Research Topics
| R H B BenedictSummaryAffiliation: University at Buffalo Country: USA Publications
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Publications
Evaluating cognitive outcome measures for MS clinical trials: what is a clinically meaningful change?Ralph H B Benedict
Department of Neurology, University at Buffalo, Buffalo General Hospital, Buffalo, NY 14203, USA
Mult Scler 18:1673-9. 2012....
Upper and lower extremity motor function and cognitive impairment in multiple sclerosisRalph H B Benedict
Department of Neurology, SUNY Buffalo School of Medicine, Buffalo, NY, USA
J Int Neuropsychol Soc 17:643-53. 2011..The findings may have implications for risk assessment and treatment of mobility dysfunction in MS...- Reliability and equivalence of alternate forms for the Symbol Digit Modalities Test: implications for multiple sclerosis clinical trialsRalph H B Benedict
SUNY Buffalo School of Medicine, Neurology, Buffalo General Hospital, Buffalo, NY 14203, USA
Mult Scler 18:1320-5. 2012..Unfortunately, there are no validated alternate SDMT forms, which are needed to mitigate practice effects... - Predicting quality of life in multiple sclerosis: accounting for physical disability, fatigue, cognition, mood disorder, personality, and behavior changeRalph H B Benedict
Department of Neurology, School of Medicine, State University of New York at Buffalo, Buffalo General Hospital, Neurology, Suite D 6, 100 High Street, Buffalo, NY 14203, USA
J Neurol Sci 231:29-34. 2005..The findings highlight core clinical problems that merit early identification and further research regarding the development of effective treatment... - Repeated assessment of neuropsychological deficits in multiple sclerosis using the Symbol Digit Modalities Test and the MS Neuropsychological Screening QuestionnaireR H B Benedict
School of Medicine, State University of New York at Buffalo, Buffalo, New York, USA
Mult Scler 14:940-6. 2008.... - Cortical atrophy and personality in multiple sclerosisRalph H B Benedict
Department of Neurology, State University of New York at Buffalo, School of Medicine, New York, USA
Neuropsychology 22:432-41. 2008..These findings suggest that cortical atrophy in MS is associated with adverse impact on personality, although longitudinal research is needed to test this hypothesis... - Validity of the minimal assessment of cognitive function in multiple sclerosis (MACFIMS)Ralph H B Benedict
State University of New York at Buffalo School of Medicine, Department of Neurology, Division of Departmental and Behavioral Neurosciences, Buffalo, New York, USA
J Int Neuropsychol Soc 12:549-58. 2006..We conclude that the MACFIMS is a valid approach to routine NP assessment of MS patients. Future work is planned to determine its psychometric properties in a longitudinal study... - Neocortical atrophy, third ventricular width, and cognitive dysfunction in multiple sclerosisRalph H B Benedict
Department of Neurology, School of Medicine, State University of New York at Buffalo, 100 High Street, Buffalo, NY 14203, USA
Arch Neurol 63:1301-6. 2006..Cognitive dysfunction is common in multiple sclerosis (MS). Correlations are reported between atrophy and neuropsychological test results... - Prediction of neuropsychological impairment in multiple sclerosis: comparison of conventional magnetic resonance imaging measures of atrophy and lesion burdenRalph H B Benedict
Department of Neurology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo General Hospital, NY 14203, USA
Arch Neurol 61:226-30. 2004..Furthermore, few studies accounted for the influence of age, premorbid intelligence, or depression... - Effects of using same- versus alternate-form memory tests during short-interval repeated assessments in multiple sclerosisRalph H B Benedict
State University of New York at Buffalo School of Medicine, Department of Neurology, Buffalo General Hospital, New York 14203, USA
J Int Neuropsychol Soc 11:727-36. 2005..Nevertheless, I conclude that the use of CVLT-II and BVMT-R alternate forms likely helps preserve test validity without compromising test-retest reliability... - Reliability and validity of neuropsychological screening and assessment strategies in MSRalph H B Benedict
SUNY Buffalo School of Medicine, Jacobs Neurological Institute, Buffalo General Hospital, 100 High Street, Buffalo, NY 14203, USA
J Neurol 254:II22-II25. 2007..Work with new non-conventional brain imaging techniques and finer analysis of reliability during serial testing protocols is underway... 
