L BenMohamed

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Protective immunity to genital herpes simplex virus type 1 and type 2 provided by self-adjuvanting lipopeptides that drive dendritic cell maturation and elicit a polarized Th1 immune response
    Ilham Bettahi
    Cellular and Molecular Immunology Laboratory, The Eye Institute, University of California Irvine, School of Medicine, Irvine, California, USA
    Viral Immunol 19:220-36. 2006
  2. pmc Linear and branched glyco-lipopeptide vaccines follow distinct cross-presentation pathways and generate different magnitudes of antitumor immunity
    Olivier Renaudet
    Laboratory of Cellular and Molecular Immunology, The Gavin Herbert Eye Institute, School of Medicine, University of California Irvine, Irvine, California, USA
    PLoS ONE 5:e11216. 2010
  3. pmc Towards a rational design of an asymptomatic clinical herpes vaccine: the old, the new, and the unknown
    Aziz Alami Chentoufi
    Laboratory of Cellular and Molecular Immunology, School of Medicine, University of California, Irvine, Irvine, CA 92697 4375, USA
    Clin Dev Immunol 2012:187585. 2012
  4. pmc Immunodominant "asymptomatic" herpes simplex virus 1 and 2 protein antigens identified by probing whole-ORFome microarrays with serum antibodies from seropositive asymptomatic versus symptomatic individuals
    Gargi Dasgupta
    Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California Irvine School of Medicine, Irvine, California, USA
    J Virol 86:4358-69. 2012
  5. pmc Interferon-γ, a valuable surrogate marker of Plasmodium falciparum pre-erythrocytic stages protective immunity
    Blanca Liliana Perlaza
    Malaria Vaccine Development Laboratory, Pasteur Institute, 25 28 rue du Dr, Roux, 75724 Paris, Cedex 15, France
    Malar J 10:27. 2011
  6. doi request reprint A genital tract peptide epitope vaccine targeting TLR-2 efficiently induces local and systemic CD8+ T cells and protects against herpes simplex virus type 2 challenge
    X Zhang
    Laboratory of Cellular and Molecular Immunology, The Gavin S Herbert Eye Institute, University of California Irvine, School of Medicine, Irvine, CA, USA
    Mucosal Immunol 2:129-43. 2009
  7. pmc Identification of novel immunodominant CD4+ Th1-type T-cell peptide epitopes from herpes simplex virus glycoprotein D that confer protective immunity
    Lbachir BenMohamed
    Department of Ophthalmology, University of California Irvine, College of Medicine, Orange, California 92868, USA
    J Virol 77:9463-73. 2003
  8. ncbi request reprint Protective immunity against ocular herpes infection and disease induced by highly immunogenic self-adjuvanting glycoprotein D lipopeptide vaccines
    Ilham Bettahi
    Laboratory of Cellular and Molecular Immunology, The Eye Institute, School of Medicine, University of California Irvine, Irvine, California 92868, USA
    Invest Ophthalmol Vis Sci 48:4643-53. 2007
  9. ncbi request reprint Lipopeptide epitopes extended by an Nepsilon-palmitoyl-lysine moiety increase uptake and maturation of dendritic cells through a Toll-like receptor-2 pathway and trigger a Th1-dependent protective immunity
    Xiaoming Zhu
    Laboratory of Cellular and Molecular Immunology, Department of Ophthalmology, University of California Irvine, College of Medicine, Irvine, CA 92868, USA
    Eur J Immunol 34:3102-14. 2004
  10. pmc New concepts in herpes simplex virus vaccine development: notes from the battlefield
    Gargi Dasgupta
    The Gavin S Herbert Eye Institute, Cellular and Molecular Immunology Laboratory, Department of Ophthalmology, University of California, Irvine, College of Medicine, Irvine, CA 92697 4375, USA
    Expert Rev Vaccines 8:1023-35. 2009

Research Grants

  1. Ocular Mucosal Immunity Induced by HSV-1 Lipopeptides
    Lbachir BenMohamed; Fiscal Year: 2003
  2. Interaction of HSV-1 LAT Gene & Dendritic Cells Function
    Lbachir BenMohamed; Fiscal Year: 2004
  3. Ocular Mucosal Immunity Induced by HSV-1 Lipopeptides
    Lbachir BenMohamed; Fiscal Year: 2004
  4. Ocular Mucosal Immunity Induced by HSV-1 Lipopeptides
    Lbachir BenMohamed; Fiscal Year: 2005
  5. Ocular Mucosal Immunity Induced by HSV-1 Lipopeptides
    Lbachir BenMohamed; Fiscal Year: 2006
  6. Ocular Mucosal Immunity Induced by HSV-1 Lipopeptides
    Lbachir BenMohamed; Fiscal Year: 2007
  7. Ocular Mucsoal Immunity Induced by HSV-1 Lipopeptides
    Lbachir BenMohamed; Fiscal Year: 2010
  8. Therapeutic Ocular HSV Vaccine in HLA Transgenic Rabbits
    Lbachir BenMohamed; Fiscal Year: 2010

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Protective immunity to genital herpes simplex virus type 1 and type 2 provided by self-adjuvanting lipopeptides that drive dendritic cell maturation and elicit a polarized Th1 immune response
    Ilham Bettahi
    Cellular and Molecular Immunology Laboratory, The Eye Institute, University of California Irvine, School of Medicine, Irvine, California, USA
    Viral Immunol 19:220-36. 2006
    ....
