W A Beltran

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi A frameshift mutation in RPGR exon ORF15 causes photoreceptor degeneration and inner retina remodeling in a model of X-linked retinitis pigmentosa
    William A Beltran
    James A. Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
    Invest Ophthalmol Vis Sci 47:1669-81. 2006
  2. ncbi Intravitreal injection of ciliary neurotrophic factor (CNTF) causes peripheral remodeling and does not prevent photoreceptor loss in canine RPGR mutant retina
    William A Beltran
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Exp Eye Res 84:753-71. 2007
  3. ncbi Transcriptional profile analysis of RPGRORF15 frameshift mutation identifies novel genes associated with retinal degeneration
    Sem Genini
    Section of Ophthalmology, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Invest Ophthalmol Vis Sci 51:6038-50. 2010
  4. ncbi Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa
    William A Beltran
    Section of Ophthalmology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 109:2132-7. 2012
  5. ncbi rAAV2/5 gene-targeting to rods:dose-dependent efficiency and complications associated with different promoters
    W A Beltran
    Section of Ophthalmology, Department of Clinical Studies School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Gene Ther 17:1162-74. 2010
  6. ncbi The use of canine models of inherited retinal degeneration to test novel therapeutic approaches
    William A Beltran
    Section of Ophthalmology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Vet Ophthalmol 12:192-204. 2009
  7. ncbi On the role of CNTF as a potential therapy for retinal degeneration: Dr. Jekyll or Mr. Hyde?
    William A Beltran
    Section of Ophthalmology, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Adv Exp Med Biol 613:45-51. 2008
  8. ncbi CREB1/ATF1 activation in photoreceptor degeneration and protection
    William A Beltran
    Section of Ophthalmology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Invest Ophthalmol Vis Sci 50:5355-63. 2009
  9. ncbi Age-dependent disease expression determines remodeling of the retinal mosaic in carriers of RPGR exon ORF15 mutations
    William A Beltran
    School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104
    Invest Ophthalmol Vis Sci 50:3985-95. 2009
  10. ncbi Human cone photoreceptor dependence on RPE65 isomerase
    Samuel G Jacobson
    Scheie Eye Institute, Department of Ophthalmology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 104:15123-8. 2007

