ALBERT S BENDELAC

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. pmc Signaling for NKT cell development: the SAP-FynT connection
    Christine Borowski
    University of Chicago, Chicago, IL 60637, USA
    J Exp Med 201:833-6. 2005
  2. pmc Expansion and long-range differentiation of the NKT cell lineage in mice expressing CD1d exclusively on cortical thymocytes
    Datsen G Wei
    Committee on Immunology, University of Chicago, Chicago, IL 60637, USA
    J Exp Med 202:239-48. 2005
  3. pmc A distal effect of microsomal triglyceride transfer protein deficiency on the lysosomal recycling of CD1d
    Yuval Sagiv
    Committee on Immunology, University of Chicago, Chicago, IL 60637, USA
    J Exp Med 204:921-8. 2007
  4. pmc Mechanisms imposing the Vbeta bias of Valpha14 natural killer T cells and consequences for microbial glycolipid recognition
    Datsen G Wei
    Committee on Immunology, University of Chicago, Chicago, IL 60637, USA
    J Exp Med 203:1197-207. 2006
  5. pmc BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs
    Rebecca Mathew
    Committee on Immunology, Department of Pathology, The Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637, USA
    Nature 491:618-21. 2012
  6. pmc Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling
    Michael P Seiler
    Committee on Immunology and the Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois, USA
    Nat Immunol 13:264-71. 2012
  7. pmc Airborne lipid antigens mobilize resident intravascular NKT cells to induce allergic airway inflammation
    Seth T Scanlon
    Committee on Immunology, Department of Pathology, Howard Hughes Medical Institute and 4 Section of Pulmonary and Critical Care Medicine, Department of Medicine University of Chicago, Chicago, IL, USA
    J Exp Med 208:2113-24. 2011
  8. pmc PLZF induces an intravascular surveillance program mediated by long-lived LFA-1-ICAM-1 interactions
    Seddon Y Thomas
    Committee on Immunology, Howard Hughes Medical Institute, University of Chicago, Chicago, IL 60637, USA
    J Exp Med 208:1179-88. 2011
  9. ncbi The biology of NKT cells
    Albert Bendelac
    Howard Hughes Medical Institute, Committee on Immunology, Department of Pathology University of Chicago, Chicago, Illinois 60637, USA
    Annu Rev Immunol 25:297-336. 2007
  10. ncbi Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections
    Jochen Mattner
    Committee on Immunology, University of Chicago, Chicago, Illinois 60637, USA
    Nature 434:525-9. 2005

Research Grants

  1. Development of CD1d-restricted NKT cells
    ALBERT S BENDELAC; Fiscal Year: 2010
  2. Development of CD1d-restricted NKT cells
    Albert Bendelac; Fiscal Year: 2004
  3. ADJUVANT EFFECTS OF ALPHA GALACTOSYLCERAMIDES
    Albert Bendelac; Fiscal Year: 2004
  4. Regulation of IDDM by NKT cells
    Albert Bendelac; Fiscal Year: 2003
  5. Regulation of IDDM by NKT cells
    Albert Bendelac; Fiscal Year: 2004
  6. Regulation of CD1d by the Invariant Chain
    Albert Bendelac; Fiscal Year: 2005
  7. Development of CD1d-restricted NKT cells
    Albert Bendelac; Fiscal Year: 2005
  8. Regulation of IDDM by NKT cells
    Albert Bendelac; Fiscal Year: 2005
  9. Regulation of CD1d by the Invariant Chain
    Albert Bendelac; Fiscal Year: 2006
  10. Glycolipid Presentation by CD1d
    Albert Bendelac; Fiscal Year: 2007

