Andrew Belmont

Summary

Affiliation: University of Illinois
Country: USA

Publications

  1. ncbi request reprint Mitotic chromosome structure and condensation
    Andrew S Belmont
    Department of Cell and Developmental Biology, University of Illinois, Urbana Champaign B107 CLSL 601 S Goodwin Ave Urbana, IL 61802, USA
    Curr Opin Cell Biol 18:632-8. 2006
  2. pmc Visualization of early chromosome condensation: a hierarchical folding, axial glue model of chromosome structure
    Natashe Kireeva
    Department of Cell and Structural Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Cell Biol 166:775-85. 2004
  3. pmc Engineered chromosome regions with altered sequence composition demonstrate hierarchical large-scale folding within metaphase chromosomes
    Yuri G Strukov
    Dept of Cell and Structural Biology, University of Illinois Urbana Champaign, B107 CLSL, 601 S Goodwin Ave, Urbana, IL 61801, USA
    J Cell Biol 162:23-35. 2003
  4. pmc Close encounters between active genes in the nucleus
    Chien Hui Chuang
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Genome Biol 6:237. 2005
  5. ncbi request reprint In vivo visualization of chromosomes using lac operator-repressor binding
    A S Belmont
    Dept of Cell and Structural Biology, University of Illinois, Urbana Champaign 61801, USA
    Trends Cell Biol 8:121-4. 1998
  6. ncbi request reprint Dynamics of chromatin, proteins, and bodies within the cell nucleus
    Andrew Belmont
    Department of Cell and Structural Biology, University of Illinois, Urbana Champaign B107, Chemical and Life Science Laboratory, 601 South Goodwin Avenue, Urbana, IL 61801, USA
    Curr Opin Cell Biol 15:304-10. 2003
  7. ncbi request reprint Estrogen fueled, nuclear kiss: did it move for you?
    Andrew S Belmont
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL, USA
    Nucleus 1:440-3. 2010
  8. pmc Mitotic chromosome scaffold structure: new approaches to an old controversy
    Andrew S Belmont
    Department of Cell and Structural Biology, University of Illinois, Urbana Champaign, IL 61801, USA
    Proc Natl Acad Sci U S A 99:15855-7. 2002
  9. ncbi request reprint Large-scale chromatin structure and function
    A S Belmont
    Department of Cell and Structural Biology, University of Illinois, Urbana Champaign, B107 CLSL, 601 South Goodwin Avenue, Urbana, IL 61801, USA
    Curr Opin Cell Biol 11:307-11. 1999
  10. ncbi request reprint Visualizing chromosome dynamics with GFP
    A S Belmont
    Dept of Cell and Structural Biology, University of Illinois, Urbana Champaign, B107 CLSL, 601 South Goodwin Ave, Urbana, IL 61801, USA
    Trends Cell Biol 11:250-7. 2001

Research Grants

  1. LARGE SCALE CHROMATIN STRUCTURE/FUNCTION
    Andrew Belmont; Fiscal Year: 2002
  2. Chromatin Domain Structure and Function
    Andrew Belmont; Fiscal Year: 2005
  3. Large-scale chromatin structure and dynamics
    Andrew Belmont; Fiscal Year: 2005
  4. Chromatin Domain Structure and Function
    Andrew Belmont; Fiscal Year: 2006
  5. Large-scale chromatin structure and dynamics
    Andrew Belmont; Fiscal Year: 2006
  6. Large-scale chromatin structure and dynamics
    Andrew Belmont; Fiscal Year: 2007
  7. Chromatin Domain Structure and Funcion
    Andrew Belmont; Fiscal Year: 2007
  8. Chromatin Domain Structure and Function
    Andrew Belmont; Fiscal Year: 2007
  9. Chromatin Domain Structure and Funcion
    Andrew Belmont; Fiscal Year: 2009
  10. Chromatin Domain Structure and Funcion
    Andrew Belmont; Fiscal Year: 2009

