Ivor Benjamin

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. ncbi request reprint Chaperones and cardiac misfolding protein diseases
    Elisabeth S Christians
    Department of Internal Medicine and Biochemistry, 30 N 1900 E Room 4A100, Salt Lake City, UT 84132, USA
    Curr Protein Pept Sci 15:189-204. 2014
  2. pmc HSPB2 is dispensable for the cardiac hypertrophic response but reduces mitochondrial energetics following pressure overload in mice
    Takahiro Ishiwata
    Laboratory of Cardiac Disease, Redox Signaling and Cell Regeneration, Division of Cardiology, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
    PLoS ONE 7:e42118. 2012
  3. pmc Glutathione-dependent reductive stress triggers mitochondrial oxidation and cytotoxicity
    Huali Zhang
    Laboratory of Cardiac Disease, Redox Signaling, and Cell Regeneration, Division of Cardiology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    FASEB J 26:1442-51. 2012
  4. pmc Reductive stress on life span extension in C. elegans
    Markus Ralser
    Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany
    BMC Res Notes 1:19. 2008
  5. pmc CRYAB and HSPB2 deficiency alters cardiac metabolism and paradoxically confers protection against myocardial ischemia in aging mice
    Ivor J Benjamin
    Center for Cardiovascular Translational Biomedicine, University of Utah, School of Medicine, Salt Lake City, UT, USA
    Am J Physiol Heart Circ Physiol 293:H3201-9. 2007
  6. pmc Learning from failure: congestive heart failure in the postgenomic age
    Ivor J Benjamin
    Division of Cardiology, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    J Clin Invest 115:495-9. 2005
  7. ncbi request reprint CRYAB and HSPB2 deficiency increases myocyte mitochondrial permeability transition and mitochondrial calcium uptake
    Toshie Kadono
    Department of Internal Medicine, Division of Cardiology, University of Utah Health Sciences Center, 50 North Medical Drive, Salt Lake City, UT 84132, USA
    J Mol Cell Cardiol 40:783-9. 2006
  8. pmc Sustained activation of nuclear erythroid 2-related factor 2/antioxidant response element signaling promotes reductive stress in the human mutant protein aggregation cardiomyopathy in mice
    Namakkal Soorappan Rajasekaran
    Division of Cardiology, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    Antioxid Redox Signal 14:957-71. 2011
  9. ncbi request reprint Mouse HSF1 disruption perturbs redox state and increases mitochondrial oxidative stress in kidney
    Liang Jun Yan
    Department of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA
    Antioxid Redox Signal 7:465-71. 2005
  10. pmc Mouse heat shock transcription factor 1 deficiency alters cardiac redox homeostasis and increases mitochondrial oxidative damage
    Liang Jun Yan
    Department of Internal Medicine, Molecular Cardiology Research Laboratories, University of Texas Southwestern Medical Center, Dallas, TX 75390 8573, USA
    EMBO J 21:5164-72. 2002

Collaborators

  • Stefan W Ryter
  • Liang Jun Yan
  • Sihem Boudina
  • William H Barry
  • RAJINDAR SOHAL
  • Joseph Loscalzo
  • Hideyuki Ishida
  • Jane A Leopold
  • R Bolli
  • BETH C LEVINE
  • Elisabeth S Christians
  • JAY LOUIS ZWEIER
  • Ilka Pinz
  • Zihai Li
  • U Schibler
  • J S Ingwall
  • Ken Shinmura
  • STUART KEITH CALDERWOOD
  • EVAN ABEL
  • Namakkal S Rajasekaran
  • Huali Zhang
  • Ryan P Taylor
  • Takahiro Ishiwata
  • Namakkal Soorappan Rajasekaran
  • Andras Orosz
  • Matthew A Firpo
  • Paul Tannous
  • Hans Reinke
  • Markus Ralser