Personality traits in women with multiple sclerosis: discrepancy in patient/partner report and disease courseRalph H B Benedict
State University of New York at Buffalo School of Medicine, Departments of Neurology and Psychiatry, Buffalo, NY, USA
J Psychosom Res 66:147-54. 2009..We endeavored to examine the extent to which patients' self-perceptions are congruent with how they are perceived by significant others across five trait domains as demarcated by the well known Five-Factor Model (FFM)...- Reliable screening for neuropsychological impairment in multiple sclerosisRalph H B Benedict
Department of Neurology, State University of New York at Buffalo, School of Medicine, Buffalo, New York, NY, USA
Mult Scler 10:675-8. 2004..It is concluded that the MSNQ is useful, although patient self-reports may be exaggerated in depressed patients or reduced in patients with severe cognitive impairment... - Cognitive reserve moderates decline in information processing speed in multiple sclerosis patientsRalph H B Benedict
Department of Neurology, Division of Cognitive and Behavioral Neurosciences, State University of New York at Buffalo School of Medicine and Biomedical Sciences, Buffalo, New York, USA
J Int Neuropsychol Soc 16:829-35. 2010..We conclude that greater cognitive reserve as indexed by either higher premorbid intelligence or more years of education protects against the progression of cognitive dysfunction in MS... - Minimal neuropsychological assessment of MS patients: a consensus approachRalph H B Benedict
Department of Neurology, State University of New York at Buffalo, Buffalo, NY, USA
Clin Neuropsychol 16:381-97. 2002..g., visual/sensory/motor impairment, fatigue, and depression) are offered, as well as strategies for improving NP assessment of MS patients in the future... - Screening for multiple sclerosis cognitive impairment using a self-administered 15-item questionnaireR H B Benedict
Department of Neurology, State University of New York SUNY at Buffalo School of Medicine, Buffalo, New York, USA
Mult Scler 9:95-101. 2003..83 and a specificity of 0.97. It is concluded, therefore, that this self-administered neuropsychological screening test is reliable and predicts neuropsychological impairment in MS patients with a reasonable degree of accuracy... - Risk factors for and management of cognitive dysfunction in multiple sclerosisRalph H B Benedict
Department of Neurology, Suite D6, Buffalo General Hospital, State University of New York at Buffalo, 100 High Street, Buffalo, NY 14203, USA
Nat Rev Neurol 7:332-42. 2011..Pharmacological treatments for neuropsychological impairment are on the horizon, although presently no firm medical indications exist for the condition... - Diffusion-weighted imaging predicts cognitive impairment in multiple sclerosisRalph H B Benedict
Department of Neurology, State University of New York SUNY at Buffalo, School of Medicine, Buffalo, NY 14203, USA
Mult Scler 13:722-30. 2007..Given its overall simplicity and moderate correlation with cognition, DWI may offer several logistic advantages over more traditional MRI measures when predicting the presence of NP impairment... - Predicting neuropsychological abnormalities in multiple sclerosisRalph H B Benedict
Department of Neurology, School of Medicine, State University of New York, SUNY at Buffalo, Buffalo General Hospital, Neurology, Suite D 6, 100 High Street, 14203, USA
J Neurol Sci 245:67-72. 2006..We conclude that the MSNQ is reliable and valid for detecting neuropsychological and neuropsychiatric complications of MS... - Effects of l-amphetamine sulfate on cognitive function in multiple sclerosis patientsR H B Benedict
Dept of Neurology, State University of New York, Buffalo School of Medicine and the Jacobs, Neurological Institute, Buffalo, NY, USA
J Neurol 255:848-52. 2008..These preliminary findings show promise for the use of l-amphetamine for the symptomatic treatment of slowed mental processing in MS. Further placebo-controlled trials are needed to confirm these findings... - Correlating brain atrophy with cognitive dysfunction, mood disturbances, and personality disorder in multiple sclerosisRalph H B Benedict
State University of New York Buffalo School of Medicine, Jacobs Neurological Institute, Department of Neurology, Buffalo General Hospital, New York 14203, USA
