Stephen Benoit

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. ncbi request reprint Use of bariatric outcomes longitudinal database (BOLD) to study variability in patient success after bariatric surgery
    Stephen C Benoit
    Psychiatry and Behavioral Neuroscience, University of Cincinnati Reading Campus, 2170 East Galbraith Road, Cincinnati, OH, USA
    Obes Surg 24:936-43. 2014
  2. ncbi request reprint Altered feeding responses in mice with targeted disruption of the dopamine-3 receptor gene
    Stephen C Benoit
    Department of Psychiatry, University of Cincinnati, Ohio 45267 0559, USA
    Behav Neurosci 117:46-54. 2003
  3. ncbi request reprint Learned meal initiation attenuates the anorexic effects of the melanocortin agonist MTII
    Stephen C Benoit
    Department of Psychiatry, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0559, USA
    Diabetes 52:2684-8. 2003
  4. ncbi request reprint Assessment of the aversive consequences of acute and chronic administration of the melanocortin agonist, MTII
    S C Benoit
    Department of Psychiatry, University of Cincinnati Medical Center, Cincinnati, OH 5267, USA
    Int J Obes Relat Metab Disord 27:550-6. 2003
  5. pmc Behavioral controls of food intake
    Stephen C Benoit
    University of Cincinnati, Department of Psychiatry, Obesity Research Center, 2170 East Galbraith Road, Cincinnati, OH 45237, USA
    Peptides 29:139-47. 2008
  6. pmc Novel functions of orexigenic hypothalamic peptides: from genes to behavior
    Stephen C Benoit
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio, USA
    Nutrition 24:843-7. 2008
  7. ncbi request reprint The catabolic action of insulin in the brain is mediated by melanocortins
    Stephen C Benoit
    Department of Psychiatry, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267 0559, USA
    J Neurosci 22:9048-52. 2002
  8. ncbi request reprint The role of previous exposure in the appetitive and consummatory effects of orexigenic neuropeptides
    Stephen C Benoit
    University of Cincinnati, Department of Psychiatry North, 2170 East Galbraith Rd, Cincinnati, OH 45243, USA
    Peptides 26:751-7. 2005
  9. pmc Learned and cognitive controls of food intake
    Stephen C Benoit
    Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45237, USA
    Brain Res 1350:71-6. 2010
  10. ncbi request reprint Small molecule insulin mimetics reduce food intake and body weight and prevent development of obesity
    Ellen L Air
    Department of Biomedical Sciences and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Nat Med 8:179-83. 2002

Research Grants

Detail Information

Publications62

  1. ncbi request reprint Use of bariatric outcomes longitudinal database (BOLD) to study variability in patient success after bariatric surgery
    Stephen C Benoit
    Psychiatry and Behavioral Neuroscience, University of Cincinnati Reading Campus, 2170 East Galbraith Road, Cincinnati, OH, USA
    Obes Surg 24:936-43. 2014
    ..This study was conducted to determine the contributions of various predictors to the large variations in absolute weight loss and percent body mass index (BMI) loss after bariatric surgery...
  2. ncbi request reprint Altered feeding responses in mice with targeted disruption of the dopamine-3 receptor gene
    Stephen C Benoit
    Department of Psychiatry, University of Cincinnati, Ohio 45267 0559, USA
    Behav Neurosci 117:46-54. 2003
    ..These results support the hypothesis that D3Rs chronically inhibit the effects of adiposity hormones, thereby contributing to a net anabolic state...
  3. ncbi request reprint Learned meal initiation attenuates the anorexic effects of the melanocortin agonist MTII
    Stephen C Benoit
    Department of Psychiatry, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0559, USA
    Diabetes 52:2684-8. 2003
    ..These results support the hypothesis that meal-feeding schedules can lead to anticipatory physiological responses that attenuate the anorexic effects of exogenous melanocortin agonists...
  4. ncbi request reprint Assessment of the aversive consequences of acute and chronic administration of the melanocortin agonist, MTII
    S C Benoit
    Department of Psychiatry, University of Cincinnati Medical Center, Cincinnati, OH 5267, USA
    Int J Obes Relat Metab Disord 27:550-6. 2003
    ..One early report on the effect of MTII suggested that part of its anorexic action may be mediated by aversive consequences. In that experiment, MTII was found to support a mild conditioned taste aversion (CTA)...
