R H B Benedict

Summary

Affiliation: University at Buffalo
Country: USA

Publications

  1. pmc Clinical correlates of chronic cerebrospinal venous insufficiency in multiple sclerosis
    Bianca Weinstock-Guttman
    Department of Neurology, State University of New York, Buffalo, NY, USA
    BMC Neurol 12:26. 2012
  2. pmc Chronic cerebrospinal venous insufficiency is not associated with cognitive impairment in multiple sclerosis
    Ralph H B Benedict
    Department of Neurology, State University of New York at Buffalo, 100 High St, Buffalo, NY 14203, USA
    BMC Med 11:167. 2013
  3. doi request reprint Influence of personality on the relationship between gray matter volume and neuropsychiatric symptoms in multiple sclerosis
    Ralph H B Benedict
    Department of Neurology, SUNY Buffalo School of Medicine, Buffalo General Hospital, Buffalo, NY 14203, USA
    Psychosom Med 75:253-61. 2013
  4. pmc Brief International Cognitive Assessment for MS (BICAMS): international standards for validation
    Ralph H B Benedict
    Buffalo General Medical Center, Department of Neurology, Suite E2, 100 High Street, Buffalo, NY 14203, USA
    BMC Neurol 12:55. 2012
  5. doi request reprint Evaluating cognitive outcome measures for MS clinical trials: what is a clinically meaningful change?
    Ralph H B Benedict
    Department of Neurology, University at Buffalo, Buffalo General Hospital, Buffalo, NY 14203, USA
    Mult Scler 18:1673-9. 2012
  6. ncbi request reprint Upper and lower extremity motor function and cognitive impairment in multiple sclerosis
    Ralph H B Benedict
    Department of Neurology, SUNY Buffalo School of Medicine, Buffalo, NY, USA
    J Int Neuropsychol Soc 17:643-53. 2011
  7. doi request reprint Reliability and equivalence of alternate forms for the Symbol Digit Modalities Test: implications for multiple sclerosis clinical trials
    Ralph H B Benedict
    SUNY Buffalo School of Medicine, Neurology, Buffalo General Hospital, Buffalo, NY 14203, USA
    Mult Scler 18:1320-5. 2012
  8. ncbi request reprint Reliability and validity of neuropsychological screening and assessment strategies in MS
    Ralph H B Benedict
    SUNY Buffalo School of Medicine, Jacobs Neurological Institute, Buffalo General Hospital, 100 High Street, Buffalo, NY 14203, USA
    J Neurol 254:II22-II25. 2007
  9. ncbi request reprint Validity of the minimal assessment of cognitive function in multiple sclerosis (MACFIMS)
    Ralph H B Benedict
    State University of New York at Buffalo School of Medicine, Department of Neurology, Division of Departmental and Behavioral Neurosciences, Buffalo, New York, USA
    J Int Neuropsychol Soc 12:549-58. 2006
  10. ncbi request reprint Neocortical atrophy, third ventricular width, and cognitive dysfunction in multiple sclerosis
    Ralph H B Benedict
    Department of Neurology, School of Medicine, State University of New York at Buffalo, 100 High Street, Buffalo, NY 14203, USA
    Arch Neurol 63:1301-6. 2006

Detail Information

Publications77

  1. pmc Clinical correlates of chronic cerebrospinal venous insufficiency in multiple sclerosis
    Bianca Weinstock-Guttman
    Department of Neurology, State University of New York, Buffalo, NY, USA
    BMC Neurol 12:26. 2012
    ..healthy controls (HC) (56.1% vs. 22.7%, p < 0.001).The objective was to evaluate the clinical correlates of venous anomalies indicative of CCSVI in patients with MS...
  2. pmc Chronic cerebrospinal venous insufficiency is not associated with cognitive impairment in multiple sclerosis
    Ralph H B Benedict
    Department of Neurology, State University of New York at Buffalo, 100 High St, Buffalo, NY 14203, USA
    BMC Med 11:167. 2013
    ..This study measured the association between the presence and severity of CCSVI and cognitive impairment in patients with MS...
  3. doi request reprint Influence of personality on the relationship between gray matter volume and neuropsychiatric symptoms in multiple sclerosis
    Ralph H B Benedict
    Department of Neurology, SUNY Buffalo School of Medicine, Buffalo General Hospital, Buffalo, NY 14203, USA
    Psychosom Med 75:253-61. 2013
    ..We examined the general hypothesis that personality influences the relationship between gray matter volume (GMV) and cognitive/neuropsychiatric MS features...