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Mitotic chromosome structure and condensation
    Andrew S Belmont
    Department of Cell and Developmental Biology, University of Illinois, Urbana Champaign B107 CLSL 601 S Goodwin Ave Urbana, IL 61802, USA
    Curr Opin Cell Biol 18:632-8. 2006
    ....
  2. pmc Visualization of early chromosome condensation: a hierarchical folding, axial glue model of chromosome structure
    Natashe Kireeva
    Department of Cell and Structural Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Cell Biol 166:775-85. 2004
    ..We propose a unified model of chromosome structure in which hierarchical levels of chromatin folding are stabilized late in mitosis by an axial "glue."..
  3. pmc Engineered chromosome regions with altered sequence composition demonstrate hierarchical large-scale folding within metaphase chromosomes
    Yuri G Strukov
    Dept of Cell and Structural Biology, University of Illinois Urbana Champaign, B107 CLSL, 601 S Goodwin Ave, Urbana, IL 61801, USA
    J Cell Biol 162:23-35. 2003
    ..Our results contradict predictions of simple radial loop models and provide the first unambiguous demonstration of a hierarchical folding subunit above the level of the 30-nm fiber within normally condensed metaphase chromosomes...
  4. pmc Close encounters between active genes in the nucleus
    Chien Hui Chuang
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Genome Biol 6:237. 2005
    ..Colocalization could be related to the earlier observation of active genes associating with foci where RNA polymerase II is concentrated...
  5. ncbi request reprint In vivo visualization of chromosomes using lac operator-repressor binding
    A S Belmont
    Dept of Cell and Structural Biology, University of Illinois, Urbana Champaign 61801, USA
    Trends Cell Biol 8:121-4. 1998
    ..Applications of this method will facilitate the investigation of interphase chromosome dynamics, as well as chromosome segregation during cell division in organisms that lack cytologically condensed chromosomes...
  6. ncbi request reprint Dynamics of chromatin, proteins, and bodies within the cell nucleus
    Andrew Belmont
    Department of Cell and Structural Biology, University of Illinois, Urbana Champaign B107, Chemical and Life Science Laboratory, 601 South Goodwin Avenue, Urbana, IL 61801, USA
    Curr Opin Cell Biol 15:304-10. 2003
    ..Also included are fast, local movements of chromosomes, together with slower but long-range movements of chromosomes and nuclear bodies...
  7. ncbi request reprint Estrogen fueled, nuclear kiss: did it move for you?
    Andrew S Belmont
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL, USA
    Nucleus 1:440-3. 2010
    ..Now, a more recent paper reports no such long-range interaction or chromosome movements in the same cell types under what appear to be well replicated conditions, forcing a reexamination of the prior results...
  8. pmc Mitotic chromosome scaffold structure: new approaches to an old controversy
    Andrew S Belmont
    Department of Cell and Structural Biology, University of Illinois, Urbana Champaign, IL 61801, USA
    Proc Natl Acad Sci U S A 99:15855-7. 2002
  9. ncbi request reprint Large-scale chromatin structure and function
    A S Belmont
    Department of Cell and Structural Biology, University of Illinois, Urbana Champaign, B107 CLSL, 601 South Goodwin Avenue, Urbana, IL 61801, USA
    Curr Opin Cell Biol 11:307-11. 1999
    ..We discuss the potential functional impact of this large-scale chromatin organization, including its possible role in regulating gene expression...
  10. ncbi request reprint Visualizing chromosome dynamics with GFP
