P Benn

Summary

Affiliation: University of Connecticut Health Center
Country: USA

Publications

  1. ncbi request reprint Non-invasive prenatal testing for aneuploidy: current status and future prospects
    P Benn
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT, USA
    Ultrasound Obstet Gynecol 42:15-33. 2013
  2. ncbi request reprint Reproducibility of risk figures in 2nd-trimester maternal serum screening for down syndrome: comparison of 2 laboratories
    Peter A Benn
    Division of Human Genetics, Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT 06030 6140, USA
    Clin Chem 52:2087-94. 2006
  3. ncbi request reprint Improved antenatal screening for Down's syndrome
    Peter Benn
    Division of Human Genetics, Department of Pediatrics, University of Connecticut Health Center, Farmington, CT 06030, USA
    Lancet 361:794-5. 2003
  4. ncbi request reprint Incorporation of inhibin-A in second-trimester screening for Down syndrome
    Peter A Benn
    Division of Human Genetics, Department of Pediatrics, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 6140, USA
    Obstet Gynecol 101:451-4. 2003
  5. ncbi request reprint Combined second-trimester biochemical and ultrasound screening for Down syndrome
    Peter A Benn
    Division of Human Genetics, Department of Pediatrics, University of Connecticut Health Center, Farmington 06030, USA
    Obstet Gynecol 100:1168-76. 2002
  6. doi request reprint Expected performance of second trimester maternal serum testing followed by a 'genetic sonogram' in screening of fetal Down syndrome
    Peter A Benn
    Division of Human Genetics, Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT, USA
    Prenat Diagn 28:230-5. 2008
  7. ncbi request reprint Advances in prenatal screening for Down syndrome: II first trimester testing, integrated testing, and future directions
    Peter A Benn
    Division of Human Genetics, Department of Pediatrics, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 6140, USA
    Clin Chim Acta 324:1-11. 2002
  8. doi request reprint Ethical challenges in providing noninvasive prenatal diagnosis
    Peter A Benn
    Department of Genetics and Developmental Biology, Division of Human Genetics, USA
    Curr Opin Obstet Gynecol 22:128-34. 2010
  9. ncbi request reprint Second trimester maternal serum analytes in triploid pregnancies: correlation with phenotype and sex chromosome complement
    P A Benn
    Division of Human Genetics, Department of Pediatrics, University of Connecticut Health Center, Farmington, CT 06030 6140, USA
    Prenat Diagn 21:680-6. 2001
  10. ncbi request reprint Evaluation of effect of analytical imprecision in maternal serum screening for Down's syndrome
    P A Benn
    Department of Pediatrics, University of Connecticut Health Center, Farmington, USA
    Ann Clin Biochem 38:28-36. 2001