Collaborators

Detail Information

Publications19

  1. pmc Signaling for NKT cell development: the SAP-FynT connection
    Christine Borowski
    University of Chicago, Chicago, IL 60637, USA
    J Exp Med 201:833-6. 2005
    ..In fact, SAP-dependent signaling may underlie the development of multiple unconventional T cell lineages whose thymic selection relies on homotypic interactions between hematopoietic cells...
  2. pmc Expansion and long-range differentiation of the NKT cell lineage in mice expressing CD1d exclusively on cortical thymocytes
    Datsen G Wei
    Committee on Immunology, University of Chicago, Chicago, IL 60637, USA
    J Exp Med 202:239-48. 2005
    ..These surprising findings suggest that, unlike thymic epithelial cells, cortical thymocytes can provide unexpected, cell type-specific signals leading to lineage expansion and NKT cell differentiation...
  3. pmc A distal effect of microsomal triglyceride transfer protein deficiency on the lysosomal recycling of CD1d
    Yuval Sagiv
    Committee on Immunology, University of Chicago, Chicago, IL 60637, USA
    J Exp Med 204:921-8. 2007
    ..These intriguing findings suggest a novel, unexpected role of MTP at a late stage of CD1d trafficking in the lysosomal compartment...
  4. pmc Mechanisms imposing the Vbeta bias of Valpha14 natural killer T cells and consequences for microbial glycolipid recognition
    Datsen G Wei
    Committee on Immunology, University of Chicago, Chicago, IL 60637, USA
    J Exp Med 203:1197-207. 2006
    ....
  5. pmc BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs
    Rebecca Mathew
    Committee on Immunology, Department of Pathology, The Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637, USA
    Nature 491:618-21. 2012
    ..We propose that this new function is essential to direct the differentiation of several T- and B-cell effector programs, and may also be involved in the oncogenic role of PLZF and BCL6 in leukaemias and lymphomas...
  6. pmc Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling
    Michael P Seiler
    Committee on Immunology and the Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois, USA
    Nat Immunol 13:264-71. 2012
    ..Thus, we propose that persistent higher expression of Egr2 specifies the early and late stages of NKT lineage differentiation, providing a discriminating mechanism that enables TCR signaling to 'instruct' a thymic lineage...
  7. pmc Airborne lipid antigens mobilize resident intravascular NKT cells to induce allergic airway inflammation
    Seth T Scanlon
    Committee on Immunology, Department of Pathology, Howard Hughes Medical Institute and 4 Section of Pulmonary and Critical Care Medicine, Department of Medicine University of Chicago, Chicago, IL, USA
    J Exp Med 208:2113-24. 2011
    ..Thus, transient recruitment and activation of lung-resident intravascular NKT cells can trigger long-term susceptibility to allergic airway inflammation...
  8. pmc PLZF induces an intravascular surveillance program mediated by long-lived LFA-1-ICAM-1 interactions
    Seddon Y Thomas
    Committee on Immunology, Howard Hughes Medical Institute, University of Chicago, Chicago, IL 60637, USA
    J Exp Med 208:1179-88. 2011
    ..These findings reveal the unique genetic and biochemical pathway that underlies the innate intravascular surveillance program of NKT cells...
  9. ncbi The biology of NKT cells
    Albert Bendelac
    Howard Hughes Medical Institute, Committee on Immunology, Department of Pathology University of Chicago, Chicago, Illinois 60637, USA
    Annu Rev Immunol 25:297-336. 2007
    ....
  10. ncbi Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections
    Jochen Mattner
    Committee on Immunology, University of Chicago, Chicago, Illinois 60637, USA
    Nature 434:525-9. 2005