  4. pmc Brief International Cognitive Assessment for MS (BICAMS): international standards for validation
    Ralph H B Benedict
    Buffalo General Medical Center, Department of Neurology, Suite E2, 100 High Street, Buffalo, NY 14203, USA
    BMC Neurol 12:55. 2012
    ..At this time, preliminary studies are underway in a number of countries as we move forward with this international assessment tool for cognition in MS...
  5. doi request reprint Evaluating cognitive outcome measures for MS clinical trials: what is a clinically meaningful change?
    Ralph H B Benedict
    Department of Neurology, University at Buffalo, Buffalo General Hospital, Buffalo, NY 14203, USA
    Mult Scler 18:1673-9. 2012
    ....
  6. ncbi request reprint Upper and lower extremity motor function and cognitive impairment in multiple sclerosis
    Ralph H B Benedict
    Department of Neurology, SUNY Buffalo School of Medicine, Buffalo, NY, USA
    J Int Neuropsychol Soc 17:643-53. 2011
    ..The findings may have implications for risk assessment and treatment of mobility dysfunction in MS...
  7. doi request reprint Reliability and equivalence of alternate forms for the Symbol Digit Modalities Test: implications for multiple sclerosis clinical trials
    Ralph H B Benedict
    SUNY Buffalo School of Medicine, Neurology, Buffalo General Hospital, Buffalo, NY 14203, USA
    Mult Scler 18:1320-5. 2012
    ..Unfortunately, there are no validated alternate SDMT forms, which are needed to mitigate practice effects...
  8. ncbi request reprint Reliability and validity of neuropsychological screening and assessment strategies in MS
    Ralph H B Benedict
    SUNY Buffalo School of Medicine, Jacobs Neurological Institute, Buffalo General Hospital, 100 High Street, Buffalo, NY 14203, USA
    J Neurol 254:II22-II25. 2007
    ..Work with new non-conventional brain imaging techniques and finer analysis of reliability during serial testing protocols is underway...
  9. ncbi request reprint Validity of the minimal assessment of cognitive function in multiple sclerosis (MACFIMS)
    Ralph H B Benedict
    State University of New York at Buffalo School of Medicine, Department of Neurology, Division of Departmental and Behavioral Neurosciences, Buffalo, New York, USA
    J Int Neuropsychol Soc 12:549-58. 2006
    ..We conclude that the MACFIMS is a valid approach to routine NP assessment of MS patients. Future work is planned to determine its psychometric properties in a longitudinal study...
  10. ncbi request reprint Neocortical atrophy, third ventricular width, and cognitive dysfunction in multiple sclerosis
    Ralph H B Benedict
    Department of Neurology, School of Medicine, State University of New York at Buffalo, 100 High Street, Buffalo, NY 14203, USA
    Arch Neurol 63:1301-6. 2006
    ..Cognitive dysfunction is common in multiple sclerosis (MS). Correlations are reported between atrophy and neuropsychological test results...
  11. ncbi request reprint Predicting neuropsychological abnormalities in multiple sclerosis
    Ralph H B Benedict
    Department of Neurology, School of Medicine, State University of New York, SUNY at Buffalo, Buffalo General Hospital, Neurology, Suite D 6, 100 High Street, 14203, USA
    J Neurol Sci 245:67-72. 2006
    ..We conclude that the MSNQ is reliable and valid for detecting neuropsychological and neuropsychiatric complications of MS...
  12. doi request reprint Cognitive reserve moderates decline in information processing speed in multiple sclerosis patients
    Ralph H B Benedict
    Department of Neurology, Division of Cognitive and Behavioral Neurosciences, State University of New York at Buffalo School of Medicine and Biomedical Sciences, Buffalo, New York, USA
    J Int Neuropsychol Soc 16:829-35. 2010
    ..We conclude that greater cognitive reserve as indexed by either higher premorbid intelligence or more years of education protects against the progression of cognitive dysfunction in MS...
  13. ncbi request reprint Diffusion-weighted imaging predicts cognitive impairment in multiple sclerosis
    Ralph H B Benedict
    Department of Neurology, State University of New York SUNY at Buffalo, School of Medicine, Buffalo, NY 14203, USA
    Mult Scler 13:722-30. 2007
    ..Given its overall simplicity and moderate correlation with cognition, DWI may offer several logistic advantages over more traditional MRI measures when predicting the presence of NP impairment...
  14. doi request reprint Cortical atrophy and personality in multiple sclerosis
    Ralph H B Benedict
    Department of Neurology, State University of New York at Buffalo, School of Medicine, New York, USA
    Neuropsychology 22:432-41. 2008
    ..These findings suggest that cortical atrophy in MS is associated with adverse impact on personality, although longitudinal research is needed to test this hypothesis...
