James D Belluzzi

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Nicotine alters limbic function in adolescent rat by a 5-HT1A receptor mechanism
    Jasmin M Dao
    Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, CA 92697 3800, USA
    Neuropsychopharmacology 36:1319-31. 2011
  2. ncbi request reprint Age-dependent effects of nicotine on locomotor activity and conditioned place preference in rats
    James D Belluzzi
    Department of Pharmacology, College of Medicine, University of California, Irvine, CA 92697 4625, USA
    Psychopharmacology (Berl) 174:389-95. 2004
  3. ncbi request reprint Acetaldehyde enhances acquisition of nicotine self-administration in adolescent rats
    James D Belluzzi
    Department of Pharmacology, College of Medicine, University of California, Irvine, CA 92697 4625, USA
    Neuropsychopharmacology 30:705-12. 2005
  4. doi request reprint Prenatal nicotine exposure changes natural and drug-induced reinforcement in adolescent male rats
    Ryan M Franke
    Department of Pharmacology, School of Medicine, University of California, Irvine, CA 92697, USA
    Eur J Neurosci 27:2952-61. 2008
  5. ncbi request reprint Involvement of alpha1-adrenergic receptors in tranylcypromine enhancement of nicotine self-administration in rat
    Anne Sophie Villegier
    Department of Pharmacology, School of Medicine, University of California, Room 360, MS2, Irvine, CA 92697, USA
    Psychopharmacology (Berl) 193:457-65. 2007
  6. pmc The monoamine oxidase (MAO) inhibitor tranylcypromine enhances nicotine self-administration in rats through a mechanism independent of MAO inhibition
    Shahrdad Lotfipour
    Department of Anatomy and Neurobiology, University of California, Irvine, CA 92697, USA
    Neuropharmacology 61:95-104. 2011
  7. pmc Age-dependent effects of low-dose nicotine treatment on cocaine-induced behavioral plasticity in rats
    Susan C McQuown
    Department of Pharmacology, School of Medicine, University of California, 360 Med Surge II, Irvine, CA 92697, USA
    Psychopharmacology (Berl) 207:143-52. 2009
  8. ncbi request reprint Acetaldehyde, a major constituent of tobacco smoke, enhances behavioral, endocrine, and neuronal responses to nicotine in adolescent and adult rats
    Junran Cao
    Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, CA, USA
    Neuropsychopharmacology 32:2025-35. 2007
  9. ncbi request reprint Gestational exposure to nicotine and monoamine oxidase inhibitors influences cocaine-induced locomotion in adolescent rats
    Ryan M Franke
    Department of Pharmacology, School of Medicine, University of California, Irvine CA, 92697, USA
    Psychopharmacology (Berl) 195:117-24. 2007
  10. pmc Allosteric modulation of related ligand-gated ion channels synergistically induces long-term potentiation in the hippocampus and enhances cognition
    Timothy B Johnstone
    Department of Pharmacology, School of Medicine, University of California, Irvine, California, USA
    J Pharmacol Exp Ther 336:908-15. 2011

