Pedro Beltrao

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Systematic functional prioritization of protein posttranslational modifications
    Pedro Beltrao
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94107, USA
    Cell 150:413-25. 2012
  2. pmc Comparative interaction networks: bridging genotype to phenotype
    Pedro Beltrao
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA
    Adv Exp Med Biol 751:139-56. 2012
  3. pmc Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species
    Pedro Beltrao
    Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California, United States of America
    PLoS Biol 7:e1000134. 2009
  4. pmc Site-specific acetylation mark on an essential chromatin-remodeling complex promotes resistance to replication stress
    Georgette M Charles
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA, 94158, USA
    Proc Natl Acad Sci U S A 108:10620-5. 2011
  5. pmc Hierarchical modularity and the evolution of genetic interactomes across species
    Colm J Ryan
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA
    Mol Cell 46:691-704. 2012
  6. pmc Quantitative genetic interactions reveal biological modularity
    Pedro Beltrao
    Department of Cellular and Molecular Pharmacology, California Institute for Quantitative Biomedical Research, University of California, San Francisco, San Francisco, CA 94158, USA
    Cell 141:739-45. 2010
  7. pmc Phenotypic landscape of a bacterial cell
    Robert J Nichols
    University of California, San Francisco, 94143, USA
    Cell 144:143-56. 2011
  8. pmc Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action
    Laura Kapitzky
    Department of Cellular and Molecular Pharmacology, QB3 Institute, University of California, San Francisco, CA 94158, USA
    Mol Syst Biol 6:451. 2010

Collaborators

Detail Information

Publications8

  1. pmc Systematic functional prioritization of protein posttranslational modifications
    Pedro Beltrao
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94107, USA
    Cell 150:413-25. 2012
    ..Finally, our analysis of the evolution of PTM regulation highlights potential routes for neutral drift in regulatory interactions and suggests that only a fraction of modification sites are likely to have a significant biological role...
  2. pmc Comparative interaction networks: bridging genotype to phenotype
    Pedro Beltrao
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA
    Adv Exp Med Biol 751:139-56. 2012
    ....
  3. pmc Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species
    Pedro Beltrao
    Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California, United States of America
    PLoS Biol 7:e1000134. 2009
    ..pombe, which demonstrated that protein kinases, and to a greater extent TFs, show lower than average conservation of genetic interactions. We propose therefore that protein kinases are an important source of phenotypic diversity...
  4. pmc Site-specific acetylation mark on an essential chromatin-remodeling complex promotes resistance to replication stress
    Georgette M Charles
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA, 94158, USA
    Proc Natl Acad Sci U S A 108:10620-5. 2011
    ..These studies offer an example of acetylation of a chromatin-remodeling enzyme controlling a biological output of the system rather than regulating its core enzymatic properties...
  5. pmc Hierarchical modularity and the evolution of genetic interactomes across species
    Colm J Ryan
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA
    Mol Cell 46:691-704. 2012
    ....
  6. pmc Quantitative genetic interactions reveal biological modularity
    Pedro Beltrao
    Department of Cellular and Molecular Pharmacology, California Institute for Quantitative Biomedical Research, University of California, San Francisco, San Francisco, CA 94158, USA
    Cell 141:739-45. 2010
    ..Here, we discuss how quantitative mapping of genetic interactions enhances our view of biological systems, allowing their deeper interrogation across different biological scales...
  7. pmc Phenotypic landscape of a bacterial cell
    Robert J Nichols
    University of California, San Francisco, 94143, USA
    Cell 144:143-56. 2011
    ....
  8. pmc Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action
    Laura Kapitzky
    Department of Cellular and Molecular Pharmacology, QB3 Institute, University of California, San Francisco, CA 94158, USA
    Mol Syst Biol 6:451. 2010
    ..Finally, using this platform, we identified a novel small molecule that acts as a DNA damaging agent and demonstrate that its MoA is conserved in human cells...