  2. pmc Linear and branched glyco-lipopeptide vaccines follow distinct cross-presentation pathways and generate different magnitudes of antitumor immunity
    Olivier Renaudet
    Laboratory of Cellular and Molecular Immunology, The Gavin Herbert Eye Institute, School of Medicine, University of California Irvine, Irvine, California, USA
    PLoS ONE 5:e11216. 2010
    ..However, the cellular and molecular mechanisms of glyco-lipopeptides (GLPs) immunogenicity and the position of the lipid moiety on immunogenicity and protective efficacy of GLPs remain to be determined...
  3. pmc Towards a rational design of an asymptomatic clinical herpes vaccine: the old, the new, and the unknown
    Aziz Alami Chentoufi
    Laboratory of Cellular and Molecular Immunology, School of Medicine, University of California, Irvine, Irvine, CA 92697 4375, USA
    Clin Dev Immunol 2012:187585. 2012
    ....
  4. pmc Immunodominant "asymptomatic" herpes simplex virus 1 and 2 protein antigens identified by probing whole-ORFome microarrays with serum antibodies from seropositive asymptomatic versus symptomatic individuals
    Gargi Dasgupta
    Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California Irvine School of Medicine, Irvine, California, USA
    J Virol 86:4358-69. 2012
    ..These newly identified ID-A-Ags could lead to the development of an efficient "asymptomatic" vaccine against ocular, orofacial, and genital herpes...
  5. pmc Interferon-γ, a valuable surrogate marker of Plasmodium falciparum pre-erythrocytic stages protective immunity
    Blanca Liliana Perlaza
    Malaria Vaccine Development Laboratory, Pasteur Institute, 25 28 rue du Dr, Roux, 75724 Paris, Cedex 15, France
    Malar J 10:27. 2011
    ....
  6. doi request reprint A genital tract peptide epitope vaccine targeting TLR-2 efficiently induces local and systemic CD8+ T cells and protects against herpes simplex virus type 2 challenge
    X Zhang
    Laboratory of Cellular and Molecular Immunology, The Gavin S Herbert Eye Institute, University of California Irvine, School of Medicine, Irvine, CA, USA
    Mucosal Immunol 2:129-43. 2009
    ..IVAG immunization with self-adjuvanting lipid-tailed peptides appears to be a novel mucosal vaccine approach, which has attractive practical and immunological features...
  7. pmc Identification of novel immunodominant CD4+ Th1-type T-cell peptide epitopes from herpes simplex virus glycoprotein D that confer protective immunity
    Lbachir BenMohamed
    Department of Ophthalmology, University of California Irvine, College of Medicine, Orange, California 92868, USA
    J Virol 77:9463-73. 2003
    ..These peptide epitopes may prove to be important components of an effective immunoprophylactic strategy against herpes...
  8. ncbi request reprint Protective immunity against ocular herpes infection and disease induced by highly immunogenic self-adjuvanting glycoprotein D lipopeptide vaccines
    Ilham Bettahi
    Laboratory of Cellular and Molecular Immunology, The Eye Institute, School of Medicine, University of California Irvine, Irvine, California 92868, USA
    Invest Ophthalmol Vis Sci 48:4643-53. 2007
    ....