    ..These findings identify two novel antigenic targets of NKT cells in antimicrobial defence, and show that glycosylceramides are an alternative to LPS for innate recognition of the Gram-negative, LPS-negative bacterial cell wall...
  11. ncbi Cutting edge: impaired glycosphingolipid trafficking and NKT cell development in mice lacking Niemann-Pick type C1 protein
    Yuval Sagiv
    Committee on Immunology, Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 177:26-30. 2006
    ..These findings reveal a blockade of lipid trafficking between endosome and lysosome as a consequence of NPC1 deficiency and suggest a common mechanism for the defects in lipid presentation and development of Valpha14-Jalpha18 NKT cells...
  12. ncbi Lysosomal glycosphingolipid recognition by NKT cells
    Dapeng Zhou
    University of Chicago, Department of Pathology, Chicago, IL 60637, USA
    Science 306:1786-9. 2004
    ..We suggest that expression of iGb3 in peripheral tissues may be involved in controlling NKT cell responses to infections and malignancy and in autoimmunity...
  13. pmc Editing of CD1d-bound lipid antigens by endosomal lipid transfer proteins
    Dapeng Zhou
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    Science 303:523-7. 2004
    ..LTPs constitute a previously unknown link between lipid metabolism and immunity and are likely to exert a profound influence on the repertoire of self, tumor, and microbial lipid antigens...
  14. pmc Lysosomal recycling terminates CD1d-mediated presentation of short and polyunsaturated variants of the NKT cell lipid antigen alphaGalCer
    Li Bai
    Department of Pathology, Howard Hughes Medical Institute, Committee on Immunology, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 106:10254-9. 2009
    ..They also suggest that direct lipid displacement is a potent mechanism underlying highly dynamic lipid exchange reactions in the lysosomal compartment that shape the repertoire of lipids associated with CD1d...
  15. pmc Liver autoimmunity triggered by microbial activation of natural killer T cells
    Jochen Mattner
    Howard Hughes Medical Institute, Committee on Immunology, Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    Cell Host Microbe 3:304-15. 2008
    ....
  16. ncbi Mechanisms governing B cell developmental defects in invariant chain-deficient mice
    Kamel Benlagha
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 172:2076-83. 2004
    ..These findings reveal unexpected consequences of Ii deficiency on the development and organization of B cell follicles...
  17. pmc Characterization of the early stages of thymic NKT cell development
    Kamel Benlagha
    Committee on Immunology, The University of Chicago, Chicago, IL 60637, USA
    J Exp Med 202:485-92. 2005
    ..1neg CD4 cells. These findings identify the HSAhigh CD4+ stage as a potential branchpoint between NKT and conventional T lineages and between the CD4 and DN NKT sublineages...
  18. pmc Homotypic interactions mediated by Slamf1 and Slamf6 receptors control NKT cell lineage development
    Klaus Griewank
    Howard Hughes Medical Institute, Committee on Immunology, Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    Immunity 27:751-62. 2007
    ..Thus, the topography of NKT cell ligand recognition determines the availability of a cosignaling pathway that is essential for NKT cell lineage development...
  19. pmc SAP protein-dependent natural killer T-like cells regulate the development of CD8(+) T cells with innate lymphocyte characteristics
    Mihalis Verykokakis
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    Immunity 33:203-15. 2010
    ..Our findings reveal that accumulation of NKT-like cells promotes conventional CD8(+) thymocytes to acquire innate lymphocyte characteristics...