  15. doi request reprint Effects of l-amphetamine sulfate on cognitive function in multiple sclerosis patients
    R H B Benedict
    Dept of Neurology, State University of New York, Buffalo School of Medicine and the Jacobs, Neurological Institute, Buffalo, NY, USA
    J Neurol 255:848-52. 2008
    ..These preliminary findings show promise for the use of l-amphetamine for the symptomatic treatment of slowed mental processing in MS. Further placebo-controlled trials are needed to confirm these findings...
  16. pmc Neuropsychological impairment in systemic lupus erythematosus: a comparison with multiple sclerosis
    R H B Benedict
    Division of Cognitive and Behavioral Neurosciences, State University of New York at Buffalo, School of Medicine, Jacobs Neurological Institute, Buffalo General Hospital, Buffalo, NY 14203, USA
    Neuropsychol Rev 18:149-66. 2008
    ..There is less evidence for neurodegenerative changes in SLE, but patients are increasingly at risk for cerebrovascular disease. We conclude by offering some suggestions for future clinical and imaging research...
  17. doi request reprint Repeated assessment of neuropsychological deficits in multiple sclerosis using the Symbol Digit Modalities Test and the MS Neuropsychological Screening Questionnaire
    R H B Benedict
    School of Medicine, State University of New York at Buffalo, Buffalo, New York, USA
    Mult Scler 14:940-6. 2008
    ....
  18. pmc Personality traits in women with multiple sclerosis: discrepancy in patient/partner report and disease course
    Ralph H B Benedict
    State University of New York at Buffalo School of Medicine, Departments of Neurology and Psychiatry, Buffalo, NY, USA
    J Psychosom Res 66:147-54. 2009
    ..We endeavored to examine the extent to which patients' self-perceptions are congruent with how they are perceived by significant others across five trait domains as demarcated by the well known Five-Factor Model (FFM)...
  19. ncbi request reprint Effects of using same- versus alternate-form memory tests during short-interval repeated assessments in multiple sclerosis
    Ralph H B Benedict
    State University of New York at Buffalo School of Medicine, Department of Neurology, Buffalo General Hospital, New York 14203, USA
    J Int Neuropsychol Soc 11:727-36. 2005
    ..Nevertheless, I conclude that the use of CVLT-II and BVMT-R alternate forms likely helps preserve test validity without compromising test-retest reliability...
  20. ncbi request reprint Correlating brain atrophy with cognitive dysfunction, mood disturbances, and personality disorder in multiple sclerosis
    Ralph H B Benedict
    State University of New York Buffalo School of Medicine, Jacobs Neurological Institute, Department of Neurology, Buffalo General Hospital, New York 14203, USA
    J Neuroimaging 14:36S-45S. 2004
    ..Continuing research focuses on the possible relationship between measures of regional brain atrophy and cognitive and emotional impairment...
  21. ncbi request reprint Minimal neuropsychological assessment of MS patients: a consensus approach
    Ralph H B Benedict
    Department of Neurology, State University of New York at Buffalo, Buffalo, NY, USA
    Clin Neuropsychol 16:381-97. 2002
    ..g., visual/sensory/motor impairment, fatigue, and depression) are offered, as well as strategies for improving NP assessment of MS patients in the future...
  22. ncbi request reprint Screening for multiple sclerosis cognitive impairment using a self-administered 15-item questionnaire
    R H B Benedict
    Department of Neurology, State University of New York SUNY at Buffalo School of Medicine, Buffalo, New York, USA
    Mult Scler 9:95-101. 2003
    ..83 and a specificity of 0.97. It is concluded, therefore, that this self-administered neuropsychological screening test is reliable and predicts neuropsychological impairment in MS patients with a reasonable degree of accuracy...
  23. doi request reprint Risk factors for and management of cognitive dysfunction in multiple sclerosis
    Ralph H B Benedict
    Department of Neurology, Suite D6, Buffalo General Hospital, State University of New York at Buffalo, 100 High Street, Buffalo, NY 14203, USA
    Nat Rev Neurol 7:332-42. 2011
    ..Pharmacological treatments for neuropsychological impairment are on the horizon, although presently no firm medical indications exist for the condition...
  24. ncbi request reprint Prediction of neuropsychological impairment in multiple sclerosis: comparison of conventional magnetic resonance imaging measures of atrophy and lesion burden
    Ralph H B Benedict
    Department of Neurology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo General Hospital, NY 14203, USA
    Arch Neurol 61:226-30. 2004
    ..Furthermore, few studies accounted for the influence of age, premorbid intelligence, or depression...
  25. ncbi request reprint Predicting quality of life in multiple sclerosis: accounting for physical disability, fatigue, cognition, mood disorder, personality, and behavior change
    Ralph H B Benedict
    Department of Neurology, School of Medicine, State University of New York at Buffalo, Buffalo General Hospital, Neurology, Suite D 6, 100 High Street, Buffalo, NY 14203, USA
    J Neurol Sci 231:29-34. 2005
    ..The findings highlight core clinical problems that merit early identification and further research regarding the development of effective treatment...