    A S Belmont
    Dept of Cell and Structural Biology, University of Illinois, Urbana Champaign, B107 CLSL, 601 South Goodwin Ave, Urbana, IL 61801, USA
    Trends Cell Biol 11:250-7. 2001
    ..In particular, we focus on active bacterial chromosome segregation, yeast mitosis and centromere dynamics, and large-scale chromatin structure and dynamics within eukaryotic interphase nuclei...
  11. doi request reprint Ectopic histone H3S10 phosphorylation causes chromatin structure remodeling in Drosophila
    Huai Deng
    Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, IA 50011, USA
    Development 135:699-705. 2008
    ..These findings provide direct evidence that the epigenetic histone tail modification of H3S10 phosphorylation at interphase can function as a causative regulator of higher-order chromatin structure in Drosophila in vivo...
  12. pmc Moving chromatin within the interphase nucleus-controlled transitions?
    Chien Hui Chuang
    Department of Cell and Developmental Biology, University of Illinois, Urbana Champaign, B107 CLSL, 601 S Goodwin Avenue, Urbana, IL 61801, USA
    Semin Cell Dev Biol 18:698-706. 2007
    ..Here we review what is known concerning chromatin mobility in relationship to physiologically regulated changes in nuclear interphase chromosome organization...
  13. ncbi request reprint Sequential recruitment of HAT and SWI/SNF components to condensed chromatin by VP16
    Sevinci Memedula
    Department of Cell and Structural Biology, University of Illinois, Urbana Champaign, Urbana, IL 61801, USA
    Curr Biol 13:241-6. 2003
    ....
  14. pmc Upstream binding factor association induces large-scale chromatin decondensation
    Danyang Chen
    Department of Cell and Molecular Biology, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 101:15106-11. 2004
    ..These studies also provide an in vivo model simulating ribosomal DNA transactivation outside the nucleolus, allowing temporal and spatial analyses of chromatin remodeling and assembly of the pol I transcription machinery...
  15. pmc Alteration of large-scale chromatin structure by estrogen receptor
    Anne C Nye
    Department of Cell and Structural Biology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Mol Cell Biol 22:3437-49. 2002
    ..This work demonstrates that when tethered or recruited to DNA, ER possesses a novel large-scale chromatin unfolding activity...
  16. doi request reprint In vivo immunogold labeling confirms large-scale chromatin folding motifs
    Igor Kireev
    Department of Cell and Developmental Biology, University of Illinois, Urbana Champaign, 601 S Goodwin Ave, Urbana, Illinois 61801, USA
    Nat Methods 5:311-3. 2008
    ..We detected large-scale chromatin folding motifs within intact interphase nuclei of CHO cells and visualized the ultrastructure of DNA replication 'factories' labeled with GFP-proliferating cell nuclear antigen (PCNA)...
  17. ncbi request reprint Effects of tethering HP1 to euchromatic regions of the Drosophila genome
    Yuhong Li
    Department of Biochemistry, University of Iowa, Iowa City, IA 52242, USA
    Development 130:1817-24. 2003
    ..Silencing was not dependent on SU(VAR)3-9 dosage, suggesting a bypass of the requirement for histone methylation...
  18. ncbi request reprint The dynamics of homologous chromosome pairing during male Drosophila meiosis
    Julio Vazquez
    Department of Biochemistry and Biophysics, University of California, San Francisco, 94143, USA
    Curr Biol 12:1473-83. 2002
    ..Due to limitations in available cytological techniques, the early stages of homologous chromosome pairing in male Drosophila have not been observed, and the mechanisms involved are poorly understood...