  5. pmc Behavioral controls of food intake
    Stephen C Benoit
    University of Cincinnati, Department of Psychiatry, Obesity Research Center, 2170 East Galbraith Road, Cincinnati, OH 45237, USA
    Peptides 29:139-47. 2008
    ....
  6. pmc Novel functions of orexigenic hypothalamic peptides: from genes to behavior
    Stephen C Benoit
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio, USA
    Nutrition 24:843-7. 2008
    ....
  7. ncbi request reprint The catabolic action of insulin in the brain is mediated by melanocortins
    Stephen C Benoit
    Department of Psychiatry, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267 0559, USA
    J Neurosci 22:9048-52. 2002
    ..These data suggest that the hypothalamic melanocortin system mediates the anorexic effects of central insulin, as well as of leptin...
  8. ncbi request reprint The role of previous exposure in the appetitive and consummatory effects of orexigenic neuropeptides
    Stephen C Benoit
    University of Cincinnati, Department of Psychiatry North, 2170 East Galbraith Rd, Cincinnati, OH 45243, USA
    Peptides 26:751-7. 2005
    ....
  9. pmc Learned and cognitive controls of food intake
    Stephen C Benoit
    Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45237, USA
    Brain Res 1350:71-6. 2010
    ..Here we review some evidence for learning about food as well as evidence that the hippocampus may play a critical role in the brain's ability to regulate body weight through such learning processes...
  10. ncbi request reprint Small molecule insulin mimetics reduce food intake and body weight and prevent development of obesity
    Ellen L Air
    Department of Biomedical Sciences and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Nat Med 8:179-83. 2002
    ..Thus, insulin mimetics have a unique advantage over insulin in the control of body weight and hold potential as a novel anti-obesity treatment...
  11. ncbi request reprint High-fat diet induced adiposity in mice with targeted disruption of the dopamine-3 receptor gene
    John Andrews McQuade
    Department of Psychiatry, University of Cincinnati, P O Box 670559, Cincinnati, OH 45267 0559, USA
    Behav Brain Res 151:313-9. 2004
    ..These findings suggest the D3-R signaling is involved in the regulation of body weight and body fat when mice are given access to diets differing in palatability and fat content...
  12. ncbi request reprint Intraventricular insulin and leptin reduce food intake and body weight in C57BL/6J mice
    Lynda M Brown
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237, USA
    Physiol Behav 89:687-91. 2006
    ..Hence, genetic manipulations that influence brain insulin sensitivity in mice can now more easily be integrated with the broader literature on energy homeostasis...
  13. ncbi request reprint Reduced anorexic effects of insulin in obesity-prone rats fed a moderate-fat diet
    Deborah J Clegg
    University of Cincinnati, Department of Psychiatry, Cincinnati, Ohio, USA
    Am J Physiol Regul Integr Comp Physiol 288:R981-6. 2005
    ....
  14. ncbi request reprint Differential sensitivity to central leptin and insulin in male and female rats
    Deborah J Clegg
    Department of Psychiatry, University of Cincinnati Medical Center, Cincinnati, OH 45267 0559, USA
    Diabetes 52:682-7. 2003
    ..Because insulin and leptin reflect different fat beds and are differentially distributed in the male and female sexes, the implication is that the male and female sexes regulate adiposity-relevant parameters differently...
  15. ncbi request reprint Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure
    Paul T Pfluger
    Department of Psychiatry, Obesity Research Centre, Genome Research Institute, University of Cincinnati College of Medicine, Cincinnati, OH 45237, USA
    Am J Physiol Gastrointest Liver Physiol 294:G610-8. 2008
    ....
  16. ncbi request reprint Characterization of mice lacking the gene for cholecystokinin
    Chun Min Lo
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Genome Research Institute, 2120 E Galbraith Rd, Bldg A, ML 0507, Cincinnati, OH 45237, USA
    Am J Physiol Regul Integr Comp Physiol 294:R803-10. 2008
    ..We conclude that CCK is involved in metabolic rate and is important for memory and exploration. CCK is intimately involved in multiple processes related to cognitive function and food intake regulation...
