Beth Bennett

Summary

Affiliation: University of Colorado
Country: USA

Publications

  1. ncbi request reprint Quantitative trait loci for ethanol sensitivity in the LS x SS recombinant inbred strains: interval mapping
    P D Markel
    Institute for Behavioral Genetics, University of Colorado, Boulder 80309 0447, USA
    Behav Genet 26:447-58. 1996
  2. ncbi request reprint Mapping quantitative trait loci for ethanol-induced anesthesia in LSxSS recombinant inbred and F2 mice: methodology and results
    B Bennett
    Institute for Behavioral Genetics, University of Colorado, Boulder 80309 0447, USA
    Alcohol Alcohol Suppl 2:79-86. 1994
  3. ncbi request reprint Fine mapping of polymorphic alcohol-related quantitative trait loci candidate genes using interval-specific congenic recombinant mice
    Marissa A Ehringer
    Department of Pharmacology and Human Medical Genetics Program, University of Colorado Health Sciences Center, Denver 80262, USA
    Alcohol Clin Exp Res 26:1603-8. 2002
  4. ncbi request reprint Differences in the urocortin 1 system between long-sleep and short-sleep mice
    Victoria F Turek
    Department of Behavioral Neuroscience, Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR 92121, USA
    Genes Brain Behav 7:113-9. 2008
  5. ncbi request reprint Genetic dissection of quantitative trait loci specifying sedative/hypnotic sensitivity to ethanol: mapping with interval-specific congenic recombinant lines
    Beth Bennett
    Institute for Behavioral Genetics, University of Colorado, Boulder 80309 0447, USA
    Alcohol Clin Exp Res 26:1615-24. 2002
  6. ncbi request reprint Genetics of body weight in the LXS recombinant inbred mouse strains
    Beth Bennett
    Institute for Behavioral Genetics, 447, University of Colorado at Boulder, Boulder, Colorado 80309 0447, USA
    Mamm Genome 16:764-74. 2005
  7. ncbi request reprint Replication of small effect quantitative trait loci for behavioral traits facilitated by estimation of effect size from independent cohorts
    B Bennett
    Institute for Behavioral Genetics, CB447, University of Colorado, Boulder, CO 80309, USA
    Genes Brain Behav 5:404-12. 2006
  8. ncbi request reprint Confirmation and fine mapping of ethanol sensitivity quantitative trait loci, and candidate gene testing in the LXS recombinant inbred mice
    Beth Bennett
    Institute for Behavioral Genetics, 447 UCB, Boulder, CO 80309 0354, USA
    J Pharmacol Exp Ther 319:299-307. 2006
  9. ncbi request reprint Mouse genetic models in alcohol research
    Beth Bennett
    Institute for Behavioral Genetics, 447 UCB, Boulder, CO 80309 0447, USA
    Trends Genet 22:367-74. 2006
  10. ncbi request reprint Quantitative trait locus mapping for acute functional tolerance to ethanol in the L x S recombinant inbred panel
    Beth Bennett
    Institute for Behavioral Genetics, Colorado 80309 0447, USA
    Alcohol Clin Exp Res 31:200-8. 2007