  26. ncbi request reprint Reliable screening for neuropsychological impairment in multiple sclerosis
    Ralph H B Benedict
    Department of Neurology, State University of New York at Buffalo, School of Medicine, Buffalo, New York, NY, USA
    Mult Scler 10:675-8. 2004
    ..It is concluded that the MSNQ is useful, although patient self-reports may be exaggerated in depressed patients or reduced in patients with severe cognitive impairment...
  27. doi request reprint Psychometrics and normative data for the Multiple Sclerosis Functional Composite: replacing the PASAT with the Symbol Digit Modalities Test
    A S Drake
    Department of Neurology, State University of New York SUNY at Buffalo School of Medicine, Buffalo, NY, USA
    Mult Scler 16:228-37. 2010
    ....
  28. doi request reprint Regression-based norms improve the sensitivity of the National MS Society Consensus Neuropsychological Battery for Pediatric Multiple Sclerosis (NBPMS)
    A M Smerbeck
    Department of Neurology, State University of New York at Buffalo, NY, USA
    Clin Neuropsychol 26:985-1002. 2012
    ..As in the case of adult MS, these results indicate that regression-based norms offer interpretive benefits over their manual-based counterparts...
  29. doi request reprint Subjective fatigue is not associated with cognitive impairment in multiple sclerosis: cross-sectional and longitudinal analysis
    S A Morrow
    School of Medicine, The Jacobs Neurological Institute, State University of New York at Buffalo, Buffalo, New York 14203, USA
    Mult Scler 15:998-1005. 2009
    ..Studies in multiple sclerosis (MS) report conflicting conclusions regarding fatigue and cognition, which may partly be due to the use of small sample sizes and frequent reliance on a cross-sectional approach...
  30. ncbi request reprint Thalamic atrophy and cognition in multiple sclerosis
    M K Houtchens
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Partners MS Center, Boston, MA 02115, USA
    Neurology 69:1213-23. 2007
    ..In this study, we tested the hypothesis that thalamic volume is lower in MS than in normal subjects, and that thalamic atrophy in MS correlates with cognitive function...
  31. doi request reprint No association between conventional brain MR imaging and chronic cerebrospinal venous insufficiency in multiple sclerosis
    R Zivadinov
    Buffalo Neuroimaging Analysis Center, Department of Neurology, School of Medicine and Biomedical Sciences, Buffalo, NY 14203, USA
    AJNR Am J Neuroradiol 33:1913-7. 2012
    ..Therefore, this study determined the associations of CCSVI and conventional MR imaging outcomes in patients with MS and in HCs...
  32. doi request reprint Regression-based pediatric norms for the brief visuospatial memory test: revised and the symbol digit modalities test
    A M Smerbeck
    Department of Neurology, State University of New York SUNY at Buffalo, Buffalo, NY, USA
    Clin Neuropsychol 25:402-12. 2011
    ..As the tests are validated in adult multiple sclerosis, they are likely to be useful in monitoring pediatric onset multiple sclerosis patients as they transition into adulthood...
  33. doi request reprint Memory impairment in multiple sclerosis: correlation with deep grey matter and mesial temporal atrophy
    R H B Benedict
    Jacobs Neurological Institute, Buffalo Neuroimaging Analysis Center, and Department of Neurology, State University of New York at Buffalo, New York 14203, USA
    J Neurol Neurosurg Psychiatry 80:201-6. 2009
    ..However, the importance of mesial temporal lobe (MTL) atrophy in MS is largely untested and poorly understood. New structural imaging techniques permit volumetric measures of multiple regions within the MTL lobe and DGM...
  34. ncbi request reprint Functional imaging during covert auditory attention in multiple sclerosis
    Michael P Santa Maria
    Department of Neurology, School of Medicine, State University of New York at Buffalo, Buffalo General Hospital, Neurology, Suite D 6 Buffalo, 100 High Street, 14203, USA
    J Neurol Sci 218:9-15. 2004
    ..This study demonstrates cingulate hypoactivity and cerebral reorganization during auditory attention in MS...
  35. ncbi request reprint Independent contributions of cortical gray matter atrophy and ventricle enlargement for predicting neuropsychological impairment in multiple sclerosis
    Ayda Tekok-Kilic
    Department of Neurology, University at Buffalo, State University of New York, USA
    Neuroimage 36:1294-300. 2007
    ..For the first time, we show an independent relationship between cortical atrophy and cognitive impairment after accounting for the effects of central atrophy...