  17. ncbi request reprint Insulin and leptin combine additively to reduce food intake and body weight in rats
    Ellen L Air
    Department of Biomedical Sciences, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267 0555, USA
    Endocrinology 143:2449-52. 2002
    ....
  18. pmc The central melanocortin system directly controls peripheral lipid metabolism
    Ruben Nogueiras
    Obesity Research Center, Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237, USA
    J Clin Invest 117:3475-88. 2007
    ..We also reveal molecular underpinnings for direct control of the CNS-Mcr over lipid metabolism. These results suggest ways to design more efficient pharmacological methods for controlling adiposity...
  19. pmc Palmitic acid mediates hypothalamic insulin resistance by altering PKC-theta subcellular localization in rodents
    Stephen C Benoit
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio, USA
    J Clin Invest 119:2577-89. 2009
    ..These results suggest that many of the deleterious effects of high-fat diets, specifically those enriched with palmitic acid, are CNS mediated via PKC-theta activation, resulting in reduced insulin activity...
  20. doi request reprint Mice with chronically increased circulating ghrelin develop age-related glucose intolerance
    Jacquelyn A Reed
    Department of Psychiatry, Genome Research Institute, University of Cincinnati, Cincinnati, OH 45237, USA
    Am J Physiol Endocrinol Metab 294:E752-60. 2008
    ..Despite the impaired glucose tolerance in L43 mice, insulin levels did not differ from those of wild-type mice. These findings suggest a role for ghrelin in age-associated impairments of glucose homeostasis...
  21. ncbi request reprint Gut hormones ghrelin, PYY, and GLP-1 in the regulation of energy balance [corrected] and metabolism
    Diego Perez-Tilve
    Department of Psychiatry, University of Cincinnati Genome Research Institute, Cincinnati, OH 45237, USA
    Endocrine 29:61-71. 2006
    ..Here, we examine the role of gut hormones in energy balance regulation and their possible use as pharmaceutical targets for obesity...
  22. ncbi request reprint Intraventricular (i3vt) ghrelin increases food intake in fatty Zucker rats
    Lynda M Brown
    Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45237, United States
    Peptides 28:612-6. 2007
    ..Fatty Zucker rats had 4.5 times more ghrelin receptor mRNA in the hypothalamus than lean Zucker rats, suggesting a possible mechanism for the increased sensitivity...
  23. pmc The regulation of alcohol intake by melanin-concentrating hormone in rats
    Elizabeth A Duncan
    Department of Psychiatry, University of Cincinnati, USA
    Pharmacol Biochem Behav 85:728-35. 2006
    ..Further, endogenous MCH does not seem to regulate alcohol drinking, however because the antagonist failed to attenuate MCH-induced alcohol intake this conclusion is tentative...
  24. ncbi request reprint Insulin and leptin as adiposity signals
    Stephen C Benoit
    Department of Psychiatry, University of Cincinnati Medical Center, Cincinnati, Ohio 45267, USA
    Recent Prog Horm Res 59:267-85. 2004
    ..Hence, insulin and leptin provide important negative feedback signals to the central nervous system, proportional to peripheral energy stores and coupled with catabolic circuits...
  25. ncbi request reprint 7-OH-DPAT selectively reduces intake of both chow and high fat diets in different food intake regimens
    John Andrews M McQuade
    Department of Psychiatry, University of Cincinnati, P O Box 670559, Cincinnati, OH 45267 0559, USA
    Pharmacol Biochem Behav 76:517-23. 2003
    ..However, in animals that had access to HF diet, 7-OH-DPAT dose-dependently reduced intake. These results support a potential role for the D3-R in ingestive behavior particularly in situations that involve a significant learned component...
  26. ncbi request reprint Apolipoprotein A-IV interacts synergistically with melanocortins to reduce food intake
    Koro Gotoh
    Department of Psychiatry, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, OH 45237, USA
    Am J Physiol Regul Integr Comp Physiol 290:R202-7. 2006
    ..In addition, c-Fos expression was not colocalized with proopiomelanocortin-positive neurons. These data support a synergistic interaction between apo A-IV and melanocortins that reduces food intake by acting downstream of the arcuate...