  • Ishwar S Singh
  • Ying Liu
  • Hiroshi Kajiya
  • Toshie Kadono
  • Md Abdul Khaleque
  • Hong Pyo Kim
  • Patrice Connell
  • XianZhong Xiao
  • Delphine Wirth
  • Laura L Corey
  • Hong Zheng
  • Richard A Altschuler
  • D Randy McMillan
  • Xiaohui Wang
  • Pattraranee Limphong
  • Gregory W Pratt
  • Soumyajit Banerjee Mustafi
  • Joel Pieper
  • Christopher K Rodesch
  • Qiang Liu
  • Christopher J Davidson
  • Gayatri D Khanderao
  • Saradhadevi Varadharaj
  • Sankaranarayanan Kannan
  • John M Shelton
  • Ashish Nagarsekar
  • Robert D Gerard
  • Zachary Cooper
  • Beverly A Rothermel
  • Joseph A Hill
  • Janet L Johnstone
  • Ju Ren He
  • Charna Dibner
  • Aditi Gupta
  • Lisa Hester
  • Cheu Manka
  • Hongxin Zhu
  • Camille Saini
  • Robert B Weiss
  • Brett A Milash
  • Lan Nguyen
  • Jeffrey D Hasday
  • Fabienne Fleury-Olela
  • Shannon J Odelberg
  • Ronald M Peshock
  • Xiu Q Zhang
  • Tamara J Stevenson
  • Can Yuan
  • Xiu Quan Zhang
  • Hayato Ohshima
  • Sathya Srinivasan
  • Junwen Liu
  • Sakamuri V Reddy
  • Daolin Tang
  • Meidong Liu
  • Shin ichi Kenmotsu
  • Jing Wang
  • Yuxin Yi
  • William L Ries
  • Masahiro Ito
  • Augustine M K Choi

Detail Information

Publications32

  1. ncbi request reprint Chaperones and cardiac misfolding protein diseases
    Elisabeth S Christians
    Department of Internal Medicine and Biochemistry, 30 N 1900 E Room 4A100, Salt Lake City, UT 84132, USA
    Curr Protein Pept Sci 15:189-204. 2014
    ....
  2. pmc HSPB2 is dispensable for the cardiac hypertrophic response but reduces mitochondrial energetics following pressure overload in mice
    Takahiro Ishiwata
    Laboratory of Cardiac Disease, Redox Signaling and Cell Regeneration, Division of Cardiology, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
    PLoS ONE 7:e42118. 2012
    ..To determine the specific requirements of HSPB2 in heart, we generated cardiac-specific HSPB2 deficient (HSPB2cKO) mice and examined their cardiac function under basal conditions and following cardiac pressure overload...
  3. pmc Glutathione-dependent reductive stress triggers mitochondrial oxidation and cytotoxicity
    Huali Zhang
    Laboratory of Cardiac Disease, Redox Signaling, and Cell Regeneration, Division of Cardiology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    FASEB J 26:1442-51. 2012
    ..Taken together, our findings reveal a novel mechanism by which GSH-dependent reductive stress triggers mitochondrial oxidation and cytotoxicity...
  4. pmc Reductive stress on life span extension in C. elegans
    Markus Ralser
    Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany
    BMC Res Notes 1:19. 2008
    ..We draw attention to this condition as an explanation for some contradictory observations including the deleterious effects from antioxidants...
  5. pmc CRYAB and HSPB2 deficiency alters cardiac metabolism and paradoxically confers protection against myocardial ischemia in aging mice
    Ivor J Benjamin
    Center for Cardiovascular Translational Biomedicine, University of Utah, School of Medicine, Salt Lake City, UT, USA
    Am J Physiol Heart Circ Physiol 293:H3201-9. 2007
    ..We discuss the implications of these disparate results in the context of phenotypic responses reported for CRYAB/HSPB2-deficient mice to different ischemic challenges...
  6. pmc Learning from failure: congestive heart failure in the postgenomic age
    Ivor J Benjamin
    Division of Cardiology, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    J Clin Invest 115:495-9. 2005
    ....