  36. ncbi request reprint Screening for cognitive impairment in multiple sclerosis using the Symbol digit Modalities Test
    B A Parmenter
    Department of Neurology, Division of Developmental and Behavioral Neurosciences, State University of New York at Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY, USA
    Mult Scler 13:52-7. 2007
    ..71, and negative predictive value (NPV) of 0.73. These results suggest that the effectiveness of the SDMT as a screen for cognitive impairment in MS is roughly equal to that of other psychometric and questionnaire methods...
  37. ncbi request reprint Interpreting patient/informant discrepancies of reported cognitive symptoms in MS
    D A Carone
    SUNY Buffalo School of Medicine and Buffalo General Hospital, Buffalo, New York 14203, USA
    J Int Neuropsychol Soc 11:574-83. 2005
    ..We conclude that patient/informant discrepancy scores on the MSNQ are associated with the aforementioned neuropsychiatric features, and that the MSNQ has potential utility for predicting euphoria and disinhibition syndromes in MS...
  38. ncbi request reprint MRI T2 hypointensity of the dentate nucleus is related to ambulatory impairment in multiple sclerosis
    C W Tjoa
    Department of Neurology, University at Buffalo, State University of New York, Buffalo, NY, USA
    J Neurol Sci 234:17-24. 2005
    ..Ambulatory dysfunction limits quality of life; however correlation with conventional MRI remains poor...
  39. ncbi request reprint Cognitive impairment is associated with subcortical magnetic resonance imaging grey matter T2 hypointensity in multiple sclerosis
    S D Brass
    Department of Neurology, Center for Neurological Imaging, Partners Multiple Sclerosis Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Mult Scler 12:437-44. 2006
    ..These data implicate a role for basal ganglia iron deposition in neuropsychological dysfunction...
  40. doi request reprint Visual-cognitive processing deficits in pediatric multiple sclerosis
    A M Smerbeck
    Department of Neurology, State University of New York, Buffalo, NY, USA
    Mult Scler 17:449-56. 2011
    ..This study investigates the sensitivity and validity in pediatric MS of two visual processing tests borrowed from the adult literature, the Brief Visuospatial Memory Test-Revised (BVMTR) and the Symbol Digit Modalities Test (SDMT)...
  41. ncbi request reprint Semi-automatic brain region extraction (SABRE) reveals superior cortical and deep gray matter atrophy in MS
    D A Carone
    Buffalo Neuroimaging Analysis Center, Buffalo, NY 14203, USA
    Neuroimage 29:505-14. 2006
    ..5%), and superior parietal (-6.1%) regions, with SP patients having lower volumes. Overall, atrophy in MS is diffuse and mostly related to GM loss particularly in deep GM and superior frontal-parietal regions...
  42. ncbi request reprint Regional lobar atrophy predicts memory impairment in multiple sclerosis
    Ralph H B Benedict
    Department of Neurology, SUNY Buffalo School of Medicine, Buffalo, NY 14203, USA
    AJNR Am J Neuroradiol 26:1824-31. 2005
    ..The relationship between regional lobar atrophy and cognitive impairment is yet to be examined. We endeavored to assess the clinical significance of regional lobar atrophy in multiple sclerosis...
  43. ncbi request reprint Validity of the Wisconsin Card Sorting and Delis-Kaplan Executive Function System (DKEFS) Sorting Tests in multiple sclerosis
    Brett A Parmenter
    Department of Neurology, State University of New York at Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY 14203, USA
    J Clin Exp Neuropsychol 29:215-23. 2007
    ..While both tests appear to have good validity in the MS population, the availability of alternative forms makes the DKEFS an attractive alternative to the WCST, as was suggested by a consensus panel...
  44. doi request reprint Multimodal imaging in systemic lupus erythematosus patients with diffuse neuropsychiatric involvement
    R Zivadinov
    Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, NY 14203, USA
    Lupus 22:675-83. 2013
    ....
  45. doi request reprint Prevalence, sensitivity, and specificity of chronic cerebrospinal venous insufficiency in MS
    R Zivadinov
    Department of Neurology, School of Medicine and Biomedical Sciences Buffalo Neuroimaging Analysis Center, Buffalo, NY 14203, USA
    Neurology 77:138-44. 2011
    ..Chronic cerebrospinal venous insufficiency (CCSVI) was recently described in patients with multiple sclerosis (MS). A subject is considered CCSVI positive if ≥ 2 venous hemodynamic (VH) criteria are fulfilled...
  46. ncbi request reprint Working memory deficits in multiple sclerosis: comparison between the n-back task and the Paced Auditory Serial Addition Test
    Brett A Parmenter
    Division of Developmental and Behavioral Neurosciences, Department of Neurology The Jacobs Neurological Institute, School of Medicine and Biomedical Sciences, University at Buffalo State University of New York, 100 High Street, Buffalo, NY 14203, USA
    J Int Neuropsychol Soc 12:677-87. 2006
    ..Although the PASAT and n-back were shown to have a significant amount of shared variance, each test has specific advantages and disadvantages for use in clinical populations...