  9. ncbi request reprint Lipopeptide epitopes extended by an Nepsilon-palmitoyl-lysine moiety increase uptake and maturation of dendritic cells through a Toll-like receptor-2 pathway and trigger a Th1-dependent protective immunity
    Xiaoming Zhu
    Laboratory of Cellular and Molecular Immunology, Department of Ophthalmology, University of California Irvine, College of Medicine, Irvine, CA 92868, USA
    Eur J Immunol 34:3102-14. 2004
    ..These findings have important implications for the development of effective lipopeptide immunization strategies against infectious pathogens...
  10. pmc New concepts in herpes simplex virus vaccine development: notes from the battlefield
    Gargi Dasgupta
    The Gavin S Herbert Eye Institute, Cellular and Molecular Immunology Laboratory, Department of Ophthalmology, University of California, Irvine, College of Medicine, Irvine, CA 92697 4375, USA
    Expert Rev Vaccines 8:1023-35. 2009
    ....
  11. pmc Stable cell lines expressing high levels of the herpes simplex virus type 1 LAT are refractory to caspase 3 activation and DNA laddering following cold shock induced apoptosis
    Dale Carpenter
    The Eye Institute, University of California Irvine, School of Medicine, Irvine, CA 92697, USA
    Virology 369:12-8. 2007
    ..To our knowledge, this is the first report providing direct evidence that LAT blocks two biochemical hallmarks of apoptosis, caspase 3 cleavage and DNA laddering, in the absence of other HSV-1 gene products...
  12. pmc A novel HLA (HLA-A*0201) transgenic rabbit model for preclinical evaluation of human CD8+ T cell epitope-based vaccines against ocular herpes
    Aziz A Chentoufi
    Laboratory of Cellular and Molecular Immunology, The Gavin Herbert Eye Institute, University of California Irvine, Irvine, CA 92697, USA
    J Immunol 184:2561-71. 2010
    ..The relevance of HLA Tg rabbits for future investigation of human CD4-CD8 epitope-based therapeutic vaccines against recurrent HSV-1 is discussed...
  13. doi request reprint Recent advances in multivalent self adjuvanting glycolipopeptide vaccine strategies against breast cancer
    Aziz Alami Chentoufi
    Laboratory of Cellular and Molecular Immunology, The Gavin S Herbert Eye Institute, University of California Irvine, School of Medicine, 101 The City Drive, Bldg 55, Room 202, Orange, CA 92868, USA
    Arch Immunol Ther Exp (Warsz) 57:409-23. 2009
    ....
  14. doi request reprint Antitumor activity of a self-adjuvanting glyco-lipopeptide vaccine bearing B cell, CD4+ and CD8+ T cell epitopes
    Ilham Bettahi
    Laboratory of Cellular and Molecular Immunology, The Gavin S Herbert Eye Institute, University of California Irvine, College of Medicine, Irvine, Orange, CA 92868, USA
    Cancer Immunol Immunother 58:187-200. 2009
    ..Our results suggest self-adjuvanting glyco-lipopeptide molecules as a platform for B Cell, CD4(+), and CD8(+) T cell epitopes-based immunotherapeutic cancer vaccines...
  15. pmc Introducing point mutations into the ATGs of the putative open reading frames of the HSV-1 gene encoding the latency associated transcript (LAT) reduces its anti-apoptosis activity
    Dale Carpenter
    The Eye Institute, University of California Irvine, School of Medicine, Irvine, CA 92697, USA
    Microb Pathog 44:98-102. 2008
    ..These studies also indicate that more than one function is present in the 1.5 kb LAT fragment...
  16. ncbi request reprint Local and systemic B cell and Th1 responses induced following ocular mucosal delivery of multiple epitopes of herpes simplex virus type 1 glycoprotein D together with cytosine-phosphate-guanine adjuvant
    Anthony B Nesburn
    Laboratory of Cellular and Molecular Immunology, Department of Ophthalmology, College of Medicine, University of California at Irvine, Irvine, CA 92697 4375, USA
    Vaccine 23:873-83. 2005
    ..The results suggest the clinical feasibility of developing an OM delivery system using epitope-based vaccines...
  17. pmc Gender-dependent HLA-DR-restricted epitopes identified from herpes simplex virus type 1 glycoprotein D
    Xiuli Zhang
    Laboratory of Cellular and Molecular Immunology, The Gavin S Herbert Eye Institute, University of California Irvine School of Medicine, Irvine, California 92697 4375, USA
    Clin Vaccine Immunol 15:1436-49. 2008
    ....
