Affiliation: University of Rochester
- Sustained mobilization of endogenous neural progenitors delays disease progression in a transgenic model of Huntington's diseaseAbdellatif Benraiss
Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA
Cell Stem Cell 12:787-99. 2013..In addition, squirrel monkeys given ICV injections of adenoviral BDNF/noggin showed similar addition of striatal neurons. Induced neuronal addition may therefore represent a promising avenue for disease amelioration in HD...
- Sustained induction of neuronal addition to the adult rat neostriatum by AAV4-delivered noggin and BDNFA Benraiss
Department of Neurology, University of Rochester Medical Center, Rochester, NY 14620, USA
Gene Ther 19:483-93. 2012..AAV4:BDNF and noggin-induced neuronal addition may thus provide a means to provide longlasting and persistent striatal neuronal replacement in conditions of striatal neuronal loss, such as HD...
- Cellular therapy and induced neuronal replacement for Huntington's diseaseAbdellatif Benraiss
Department of Neurology, Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, USA
Neurotherapeutics 8:577-90. 2011..We will then consider the potential application of gene therapy toward the induction of striatal neurogenesis and neuronal recruitment, with an eye toward its potential therapeutic use in HD...
- Induction of neostriatal neurogenesis slows disease progression in a transgenic murine model of Huntington diseaseSung Rae Cho
Department of Neurology, University of Rochester Medical Center, Rochester, New York, USA
J Clin Invest 117:2889-902. 2007..Thus, BDNF and Noggin induced striatal neuronal regeneration, delayed motor impairment, and extended survival in R6/2 mice, suggesting a new therapeutic strategy in Huntington disease...