  27. pmc Ghrelin enhances olfactory sensitivity and exploratory sniffing in rodents and humans
    Jenny Tong
    Division of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Neurosci 31:5841-6. 2011
    ..This novel role is consistent with ghrelin's overall function as a signal amplifier at the molecular interface between environmental and nutritional cues and neuroendocrine circuits controlling energy homeostasis...
  28. ncbi request reprint Comparison of central and peripheral administration of C75 on food intake, body weight, and conditioned taste aversion
    Deborah J Clegg
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio, USA
    Diabetes 51:3196-201. 2002
    ..Understanding the mechanisms by which FAS inhibition in the CNS reduces food intake could lead to specific targets for the manipulation of energy balance and the treatment of obesity...
  29. pmc Insulin, leptin and reward
    Jon F Davis
    Department of Psychiatry North, E, Lab 334, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, OH 45237, USA
    Trends Endocrinol Metab 21:68-74. 2010
    ..This review describes the capacity of both insulin and leptin to regulate reward-related behavior...
  30. ncbi request reprint Acute third ventricular administration of insulin decreases food intake in two paradigms
    Ellen L Air
    Department of Biomedical Sciences, University of Cincinnati, Cincinnati, OH 45267, USA
    Pharmacol Biochem Behav 72:423-9. 2002
    ..These data suggest that insulin can reduce food intake in acute delivery paradigms and provide another means by which to assess the roles of other central systems in the mediation of insulin's effects on energy homeostasis...
  31. pmc The melanocortin antagonist AgRP (83-132) increases appetitive responding for a fat, but not a carbohydrate, reinforcer
    Andrea L Tracy
    Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45237, USA
    Pharmacol Biochem Behav 89:263-71. 2008
    ..These results suggest a possible role for AgRP in the increased fat intake associated with obesity...
  32. ncbi request reprint Two novel paradigms for the simultaneous assessment of conditioned taste aversion and food intake effects of anorexic agents
    Stephen C Benoit
    Department of Psychiatry, University of Cincinnati Medical Center, P O Box 670559, Cincinnati, OH 45267, USA
    Physiol Behav 79:761-6. 2003
    ..These results suggest that both the appetitive and aversive consequences of anorexic agents can be assessed simultaneously during either acute or chronic drug administration...
  33. pmc Voluntary consumption of ethyl oleate reduces food intake and body weight in rats
    Christopher J Kemp
    Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45237 USA
    Physiol Behav 93:912-8. 2008
    ..These data indicate that voluntary access to EO promoted short-term satiety, compared to SO diet, and that these effects contributed to an important and novel attenuated weight gain in EO-fed animals...
  34. ncbi request reprint Increased dietary fat attenuates the anorexic effects of intracerebroventricular injections of MTII
    Deborah J Clegg
    Department of Psychiatry, University of Cincinnati Medical Center, PO Box 670559, Cincinnati, OH 45267 0559, USA
    Endocrinology 144:2941-6. 2003
    ..These results indicate that consumption of a HF diet decreases signaling through the melanocortin system, an abnormality that could contribute to diet-induced obesity...
  35. pmc Melanocortin signaling in the CNS directly regulates circulating cholesterol
    Diego Perez-Tilve
    Metabolic Diseases Institute, Division of Endocrinology, Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Nat Neurosci 13:877-82. 2010
    ..Our data suggest that a neural circuit in the brain is directly involved in the control of cholesterol metabolism by the liver...
  36. ncbi request reprint Intraventricular melanin-concentrating hormone stimulates water intake independent of food intake
    Deborah J Clegg
    Department of Psychiatry, University of Cincinnati, Ohio 45267, USA
    Am J Physiol Regul Integr Comp Physiol 284:R494-9. 2003
    ..Hence, in contrast to AgRP, MCH elicits increased water intake independent of food intake. These results are consistent with historical data linking activity of the LH with water as well as food intake...
  37. pmc Exposure to elevated levels of dietary fat attenuates psychostimulant reward and mesolimbic dopamine turnover in the rat
    Jon F Davis
    Department of Psychiatry, Genome Research Institute, University of Cincinnati, Cincinnati, OH 45237, USA
    Behav Neurosci 122:1257-63. 2008
    ....
