Affiliation: University of Utah
- Chaperones and cardiac misfolding protein diseasesElisabeth S Christians
Department of Internal Medicine and Biochemistry, 30 N 1900 E Room 4A100, Salt Lake City, UT 84132, USA
Curr Protein Pept Sci 15:189-204. 2014....
- HSPB2 is dispensable for the cardiac hypertrophic response but reduces mitochondrial energetics following pressure overload in miceTakahiro Ishiwata
Laboratory of Cardiac Disease, Redox Signaling and Cell Regeneration, Division of Cardiology, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
PLoS ONE 7:e42118. 2012..To determine the specific requirements of HSPB2 in heart, we generated cardiac-specific HSPB2 deficient (HSPB2cKO) mice and examined their cardiac function under basal conditions and following cardiac pressure overload...
- Glutathione-dependent reductive stress triggers mitochondrial oxidation and cytotoxicityHuali Zhang
Laboratory of Cardiac Disease, Redox Signaling, and Cell Regeneration, Division of Cardiology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
FASEB J 26:1442-51. 2012..Taken together, our findings reveal a novel mechanism by which GSH-dependent reductive stress triggers mitochondrial oxidation and cytotoxicity...
- Reductive stress on life span extension in C. elegansMarkus Ralser
Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany
BMC Res Notes 1:19. 2008..We draw attention to this condition as an explanation for some contradictory observations including the deleterious effects from antioxidants...
- CRYAB and HSPB2 deficiency alters cardiac metabolism and paradoxically confers protection against myocardial ischemia in aging miceIvor J Benjamin
Center for Cardiovascular Translational Biomedicine, University of Utah, School of Medicine, Salt Lake City, UT, USA
Am J Physiol Heart Circ Physiol 293:H3201-9. 2007..We discuss the implications of these disparate results in the context of phenotypic responses reported for CRYAB/HSPB2-deficient mice to different ischemic challenges...
- Learning from failure: congestive heart failure in the postgenomic ageIvor J Benjamin
Division of Cardiology, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
J Clin Invest 115:495-9. 2005....
- CRYAB and HSPB2 deficiency increases myocyte mitochondrial permeability transition and mitochondrial calcium uptakeToshie Kadono
Department of Internal Medicine, Division of Cardiology, University of Utah Health Sciences Center, 50 North Medical Drive, Salt Lake City, UT 84132, USA
J Mol Cell Cardiol 40:783-9. 2006..This can predispose to the development of MPT, and increased VM injury during I/R. These findings indicate an important role of CRYAB and/or HSPB2 in mitochondrial function...
- Sustained activation of nuclear erythroid 2-related factor 2/antioxidant response element signaling promotes reductive stress in the human mutant protein aggregation cardiomyopathy in miceNamakkal Soorappan Rajasekaran
Division of Cardiology, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
Antioxid Redox Signal 14:957-71. 2011..Our findings implicate a novel pathway for therapeutic targeting and abrogating RS linked to experimental cardiomyopathy in humans. Antioxid...
- Mouse HSF1 disruption perturbs redox state and increases mitochondrial oxidative stress in kidneyLiang Jun Yan
Department of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA
Antioxid Redox Signal 7:465-71. 2005..The source of mitochondrial superoxide generation is discussed...
- Mouse heat shock transcription factor 1 deficiency alters cardiac redox homeostasis and increases mitochondrial oxidative damageLiang Jun Yan
Department of Internal Medicine, Molecular Cardiology Research Laboratories, University of Texas Southwestern Medical Center, Dallas, TX 75390 8573, USA
EMBO J 21:5164-72. 2002....
- Human alpha B-crystallin mutation causes oxido-reductive stress and protein aggregation cardiomyopathy in miceNamakkal S Rajasekaran
Center for Cardiovascular Translational Biomedicine, Division of Cardiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
Cell 130:427-39. 2007..These findings demonstrate that dysregulation of G6PD activity is necessary and sufficient for maladaptive reductive stress and suggest a novel therapeutic target for abrogating R120GCryAB cardiomyopathy and heart failure in humans...
- Heat shock factor 1 and heat shock proteins: critical partners in protection against acute cell injuryElisabeth S Christians
Department of Internal Medicine, Molecular Cardiology Research Laboratories, The University of Texas Southwestern Medical Center, Dallas, TX, USA
Crit Care Med 30:S43-50. 2002....
