  2. pmc Acid-sensing ion channels (ASICs) are differentially modulated by anions dependent on their subunit composition
    Nobuyoshi Kusama
    Dept of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Am J Physiol Cell Physiol 304:C89-101. 2013
    ..We speculate that modulation of ASIC gating by Cl(-) is a novel mechanism to sense shifts in extracellular fluid composition...
  3. ncbi request reprint Toward an understanding of the molecules that sense myocardial ischemia
    C J Benson
    Department of Medicine, University of Iowa College of Medicine, 371 EMRB, Iowa City, IA 52242, USA
    Ann N Y Acad Sci 940:96-109. 2001
    ..By comparison, the responses to other potential chemical mediators were inconsistent and much smaller. The biophysical properties of the acid-evoked currents in cardiac afferents match the acid-sensing ion channel 3 (ASIC3)...
  4. pmc Heteromultimers of DEG/ENaC subunits form H+-gated channels in mouse sensory neurons
    Christopher J Benson
    Department of Internal Medicine and Psychiatry, and Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 99:2338-43. 2002
    ..These data indicate that combinations of two or more DEG/ENaC subunits coassemble as heteromultimers to generate transient H(+)-gated currents in mouse DRG neurons...
  5. pmc DEG/ENaC ion channels involved in sensory transduction are modulated by cold temperature
    C C Askwith
    Department of Internal Medicine and Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 98:6459-63. 2001
    ..The finding that cold temperature modulates DEG/ENaC channel function may provide a molecular explanation for the widely recognized ability of temperature to modify taste sensation and mechanosensation...
  6. pmc The ion channel ASIC2 is required for baroreceptor and autonomic control of the circulation
    Yongjun Lu
    Department of Internal Medicine and Cardiovascular Research Center, University of Iowa, Iowa City, IA 52242, USA
    Neuron 64:885-97. 2009
    ..The genetic disruption of ASIC2 recapitulates the pathological dysautonomia seen in heart failure and hypertension and defines a molecular defect that may be relevant to its development...
  7. ncbi request reprint The mammalian sodium channel BNC1 is required for normal touch sensation
    M P Price
    Howard Hughes Medical Institute, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242, USA
    Nature 407:1007-11. 2000
    ..These data identify the BNC1 channel as essential for the normal detection of light touch and indicate that BNC1 may be a central component of a mechanosensory complex...
  8. ncbi request reprint Acid-sensing ion channels contribute to transduction of extracellular acidosis in rat carotid body glomus cells
    Zhi Yong Tan
    Cardiovascular Center and Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    Circ Res 101:1009-19. 2007
    ....
  9. pmc Acid-sensing ion channel 3 (ASIC3) cell surface expression is modulated by PSD-95 within lipid rafts
    Jayasheel O Eshcol
    Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Physiol Cell Physiol 295:C732-9. 2008
    ..In addition, we found that cell surface ASIC3 is enriched in the lipid raft fraction. These data suggest that PSD-95 and ASIC3 interact within lipid rafts and that this raft interaction is required for PSD-95 to modulate ASIC3...
  10. ncbi request reprint Stomatin modulates gating of acid-sensing ion channels
    Margaret P Price
    Department of Internal Medicine, University of Iowa College of Medicine, 200 Hawkins Dr, Iowa City, IA 52242, USA
    J Biol Chem 279:53886-91. 2004
    ..Our findings indicate that modulation of DEG/ENaC channels by stomatin-like proteins is evolutionarily conserved and may have important implications for mammalian nociception and mechanosensation...
  11. ncbi request reprint PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current
    Alesia M Hruska-Hageman
    Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 279:46962-8. 2004
    ..The finding that multiple PDZ-containing proteins bind ASIC3 and can influence its presence in the plasma membrane suggests that they may play an important role in the contribution of ASIC3 to nociception and mechanosensation...
  12. pmc ASIC3 in muscle mediates mechanical, but not heat, hyperalgesia associated with muscle inflammation
    Kathleen A Sluka
    Graduate Program in Physical Therapy and Rehabilitation Science, 1 252 Medical Education Bldg, The University of Iowa, Iowa City, IA 52242, USA
    Pain 129:102-12. 2007
    ..Thus, ASIC3 in primary afferent fibers innervating muscle is critical to development of hyperalgesia that results from muscle insult...

Research Grants5

  1. Acid-Sensing Ion Channels in Cardiac Ischemia
    Christopher Benson; Fiscal Year: 2009
    ..This work will provide new insights into the signals and sensors that respond to cardiac ischemia, and define new therapeutic targets and novel approaches for its treatment. ..
  2. Acid-Sensing Ion Channels in Cardiac Ischemia
    Christopher Benson; Fiscal Year: 2009
    ..This work will provide new insights into the signals and sensors that respond to cardiac ischemia, and define new therapeutic targets and novel approaches for its treatment. ..