  47. doi request reprint Extent of cerebellum, subcortical and cortical atrophy in patients with MS: a case-control study
    Deepa Preeti Ramasamy
    Buffalo Neuroimaging Analysis Center, Department of Neurology, State University of New York at Buffalo, Buffalo, NY, USA
    J Neurol Sci 282:47-54. 2009
    ..This study confirmed selective deep gray matter atrophy (mostly thalamic), revealed cerebellum WM atrophy from the earliest clinical stages, and showed that cortical thinning advances with disease progression...
  48. doi request reprint Effects of acute relapses on neuropsychological status in multiple sclerosis patients
    S A Morrow
    Jacobs Neurological Institute, State University of New York at Buffalo, Buffalo, NY, USA
    J Neurol 258:1603-8. 2011
    ..These results confirm the involvement of cognitive function during some MS relapses suggesting the SDMT or MSNQ can be used to identify transitory neuropsychological status changes and cognitive relapses...
  49. pmc Multicenter randomized clinical trial of donepezil for memory impairment in multiple sclerosis
    L B Krupp
    Department of Neurology, State University of New York at Stony Brook, Stony Brook, NY 11794 8121, USA
    Neurology 76:1500-7. 2011
    ..The goal of this study was to determine if memory would be improved by donepezil as compared to placebo in a multicenter, double-blind, randomized clinical trial (RCT)...
  50. doi request reprint Brain atrophy and white matter hyperintensities in early Parkinson's disease(a)
    Turi O Dalaker
    Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York 14203, USA
    Mov Disord 24:2233-41. 2009
    ..We conclude that global structural brain changes are not a major feature in patients with incident PD...
  51. ncbi request reprint New error type and recall consistency indices for the Brief Visuospatial Memory Test - Revised: performance in healthy adults and multiple sclerosis patients
    Jeffrey J Gaines
    Department of Neurology, State University of New York at Buffalo School of Medicine, NY, USA
    Clin Neuropsychol 22:851-63. 2008
    ..Findings suggest these error types and inconsistent learning contribute to poorer recall of visual material in MS...
  52. doi request reprint Regional specificity of magnetization transfer imaging in multiple sclerosis
    Christopher W Tjoa
    Buffalo Neuroimaging Analysis Center, Department of Neurology, University at Buffalo, State University of New York, Buffalo, New York, USA
    J Neuroimaging 18:130-6. 2008
    ..We also studied the topography of MTR changes in multiple sclerosis (MS) and in normal controls (NC), and preliminarily examined the clinical usefulness of this method...
  53. doi request reprint The effects of L-amphetamine sulfate on cognition in MS patients: results of a randomized controlled trial
    Sarah A Morrow
    Jacobs Neurological Institute, State University of New York at Buffalo, 100 High Street, Buffalo, NY 14215, USA
    J Neurol 256:1095-102. 2009
    ..However, because the positive findings were observed on secondary outcome measures, the study requires replication before L: -amphetamine sulfate can be recommended for the treatment of cognitive impairment in MS...
  54. ncbi request reprint Gray and white matter brain atrophy and neuropsychological impairment in multiple sclerosis
    Michael P Sanfilipo
    Department of Neurology, SUNY University, School of Medicine and Biomedical Sciences, Buffalo, NY, USA
    Neurology 66:685-92. 2006
    ..The relationship of gray and white matter atrophy in multiple sclerosis (MS) to neuropsychological and neuropsychiatric impairment has not been examined...
  55. ncbi request reprint Validity of the Beck Depression Inventory-Fast Screen in multiple sclerosis
    R H B Benedict
    Department of Neurology, State University of New York SUNY, Buffalo School of Medicine and Biomedical Sciences, Buffalo General Hospital, Buffalo, New York 14203, USA
    Mult Scler 9:393-6. 2003
    ..The BDI-FS may be useful in this regard although, to date, its validity in MS patients has not been assessed...
  56. doi request reprint Evaluation of the symbol digit modalities test (SDMT) and MS neuropsychological screening questionnaire (MSNQ) in natalizumab-treated MS patients over 48 weeks
    S A Morrow
    Jacobs Neurological Institute, State University of New York at Buffalo, Buffalo, NY, USA
    Mult Scler 16:1385-92. 2010
    ..Brief cognitive tests to monitor cognitive impairment in patients with multiple sclerosis (MS) are needed...