  7. ncbi request reprint CRYAB and HSPB2 deficiency increases myocyte mitochondrial permeability transition and mitochondrial calcium uptake
    Toshie Kadono
    Department of Internal Medicine, Division of Cardiology, University of Utah Health Sciences Center, 50 North Medical Drive, Salt Lake City, UT 84132, USA
    J Mol Cell Cardiol 40:783-9. 2006
    ..This can predispose to the development of MPT, and increased VM injury during I/R. These findings indicate an important role of CRYAB and/or HSPB2 in mitochondrial function...
  8. pmc Sustained activation of nuclear erythroid 2-related factor 2/antioxidant response element signaling promotes reductive stress in the human mutant protein aggregation cardiomyopathy in mice
    Namakkal Soorappan Rajasekaran
    Division of Cardiology, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    Antioxid Redox Signal 14:957-71. 2011
    ..Our findings implicate a novel pathway for therapeutic targeting and abrogating RS linked to experimental cardiomyopathy in humans. Antioxid...
  9. ncbi request reprint Mouse HSF1 disruption perturbs redox state and increases mitochondrial oxidative stress in kidney
    Liang Jun Yan
    Department of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA
    Antioxid Redox Signal 7:465-71. 2005
    ..The source of mitochondrial superoxide generation is discussed...
  10. pmc Mouse heat shock transcription factor 1 deficiency alters cardiac redox homeostasis and increases mitochondrial oxidative damage
    Liang Jun Yan
    Department of Internal Medicine, Molecular Cardiology Research Laboratories, University of Texas Southwestern Medical Center, Dallas, TX 75390 8573, USA
    EMBO J 21:5164-72. 2002
    ....
  11. pmc Human alpha B-crystallin mutation causes oxido-reductive stress and protein aggregation cardiomyopathy in mice
    Namakkal S Rajasekaran
    Center for Cardiovascular Translational Biomedicine, Division of Cardiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Cell 130:427-39. 2007
    ..These findings demonstrate that dysregulation of G6PD activity is necessary and sufficient for maladaptive reductive stress and suggest a novel therapeutic target for abrogating R120GCryAB cardiomyopathy and heart failure in humans...
  12. ncbi request reprint Heat shock factor 1 and heat shock proteins: critical partners in protection against acute cell injury
    Elisabeth S Christians
    Department of Internal Medicine, Molecular Cardiology Research Laboratories, The University of Texas Southwestern Medical Center, Dallas, TX, USA
    Crit Care Med 30:S43-50. 2002
    ....
  13. pmc Autophagy is an adaptive response in desmin-related cardiomyopathy
    Paul Tannous
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 105:9745-50. 2008
    ..This study reports activation of autophagy in DRCM. Further, our findings point to autophagy as an adaptive response in this proteotoxic form of heart disease...
  14. pmc Global expression profiling identifies a novel biosignature for protein aggregation R120GCryAB cardiomyopathy in mice
    Namakkal S Rajasekaran
    Departments of Internal Medicine, Division of Cardiology, Center for Cardiovascular Translational Biomedicine, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    Physiol Genomics 35:165-72. 2008
    ....
  15. ncbi request reprint Heat shock protein-70 mediates the cytoprotective effect of carbon monoxide: involvement of p38 beta MAPK and heat shock factor-1
    Hong Pyo Kim
    Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Immunol 175:2622-9. 2005
    ..These data provide a novel mechanism for the protective effects of CO and underscore a potential application of this gaseous molecule in anti-inflammatory therapies...
  16. ncbi request reprint Small heat shock proteins: a new classification scheme in mammals
    Ryan P Taylor
    The University of Utah Health Sciences Center, Division of Cardiology, Salt Lake City, UT 84112, USA
    J Mol Cell Cardiol 38:433-44. 2005
    ....
  17. ncbi request reprint Heat shock proteins in mammalian development
    Elisabeth S Christians
    Department of Internal Medicine, Division of Cardiology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Semin Cell Dev Biol 14:283-90. 2003
    ..g. Hsp70.2 for spermatogenesis). In the present paper, we will review available data on Hsp function and discuss the roles of heat shock factors (HSF), their major regulators, in mammalian development...