Collaborators

Detail Information

Publications22

  1. pmc Nicotine alters limbic function in adolescent rat by a 5-HT1A receptor mechanism
    Jasmin M Dao
    Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, CA 92697 3800, USA
    Neuropsychopharmacology 36:1319-31. 2011
    ..These findings indicate that early adolescent nicotine exposure uniquely alters limbic function by both 5-HT1A and non-5-HT1A receptor mechanisms...
  2. ncbi request reprint Age-dependent effects of nicotine on locomotor activity and conditioned place preference in rats
    James D Belluzzi
    Department of Pharmacology, College of Medicine, University of California, Irvine, CA 92697 4625, USA
    Psychopharmacology (Berl) 174:389-95. 2004
    ..This adolescent initiation may be due to multiple factors, but little evidence is available regarding whether their brains are differentially sensitive to the addictive effects of nicotine during adolescence...
  3. ncbi request reprint Acetaldehyde enhances acquisition of nicotine self-administration in adolescent rats
    James D Belluzzi
    Department of Pharmacology, College of Medicine, University of California, Irvine, CA 92697 4625, USA
    Neuropsychopharmacology 30:705-12. 2005
    ..Animal models of tobacco addiction could be improved by combining acetaldehyde, and possibly other smoke components, with nicotine to more accurately reflect the pharmacological profile of tobacco smoke...
  4. doi request reprint Prenatal nicotine exposure changes natural and drug-induced reinforcement in adolescent male rats
    Ryan M Franke
    Department of Pharmacology, School of Medicine, University of California, Irvine, CA 92697, USA
    Eur J Neurosci 27:2952-61. 2008
    ..At FR2 and FR5 schedules, the responding maintained by sucrose pellets was lower in nicotine-exposed offspring. These findings suggest that nicotine exposure during gestation may induce changes in both natural and drug reward pathways...
  5. ncbi request reprint Involvement of alpha1-adrenergic receptors in tranylcypromine enhancement of nicotine self-administration in rat
    Anne Sophie Villegier
    Department of Pharmacology, School of Medicine, University of California, Room 360, MS2, Irvine, CA 92697, USA
    Psychopharmacology (Berl) 193:457-65. 2007
    ..The aim of the present study was to evaluate the role of noradrenergic systems in mediating this enhancement of nicotine reward...
  6. pmc The monoamine oxidase (MAO) inhibitor tranylcypromine enhances nicotine self-administration in rats through a mechanism independent of MAO inhibition
    Shahrdad Lotfipour
    Department of Anatomy and Neurobiology, University of California, Irvine, CA 92697, USA
    Neuropharmacology 61:95-104. 2011
    ..Together, our data suggests TCP enhancement of nicotine self-administration are mediated through mechanisms independent of MAO inhibition, including nicotine-paired cues and monoamine uptake inhibition...
  7. pmc Age-dependent effects of low-dose nicotine treatment on cocaine-induced behavioral plasticity in rats
    Susan C McQuown
    Department of Pharmacology, School of Medicine, University of California, 360 Med Surge II, Irvine, CA 92697, USA
    Psychopharmacology (Berl) 207:143-52. 2009
    ....
  8. ncbi request reprint Acetaldehyde, a major constituent of tobacco smoke, enhances behavioral, endocrine, and neuronal responses to nicotine in adolescent and adult rats
    Junran Cao
    Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, CA, USA
    Neuropsychopharmacology 32:2025-35. 2007
    ..Although pharmacokinetic studies showed that acetaldehyde did not change nicotine levels in either brain or serum, nicotine penetration into the brain was slower in juveniles as compared to adults...
  9. ncbi request reprint Gestational exposure to nicotine and monoamine oxidase inhibitors influences cocaine-induced locomotion in adolescent rats
    Ryan M Franke
    Department of Pharmacology, School of Medicine, University of California, Irvine CA, 92697, USA
    Psychopharmacology (Berl) 195:117-24. 2007
    ..Although gestational nicotine (GN) treatment in rodents is used as the primary animal model of maternal smoking, tobacco smoke contains more than 4,000 constituents, including monoamine oxidase inhibitors (MAOIs)...
  10. pmc Allosteric modulation of related ligand-gated ion channels synergistically induces long-term potentiation in the hippocampus and enhances cognition
    Timothy B Johnstone
    Department of Pharmacology, School of Medicine, University of California, Irvine, California, USA
    J Pharmacol Exp Ther 336:908-15. 2011
    ..These observations may translate into therapeutic utility of dual action compounds in diseases of hippocampal-based cognitive impairment...
  11. pmc Limiting activity at beta1-subunit-containing GABAA receptor subtypes reduces ataxia
    Kelvin W Gee
    Department of Pharmacology, School of Medicine, University of California, Irvine, CA 92697, USA