  57. doi request reprint Validity of the California Verbal Learning Test-II in multiple sclerosis
    Shane Stegen
    Department of Neurology, State University of New York SUNY at Buffalo, Buffalo, NY, USA
    Clin Neuropsychol 24:189-202. 2010
    ..We conclude that the CVLT-II is a valid test in MS and provides a rich constellation of verbal memory measures...
  58. ncbi request reprint Covert auditory attention generates activation in the rostral/dorsal anterior cingulate cortex
    Ralph H B Benedict
    State University of New York and VA Western New York Healthcare System of Buffalo, NY 14203, USA
    J Cogn Neurosci 14:637-45. 2002
    ..We conclude that a rostral/dorsal subdivision of the right ACC is specific for conscious attention during auditory processing, in contrast to premotor response formation...
  59. ncbi request reprint Frontal cortex atrophy predicts cognitive impairment in multiple sclerosis
    Ralph H B Benedict
    Department of Neurology, State University of New York at Buffalo School of Medicine, Buffalo, USA
    J Neuropsychiatry Clin Neurosci 14:44-51. 2002
    ..The authors conclude that cerebral atrophy predicts NP impairment while accounting for the influence of TLA or 3VW. Regions of cortex most susceptible to atrophic and cognitive changes in MS are the right and left superior frontal lobes...
  60. ncbi request reprint Construct validity and frequency of euphoria sclerotica in multiple sclerosis
    Inna Fishman
    State University of New York SUNY Buffalo School of Medicine and Biomedical Sciences, Buffalo General Hospital, Buffalo, New York, USA
    J Neuropsychiatry Clin Neurosci 16:350-6. 2004
    ..Thus, we used the NPI to validate the euphoria syndrome in multiple sclerosis (MS) and determined its frequency, and its neurological and psychological correlates...
  61. ncbi request reprint T2 hypointensity in the deep gray matter of patients with multiple sclerosis: a quantitative magnetic resonance imaging study
    Rohit Bakshi
    Department of Neurology, University at Buffalo, State University of New York, USA
    Arch Neurol 59:62-8. 2002
    ..While gray matter T2 hypointensity in multiple sclerosis (MS) has been associated with physical disability and clinical course, previous studies have relied on visual magnetic resonance imaging (MRI) assessments...
  62. doi request reprint Influence of recruitment and participation bias in neuropsychological research among MS patients
    J Aubrey Duquin
    Department of Neurology, Division of Cognitive and Behavioral Neurosciences, SUNY at Buffalo School of Medicine and Biomedical Sciences, Buffalo, New York 14203, USA
    J Int Neuropsychol Soc 14:494-8. 2008
    ..NP testing significantly predicted vocational outcomes in all groups. These results suggest that greater attention should be paid to the reasons patients agree to participate in NP testing...
  63. ncbi request reprint Multi-site phasic neural activity mediates the execution of an auditory continuous performance task: a PET and electrophysiological study
    Alan H Lockwood
    Center for PET, VA Western NY Healthcare System, University at Buffalo, Buffalo, NY 14215, USA
    J Neuroimaging 18:364-74. 2008
    ..We studied an auditory continuous performance task with positron emission tomography(PET) and EEG-derived current density reconstructions (CDRs) to define the spatial and temporal aspects of auditory attention...
  64. ncbi request reprint Working memory and processing speed deficits in systemic lupus erythematosus as measured by the paced auditory serial addition test
    Janet L Shucard
    Department of Neurology, Division of Developmental and Behavioral Neurosciences, State University of New York at Buffalo School of Medicine and Biomedical Sciences, USA
    J Int Neuropsychol Soc 10:35-45. 2004
    ..The findings suggest that SLE patients, like MS patients, chunk responses more often than controls, and that this scoring procedure may better reflect the working memory and processing speed deficits present in SLE...
  65. doi request reprint Multi-site phasic neural activity mediates the execution of an auditory continuous performance task: a PET and electrophysiological study
    Alan H Lockwood
    VA Western NY Healthcare System, University at Buffalo, Buffalo, NY 14215, USA
    J Neuroimaging 18:241-51. 2008
    ..We studied an auditory continuous performance task with positron emission tomography (PET) and EEG-derived current density reconstructions (CDRs) to define the spatial and temporal aspects of auditory attention...
  66. ncbi request reprint The relationship between whole brain volume and disability in multiple sclerosis: a comparison of normalized gray vs. white matter with misclassification correction
    Michael P Sanfilipo
    Department of Neurology, SUNY University at Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY 14203, USA
    Neuroimage 26:1068-77. 2005
    ..These findings suggest that gray matter loss is related to other aspects of brain pathology and has more clinical relevance than white matter atrophy in MS...