J Neuroimaging 14:36S-45S. 2004..Continuing research focuses on the possible relationship between measures of regional brain atrophy and cognitive and emotional impairment... - Neuropsychological impairment in systemic lupus erythematosus: a comparison with multiple sclerosisR H B Benedict
Division of Cognitive and Behavioral Neurosciences, State University of New York at Buffalo, School of Medicine, Jacobs Neurological Institute, Buffalo General Hospital, Buffalo, NY 14203, USA
Neuropsychol Rev 18:149-66. 2008..There is less evidence for neurodegenerative changes in SLE, but patients are increasingly at risk for cerebrovascular disease. We conclude by offering some suggestions for future clinical and imaging research... - Psychometrics and normative data for the Multiple Sclerosis Functional Composite: replacing the PASAT with the Symbol Digit Modalities TestA S Drake
Department of Neurology, State University of New York SUNY at Buffalo School of Medicine, Buffalo, NY, USA
Mult Scler 16:228-37. 2010.... - Regression-based norms improve the sensitivity of the National MS Society Consensus Neuropsychological Battery for Pediatric Multiple Sclerosis (NBPMS)A M Smerbeck
Department of Neurology, State University of New York at Buffalo, NY, USA
Clin Neuropsychol 26:985-1002. 2012..As in the case of adult MS, these results indicate that regression-based norms offer interpretive benefits over their manual-based counterparts... - Subjective fatigue is not associated with cognitive impairment in multiple sclerosis: cross-sectional and longitudinal analysisS A Morrow
School of Medicine, The Jacobs Neurological Institute, State University of New York at Buffalo, Buffalo, New York 14203, USA
Mult Scler 15:998-1005. 2009..Studies in multiple sclerosis (MS) report conflicting conclusions regarding fatigue and cognition, which may partly be due to the use of small sample sizes and frequent reliance on a cross-sectional approach... - Thalamic atrophy and cognition in multiple sclerosisM K Houtchens
Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Partners MS Center, Boston, MA 02115, USA
Neurology 69:1213-23. 2007..In this study, we tested the hypothesis that thalamic volume is lower in MS than in normal subjects, and that thalamic atrophy in MS correlates with cognitive function... - Regression-based pediatric norms for the brief visuospatial memory test: revised and the symbol digit modalities testA M Smerbeck
Department of Neurology, State University of New York SUNY at Buffalo, Buffalo, NY, USA
Clin Neuropsychol 25:402-12. 2011..As the tests are validated in adult multiple sclerosis, they are likely to be useful in monitoring pediatric onset multiple sclerosis patients as they transition into adulthood... - Memory impairment in multiple sclerosis: correlation with deep grey matter and mesial temporal atrophyR H B Benedict
Jacobs Neurological Institute, Buffalo Neuroimaging Analysis Center, and Department of Neurology, State University of New York at Buffalo, New York 14203, USA
J Neurol Neurosurg Psychiatry 80:201-6. 2009..However, the importance of mesial temporal lobe (MTL) atrophy in MS is largely untested and poorly understood. New structural imaging techniques permit volumetric measures of multiple regions within the MTL lobe and DGM... - Functional imaging during covert auditory attention in multiple sclerosisMichael P Santa Maria
Department of Neurology, School of Medicine, State University of New York at Buffalo, Buffalo General Hospital, Neurology, Suite D-6 Buffalo, 100 High Street, 14203, USA
J Neurol Sci 218:9-15. 2004..This study demonstrates cingulate hypoactivity and cerebral reorganization during auditory attention in MS... - Independent contributions of cortical gray matter atrophy and ventricle enlargement for predicting neuropsychological impairment in multiple sclerosisAyda Tekok Kilic
Department of Neurology, University at Buffalo, State University of New York, USA
Neuroimage 36:1294-300. 2007..For the first time, we show an independent relationship between cortical atrophy and cognitive impairment after accounting for the effects of central atrophy... - MRI T2 hypointensity of the dentate nucleus is related to ambulatory impairment in multiple sclerosisC W Tjoa
Department of Neurology, University at Buffalo, State University of New York, Buffalo, NY, USA
J Neurol Sci 234:17-24. 2005..This study adds more weight to the notion that T2 hypointensity is a clinically relevant marker of tissue damage in MS... - Screening for cognitive impairment in multiple sclerosis using the Symbol digit Modalities TestB A Parmenter