  38. pmc Angiotensin type 1 receptors in the subfornical organ mediate the drinking and hypothalamic-pituitary-adrenal response to systemic isoproterenol
    Eric G Krause
    University of Cincinnati, Department of Psychiatry, Genome Research Institute, Cincinnati, Ohio 45237, USA
    Endocrinology 149:6416-24. 2008
    ..Delivery of AT1R AS into the SFO or OVLT had no effect on water intake, ACTH, or CORT after hypertonic saline. The results imply that AT1R within the SFO mediate drinking and HPA responses to stimuli that increase circulating ANGII...
  39. ncbi request reprint Consumption of a high-fat diet alters the homeostatic regulation of energy balance
    Stephen C Woods
    Department of Psychiatry, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, OH 45237, USA
    Physiol Behav 83:573-8. 2004
    ..HF-fed animals, independent of whether they become obese or not, also have central insulin and MTII insensitivity. Finally, HF rats have a down-regulated hypothalamic apo A-IV system that could contribute to their hyperphagia...
  40. ncbi request reprint Estradiol-dependent decrease in the orexigenic potency of ghrelin in female rats
    Deborah J Clegg
    Department of Psychiatry, University of Cincinnati, P O Box 670559, Cincinnati, OH 45267 0559, USA
    Diabetes 56:1051-8. 2007
    ....
  41. ncbi request reprint Clinical endocrinology and metabolism. Regulation of energy homeostasis by peripheral signals
    Stephen C Woods
    Department of Psychiatry, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, OH 45237, USA
    Best Pract Res Clin Endocrinol Metab 18:497-515. 2004
    ..Considerable effort is being directed towards finding ways to intervene in specific circuits to help accomplish weight loss...
  42. ncbi request reprint Gonadal hormones determine sensitivity to central leptin and insulin
    Deborah J Clegg
    Department of Psychiatry, University of Cincinnati, PO Box 670559, Cincinatti, OH 45267 0559, USA
    Diabetes 55:978-87. 2006
    ..These data indicate that estrogen acts within the brain to increase leptin sensitivity, decrease insulin sensitivity, and favor subcutaneous over visceral fat...
  43. pmc Comparison of hydrogenated vegetable shortening and nutritionally complete high-fat diet on limited access-binge behavior in rats
    Jon F Davis
    University of Cincinnati, Department of Psychiatry, ML 0506, Reading, OH 45237, United States
    Physiol Behav 92:924-30. 2007
    ..These results suggest that binge-intake behavior occurs on a nutritionally complete high-fat diet and that this regimen is capable of altering both body composition and endocrine profile...
  44. ncbi request reprint Modulation of phosphoinositide-protein kinase C signal transduction by omega-3 fatty acids: implications for the pathophysiology and treatment of recurrent neuropsychiatric illness
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Prostaglandins Leukot Essent Fatty Acids 75:237-57. 2006
    ..The data reviewed in this paper outline a potential molecular mechanism by which omega-3 fatty acids could contribute to the pathophysiology and treatment of recurrent neuropsychiatric illness...
  45. pmc Mice lacking the syndecan-3 gene are resistant to diet-induced obesity
    April D Strader
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237, USA
    J Clin Invest 114:1354-60. 2004
    ..The data implicate syndecan-3 in the regulation of body weight and suggest that inhibition of syndecan-3 may provide a therapeutic approach for the treatment of obesity resulting from exposure to high-fat diets...
  46. pmc Leptin regulates energy balance and motivation through action at distinct neural circuits
    Jon F Davis
    Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, Ohio 45237 0506, USA
    Biol Psychiatry 69:668-74. 2011
    ..The current study asked whether leptin signaling within the lateral hypothalamus (LH) and midbrain is involved in effort-based responding for food rewards and/or the modulation of mesolimbic dopamine...
  47. pmc Signaling through the ghrelin receptor modulates hippocampal function and meal anticipation in mice
    Jon F Davis
    University of Cincinnati, Department of Psychiatry, Cincinnati, OH, USA
    Physiol Behav 103:39-43. 2011
    ..Collectively, these results suggest that ghrelin receptor signaling is necessary for adaptations in the anticipatory responses that accompany restricted feeding...