    J Pharmacol Exp Ther 332:1040-53. 2010
    ..Our findings provide an alternative strategy for designing anxioselective allosteric modulators of the GABA(A)R with BZ-like anxiolytic efficacy by reducing or eliminating activity at beta(1)-subunit-containing GABA(A)Rs...
  12. pmc Low dose nicotine treatment during early adolescence increases subsequent cocaine reward
    Susan C McQuown
    Department of Pharmacology, School of Medicine, University of California, Irvine, CA 92697, USA
    Neurotoxicol Teratol 29:66-73. 2007
    ..These findings provide evidence that the adolescent brain is uniquely vulnerable to the effects of nicotine on subsequent drug reward...
  13. ncbi request reprint Tranylcypromine enhancement of nicotine self-administration
    Anne Sophie Villegier
    Department of Pharmacology, School of Medicine, University of California, Irvine, CA 92697, USA
    Neuropharmacology 52:1415-25. 2007
    ..Taken together, these results indicate that in a stringent self-administration acquisition test, MAO inhibition increases the rewarding effect of low doses of nicotine, possibly via a dopamine-dependent mechanism...
  14. pmc Age influences the effects of nicotine and monoamine oxidase inhibition on mood-related behaviors in rats
    Anne Sophie Villegier
    Department of Pharmacology, School of Medicine, University of California, Irvine, CA 92697, USA
    Psychopharmacology (Berl) 208:593-601. 2010
    ..However, few animal studies have considered possible synergistic interactions between nicotine and other tobacco smoke constituents, such as monoamine oxidase (MAO) inhibitors, in the regulation of mood...
  15. pmc The melanin-concentrating hormone system modulates cocaine reward
    Shinjae Chung
    Department of Pharmacology, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 106:6772-7. 2009
    ..Thus, the MCH system has an important modulatory role in cocaine reward and reinforcement by potentiating the dopaminergic system in the NAcSh, which may provide a new rationale for treating cocaine addiction...
  16. ncbi request reprint Negative allosteric modulation of nicotinic acetylcholine receptors blocks nicotine self-administration in rats
    Ryan F Yoshimura
    Department of Pharmacology, School of Medicine, University of California, Irvine, CA 92697, USA
    J Pharmacol Exp Ther 323:907-15. 2007
    ..UCI-30002 represents validation of the concept that negative allosteric modulators may have significant benefits as a strategy for treating nicotine addiction and encourages the development of subtype-selective modulators...
  17. ncbi request reprint Age, sex and early environment contribute to individual differences in nicotine/acetaldehyde-induced behavioral and endocrine responses in rats
    Minjung K Park
    Department of Pharmacology, School of Medicine, University of California, Irvine, California 92697, USA
    Pharmacol Biochem Behav 86:297-305. 2007
    ..Furthermore, the current study indicates that stress reactivity, age and sex may play differential roles in initiating smoking behavior...
  18. pmc The melanin-concentrating hormone (MCH) system modulates behaviors associated with psychiatric disorders
    Shinjae Chung
    Department of Pharmacology, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 6:e19286. 2011
    ..Thus, our data present the MCH system as a regulator of sensorimotor gating, and provide a new rationale to understand the etiologies of schizophrenia and related psychiatric disorders...
  19. pmc Serotonergic mechanism underlying tranylcypromine enhancement of nicotine self-administration
    Anne Sophie Villegier
    Department of Pharmacology, School of Medicine, University of California, Irvine, California 92697, USA
    Synapse 65:479-89. 2011
    ..These findings suggest that MAO inhibition enhances serotonergic transmission, which serves a critical role in the reinforcing effects of nicotine...
  20. doi request reprint Smoking to self-medicate attentional and emotional dysfunctions
    JEAN G GEHRICKE
    Department of Psychiatry and Human Behavior, D402 Medical Sciences I, Irvine, California 92697 1674, USA
    Nicotine Tob Res 9:S523-36. 2007
    ....
  21. doi request reprint Age-dependent alterations in reward-seeking behavior after brief nicotine exposure
    Celina Y Mojica
    Department of Pharmacology, School of Medicine, University of California, Irvine, CA, 92697, USA
    Psychopharmacology (Berl) 231:1763-73. 2014
    ..The aim of the present study was to determine whether these nicotine pretreatment effects extend to extinction and reinstatement of reward-seeking behavior...
  22. ncbi request reprint Monoamine oxidase inhibitors allow locomotor and rewarding responses to nicotine
    Anne Sophie Villegier
    INSERM U 114, College de France
    Neuropsychopharmacology 31:1704-13. 2006
    ..Our data suggest that MAOIs contained in tobacco and tobacco smoke act in synergy with nicotine to enhance its rewarding effects...