Research Grants35

  1. Development of CD1d-restricted NKT cells
    ALBERT S BENDELAC; Fiscal Year: 2010
    ....
  2. Development of CD1d-restricted NKT cells
    Albert Bendelac; Fiscal Year: 2004
    ..The deletion will therefore be introduced into the germline through homologous recombination to assess its impact on the various stages of NKT development in vivo. ..
  3. ADJUVANT EFFECTS OF ALPHA GALACTOSYLCERAMIDES
    Albert Bendelac; Fiscal Year: 2004
    ....
  4. Regulation of IDDM by NKT cells
    Albert Bendelac; Fiscal Year: 2003
    ..These combined studies of mouse and human NKT cells have the potential to lead to novel strategies for the prediction and prevention of autoimmune diabetes in humans at risk for this disease. ..
  5. Regulation of IDDM by NKT cells
    Albert Bendelac; Fiscal Year: 2004
    ..These combined studies of mouse and human NKT cells have the potential to lead to novel strategies for the prediction and prevention of autoimmune diabetes in humans at risk for this disease. ..
  6. Regulation of CD1d by the Invariant Chain
    Albert Bendelac; Fiscal Year: 2005
    ..2) genetically dissect the Ii associated MZB phenotype by crossing Ii deficient mice to mice lacking Ii partners such as CD1d, H-2M and IA, and to BCR transgenic mice expressing MZB-included or excluded specificities. ..
  7. Development of CD1d-restricted NKT cells
    Albert Bendelac; Fiscal Year: 2005
    ..The deletion will therefore be introduced into the germline through homologous recombination to assess its impact on the various stages of NKT development in vivo. ..
  8. Regulation of IDDM by NKT cells
    Albert Bendelac; Fiscal Year: 2005
    ..These combined studies of mouse and human NKT cells have the potential to lead to novel strategies for the prediction and prevention of autoimmune diabetes in humans at risk for this disease. ..
  9. Regulation of CD1d by the Invariant Chain
    Albert Bendelac; Fiscal Year: 2006
    ..2) genetically dissect the Ii associated MZB phenotype by crossing Ii deficient mice to mice lacking Ii partners such as CD1d, H-2M and IA, and to BCR transgenic mice expressing MZB-included or excluded specificities. ..
  10. Glycolipid Presentation by CD1d
    Albert Bendelac; Fiscal Year: 2007
    ..Project 3, Bendelac: T cell repertoire and functions associated with glycosylceramide recognition in vivo in mice and intracellular trafficking properties of glycosylceramides. ..
  11. INTERDISCIPLINARY TRAINING PROGRAM IN IMMUNOLOGY
    Albert Bendelac; Fiscal Year: 2007
    ..With a large number of outstanding applicants accompanying the growth of world-renowned faculty, this program continues to rank among the best programs in the country. ..
  12. Development of CD1d-restricted NKT cells
    Albert Bendelac; Fiscal Year: 2007
    ....
  13. Development of CD1d-restricted NKT cells
    Albert Bendelac; Fiscal Year: 2009
    ....
  14. Development of CD1d-restricted NKT cells
    Albert Bendelac; Fiscal Year: 2003
    ..The deletion will therefore be introduced into the germline through homologous recombination to assess its impact on the various stages of NKT development in vivo. ..
  15. Regulation of CD1d by the Invariant Chain
    Albert Bendelac; Fiscal Year: 2004
    ..2) genetically dissect the Ii associated MZB phenotype by crossing Ii deficient mice to mice lacking Ii partners such as CD1d, H-2M and IA, and to BCR transgenic mice expressing MZB-included or excluded specificities. ..
  16. ADJUVANT EFFECTS OF ALPHA GALACTOSYLCERAMIDES
    Albert Bendelac; Fiscal Year: 2003
    ....
  17. NK11 AND T LYMPHOCYTES
    Albert Bendelac; Fiscal Year: 1999
    ..1 + T cells to the site of normal immune responses in order to formally test the hypothesis that the NK1.1+ T cells influence the Th1/Th2 phenotype of immune responses. ..
  18. ADJUVANT EFFECTS OF ALPHA GALACTOSYLCERAMIDES
    Albert Bendelac; Fiscal Year: 2000
    ....
  19. NK11 AND T LYMPHOCYTES
    Albert Bendelac; Fiscal Year: 2000
    ..1 + T cells to the site of normal immune responses in order to formally test the hypothesis that the NK1.1+ T cells influence the Th1/Th2 phenotype of immune responses. ..
  20. Development of CD1d-restricted NKT cells
    Albert Bendelac; Fiscal Year: 2001
    ..The deletion will therefore be introduced into the germline through homologous recombination to assess its impact on the various stages of NKT development in vivo. ..
  21. ADJUVANT EFFECTS OF ALPHA GALACTOSYLCERAMIDES
    Albert Bendelac; Fiscal Year: 2001
    ....
  22. Regulation of IDDM by NKT cells
    Albert Bendelac; Fiscal Year: 2002
    ..These combined studies of mouse and human NKT cells have the potential to lead to novel strategies for the prediction and prevention of autoimmune diabetes in humans at risk for this disease. ..
  23. Development of CD1d-restricted NKT cells
    Albert Bendelac; Fiscal Year: 2002
    ..The deletion will therefore be introduced into the germline through homologous recombination to assess its impact on the various stages of NKT development in vivo. ..
  24. ADJUVANT EFFECTS OF ALPHA GALACTOSYLCERAMIDES
    Albert Bendelac; Fiscal Year: 2002
    ....
  25. Regulation of CD1d by the Invariant Chain
    Albert Bendelac; Fiscal Year: 2002
    ..2) genetically dissect the Ii associated MZB phenotype by crossing Ii deficient mice to mice lacking Ii partners such as CD1d, H-2M and IA, and to BCR transgenic mice expressing MZB-included or excluded specificities. ..
  26. Regulation of IDDM by NKT cells
    Albert Bendelac; Fiscal Year: 2002
    ..These combined studies of mouse and human NKT cells have the potential to lead to novel strategies for the prediction and prevention of autoimmune diabetes in humans at risk for this disease. ..
  27. Development of CD1d-restricted NKT cells
    Albert Bendelac; Fiscal Year: 2002
    ..The deletion will therefore be introduced into the germline through homologous recombination to assess its impact on the various stages of NKT development in vivo. ..
  28. ADJUVANT EFFECTS OF ALPHA GALACTOSYLCERAMIDES
    Albert Bendelac; Fiscal Year: 2002
    ....
  29. Regulation of CD1d by the Invariant Chain
    Albert Bendelac; Fiscal Year: 2003
    ..2) genetically dissect the Ii associated MZB phenotype by crossing Ii deficient mice to mice lacking Ii partners such as CD1d, H-2M and IA, and to BCR transgenic mice expressing MZB-included or excluded specificities. ..