  18. pmc Th-cytotoxic T-lymphocyte chimeric epitopes extended by Nepsilon-palmitoyl lysines induce herpes simplex virus type 1-specific effector CD8+ Tc1 responses and protect against ocular infection
    Xiuli Zhang
    Laboratory of Cellular and Molecular Immunology, University of California, Irvine, College of Medicine, Bldg 55, Room 202, Orange, CA 92868, USA
    J Virol 79:15289-301. 2005
    ..The rational of the molecularly defined vaccine approach presented in this study may be applied to ocular herpes and other viral infections in humans, providing steps are taken to include appropriate Th and CTL epitopes and lipid groups...
  19. pmc Nasolacrimal duct closure modulates ocular mucosal and systemic CD4(+) T-cell responses induced following topical ocular or intranasal immunization
    Aziz Alami Chentoufi
    Laboratory of Cellular and Molecular Immunology, University of California, Irvine, Medical Center, Orange, CA 92868, USA
    Clin Vaccine Immunol 17:342-53. 2010
    ..001). The study suggests that NALT and the OMIS are immunologically interconnected...
  20. pmc Asymptomatic human CD4+ cytotoxic T-cell epitopes identified from herpes simplex virus glycoprotein B
    Aziz Alami Chentoufi
    Laboratory of Cellular and Molecular Immunology, The Gavin S Herbert Eye Institute, University of California Irvine, School of Medicine, Irvine, California 92697 4375, USA
    J Virol 82:11792-802. 2008
    ..Among these, gB(166-180) and gB(666-680) appear to be "asymptomatic" peptide epitopes and therefore should be considered in the design of future herpes vaccines...
  21. ncbi request reprint HLA-A*0201-restricted CD8+ cytotoxic T lymphocyte epitopes identified from herpes simplex virus glycoprotein D
    Aziz Alami Chentoufi
    Laboratory of Cellular and Molecular Immunology, Eye Institute, University of California Irvine, School of Medicine, Irvine, CA 92697, USA
    J Immunol 180:426-37. 2008
    ..The functional gD CD8+ T cell epitopes described herein are potentially important components of clinical immunotherapeutic and immunoprophylactic herpes vaccines...
  22. pmc The herpes simplex virus 1 latency-associated transcript promotes functional exhaustion of virus-specific CD8+ T cells in latently infected trigeminal ganglia: a novel immune evasion mechanism
    Aziz A Chentoufi
    Laboratory of Cellular and Molecular Immunology, The Gavin Herbert Eye Institute, University of California Irvine, School of Medicine, Irvine, California 92697, USA
    J Virol 85:9127-38. 2011
    ..e., dysfunction) of HSV-specific CD8(+) T cells in latently infected TG, resulting in increased virus reactivation...
  23. ncbi request reprint Systemic immune responses induced by mucosal administration of lipopeptides without adjuvant
    Lbachir BenMohamed
    Biomedical Parasitology Unit, Pasteur Institute, Paris, France
    Eur J Immunol 32:2274-81. 2002
    ....
  24. pmc The locus encompassing the latency-associated transcript of herpes simplex virus type 1 interferes with and delays interferon expression in productively infected neuroblastoma cells and trigeminal Ganglia of acutely infected mice
    Weiping Peng
    Department of Veterinary and Biomedical Sciences, Nebraska Center for Virology, University of Nebraska, Lincoln, Fair Street at East Campus Loop, Lincoln, NE 68583 0905, USA
    J Virol 79:6162-71. 2005
    ..Collectively, these studies suggest that the LAT locus interferes with and delays IFN expression...
  25. ncbi request reprint Lipopeptide vaccines--yesterday, today, and tomorrow
    Lbachir BenMohamed
    Ophthalmology Research Laboratories, Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Lancet Infect Dis 2:425-31. 2002
    ..In particular, the recent development of mucosal application of lipopeptide vaccines may present an ideal strategy against many pathogens that infect mucosal surfaces...
  26. pmc A novel herpes simplex virus type 1 transcript (AL-RNA) antisense to the 5' end of the latency-associated transcript produces a protein in infected rabbits
    Guey Chuen Perng
    Ophthalmology Research Laboratories, Cedars Sinai Medical Center Burns and Allen Research Institute, Los Angeles, California 90048, USA
    J Virol 76:8003-10. 2002
    ..In addition, four of six rabbits infected with wild-type virus developed enzyme-linked immunosorbent assay titers against one or more AL synthetic peptides. These results suggest that an AL protein is produced in vivo...