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Non-invasive prenatal testing for aneuploidy: current status and future prospects
    P Benn
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT, USA
    Ultrasound Obstet Gynecol 42:15-33. 2013
    ..Providing adequate prenatal counseling poses a substantial challenge given the broad range of prenatal testing options now available...
  2. ncbi request reprint Reproducibility of risk figures in 2nd-trimester maternal serum screening for down syndrome: comparison of 2 laboratories
    Peter A Benn
    Division of Human Genetics, Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT 06030 6140, USA
    Clin Chem 52:2087-94. 2006
    ..Analytical error affects 2nd-trimester maternal serum screening for Down syndrome risk estimation. We analyzed the between-laboratory reproducibility of risk estimates from 2 laboratories...
  3. ncbi request reprint Improved antenatal screening for Down's syndrome
    Peter Benn
    Division of Human Genetics, Department of Pediatrics, University of Connecticut Health Center, Farmington, CT 06030, USA
    Lancet 361:794-5. 2003
  4. ncbi request reprint Incorporation of inhibin-A in second-trimester screening for Down syndrome
    Peter A Benn
    Division of Human Genetics, Department of Pediatrics, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 6140, USA
    Obstet Gynecol 101:451-4. 2003
    ..To evaluate the efficacy of the second-trimester quadruple test (maternal serum alpha-fetoprotein, unconjugated estriol, human chorionic gonadotropin, and inhibin-A) in prenatal screening for Down syndrome...
  5. ncbi request reprint Combined second-trimester biochemical and ultrasound screening for Down syndrome
    Peter A Benn
    Division of Human Genetics, Department of Pediatrics, University of Connecticut Health Center, Farmington 06030, USA
    Obstet Gynecol 100:1168-76. 2002
    ..To evaluate the efficacy of a Down syndrome screening protocol that combines second-trimester maternal serum analytes and the continuous ultrasound measures of nuchal fold thickness and proximal long bone length...
  6. doi request reprint Expected performance of second trimester maternal serum testing followed by a 'genetic sonogram' in screening of fetal Down syndrome
    Peter A Benn
    Division of Human Genetics, Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT, USA
    Prenat Diagn 28:230-5. 2008
    ..To assess the efficacy of screening for fetal Down syndrome through the sequential provision of second trimester maternal serum tests and fetal ultrasound (the 'genetic sonogram')...
  7. ncbi request reprint Advances in prenatal screening for Down syndrome: II first trimester testing, integrated testing, and future directions
    Peter A Benn
    Division of Human Genetics, Department of Pediatrics, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 6140, USA
    Clin Chim Acta 324:1-11. 2002
    ..First trimester screening could be advantageous if it has sufficient efficacy and can be effectively delivered...
  8. doi request reprint Ethical challenges in providing noninvasive prenatal diagnosis
    Peter A Benn
    Department of Genetics and Developmental Biology, Division of Human Genetics, USA
    Curr Opin Obstet Gynecol 22:128-34. 2010
    ..Noninvasive prenatal diagnosis (NIPD) can potentially allow early detection of fetal genetic disorders, sex, other nonmedical traits, and paternity. We review ethical concerns associated with the imminent introduction of this testing...
  9. ncbi request reprint Second trimester maternal serum analytes in triploid pregnancies: correlation with phenotype and sex chromosome complement
    P A Benn
    Division of Human Genetics, Department of Pediatrics, University of Connecticut Health Center, Farmington, CT 06030 6140, USA
    Prenat Diagn 21:680-6. 2001
    ..It is suggested that the sex chromosome complement in triploidy is an important factor in determining risk for partial mole development and in utero survival...
  10. ncbi request reprint Evaluation of effect of analytical imprecision in maternal serum screening for Down's syndrome
    P A Benn
    Department of Pediatrics, University of Connecticut Health Center, Farmington, USA
    Ann Clin Biochem 38:28-36. 2001
    ..The need for strict quality control and test reproducibility is emphasized. The effect of analytical imprecision should be of particular concern to laboratories that provide screening for women of advanced maternal age...
  11. ncbi request reprint Estimates for the sensitivity and false-positive rates for second trimester serum screening for Down syndrome and trisomy 18 with adjustment for cross-identification and double-positive results
    P A Benn
    Division of Human Genetics, Department of Pediatrics, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 6140, USA
    Prenat Diagn 21:46-51. 2001
    ..Sensitivity and false-positive rates that take into consideration cross-identification and double-positives should be helpful for pre-test counseling and the evaluation of serum screening programs...
  12. ncbi request reprint Elevated maternal serum alpha-fetoprotein with low unconjugated estriol and the risk for lethal perinatal outcome
    P A Benn
    Department of Pediatrics, University of Connecticut Health Center, Farmington 06030 6140, USA
    J Matern Fetal Med 9:165-9. 2000
    ..To determine whether a combination of elevated maternal serum alpha-fetoprotein (MSAFP) and low unconjugated estriol (E3) concentration identifies pregnancies at particularly high risk for fetal abnormality or poor outcome...
  13. ncbi request reprint Maternal serum screening for fetal trisomy 18: a comparison of fixed cutoff and patient-specific risk protocols
    P A Benn
    Department of Pediatrics, University of Connecticut Health Center, Farmington 06030 6140, USA
    Obstet Gynecol 93:707-11. 1999
    ..To compare the effectiveness of two widely used protocols for second-trimester screening for fetal trisomy 18...
  14. ncbi request reprint Cost-effectiveness of estimating gestational age by ultrasonography in Down syndrome screening
    P A Benn
    Department of Pediatrics, University of Connecticut Health Center, Farmington 06030 6140, USA
    Obstet Gynecol 94:29-33. 1999
    ..To quantify the financial benefits of using ultrasound estimation of gestational age in maternal serum screening for Down syndrome...
  15. ncbi request reprint Trisomy 16 and trisomy 16 Mosaicism: a review
    P Benn
    Department of Pediatrics, University of Connecticut Health Center, Farmington 06030 6140, USA
    Am J Med Genet 79:121-33. 1998
    ..The term "occult mosaicism" is suggested to describe the situation in which the presence of an abnormal cell line is suspected on the basis of clinical data but unproven by laboratory analysis...