- Autophagy is an adaptive response in desmin-related cardiomyopathyPaul Tannous
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Proc Natl Acad Sci U S A 105:9745-50. 2008..This study reports activation of autophagy in DRCM. Further, our findings point to autophagy as an adaptive response in this proteotoxic form of heart disease...
- Global expression profiling identifies a novel biosignature for protein aggregation R120GCryAB cardiomyopathy in miceNamakkal S Rajasekaran
Departments of Internal Medicine, Division of Cardiology, Center for Cardiovascular Translational Biomedicine, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
Physiol Genomics 35:165-72. 2008....
- Heat shock protein-70 mediates the cytoprotective effect of carbon monoxide: involvement of p38 beta MAPK and heat shock factor-1Hong Pyo Kim
Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
J Immunol 175:2622-9. 2005..These data provide a novel mechanism for the protective effects of CO and underscore a potential application of this gaseous molecule in anti-inflammatory therapies...
- Small heat shock proteins: a new classification scheme in mammalsRyan P Taylor
The University of Utah Health Sciences Center, Division of Cardiology, Salt Lake City, UT 84112, USA
J Mol Cell Cardiol 38:433-44. 2005....
- Heat shock proteins in mammalian developmentElisabeth S Christians
Department of Internal Medicine, Division of Cardiology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
Semin Cell Dev Biol 14:283-90. 2003..g. Hsp70.2 for spermatogenesis). In the present paper, we will review available data on Hsp function and discuss the roles of heat shock factors (HSF), their major regulators, in mammalian development...
- Unmasking different mechanical and energetic roles for the small heat shock proteins CryAB and HSPB2 using genetically modified mouse heartsIlka Pinz
NMR Laboratory for Physiological Chemistry, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
FASEB J 22:84-92. 2008..5 +/- 0.8 kJ/mol compared with only approximately 3.3 kJ/mol in WT and mCryAB(Tg). Thus, CryAB and HSPB2 proteins play nonredundant roles in the heart, CryAB in structural remodeling and HSPB2 in maintaining energetic balance...
- Discovering the full spectrum of cardiovascular disease: Minority Health Summit 2003: report of the Basic Science Writing GroupIvor J Benjamin
Circulation 111:e120-3. 2005
- Heat shock factor 1-independent activation of dendritic cells by heat shock: implication for the uncoupling of heat-mediated immunoregulation from the heat shock responseHong Zheng
Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine, Farmington 06030, USA
Eur J Immunol 33:1754-62. 2003..Our novel findings demonstrate that heat shock, one of the most primitive biological responses, can modulate the immune response without the requirement for the transcriptional induction/repression of target genes mediated by Hsf1...
- Heat shock transcription factor 2 is not essential for embryonic development, fertility, or adult cognitive and psychomotor function in miceD Randy McMillan
Departments of Internal Medicine Pediatrics Pathology Division of Cell and Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235, USA
Mol Cell Biol 22:8005-14. 2002..We conclude that HSF2, most probably because its physiological roles are integrated into a redundant network of gene regulation and function, is dispensable for normal development, fertility, and postnatal psychomotor function...
- Stress pathways in the rat cochlea and potential for protection from acquired deafnessRichard A Altschuler
Department of Otolaryngology, Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI 48109 0506, USA
Audiol Neurootol 7:152-6. 2002..Differential expression of several immediate early genes was found following the intense but not the mild noise exposure...
- Exercise, estrogen, and ischemic cardioprotection by heat shock protein 70Ivor J Benjamin
Circ Res 90:833-5. 2002
- Localized recruitment of a chromatin-remodeling activity by an activator in vivo drives transcriptional elongationLaura L Corey
Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Genes Dev 17:1392-401. 2003..These data suggest that localized recruitment of SWI/SNF drives a specialized remodeling reaction necessary for the production of full-length hsp70 mRNA...
- Heat shock co-activates interleukin-8 transcriptionIshwar S Singh
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
Am J Respir Cell Mol Biol 39:235-42. 2008..We speculate that during evolution the CXC chemokine genes may have co-opted elements of the HS response to amplify their expression and enhance neutrophil delivery during febrile illnesses...
- Differential display of DNA-binding proteins reveals heat-shock factor 1 as a circadian transcription factorHans Reinke
Department of Molecular Biology, University of Geneva, CH 1211 Geneva, Switzerland
Genes Dev 22:331-45. 2008..Our results also suggest that the new screening method DDDP is not limited to the identification of circadian transcription factors but can be applied to discover novel transcriptional regulators in various biological systems...