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Quantitative trait loci for ethanol sensitivity in the LS x SS recombinant inbred strains: interval mapping
    P D Markel
    Institute for Behavioral Genetics, University of Colorado, Boulder 80309 0447, USA
    Behav Genet 26:447-58. 1996
    ..These results are compared to those from an F2 cross which confirms QTLs on chromosomes 1, 2, 4, and 18...
  2. ncbi request reprint Mapping quantitative trait loci for ethanol-induced anesthesia in LSxSS recombinant inbred and F2 mice: methodology and results
    B Bennett
    Institute for Behavioral Genetics, University of Colorado, Boulder 80309 0447, USA
    Alcohol Alcohol Suppl 2:79-86. 1994
    ..A new statistical technique, interval mapping, allows the use of all polymorphic markers simultaneously to locate QTLs...
  3. ncbi request reprint Fine mapping of polymorphic alcohol-related quantitative trait loci candidate genes using interval-specific congenic recombinant mice
    Marissa A Ehringer
    Department of Pharmacology and Human Medical Genetics Program, University of Colorado Health Sciences Center, Denver 80262, USA
    Alcohol Clin Exp Res 26:1603-8. 2002
    ..Here, recently developed interval-specific congenic recombinant mice (ISCRs) have been used to map these genes in relationship to newly narrowed QTL regions...
  4. ncbi request reprint Differences in the urocortin 1 system between long-sleep and short-sleep mice
    Victoria F Turek
    Department of Behavioral Neuroscience, Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR 92121, USA
    Genes Brain Behav 7:113-9. 2008
    ..In addition, these results lend further support to previous findings implicating Ucn1-containing projections from npEW to the dorsal raphe in ethanol-induced hypothermia...
  5. ncbi request reprint Genetic dissection of quantitative trait loci specifying sedative/hypnotic sensitivity to ethanol: mapping with interval-specific congenic recombinant lines
    Beth Bennett
    Institute for Behavioral Genetics, University of Colorado, Boulder 80309 0447, USA
    Alcohol Clin Exp Res 26:1615-24. 2002
    ....
  6. ncbi request reprint Genetics of body weight in the LXS recombinant inbred mouse strains
    Beth Bennett
    Institute for Behavioral Genetics, 447, University of Colorado at Boulder, Boulder, Colorado 80309 0447, USA
    Mamm Genome 16:764-74. 2005
    ..Large reference panels of RI strains, such as the LXS, are invaluable for identifying genetic correlations, GXE (Gene X Environment) interactions, and replicating previously identified QTLs...
  7. ncbi request reprint Replication of small effect quantitative trait loci for behavioral traits facilitated by estimation of effect size from independent cohorts
    B Bennett
    Institute for Behavioral Genetics, CB447, University of Colorado, Boulder, CO 80309, USA
    Genes Brain Behav 5:404-12. 2006
    ..Such a reduction will have important consequences for power analyses in which sample sizes are determined for subsequent confirmation studies...
  8. ncbi request reprint Confirmation and fine mapping of ethanol sensitivity quantitative trait loci, and candidate gene testing in the LXS recombinant inbred mice
    Beth Bennett
    Institute for Behavioral Genetics, 447 UCB, Boulder, CO 80309 0354, USA
    J Pharmacol Exp Ther 319:299-307. 2006
    ..Finally, we present an approach for using these RI strains to assess evidence for candidate genes in the narrowed intervals, and we apply this method to a strong candidate, the serotonin transporter...
  9. ncbi request reprint Mouse genetic models in alcohol research
    Beth Bennett
    Institute for Behavioral Genetics, 447 UCB, Boulder, CO 80309 0447, USA
    Trends Genet 22:367-74. 2006
    ..Many of the underlying genes should be identified in the near future...
  10. ncbi request reprint Quantitative trait locus mapping for acute functional tolerance to ethanol in the L x S recombinant inbred panel
    Beth Bennett
    Institute for Behavioral Genetics, Colorado 80309 0447, USA
    Alcohol Clin Exp Res 31:200-8. 2007
    ..We report replication of QTL regions reported by earlier studies of AFT and preliminary application of a coarse single nucleotide polymorphism map analysis to limit QTL intervals for subsequent candidate gene hypotheses...
  11. ncbi request reprint Possible pleiotropic effects of genes specifying sedative/hypnotic sensitivity to ethanol on other alcohol-related traits
    Jeremy C Owens
    Institute for Behavioral Genetics, and the Department of Psychology, University of Colorado, Boulder, Colorado 80309 0447, USA
    Alcohol Clin Exp Res 26:1461-7. 2002
    ..We assessed congenic mice carrying a single quantitative trait locus (QTL) from the inbred long-sleep (ILS) or inbred short-sleep (ISS) strain on the reciprocal background for a number of ethanol- and pentobarbital-related phenotypes...
  12. ncbi request reprint QTL mapping for low-dose ethanol activation in the LXS recombinant inbred strains
    Chris Downing
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado, USA
    Alcohol Clin Exp Res 30:1111-20. 2006
    ..The LXS RI panel has additional genetic variation, and greater power due to a larger number of strains, compared with other RI panels and strain crosses...
  13. ncbi request reprint Confirmation and genetic dissection of a major quantitative trait locus for alcohol preference drinking