  18. ncbi request reprint Unmasking different mechanical and energetic roles for the small heat shock proteins CryAB and HSPB2 using genetically modified mouse hearts
    Ilka Pinz
    NMR Laboratory for Physiological Chemistry, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    FASEB J 22:84-92. 2008
    ..5 +/- 0.8 kJ/mol compared with only approximately 3.3 kJ/mol in WT and mCryAB(Tg). Thus, CryAB and HSPB2 proteins play nonredundant roles in the heart, CryAB in structural remodeling and HSPB2 in maintaining energetic balance...
  19. ncbi request reprint Discovering the full spectrum of cardiovascular disease: Minority Health Summit 2003: report of the Basic Science Writing Group
    Ivor J Benjamin
    Circulation 111:e120-3. 2005
  20. ncbi request reprint Heat shock factor 1-independent activation of dendritic cells by heat shock: implication for the uncoupling of heat-mediated immunoregulation from the heat shock response
    Hong Zheng
    Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine, Farmington 06030, USA
    Eur J Immunol 33:1754-62. 2003
    ..Our novel findings demonstrate that heat shock, one of the most primitive biological responses, can modulate the immune response without the requirement for the transcriptional induction/repression of target genes mediated by Hsf1...
  21. pmc Heat shock transcription factor 2 is not essential for embryonic development, fertility, or adult cognitive and psychomotor function in mice
    D Randy McMillan
    Departments of Internal Medicine Pediatrics Pathology Division of Cell and Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235, USA
    Mol Cell Biol 22:8005-14. 2002
    ..We conclude that HSF2, most probably because its physiological roles are integrated into a redundant network of gene regulation and function, is dispensable for normal development, fertility, and postnatal psychomotor function...
  22. ncbi request reprint Stress pathways in the rat cochlea and potential for protection from acquired deafness
    Richard A Altschuler
    Department of Otolaryngology, Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI 48109 0506, USA
    Audiol Neurootol 7:152-6. 2002
    ..Differential expression of several immediate early genes was found following the intense but not the mild noise exposure...
  23. ncbi request reprint Exercise, estrogen, and ischemic cardioprotection by heat shock protein 70
    Ivor J Benjamin
    Circ Res 90:833-5. 2002
  24. pmc Localized recruitment of a chromatin-remodeling activity by an activator in vivo drives transcriptional elongation
    Laura L Corey
    Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Genes Dev 17:1392-401. 2003
    ..These data suggest that localized recruitment of SWI/SNF drives a specialized remodeling reaction necessary for the production of full-length hsp70 mRNA...
  25. pmc Heat shock co-activates interleukin-8 transcription
    Ishwar S Singh
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Am J Respir Cell Mol Biol 39:235-42. 2008
    ..We speculate that during evolution the CXC chemokine genes may have co-opted elements of the HS response to amplify their expression and enhance neutrophil delivery during febrile illnesses...
  26. pmc Differential display of DNA-binding proteins reveals heat-shock factor 1 as a circadian transcription factor
    Hans Reinke
    Department of Molecular Biology, University of Geneva, CH 1211 Geneva, Switzerland
    Genes Dev 22:331-45. 2008
    ..Our results also suggest that the new screening method DDDP is not limited to the identification of circadian transcription factors but can be applied to discover novel transcriptional regulators in various biological systems...
  27. ncbi request reprint Use of Hsf1(-/-) mice reveals an essential role for HSF1 to protect lung against cadmium-induced injury
    Delphine Wirth
    Unit of Pharmacology, Pharmacotherapy and Toxicology Department of Functional Sciences, Faculty of Veterinary Medicine, University of Liege, Belgium
    Toxicol Appl Pharmacol 192:12-20. 2003
    ..Altogether, our data demonstrate that HS response elicited both by prior HS and by Cd itself moderates pulmonary injuries due to Cd instillation, and that HSF1 is a major mediator in this protection...