Department of Neurology, Division of Developmental and Behavioral Neurosciences, State University of New York at Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY, USA
Mult Scler 13:52-7. 2007..71, and negative predictive value (NPV) of 0.73. These results suggest that the effectiveness of the SDMT as a screen for cognitive impairment in MS is roughly equal to that of other psychometric and questionnaire methods... - Interpreting patient/informant discrepancies of reported cognitive symptoms in MSD A Carone
SUNY Buffalo School of Medicine and Buffalo General Hospital, Buffalo, New York 14203, USA
J Int Neuropsychol Soc 11:574-83. 2005..We conclude that patient/informant discrepancy scores on the MSNQ are associated with the aforementioned neuropsychiatric features, and that the MSNQ has potential utility for predicting euphoria and disinhibition syndromes in MS... - Visual-cognitive processing deficits in pediatric multiple sclerosisA M Smerbeck
Department of Neurology, State University of New York, Buffalo, NY, USA
Mult Scler 17:449-56. 2011..This study investigates the sensitivity and validity in pediatric MS of two visual processing tests borrowed from the adult literature, the Brief Visuospatial Memory Test-Revised (BVMTR) and the Symbol Digit Modalities Test (SDMT)... - Cognitive impairment is associated with subcortical magnetic resonance imaging grey matter T2 hypointensity in multiple sclerosisS D Brass
Department of Neurology, Center for Neurological Imaging, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
Mult Scler 12:437-44. 2006..These data implicate a role for basal ganglia iron deposition in neuropsychological dysfunction... - Semi-automatic brain region extraction (SABRE) reveals superior cortical and deep gray matter atrophy in MSD A Carone
Buffalo Neuroimaging Analysis Center, Buffalo, NY 14203, USA
Neuroimage 29:505-14. 2006..5%), and superior parietal (-6.1%) regions, with SP patients having lower volumes. Overall, atrophy in MS is diffuse and mostly related to GM loss particularly in deep GM and superior frontal-parietal regions... - Regional lobar atrophy predicts memory impairment in multiple sclerosisRalph H B Benedict
Department of Neurology, SUNY Buffalo School of Medicine, Buffalo, NY 14203, USA
AJNR Am J Neuroradiol 26:1824-31. 2005..42-0.64). CONCLUSION: Regional atrophy accounts for more variance than lesion burden, whole brain atrophy, or lateral ventricle volume in predicting multiple sclerosis-associated memory dysfunction... - Validity of the Wisconsin Card Sorting and Delis-Kaplan Executive Function System (DKEFS) Sorting Tests in multiple sclerosisBrett A Parmenter
Department of Neurology, State University of New York at Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY 14203, USA
J Clin Exp Neuropsychol 29:215-23. 2007..While both tests appear to have good validity in the MS population, the availability of alternative forms makes the DKEFS an attractive alternative to the WCST, as was suggested by a consensus panel... - Extent of cerebellum, subcortical and cortical atrophy in patients with MS: a case-control studyDeepa Preeti Ramasamy
Buffalo Neuroimaging Analysis Center, Department of Neurology, State University of New York at Buffalo, Buffalo, NY, USA
J Neurol Sci 282:47-54. 2009..This study confirmed selective deep gray matter atrophy (mostly thalamic), revealed cerebellum WM atrophy from the earliest clinical stages, and showed that cortical thinning advances with disease progression... - Working memory deficits in multiple sclerosis: comparison between the n-back task and the Paced Auditory Serial Addition TestBrett A Parmenter
Division of Developmental and Behavioral Neurosciences, Department of Neurology/The Jacobs Neurological Institute, School of Medicine and Biomedical Sciences, University at Buffalo-State University of New York, 100 High Street, Buffalo, NY 14203, USA
J Int Neuropsychol Soc 12:677-87. 2006..Although the PASAT and n-back were shown to have a significant amount of shared variance, each test has specific advantages and disadvantages for use in clinical populations... - Effects of acute relapses on neuropsychological status in multiple sclerosis patientsS A Morrow
Jacobs Neurological Institute, State University of New York at Buffalo, Buffalo, NY, USA