  19. ncbi request reprint High-pressure treatment of polytene chromosomes improves structural resolution
    Dmitri V Novikov
    Department of Cell and Developmental Biology, University of Illinois, Urbana Champaign, B107 Chemical and Life Sciences Building, 601 S Goodwin Ave, Urbana, Illinois 61801, USA
    Nat Methods 4:483-5. 2007
    ..We demonstrate applications to immunofluorescence and in situ hybridization...
  20. ncbi request reprint Direct visualization of transcription factor-induced chromatin remodeling and cofactor recruitment in vivo
    Anne E Carpenter
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Methods Enzymol 375:366-81. 2004
  21. ncbi request reprint Long-range directional movement of an interphase chromosome site
    Chien Hui Chuang
    Department of Cell and Developmental Biology, University of Illinois, Urbana Champaign, 61801, USA
    Curr Biol 16:825-31. 2006
    ..1-0.9 microm/min over distances of 1-5 microm. Our results suggest an active mechanism for fast and directed long-range interphase chromosome movements dependent directly or indirectly on actin/myosin...
  22. ncbi request reprint Truncated HP1 lacking a functional chromodomain induces heterochromatinization upon in vivo targeting
    Maartje C Brink
    Swammerdam Institute for Life Sciences, BioCentrum Amsterdam, University of Amsterdam, Kruislaan 318, 1098 SM, Amsterdam, The Netherlands
    Histochem Cell Biol 125:53-61. 2006
    ..Our results demonstrate that after lac repressor-mediated targeting, HP1alpha and HP1beta without a functional CD are able to induce heterochromatinization...
  23. ncbi request reprint Automated microscopy identifies estrogen receptor subdomains with large-scale chromatin structure unfolding activity
    Anne E Carpenter
    Department of Cell and Structural Biology, University of Illinois at Urbana Champaign, Urbana, Illinois, USA
    Cytometry A 58:157-66. 2004
    ..This type of experiment is impeded by the low throughput of traditional microscopy...
  24. pmc Chromatin dynamics in interphase cells revealed by tracking in a two-photon excitation microscope
    Valeria Levi
    Laboratory for Fluorescence Dynamics, and Department of Cell and Structural Biology, Chemical and Life Science Laboratory, University of Illinois at Urbana Champaign, Urbana, Illinois 61801 3080, USA
    Biophys J 89:4275-85. 2005
    ..Additionally, the jumps were sensitive to the temperature and absent after ATP depletion. These experimental results point to an energy-dependent mechanism driving fast motion of chromatin in interphase cells...
  25. ncbi request reprint Differential large-scale chromatin compaction and intranuclear positioning of transcribed versus non-transcribed transgene arrays containing beta-globin regulatory sequences
    Steffen Dietzel
    Department Biologie II, Ludwig Maximilians Universitat Munchen, Grosshaderner Str 2, 82152 Martinsried, Germany
    J Cell Sci 117:4603-14. 2004
    ....
  26. pmc Common effects of acidic activators on large-scale chromatin structure and transcription
    Anne E Carpenter
    Department of Cell and Structural Biology, B107 CLSL, 601 S Goodwin Avenue, Urbana, IL 61801, USA
    Mol Cell Biol 25:958-68. 2005
    ....
  27. pmc In vivo HP1 targeting causes large-scale chromatin condensation and enhanced histone lysine methylation
    Pernette J Verschure
    Swammerdam Institute for Life Sciences, BioCentrum Amsterdam, University of Amsterdam, P O Box 94062, 1090 GB Amsterdam, The Netherlands
    Mol Cell Biol 25:4552-64. 2005
    ..Our findings indicate that HP1alpha and HP1beta targeting is sufficient to induce heterochromatin formation...