  28. pmc Induction of KLF4 in response to heat stress
    Ying Liu
    Laboratory of Shock, Department of Pathophysiology, Xiangya School of Medicine, Central South University, 110 Xiangya Road, Changsha, Hunan 410008, People s Republic of China
    Cell Stress Chaperones 11:379-89. 2006
    ..KLF4 might be an immediate early response gene and could play an important role in cell injury induced by heat stress...
  29. ncbi request reprint The stress or heat shock (HS) response: insights from transgenic mouse models
    Elisabeth S Christians
    Centre de Biologie du Developpement UMR5547 118 route de Narbonne, 31062 Toulouse, France
    Methods 35:170-5. 2005
    ..Genetically modified mice, developed to generate gain- and loss-of-function, are described. The challenges of using the transgenic mouse model are also discussed...
  30. ncbi request reprint RANK ligand expression in heat shock factor-2 deficient mouse bone marrow stromal/preosteoblast cells
    Hiroshi Kajiya
    Department of Physiological Science and Molecular Biology, Fukuoka Dental College, Sawara ku, Fukuoka, 814 0193, Japan
    J Cell Biochem 97:1362-9. 2006
    ..Novel therapeutic agents that modulate HSF-2 activation may have therapeutic utility against increased levels of FGF-2 and bone destruction associated with pathologic conditions...
  31. ncbi request reprint Induction of heat shock proteins by heregulin beta1 leads to protection from apoptosis and anchorage-independent growth
    Md Abdul Khaleque
    Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Oncogene 24:6564-73. 2005
    ..HSF1 activated by this pathway plays a key role in the protection of cells from apoptosis and the mediation of anchorage independent growth by HRGbeta1, indicating a role for HSF1 in this tumorigenic pathway...
  32. pmc A murine world without HSFs: meeting report
    Elisabeth Christians
    Equipe Proteines de Stress, Chaperons et Developpement des vértérbrés, Centre de Biologie du Développement UMR5547, Universite Paul Sabatier, Toulouse, France
    Cell Stress Chaperones 10:265-7. 2005

Research Grants22

  1. MECHANISMS FOR CARDIOPROTECTION IN HSF1 KNOCKOUT MICE
    Ivor Benjamin; Fiscal Year: 2001
    ....
  2. HSF 1 Requirements in Extraembryonic Development
    Ivor Benjamin; Fiscal Year: 2005
    ..abstract_text> ..
  3. TRAINING IN CARDIOVASCULAR RESEARCH
    Ivor Benjamin; Fiscal Year: 2007
    ..abstract_text> ..
  4. Mechanisms of HSPB2 in Cardiac Metabolism and Ischemic Cardioprotection
    Ivor Benjamin; Fiscal Year: 2009
    ..This research proposal will examine the specific roles of HSPB2 for mitochondrial function and cardiac energetics using genetically engineered mouse models of human diseases. ..
  5. Reductive Stress in the Pathogenesis of R120GCryAB Cardiomyopathy
    Ivor Benjamin; Fiscal Year: 2009
    ..Our discovery establishes that G6PD plays a key role and supports the rationale for further studies that might lead to new therapies for human cardiac and degenerative diseases. ..
  6. Mechanisms of HSPB2 in Cardiac Metabolism and Ischemic Cardioprotection
    Ivor J Benjamin; Fiscal Year: 2010
    ..This research proposal will examine the specific roles of HSPB2 for mitochondrial function and cardiac energetics using genetically engineered mouse models of human diseases. ..
  7. Protein Misfolding Diseases and Oxido-Reductive Pathways
    Ivor Benjamin; Fiscal Year: 2009
    ..Validation in mice of interacting genes and pathways will provide us target candidates for pharmacolog ..
  8. ALPHA BETA-CRYSTALLIN R12OG CARDIOMYOPATHY
    Ivor Benjamin; Fiscal Year: 2003
    ..abstract_text> ..
  9. Reductive Stress in the Pathogenesis of R120GCryAB Cardiomyopathy
    Ivor J Benjamin; Fiscal Year: 2010
    ..Our discovery establishes that G6PD plays a key role and supports the rationale for further studies that might lead to new therapies for human cardiac and degenerative diseases. ..