  48. pmc Central melanocortins modulate mesocorticolimbic activity and food seeking behavior in the rat
    Jon F Davis
    Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45237, USA
    Physiol Behav 102:491-5. 2011
    ..These results suggest that the melanocortin system is capable of regulating mesocorticolimbic activity and food seeking behavior...
  49. pmc Bsx, a novel hypothalamic factor linking feeding with locomotor activity, is regulated by energy availability
    Ruben Nogueiras
    Department of Psychiatry, Obesity Research Center, University of Cincinnati, Cincinnati, Ohio 45237, USA
    Endocrinology 149:3009-15. 2008
    ..Future studies will be necessary to test if Bsx may be involved in the pathogenesis of leptin resistance...
  50. ncbi request reprint Ethanol consumption in mice with a targeted disruption of the dopamine-3 receptor gene
    John Andrews McQuade
    Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45267 0559, USA
    Addict Biol 8:295-303. 2003
    ..Furthermore, the D3-R -/- mice adequately learn a CTA to ethanol and do not ham differing taste reactivity to saccharin or quinine. However, D3-R -/- mice do appear to have a slower rate of ethanol metabolism...
  51. ncbi request reprint Role for dopamine-3 receptor in the hyperphagia of an unanticipated high-fat meal in rats
    Jon F Davis
    University of Cincinnati, Department of Psychiatry, Reading, OH 45237, USA
    Pharmacol Biochem Behav 85:190-7. 2006
    ..Raclopride was ineffective at disrupting food intake. These results support the hypothesis that the dopamine-3 receptor is involved in the hyperphagia of an unexpected high fat meal...
  52. pmc Modulatory calcineurin-interacting proteins 1 and 2 function as calcineurin facilitators in vivo
    Bastiano Sanna
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 103:7327-32. 2006
    ..Thus, a loss-of-function analysis suggests that MCIPs serve either a permissive or facilitative function for calcineurin-NFAT signaling in vivo...
  53. pmc Long-term behavioral consequences of prenatal MDMA exposure
    Valerie B Thompson
    Neuroscience Graduate Program, University of Cincinnati, 231 Albert Sabin Way, CVC Room 5940, ML 0537, Cincinnati, OH 45267, USA
    Physiol Behav 96:593-601. 2009
    ....
  54. ncbi request reprint A role for syndecan-3 in the melanocortin regulation of energy balance
    Ofer Reizes
    Procter and Gamble Pharmaceuticals Inc Health Care Research Center, Mason, OH 45040, USA
    Peptides 27:274-80. 2006
    ..In this review, we present an overview of the biology and potential functions of syndecan-3 and describe a novel hypothesis for its regulation of energy balance...
  55. ncbi request reprint Ghrelin controls hippocampal spine synapse density and memory performance
    Sabrina Diano
    Department of Obstetrics and Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Neurosci 9:381-8. 2006
    ..Our observations reveal an endogenous function of ghrelin that links metabolic control with higher brain functions and suggest novel therapeutic strategies to enhance learning and memory processes...
  56. ncbi request reprint The interoceptive cue properties of ghrelin generalize to cues produced by food deprivation
    T L Davidson
    Ingestive Behavior Research Center, Purdue University, 703 Third Street, West Lafayette, IN 47907, USA
    Peptides 26:1602-10. 2005
    ..These results support the notion that endogenous ghrelin contributes to an interoceptive hunger cue, and that this may be a mechanism by which ghrelin influences food intake and appetitive behavior...
  57. pmc A potential role for the hippocampus in energy intake and body weight regulation
    Terry L Davidson
    Department of Psychological Sciences, Ingestive Behavior Research Center, Purdue University, West Lafayette, IN, USA
    Curr Opin Pharmacol 7:613-6. 2007
    ..The present paper summarizes these findings and ideas and considers the hypothesis that excessive caloric intake and obesity may be produced by dietary and other factors that are known to alter hippocampal functioning...