  27. doi request reprint Towards a self-adjuvanting multivalent B and T cell epitope containing synthetic glycolipopeptide cancer vaccine
    Olivier Renaudet
    Departement de Chimie Moleculaire, UMR CNRS 5250 and ICMG FR 2607, Universite Joseph Fourier, 38041 Grenoble Cedex 9, France
    ChemMedChem 3:737-41. 2008
  28. ncbi request reprint A fully synthetic therapeutic vaccine candidate targeting carcinoma-associated Tn carbohydrate antigen induces tumor-specific antibodies in nonhuman primates
    Richard Lo-Man
    Unité de Biologie des Régulations Immunitaires Institut National de la Santé et de la Recherche Médicale E352 Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris, France
    Cancer Res 64:4987-94. 2004
    ....
  29. pmc Long-term multiepitopic cytotoxic-T-lymphocyte responses induced in chimpanzees by combinations of Plasmodium falciparum liver-stage peptides and lipopeptides
    Lbachir BenMohamed
    Unité de Parasitologie Bio Médicale, Institut Pasteur, 75015 Paris, France
    Infect Immun 72:4376-84. 2004
    ..The successful immunization of nonhuman primates with combinations of corresponding peptides in a mineral oil emulsion (ISA51) and lipopeptides in saline provide a vaccine formulation that can be tested in humans...
  30. pmc Intranasal administration of a synthetic lipopeptide without adjuvant induces systemic immune responses
    Lbachir BenMohamed
    Laboratory of Vaccine Research, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA
    Immunology 106:113-21. 2002
    ..05). These results highlight the usefulness and potential of lipopeptides delivered via mucosal routes as painless, safe, and non-invasive vaccines...

Research Grants8

  1. Ocular Mucosal Immunity Induced by HSV-1 Lipopeptides
    Lbachir BenMohamed; Fiscal Year: 2003
    ..Lipopeptides will be compared to peptide + mucosal adjuvant. Uptake and functional presentation of lipopeptide epitopes by DC to T-cells and subsequent DC maturation will be examined. ..
  2. Interaction of HSV-1 LAT Gene & Dendritic Cells Function
    Lbachir BenMohamed; Fiscal Year: 2004
    ..a)Determine if LAT modulates cytokine and chemokine secretion by DC and chemokine-receptor expression on DC, all of which are involved in migratory activity of DC. (b)Determine if LAT changes the observed migratory activity of DC. ..
  3. Ocular Mucosal Immunity Induced by HSV-1 Lipopeptides
    Lbachir BenMohamed; Fiscal Year: 2004
    ..Lipopeptides will be compared to peptide + mucosal adjuvant. Uptake and functional presentation of lipopeptide epitopes by DC to T-cells and subsequent DC maturation will be examined. ..
  4. Ocular Mucosal Immunity Induced by HSV-1 Lipopeptides
    Lbachir BenMohamed; Fiscal Year: 2005
    ..Lipopeptides will be compared to peptide + mucosal adjuvant. Uptake and functional presentation of lipopeptide epitopes by DC to T-cells and subsequent DC maturation will be examined. ..
  5. Ocular Mucosal Immunity Induced by HSV-1 Lipopeptides
    Lbachir BenMohamed; Fiscal Year: 2006
    ..Lipopeptides will be compared to peptide + mucosal adjuvant. Uptake and functional presentation of lipopeptide epitopes by DC to T-cells and subsequent DC maturation will be examined. ..
  6. Ocular Mucosal Immunity Induced by HSV-1 Lipopeptides
    Lbachir BenMohamed; Fiscal Year: 2007
    ..Lipopeptides will be compared to peptide + mucosal adjuvant. Uptake and functional presentation of lipopeptide epitopes by DC to T-cells and subsequent DC maturation will be examined. ..
  7. Ocular Mucsoal Immunity Induced by HSV-1 Lipopeptides
    Lbachir BenMohamed; Fiscal Year: 2010
    ..The proposal requests one-year funding support of the previously funded parent RO1 grant NEI 14900 "Ocular Mucosal Immunity Induced by HSV-1 Lipopeptides". ..
  8. Therapeutic Ocular HSV Vaccine in HLA Transgenic Rabbits
    Lbachir BenMohamed; Fiscal Year: 2010
    ....