    Cathy Ruf
    Institute for Behavioral Genetics, CB 447, University of Colorado, Boulder, CO 80309 0447, USA
    Alcohol Clin Exp Res 28:1613-21. 2004
    ..Here, we report construction and testing of interval-specific congenic recombinant strains (ISCRSs) for the purpose of narrowing the quantitative trait loci (QTL) interval...
  14. ncbi request reprint Development of congenics for hypnotic sensitivity to ethanol by QTL-marker-assisted counter selection
    B Bennett
    Institute for Behavioral Genetics, CB447, University of Colorado, Boulder, Colorado 80309 0447, USA
    Mamm Genome 9:969-74. 1998
    ..The parent-offspring correlation over all QTLs was significant, supporting the use of phenotypic selection in congenic construction...
  15. ncbi request reprint Norepinephrine transporter: a candidate gene for initial ethanol sensitivity in inbred long-sleep and short-sleep mice
    Heather M Haughey
    Department of Pharmacology, University of Colorado Health Sciences Center, Aurora, Colorado, USA
    Alcohol Clin Exp Res 29:1759-68. 2005
    ....
  16. ncbi request reprint Reciprocal congenics defining individual quantitative trait Loci for sedative/hypnotic sensitivity to ethanol
    B Bennett
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309, USA
    Alcohol Clin Exp Res 26:149-57. 2002
    ..The derivation of these strains is reviewed here...
  17. ncbi request reprint Evidence that the Lore-1 region specifies ethanol-induced activation in addition to sedative/hypnotic sensitivity to ethanol
    J C Owens
    Institute for Behavioral Genetics (JCO, BB, TEJ) and the Department of Psychology (JCO, TEJ, University of Colorado, Boulder, Colorado 80309-0447, USA
    Alcohol Clin Exp Res 25:1551-7. 2001
    ..8 and 2.4 g/kg of ethanol. CONCLUSIONS: The Lore-2 and Lore-5 congenic regions do not affect LDA. In contrast, the Lore-1 congenic region carries one or more genes specifying both initial hypnotic sensitivity to ethanol and LDA...
  18. ncbi request reprint Congenic strains developed for alcohol- and drug-related phenotypes
    B Bennett
    Institute for Behavioral Genetics, CB 447, University of Colorado, Boulder, CO 80309 0447, USA
    Pharmacol Biochem Behav 67:671-81. 2000
    ..Most researchers developing such strains are willing to share these resources to facilitate localization of the genetic bases of other phenotypes...
  19. ncbi request reprint Confirmation of quantitative trait loci for ethanol sensitivity in long-sleep and short-sleep mice
    P D Markel
    Institute for Behavioral Genetics, University of Colorado, Boulder 80309, USA
    Genome Res 7:92-9. 1997
    ..This represents the first report of linkages for genes influencing alcohol action in any mammalian system using stringent, genome-wide mapping criteria...
  20. doi request reprint Genetic dissection of quantitative trait locus for ethanol sensitivity in long- and short-sleep mice
    B Bennett
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309 0447, USA
    Genes Brain Behav 7:659-68. 2008
    ..Genetic background effects can be important in detection of single QTL; combining this information with the generation of congenics on both backgrounds, as described here, is a powerful approach for fine mapping QTL...
  21. pmc Expression profiling identifies novel candidate genes for ethanol sensitivity QTLs
    Erik J MacLaren
    Department of Pharmacology, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado 80045, USA
    Mamm Genome 17:147-56. 2006
    ..These genes represent novel candidates for the LORR phenotype and provide new targets for future studies into the neuronal processes underlying ethanol sensitivity...
  22. ncbi request reprint The Collaborative Cross, a community resource for the genetic analysis of complex traits
    Gary A Churchill
    The Jackson Laboratory, 600 Main Street Bar Harbor, Maine 04609, USA
    Nat Genet 36:1133-7. 2004
    ..The Collaborative Cross will provide a common reference panel specifically designed for the integrative analysis of complex systems and will change the way we approach human health and disease...
  23. ncbi request reprint Differential effects of ethanol on gamma-aminobutyric acid-A receptor-mediated synaptic currents in congenic strains of inbred long and short-sleep mice
    William R Proctor
    Veterans Affairs Eastern Colorado Health Care System, Denver, Colorado, USA
    Alcohol Clin Exp Res 28:1277-83. 2004
    ..These congenic mouse strains are ideally suited for asking which QTL regions might correlate with other phenotypes that differ between ILS and ISS mice. Here we used the congenics to investigate altered GABAA responses to ethanol...
  24. ncbi request reprint Genetic structure of the LXS panel of recombinant inbred mouse strains: a powerful resource for complex trait analysis
    Robert W Williams
    Portland Alcohol Research Center, Oregon Health Sciences University, 97239, USA
    Mamm Genome 15:637-47. 2004
    ..Thus, the LXS panel provides a powerful new resource for mapping complex traits across many systems and disciplines and should prove to be of great utility in modeling the genetics of complex diseases in human populations...
  25. pmc The nature and identification of quantitative trait loci: a community's view
    Oduola Abiola
    Nat Rev Genet 4:911-6. 2003
    ..Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?..