Detail Information

Publications16

  1. ncbi A frameshift mutation in RPGR exon ORF15 causes photoreceptor degeneration and inner retina remodeling in a model of X-linked retinitis pigmentosa
    William A Beltran
    James A. Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
    Invest Ophthalmol Vis Sci 47:1669-81. 2006
    ..The results suggest that therapeutic strategies for this retinal degeneration should target not solely photoreceptor cells but also inner retinal neurons...
  2. ncbi Intravitreal injection of ciliary neurotrophic factor (CNTF) causes peripheral remodeling and does not prevent photoreceptor loss in canine RPGR mutant retina
    William A Beltran
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Exp Eye Res 84:753-71. 2007
    ..Our findings suggest that some inherited forms of retinal degeneration may not respond to CNTF's neuroprotective effects...
  3. ncbi Transcriptional profile analysis of RPGRORF15 frameshift mutation identifies novel genes associated with retinal degeneration
    Sem Genini
    Section of Ophthalmology, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Invest Ophthalmol Vis Sci 51:6038-50. 2010
    ..qRT-PCR, Western blot analysis, and immunohistochemistry (IHC) were applied to selected genes, to confirm and expand the microarray results...
  4. ncbi Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa
    William A Beltran
    Section of Ophthalmology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 109:2132-7. 2012
    ..Efficacy of gene therapy in these large animal models of X-linked retinitis pigmentosa provides a path for translation to human treatment...
  5. ncbi rAAV2/5 gene-targeting to rods:dose-dependent efficiency and complications associated with different promoters
    W A Beltran
    Section of Ophthalmology, Department of Clinical Studies School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Gene Ther 17:1162-74. 2010
    ..Efficient and specific rod transduction, together with preservation of retinal structure was achieved with both mOP and hGRK1 promoters when viral titers in the order of 10(11)vg ml(-1) were used...
  6. ncbi The use of canine models of inherited retinal degeneration to test novel therapeutic approaches
    William A Beltran
    Section of Ophthalmology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Vet Ophthalmol 12:192-204. 2009
    ..This review briefly summarizes the drug delivery approaches and therapeutic strategies that have been and are currently tested in dogs, with a particular emphasis on corrective gene therapy, and retinal neuroprotection...
  7. ncbi On the role of CNTF as a potential therapy for retinal degeneration: Dr. Jekyll or Mr. Hyde?
    William A Beltran
    Section of Ophthalmology, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Adv Exp Med Biol 613:45-51. 2008
  8. ncbi CREB1/ATF1 activation in photoreceptor degeneration and protection
    William A Beltran
    Section of Ophthalmology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Invest Ophthalmol Vis Sci 50:5355-63. 2009
    ..Both are activated in response to a wide array of stimuli, including cellular stress. This study was conducted to assess the CREB1/ATF1 pathway in photoreceptor disease and protection...
  9. ncbi Age-dependent disease expression determines remodeling of the retinal mosaic in carriers of RPGR exon ORF15 mutations
    William A Beltran
    School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104
    Invest Ophthalmol Vis Sci 50:3985-95. 2009
    ..To characterize the retinal histopathology in carriers of X-linked progressive retinal atrophy (XLPRA1 and XLPRA2), two canine models of X-linked retinitis pigmentosa caused, respectively, by a stop and a frameshift mutation in RPGRORF15...
  10. ncbi Human cone photoreceptor dependence on RPE65 isomerase
    Samuel G Jacobson
    Scheie Eye Institute, Department of Ophthalmology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 104:15123-8. 2007
    ....
  11. ncbi Clinical light exposure, photoreceptor degeneration, and AP-1 activation: a cell death or cell survival signal in the rhodopsin mutant retina?
    Danian Gu
    Section of Ophthalmology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Invest Ophthalmol Vis Sci 48:4907-18. 2007
    ....
  12. ncbi Steroids do not prevent photoreceptor degeneration in the light-exposed T4R rhodopsin mutant dog retina irrespective of AP-1 inhibition
    Danian Gu
    Section of Ophthalmology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Invest Ophthalmol Vis Sci 50:3482-94. 2009
    ..In this study the role of steroids in inhibiting AP-1 activation and/or in preventing photoreceptor degeneration was examined in the rhodopsin mutant dog model...
  13. ncbi Ocular findings in two colonies of gray mouse lemurs (Microcebus murinus)
    William A Beltran
    Section of Ophthalmology, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 6010, USA
    Vet Ophthalmol 10:43-9. 2007
    ..To determine the incidence and describe the characteristics of cataracts and other ocular lesions found in two colonies of gray mouse lemurs (Microcebus murinus)...
  14. ncbi Immunolocalization of ciliary neurotrophic factor receptor alpha (CNTFRalpha) in mammalian photoreceptor cells
    William A Beltran
    James A. Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
    Mol Vis 11:232-44. 2005
    ..The expression of CNTFRalpha by rods and cones in non-rodent species may suggest a direct mechanism of action if CNTF administration results in photoreceptor rescue...
  15. ncbi Comparative analysis and expression of CLUL1, a cone photoreceptor-specific gene
    Qi Zhang
    James A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    Invest Ophthalmol Vis Sci 44:4542-9. 2003
    ..To characterize CLUL1, a cone photoreceptor-specific gene...
  16. ncbi Cloning, mapping, and retinal expression of the canine ciliary neurotrophic factor receptor alpha (CNTFRalpha)
    William A Beltran
    James A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
    Invest Ophthalmol Vis Sci 44:3642-9. 2003
    ..To clone, map, and determine the site of expression (mRNA and protein) of the alpha subunit of the receptor for ciliary neurotrophic factor (CNTFRalpha) in the normal adult canine retina...