J Neurol 258:1603-8. 2011..These results confirm the involvement of cognitive function during some MS relapses suggesting the SDMT or MSNQ can be used to identify transitory neuropsychological status changes and cognitive relapses... - Multicenter randomized clinical trial of donepezil for memory impairment in multiple sclerosisL B Krupp
Department of Neurology, State University of New York at Stony Brook, Stony Brook, NY 11794 8121, USA
Neurology 76:1500-7. 2011..The goal of this study was to determine if memory would be improved by donepezil as compared to placebo in a multicenter, double-blind, randomized clinical trial (RCT)... - Brain atrophy and white matter hyperintensities in early Parkinson's disease(a)Turi O Dalaker
Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York 14203, USA
Mov Disord 24:2233-41. 2009..We conclude that global structural brain changes are not a major feature in patients with incident PD... - The effects of L-amphetamine sulfate on cognition in MS patients: results of a randomized controlled trialSarah A Morrow
Jacobs Neurological Institute, State University of New York at Buffalo, 100 High Street, Buffalo, NY 14215, USA
J Neurol 256:1095-102. 2009..However, because the positive findings were observed on secondary outcome measures, the study requires replication before L: -amphetamine sulfate can be recommended for the treatment of cognitive impairment in MS... - Gray and white matter brain atrophy and neuropsychological impairment in multiple sclerosisMichael P Sanfilipo
Department of Neurology, SUNY-University, School of Medicine and Biomedical Sciences, Buffalo, NY, USA
Neurology 66:685-92. 2006..CONCLUSION: Both gray and white brain matter atrophy contribute to neuropsychological deficits in multiple sclerosis... - New error type and recall consistency indices for the Brief Visuospatial Memory Test - Revised: performance in healthy adults and multiple sclerosis patientsJeffrey J Gaines
Department of Neurology, State University of New York at Buffalo School of Medicine, NY, USA
Clin Neuropsychol 22:851-63. 2008..Findings suggest these error types and inconsistent learning contribute to poorer recall of visual material in MS... - Regional specificity of magnetization transfer imaging in multiple sclerosisChristopher W Tjoa
Buffalo Neuroimaging Analysis Center, Department of Neurology, University at Buffalo, State University of New York, Buffalo, New York, USA
J Neuroimaging 18:130-6. 2008..We also studied the topography of MTR changes in multiple sclerosis (MS) and in normal controls (NC), and preliminarily examined the clinical usefulness of this method... - Evaluation of the symbol digit modalities test (SDMT) and MS neuropsychological screening questionnaire (MSNQ) in natalizumab-treated MS patients over 48 weeksS A Morrow
Jacobs Neurological Institute, State University of New York at Buffalo, Buffalo, NY, USA
Mult Scler 16:1385-92. 2010..Brief cognitive tests to monitor cognitive impairment in patients with multiple sclerosis (MS) are needed... - Prevalence, sensitivity, and specificity of chronic cerebrospinal venous insufficiency in MSR Zivadinov
Department of Neurology, School of Medicine and Biomedical Sciences Buffalo Neuroimaging Analysis Center, Buffalo, NY 14203, USA
Neurology 77:138-44. 2011..Chronic cerebrospinal venous insufficiency (CCSVI) was recently described in patients with multiple sclerosis (MS). A subject is considered CCSVI positive if ≥ 2 venous hemodynamic (VH) criteria are fulfilled... - Validity of the Beck Depression Inventory-Fast Screen in multiple sclerosisR H B Benedict
Department of Neurology, State University of New York SUNY, Buffalo School of Medicine and Biomedical Sciences, Buffalo General Hospital, Buffalo, New York 14203, USA
Mult Scler 9:393-6. 2003..The BDI-FS may be useful in this regard although, to date, its validity in MS patients has not been assessed... - Covert auditory attention generates activation in the rostral/dorsal anterior cingulate cortexRalph H B Benedict
State University of New York and VA Western New York Healthcare System of Buffalo, NY 14203, USA
J Cogn Neurosci 14:637-45. 2002..We conclude that a rostral/dorsal subdivision of the right ACC is specific for conscious attention during auditory processing, in contrast to premotor response formation... - Working memory and processing speed deficits in systemic lupus erythematosus as measured by the paced auditory serial addition testJanet L Shucard