  16. ncbi request reprint Practical strategies in contingent sequential screening for Down syndrome
    Peter Benn
    Department of Genetics and Developmental Biology, University of Connecticut, Health Center, Farmington, CT 06030 6140, USA
    Prenat Diagn 25:645-52. 2005
    ..To design and assess the performance of protocols for contingent sequential Down syndrome screening that can be implemented in practice...
  17. ncbi request reprint Economic evaluation of prenatal screening for Down syndrome in the U.S.A
    T Beazoglou
    Department of Pediatric Dentistry, University of Connecticut Health Center, Farmington 06032 1610, USA
    Prenat Diagn 18:1241-52. 1998
    ..The optimization of societal net benefit provides a powerful approach to evaluating screening strategies, but the policies used must also consider individuals' freedom in decision making at each step of the prenatal diagnosis pathway...
  18. ncbi request reprint Aging chromosome telomeres: parallel studies with terminal repeat and telomere associated DNA probes
    P Benn
    Department of Pediatrics, University of Connecticut Health Center, Farmington 06030 6140, USA
    Mech Ageing Dev 99:153-66. 1997
    ..Variation in terminal repeat length may be related to the extent that telomeres participate in chromosome rearrangement...
  19. doi request reprint The role of second-trimester serum screening in the post-first-trimester screening era
    Alireza A Shamshirsaz
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 2947, USA
    Clin Lab Med 30:667-76. 2010
    ..However, the most efficacious protocols are based on the combination of first- and second-trimester tests. In this article the advantages and best strategies in providing these sequential screening protocols are discussed...
  20. doi request reprint Down syndrome screening in the United States in 2001 and 2007: a survey of maternal-fetal medicine specialists
    Yu Ming Victor Fang
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Connecticut School of Medicine, Farmington, CT, USA
    Am J Obstet Gynecol 201:97.e1-5. 2009
    ..The purpose of this study was to determine changes in screening and performance of invasive diagnostic procedures for Down syndrome between 2001 and 2007...
  21. ncbi request reprint Sequential Down syndrome screening: the importance of first and second trimester test correlations when calculating risk
    Peter Benn
    Division of Human Genetics, Department of Genetics and Developmental Biology, University of Connecticut, Farmington, USA
    J Genet Couns 14:409-13. 2005
    ..Counseling issues in the delivery of sequential screening are discussed...
  22. ncbi request reprint Changes in the utilization of prenatal diagnosis
    Peter A Benn
    Division of Human Genetics, Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 6140, USA
    Obstet Gynecol 103:1255-60. 2004
    ..To measure the overall effectiveness in actual clinical practice, we analyzed the tests performed by a single cytogenetics laboratory...
  23. ncbi request reprint Advances in prenatal screening for Down syndrome: I. general principles and second trimester testing
    Peter A Benn
    Division of Human Genetics, Department of Pediatrics, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 6140, USA
    Clin Chim Acta 323:1-16. 2002
    ..The purpose of prenatal screening is to identify those women at the increased risk for an affected pregnancy and to maximize the options available to these women...
  24. ncbi request reprint Antenatal Down syndrome screening in the United States in 2001: a survey of maternal-fetal medicine specialists
    James F X Egan
    Division of Maternal Fetal Medicine, Department of Obstetrics, St Francis Hospital and Medical Center, Hartford, Conn, USA
    Am J Obstet Gynecol 187:1230-4. 2002
    ..Our objectives were to determine patterns of antenatal Down syndrome screening and risk adjustment by maternal-fetal medicine specialists in the United States in 2001...
  25. ncbi request reprint Second trimester prenatal ultrasound and screening for Down syndrome
    Peter A Benn
    Prenat Diagn 27:884. 2007
  26. ncbi request reprint Absent or shortened nasal bone length and the detection of Down Syndrome in second-trimester fetuses
    Elisa A Gianferrari
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Connecticut Health Center, 114 Woodland Street, Farmington, CT 06105, USA
    Obstet Gynecol 109:371-5. 2007
    ..To estimate the accuracy of evaluating nasal bone length, expressed as multiples of the median (MoM), for the detection of Down syndrome in second- trimester fetuses...
  27. ncbi request reprint Correlation of second-trimester sonographic and biochemical markers
    Vivienne L Souter
    Center for Perinatal Studies, Swedish Medical Center, Seattle, Washington, USA
    J Ultrasound Med 23:505-11. 2004
    ..To investigate correlations between sonographic soft markers and biochemical markers (human chorionic gonadotrophin, alpha-fetoprotein, and estriol) for Down syndrome in the second trimester of pregnancy...
  28. ncbi request reprint Trends in the use of second trimester maternal serum screening from 1991 to 2003
    Peter A Benn
    Division of Human Genetics, Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Genet Med 7:328-31. 2005
    ..To identify trends in the utilization of second trimester maternal serum screening, follow-up amniocenteses, and the detection of Down syndrome-affected pregnancies between 1991 and 2003...
  29. ncbi request reprint Down syndrome births in the United States from 1989 to 2001
    James F X Egan
    Department of Obstetrics and Gynecology, University of Connecticut Health Center, Farmington, USA
    Am J Obstet Gynecol 191:1044-8. 2004
    ..We investigated the observed and expected Down syndrome livebirths in the US from 1989 to 2001...
  30. ncbi request reprint Combined sonographic and biochemical markers for Down syndrome screening
    Michael G Pinette
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Maine Medical Center, Portland, Maine, USA
    J Ultrasound Med 22:1185-90. 2003
    ..To evaluate the efficacy of fetal nuchal fold thickness and proximal long bone biometric measurements in modifying Down syndrome serum screening risk in a population of women referred for second-trimester sonography...
  31. ncbi request reprint Stepwise sequential screening for fetal aneuploidy
    Peter A Benn
    Division of Human Genetics, Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT, USA
    Am J Obstet Gynecol 197:312.e1-5. 2007
    ..The purpose of this study was to evaluate stepwise sequential screening for fetal aneuploidy...