Research Grants27

  1. LARGE SCALE CHROMATIN STRUCTURE/FUNCTION
    Andrew Belmont; Fiscal Year: 2002
    ..Knowledge gained from this research should provide valuable insight into regulation of transcription and improved design of gene therapy vectors and stable transgene expression. ..
  2. Chromatin Domain Structure and Function
    Andrew Belmont; Fiscal Year: 2005
    ..Insight from these studies should be of help in guiding the design of future constructs and artificial chromosomes used in gene therapy. ..
  3. Large-scale chromatin structure and dynamics
    Andrew Belmont; Fiscal Year: 2005
    ..Knowledge gained from this research should provide valuable insight into regulation of basic molecular processes and may serve to guide design of future gene therapy vectors and stable transgene expression. ..
  4. Chromatin Domain Structure and Function
    Andrew Belmont; Fiscal Year: 2006
    ..Insight from these studies should be of help in guiding the design of future constructs and artificial chromosomes used in gene therapy. ..
  5. Large-scale chromatin structure and dynamics
    Andrew Belmont; Fiscal Year: 2006
    ..Knowledge gained from this research should provide valuable insight into regulation of basic molecular processes and may serve to guide design of future gene therapy vectors and stable transgene expression. ..
  6. Large-scale chromatin structure and dynamics
    Andrew Belmont; Fiscal Year: 2007
    ..Knowledge gained from this research should provide valuable insight into regulation of basic molecular processes and may serve to guide design of future gene therapy vectors and stable transgene expression. ..
  7. Chromatin Domain Structure and Funcion
    Andrew Belmont; Fiscal Year: 2007
    ..Insight from our studies should be useful in guiding the design of future gene constructs and artificial chromosomes used in gene therapy. ..
  8. Chromatin Domain Structure and Function
    Andrew Belmont; Fiscal Year: 2007
    ..Insight from our studies should be useful in guiding the design of future gene constructs and artificial chromosomes used in gene therapy. ..
  9. Chromatin Domain Structure and Funcion
    Andrew Belmont; Fiscal Year: 2009
    ..Insight from our studies should be useful in guiding the design of future gene constructs and artificial chromosomes used in gene therapy. ..
  10. Chromatin Domain Structure and Funcion
    Andrew Belmont; Fiscal Year: 2009
    ..Insight from our studies should be useful in guiding the design of future gene constructs and artificial chromosomes used in gene therapy. ..
  11. Large-scale chromatin structure and dynamics
    Andrew Belmont; Fiscal Year: 2004
    ..Knowledge gained from this research should provide valuable insight into regulation of basic molecular processes and may serve to guide design of future gene therapy vectors and stable transgene expression. ..
  12. Chromatin Domain Structure and Function
    Andrew Belmont; Fiscal Year: 2004
    ..Insight from these studies should be of help in guiding the design of future constructs and artificial chromosomes used in gene therapy. ..
  13. Chromatin Domain Structure and Function
    Andrew Belmont; Fiscal Year: 2003
    ..Insight from these studies should be of help in guiding the design of future constructs and artificial chromosomes used in gene therapy. ..
  14. CHROMATIN DOMAIN STRUCTURE/FUNCTION
    Andrew Belmont; Fiscal Year: 1999
    ..Insight acquired from these studies should be of help in guiding the design of future constructs and artificial chromosomes used in gene therapy. ..
  15. LARGE SCALE CHROMATIN STRUCTURE/FUNCTION
    Andrew Belmont; Fiscal Year: 1999
    ..Knowledge gained from this research should provide valuable insight into regulation of transcription and improved design of gene therapy vectors and stable transgene expression. ..
  16. CHROMATIN DOMAIN STRUCTURE/FUNCTION
    Andrew Belmont; Fiscal Year: 2000
    ..Insight acquired from these studies should be of help in guiding the design of future constructs and artificial chromosomes used in gene therapy. ..
  17. LARGE SCALE CHROMATIN STRUCTURE/FUNCTION
    Andrew Belmont; Fiscal Year: 2000
    ..Knowledge gained from this research should provide valuable insight into regulation of transcription and improved design of gene therapy vectors and stable transgene expression. ..
  18. CHROMATIN DOMAIN STRUCTURE/FUNCTION
    Andrew Belmont; Fiscal Year: 2001
    ..Insight acquired from these studies should be of help in guiding the design of future constructs and artificial chromosomes used in gene therapy. ..
  19. LARGE SCALE CHROMATIN STRUCTURE/FUNCTION
    Andrew Belmont; Fiscal Year: 2001
    ..Knowledge gained from this research should provide valuable insight into regulation of transcription and improved design of gene therapy vectors and stable transgene expression. ..
  20. CHROMATIN DOMAIN STRUCTURE/FUNCTION
    Andrew Belmont; Fiscal Year: 2002
    ..Insight acquired from these studies should be of help in guiding the design of future constructs and artificial chromosomes used in gene therapy. ..
  21. Chromatin Domain Structure and Funcion
    Andrew S Belmont; Fiscal Year: 2010
    ..Insight from our studies should be useful in guiding the design of future gene constructs and artificial chromosomes used in gene therapy. ..