Department of Neurology, Division of Developmental and Behavioral Neurosciences, State University of New York at Buffalo School of Medicine and Biomedical Sciences, USA
J Int Neuropsychol Soc 10:35-45. 2004..The findings suggest that SLE patients, like MS patients, chunk responses more often than controls, and that this scoring procedure may better reflect the working memory and processing speed deficits present in SLE... - T2 hypointensity in the deep gray matter of patients with multiple sclerosis: a quantitative magnetic resonance imaging studyRohit Bakshi
Department of Neurology, University at Buffalo, State University of New York, USA
Arch Neurol 59:62-8. 2002..While gray matter T2 hypointensity in multiple sclerosis (MS) has been associated with physical disability and clinical course, previous studies have relied on visual magnetic resonance imaging (MRI) assessments... - Frontal cortex atrophy predicts cognitive impairment in multiple sclerosisRalph H B Benedict
Department of Neurology, State University of New York at Buffalo School of Medicine, Buffalo, USA
J Neuropsychiatry Clin Neurosci 14:44-51. 2002..The authors conclude that cerebral atrophy predicts NP impairment while accounting for the influence of TLA or 3VW. Regions of cortex most susceptible to atrophic and cognitive changes in MS are the right and left superior frontal lobes... - Construct validity and frequency of euphoria sclerotica in multiple sclerosisInna Fishman
State University of New York (SUNY) Buffalo School of Medicine and Biomedical Sciences, Buffalo General Hospital, Buffalo, New York, USA
J Neuropsychiatry Clin Neurosci 16:350-6. 2004..Thus, we used the NPI to validate the euphoria syndrome in multiple sclerosis (MS) and determined its frequency, and its neurological and psychological correlates... - Validity of the California Verbal Learning Test-II in multiple sclerosisShane Stegen
Department of Neurology, State University of New York SUNY at Buffalo, Buffalo, NY, USA
Clin Neuropsychol 24:189-202. 2010..We conclude that the CVLT-II is a valid test in MS and provides a rich constellation of verbal memory measures... - Multi-site phasic neural activity mediates the execution of an auditory continuous performance task: a PET and electrophysiological studyAlan H Lockwood
VA Western NY Healthcare System, University at Buffalo, Buffalo, NY 14215, USA
J Neuroimaging 18:241-51. 2008..We studied an auditory continuous performance task with positron emission tomography (PET) and EEG-derived current density reconstructions (CDRs) to define the spatial and temporal aspects of auditory attention... - The relationship between whole brain volume and disability in multiple sclerosis: a comparison of normalized gray vs. white matter with misclassification correctionMichael P Sanfilipo
Department of Neurology, SUNY-University at Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY 14203, USA
Neuroimage 26:1068-77. 2005..These findings suggest that gray matter loss is related to other aspects of brain pathology and has more clinical relevance than white matter atrophy in MS... - Multi-site phasic neural activity mediates the execution of an auditory continuous performance task: a PET and electrophysiological studyAlan H Lockwood
Center for PET, VA Western NY Healthcare System, University at Buffalo, Buffalo, NY 14215, USA
J Neuroimaging 18:364-74. 2008..We studied an auditory continuous performance task with positron emission tomography(PET) and EEG-derived current density reconstructions (CDRs) to define the spatial and temporal aspects of auditory attention... - Influence of recruitment and participation bias in neuropsychological research among MS patientsJ Aubrey Duquin
Department of Neurology, Division of Cognitive and Behavioral Neurosciences, SUNY at Buffalo School of Medicine and Biomedical Sciences, Buffalo, New York 14203, USA
J Int Neuropsychol Soc 14:494-8. 2008..NP testing significantly predicted vocational outcomes in all groups. These results suggest that greater attention should be paid to the reasons patients agree to participate in NP testing... - Plasma pentosidine: a potential biomarker in the management of multiple sclerosisZohara Sternberg
Department of Neurology, Baird MS Center, Jacobs Neurological Institute, Buffalo, NY, USA