  58. ncbi request reprint Intraventricular insulin and leptin reverse place preference conditioned with high-fat diet in rats
    Dianne P Figlewicz
    Metabolism Endocrinology 151, Veterans Affairs Puget Sound Health Care System, 1660 South Columbian Way, Seattle, WA 98108, USA
    Behav Neurosci 118:479-87. 2004
    ..Food-restricted rats receiving cerebrospinal fluid, insulin, or leptin had comparable CPPs. Results indicate that the CNS roles of insulin and leptin may include processes involving memory and reward...
  59. ncbi request reprint Syndecan-3 modulates food intake by interacting with the melanocortin/AgRP pathway
    Ofer Reizes
    Procter Gamble Pharmaceuticals, Inc, Health Care Research Center, Mason, Ohio 45040, USA
    Ann N Y Acad Sci 994:66-73. 2003
    ..Collectively, the data suggest that the modulation of melanocortin regulation of energy balance by syndecan-3 is modulated by the action of a TIMP-3-sensitive metalloprotease...
  60. ncbi request reprint Small-molecule melanin-concentrating hormone-1 receptor antagonists require brain penetration for inhibition of food intake and reduction in body weight
    X Eric Hu
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, OH 44195, USA
    J Pharmacol Exp Ther 324:206-13. 2008
    ..The effect is dose-dependent and appears to be partially driven by a reduction in food intake. Finally, these studies show the utility of a medicinal chemistry approach to address an important biological and pharmacological question...
  61. ncbi request reprint The many faces of ghrelin: new perspectives for nutrition research?
    Bärbel Otto
    Medical Department Innenstadt, University Hospital Munich, Germany
    Br J Nutr 93:765-71. 2005
    ..This review summarizes the known functions of ghrelin and its role in the regulation of the gut-brain axis...
  62. ncbi request reprint PYY3-36 "monkeys around" with energy balance
    Stephen C Benoit
    Am J Physiol Regul Integr Comp Physiol 288:R358-9. 2005

Research Grants9

  1. Role of CNS Insulin in Learning and Memory
    Stephen Benoit; Fiscal Year: 2003
    ..Ultimately, this line of investigation may offer novel therapeutic strategies for treating individuals with cognitive disorders such as Alzheimer' s disease. ..
  2. Syndecan & CNS Melanocortin Signaling in Energy Balance
    Stephen Benoit; Fiscal Year: 2004
    ..The results may provide important, basic insights into the control of body weight by the central melanocortin system and its recently identified co-receptor, syndecan-3. ..
  3. Behavioral Mechanisms of CNS Melanocortin Action
    Stephen Benoit; Fiscal Year: 2004
    ..These results will expand our understanding of this critical system for the regulation of food intake and body weight and, hopefully, provide insight into important structures and systems that are downstream of the melanocortins. ..
  4. Syndecan & CNS Melanocortin Signaling in Energy Balance
    Stephen Benoit; Fiscal Year: 2005
    ..The results may provide important, basic insights into the control of body weight by the central melanocortin system and its recently identified co-receptor, syndecan-3. ..
  5. Behavioral Mechanisms of CNS Melanocortin Action
    Stephen Benoit; Fiscal Year: 2005
    ..These results will expand our understanding of this critical system for the regulation of food intake and body weight and, hopefully, provide insight into important structures and systems that are downstream of the melanocortins. ..
  6. Syndecan & CNS Melanocortin Signaling in Energy Balance
    Stephen Benoit; Fiscal Year: 2006
    ..The results may provide important, basic insights into the control of body weight by the central melanocortin system and its recently identified co-receptor, syndecan-3. ..
  7. Behavioral Mechanisms of CNS Melanocortin Action
    Stephen Benoit; Fiscal Year: 2006
    ..These results will expand our understanding of this critical system for the regulation of food intake and body weight and, hopefully, provide insight into important structures and systems that are downstream of the melanocortins. ..
  8. Syndecan & CNS Melanocortin Signaling in Energy Balance
    Stephen Benoit; Fiscal Year: 2007
    ..The results may provide important, basic insights into the control of body weight by the central melanocortin system and its recently identified co-receptor, syndecan-3. ..
  9. Behavioral Mechanisms of CNS Melanocortin Action
    Stephen Benoit; Fiscal Year: 2007
    ..These results will expand our understanding of this critical system for the regulation of food intake and body weight and, hopefully, provide insight into important structures and systems that are downstream of the melanocortins. ..