- Use of Hsf1(-/-) mice reveals an essential role for HSF1 to protect lung against cadmium-induced injuryDelphine Wirth
Unit of Pharmacology, Pharmacotherapy and Toxicology Department of Functional Sciences, Faculty of Veterinary Medicine, University of Liege, Belgium
Toxicol Appl Pharmacol 192:12-20. 2003..Altogether, our data demonstrate that HS response elicited both by prior HS and by Cd itself moderates pulmonary injuries due to Cd instillation, and that HSF1 is a major mediator in this protection...
- Induction of KLF4 in response to heat stressYing Liu
Laboratory of Shock, Department of Pathophysiology, Xiangya School of Medicine, Central South University, 110 Xiangya Road, Changsha, Hunan 410008, People s Republic of China
Cell Stress Chaperones 11:379-89. 2006..KLF4 might be an immediate early response gene and could play an important role in cell injury induced by heat stress...
- The stress or heat shock (HS) response: insights from transgenic mouse modelsElisabeth S Christians
Centre de Biologie du Developpement UMR5547 118 route de Narbonne, 31062 Toulouse, France
Methods 35:170-5. 2005..Genetically modified mice, developed to generate gain- and loss-of-function, are described. The challenges of using the transgenic mouse model are also discussed...
- RANK ligand expression in heat shock factor-2 deficient mouse bone marrow stromal/preosteoblast cellsHiroshi Kajiya
Department of Physiological Science and Molecular Biology, Fukuoka Dental College, Sawara ku, Fukuoka, 814 0193, Japan
J Cell Biochem 97:1362-9. 2006..Novel therapeutic agents that modulate HSF-2 activation may have therapeutic utility against increased levels of FGF-2 and bone destruction associated with pathologic conditions...
- Induction of heat shock proteins by heregulin beta1 leads to protection from apoptosis and anchorage-independent growthMd Abdul Khaleque
Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Oncogene 24:6564-73. 2005..HSF1 activated by this pathway plays a key role in the protection of cells from apoptosis and the mediation of anchorage independent growth by HRGbeta1, indicating a role for HSF1 in this tumorigenic pathway...
- A murine world without HSFs: meeting reportElisabeth Christians
Equipe Proteines de Stress, Chaperons et Developpement des vértérbrés, Centre de Biologie du Développement UMR5547, Universite Paul Sabatier, Toulouse, France
Cell Stress Chaperones 10:265-7. 2005
- MECHANISMS FOR CARDIOPROTECTION IN HSF1 KNOCKOUT MICEIvor Benjamin; Fiscal Year: 2001....
- HSF 1 Requirements in Extraembryonic DevelopmentIvor Benjamin; Fiscal Year: 2005..abstract_text> ..
- TRAINING IN CARDIOVASCULAR RESEARCHIvor Benjamin; Fiscal Year: 2007..abstract_text> ..
- Mechanisms of HSPB2 in Cardiac Metabolism and Ischemic CardioprotectionIvor Benjamin; Fiscal Year: 2009..This research proposal will examine the specific roles of HSPB2 for mitochondrial function and cardiac energetics using genetically engineered mouse models of human diseases. ..
- Reductive Stress in the Pathogenesis of R120GCryAB CardiomyopathyIvor Benjamin; Fiscal Year: 2009..Our discovery establishes that G6PD plays a key role and supports the rationale for further studies that might lead to new therapies for human cardiac and degenerative diseases. ..
- Mechanisms of HSPB2 in Cardiac Metabolism and Ischemic CardioprotectionIvor J Benjamin; Fiscal Year: 2010..This research proposal will examine the specific roles of HSPB2 for mitochondrial function and cardiac energetics using genetically engineered mouse models of human diseases. ..
- Protein Misfolding Diseases and Oxido-Reductive PathwaysIvor Benjamin; Fiscal Year: 2009..Validation in mice of interacting genes and pathways will provide us target candidates for pharmacolog ..
- ALPHA BETA-CRYSTALLIN R12OG CARDIOMYOPATHYIvor Benjamin; Fiscal Year: 2003..abstract_text> ..
- Reductive Stress in the Pathogenesis of R120GCryAB CardiomyopathyIvor J Benjamin; Fiscal Year: 2010..Our discovery establishes that G6PD plays a key role and supports the rationale for further studies that might lead to new therapies for human cardiac and degenerative diseases. ..