Mult Scler 17:157-63. 2011..The chronic inflammation associated with multiple sclerosis (MS) may lead to the upregulation of pentosidine... - Semantic clustering indexes for the Hopkins Verbal Learning Test-Revised: initial exploration in elder control and dementia groupsJeffrey J Gaines
Department of Neurology, State University of New York SUNY at Buffalo School of Medicine, NY, USA
Appl Neuropsychol 13:213-22. 2006..Results suggest that these newly developed semantic clustering indexes are easily calculated and potentially useful for discriminating between elder controls and dementia patients... - Quantitative diffusion weighted imaging measures in patients with multiple sclerosisEleonora Tavazzi
Buffalo Neuroimaging Analysis Center, Department of Neurology, University at Buffalo, State University of New York, Buffalo, NY, USA
Neuroimage 36:746-54. 2007..ENT is a sensitive marker of overall brain damage that is strongly related to clinical impairment in patients with SP MS... - Integrating cognitive function screening and assessment into the routine care of multiple sclerosis patientsRalph H B Benedict
Department of Neurology, State University of New York at Buffalo, Buffalo, NY, USA
CNS Spectr 10:384-91. 2005..Thus, these or similar methods should be employed for the routine monitoring of cognitive functioning of MS patients... - Correction for intracranial volume in analysis of whole brain atrophy in multiple sclerosis: the proportion vs. residual methodMichael P Sanfilipo
Department of Neurology, SUNY-University at Buffalo School of Medicine and Biomedical Sciences, NY 14203, USA
Neuroimage 22:1732-43. 2004..Our findings suggest that head size correction of brain regions with the residual method generally may provide advantages over the proportion method... - Progressive cerebral disease in lymphomatoid granulomatosis causes anterograde amnesia and neuropsychiatric disorderDominic A Carone
Department of Neurology, State University of New York (SUNY) at Buffalo School of Medicine, and Jacobs Neurological Institute, USA
J Neuroimaging 16:163-6. 2006..We speculate that temporal lobe atrophy was influenced by the established susceptibility of this region in various neurological diseases... - Multiple sclerosisRalph H B Benedict
Department of Neurology, State University of New York SUNY at Buffalo, Jacobs Neurological Institute, Buffalo, New York, USA
Semin Neurol 27:78-85. 2007..Recent developments in pharmacological treatment for disease progression and management of cognitive symptoms hold promise for patients suffering from the degenerative aspects of MS... - Whole-brain atrophy in multiple sclerosis measured by automated versus semiautomated MR imaging segmentationJitendra Sharma
Buffalo Neuroimaging Analysis Center, University at Buffalo, State University of New York, Buffalo, NY, USA
AJNR Am J Neuroradiol 25:985-96. 2004..They discriminated MS from healthy individuals and showed similar relationships to established disease variables... - Update on the relationships between neuropsychological dysfunction and structural MRI in multiple sclerosisAyda Tekok-Kilic
Department of Neurology, State University of New York, Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY, USA
Expert Rev Neurother 6:323-31. 2006..In this article, recent contributions to the literature regarding the correlation between MRI and neuropsychological function in MS are reviewed... - Clinical efficacy, effects on MRI and tolerability of weekly intramuscular interferon-beta-1a in patients with MS and CISRobert Zivadinov
Buffalo Neuroimaging Analysis Center, Department of Neurology, University at Buffalo, State University of New York, Buffalo, New York 14203, USA
Drugs Today (Barc) 44:601-13. 2008..Early initiation of disease-modifying therapy after the diagnosis of relapsing-remitting MS or after a single demyelinating event (and evidence of lesions on MRI) allows patients the opportunity to obtain maximal long-term benefits... - Oralmotor slowing in multiple sclerosis: relationship to neuropsychological tasks requiring an oral responsePeter A Arnett
Psychology Department, The Pennsylvania State University, University Park, Pennsylvania, USA
J Int Neuropsychol Soc 14:454-62. 2008..Our data suggest that rudimentary oral motor speed is slowed in MS patients and makes an important contribution to group differences in performance on commonly used neuropsychological tasks requiring a rapid spoken response...