  67. doi request reprint Plasma pentosidine: a potential biomarker in the management of multiple sclerosis
    Zohara Sternberg
    Department of Neurology, Baird MS Center, Jacobs Neurological Institute, Buffalo, NY, USA
    Mult Scler 17:157-63. 2011
    ..The chronic inflammation associated with multiple sclerosis (MS) may lead to the upregulation of pentosidine...
  68. ncbi request reprint Semantic clustering indexes for the Hopkins Verbal Learning Test-Revised: initial exploration in elder control and dementia groups
    Jeffrey J Gaines
    Department of Neurology, State University of New York SUNY at Buffalo School of Medicine, NY, USA
    Appl Neuropsychol 13:213-22. 2006
    ..Results suggest that these newly developed semantic clustering indexes are easily calculated and potentially useful for discriminating between elder controls and dementia patients...
  69. ncbi request reprint Quantitative diffusion weighted imaging measures in patients with multiple sclerosis
    Eleonora Tavazzi
    Buffalo Neuroimaging Analysis Center, Department of Neurology, University at Buffalo, State University of New York, Buffalo, NY, USA
    Neuroimage 36:746-54. 2007
    ..ENT is a sensitive marker of overall brain damage that is strongly related to clinical impairment in patients with SP MS...
  70. ncbi request reprint Integrating cognitive function screening and assessment into the routine care of multiple sclerosis patients
    Ralph H B Benedict
    Department of Neurology, State University of New York at Buffalo, Buffalo, NY, USA
    CNS Spectr 10:384-91. 2005
    ..Thus, these or similar methods should be employed for the routine monitoring of cognitive functioning of MS patients...
  71. ncbi request reprint Multiple sclerosis
    Ralph H B Benedict
    Department of Neurology, State University of New York SUNY at Buffalo, Jacobs Neurological Institute, Buffalo, New York, USA
    Semin Neurol 27:78-85. 2007
    ..Recent developments in pharmacological treatment for disease progression and management of cognitive symptoms hold promise for patients suffering from the degenerative aspects of MS...
  72. ncbi request reprint Correction for intracranial volume in analysis of whole brain atrophy in multiple sclerosis: the proportion vs. residual method
    Michael P Sanfilipo
    Department of Neurology, SUNY University at Buffalo School of Medicine and Biomedical Sciences, NY 14203, USA
    Neuroimage 22:1732-43. 2004
    ..Our findings suggest that head size correction of brain regions with the residual method generally may provide advantages over the proportion method...
  73. ncbi request reprint Progressive cerebral disease in lymphomatoid granulomatosis causes anterograde amnesia and neuropsychiatric disorder
    Dominic A Carone
    Department of Neurology, State University of New York SUNY at Buffalo School of Medicine, and Jacobs Neurological Institute, USA
    J Neuroimaging 16:163-6. 2006
    ..We speculate that temporal lobe atrophy was influenced by the established susceptibility of this region in various neurological diseases...
  74. ncbi request reprint Whole-brain atrophy in multiple sclerosis measured by automated versus semiautomated MR imaging segmentation
    Jitendra Sharma
    Buffalo Neuroimaging Analysis Center, University at Buffalo, State University of New York, Buffalo, NY, USA
    AJNR Am J Neuroradiol 25:985-96. 2004
    ..Semiautomated and automated methods are used to measure whole-brain atrophy in multiple sclerosis (MS), but their comparative reliability, sensitivity, and validity are unknown...
  75. ncbi request reprint Update on the relationships between neuropsychological dysfunction and structural MRI in multiple sclerosis
    Ayda Tekok-Kilic
    Department of Neurology, State University of New York, Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY, USA
    Expert Rev Neurother 6:323-31. 2006
    ..In this article, recent contributions to the literature regarding the correlation between MRI and neuropsychological function in MS are reviewed...
  76. doi request reprint Clinical efficacy, effects on MRI and tolerability of weekly intramuscular interferon-beta-1a in patients with MS and CIS
    Robert Zivadinov
    Buffalo Neuroimaging Analysis Center, Department of Neurology, University at Buffalo, State University of New York, Buffalo, New York 14203, USA
    Drugs Today (Barc) 44:601-13. 2008
    ..Early initiation of disease-modifying therapy after the diagnosis of relapsing-remitting MS or after a single demyelinating event (and evidence of lesions on MRI) allows patients the opportunity to obtain maximal long-term benefits...
  77. doi request reprint Oralmotor slowing in multiple sclerosis: relationship to neuropsychological tasks requiring an oral response
    Peter A Arnett
    Psychology Department, The Pennsylvania State University, University Park, Pennsylvania, USA
    J Int Neuropsychol Soc 14:454-62. 2008
    ..Our data suggest that rudimentary oral motor speed is slowed in MS patients and makes an important contribution to group differences in performance on commonly used neuropsychological tasks requiring a rapid spoken response...