Lynn M Bekris

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Chronic beryllium disease and glutathione biosynthesis genes
    Lynn M Bekris
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98195, USA
    J Occup Environ Med 48:599-606. 2006
  2. pmc ADAM10 expression and promoter haplotype in Alzheimer's disease
    Lynn M Bekris
    Geriatric Research, Education, and Clinical Center GRECC, VA Puget Sound Health Care System, Seattle, WA, USA
    Neurobiol Aging 33:2229.e1-2229.e9. 2012
  3. pmc Tau phosphorylation pathway genes and cerebrospinal fluid tau levels in Alzheimer's disease
    Lynn M Bekris
    Geriatric Research, Education, and Clinical Center GRECC, VA Puget Sound Health Care System, Seattle, Washington 98108, USA
    Am J Med Genet B Neuropsychiatr Genet 159:874-83. 2012
  4. pmc Functional analysis of APOE locus genetic variation implicates regional enhancers in the regulation of both TOMM40 and APOE
    Lynn M Bekris
    Geriatric Research, Education and Clinical Center, VA Puget Sound Health Care System, 1660 South Columbian Way, Seattle, WA 98108, USA
    J Hum Genet 57:18-25. 2012
  5. ncbi request reprint Glutathione-s-transferase M1 and T1 polymorphisms and associations with type 1 diabetes age-at-onset
    Lynn M Bekris
    Department of Environmental and Occupational Health Sciences, University of Washington, Box 357710, Seattle, WA 98195, USA
    Autoimmunity 38:567-75. 2005
  6. pmc Amyloid precursor protein (APP) processing genes and cerebrospinal fluid APP cleavage product levels in Alzheimer's disease
    L M Bekris
    Geriatric Research, Education and Clinical Center GRECC, VA Puget Sound Health Care System, Seattle, WA, USA
    Neurobiol Aging 32:556.e13-23. 2011
  7. pmc The genetics of Parkinson disease
    Lynn M Bekris
    Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    J Geriatr Psychiatry Neurol 23:228-42. 2010
  8. pmc APOE mRNA and protein expression in postmortem brain are modulated by an extended haplotype structure
    Lynn M Bekris
    Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    Am J Med Genet B Neuropsychiatr Genet 153:409-17. 2010
  9. pmc Multiple SNPs within and surrounding the apolipoprotein E gene influence cerebrospinal fluid apolipoprotein E protein levels
    Lynn M Bekris
    Geriatric Research, Education, and Clinical Center GRECC, VA Puget Sound Health Care System, Seattle, WA 98108, USA
    J Alzheimers Dis 13:255-66. 2008
  10. ncbi request reprint Targeting type 1 diabetes before and at the clinical onset of disease
    L M Bekris
    Department of Medicine, University of Washington, Box 357710, Seattle, WA 206 543 0756, USA
    Endocr Metab Immune Disord Drug Targets 6:103-24. 2006

Detail Information

Publications24

  1. ncbi request reprint Chronic beryllium disease and glutathione biosynthesis genes
    Lynn M Bekris
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98195, USA
    J Occup Environ Med 48:599-606. 2006
    ..Glutamate cysteine ligase consists of a catalytic subunit (GCLC) and modifier subunit (GCLM)...
  2. pmc ADAM10 expression and promoter haplotype in Alzheimer's disease
    Lynn M Bekris
    Geriatric Research, Education, and Clinical Center GRECC, VA Puget Sound Health Care System, Seattle, WA, USA
    Neurobiol Aging 33:2229.e1-2229.e9. 2012
    ..Taken together, these findings suggest that ADAM10 expression is modulated according to a promoter haplotype that is influenced in a brain region- and cell type-specific manner...
  3. pmc Tau phosphorylation pathway genes and cerebrospinal fluid tau levels in Alzheimer's disease
    Lynn M Bekris
    Geriatric Research, Education, and Clinical Center GRECC, VA Puget Sound Health Care System, Seattle, Washington 98108, USA
    Am J Med Genet B Neuropsychiatr Genet 159:874-83. 2012
    ..These results suggest that rs7768046 and rs913275 both influence CSF tau levels in an AD-associated manner...
  4. pmc Functional analysis of APOE locus genetic variation implicates regional enhancers in the regulation of both TOMM40 and APOE
    Lynn M Bekris
    Geriatric Research, Education and Clinical Center, VA Puget Sound Health Care System, 1660 South Columbian Way, Seattle, WA 98108, USA
    J Hum Genet 57:18-25. 2012
    ....
  5. ncbi request reprint Glutathione-s-transferase M1 and T1 polymorphisms and associations with type 1 diabetes age-at-onset
    Lynn M Bekris
    Department of Environmental and Occupational Health Sciences, University of Washington, Box 357710, Seattle, WA 98195, USA
    Autoimmunity 38:567-75. 2005
    ..035) may be a susceptibility factor in T1D 14-20 years old. These results suggest that the GSTM1 null genotype is associated with T1D protection and T1D age-at-onset and that susceptibility to T1D may involve GST conjugation...
  6. pmc Amyloid precursor protein (APP) processing genes and cerebrospinal fluid APP cleavage product levels in Alzheimer's disease
    L M Bekris
    Geriatric Research, Education and Clinical Center GRECC, VA Puget Sound Health Care System, Seattle, WA, USA
    Neurobiol Aging 32:556.e13-23. 2011
    ..These results suggest that genetic variation within ADAM10, an APP processing gene, influences CSF APPα levels in an AD specific manner...
  7. pmc The genetics of Parkinson disease
    Lynn M Bekris
    Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    J Geriatr Psychiatry Neurol 23:228-42. 2010
    ..The function of these genes and their contribution to PD pathogenesis remain to be fully elucidated. The prevalence, incidence, clinical manifestations, and genetic components of PD are discussed in this review...
  8. pmc APOE mRNA and protein expression in postmortem brain are modulated by an extended haplotype structure
    Lynn M Bekris
    Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    Am J Med Genet B Neuropsychiatr Genet 153:409-17. 2010
    ....
  9. pmc Multiple SNPs within and surrounding the apolipoprotein E gene influence cerebrospinal fluid apolipoprotein E protein levels
    Lynn M Bekris
    Geriatric Research, Education, and Clinical Center GRECC, VA Puget Sound Health Care System, Seattle, WA 98108, USA
    J Alzheimers Dis 13:255-66. 2008
    ..Further investigation of the genetic influence of these loci on apoE expression levels in the central nervous system is likely to provide new insight into apoE regulation as well as AD pathogenesis...
  10. ncbi request reprint Targeting type 1 diabetes before and at the clinical onset of disease
    L M Bekris
    Department of Medicine, University of Washington, Box 357710, Seattle, WA 206 543 0756, USA
    Endocr Metab Immune Disord Drug Targets 6:103-24. 2006
    ..It is speculated that drug targets of factors important to disease pathogenesis may provide safe and effective adductive treatment to preserve beta cell function in autoantibody positive subjects who are at maximum risk for disease...
  11. pmc TOMM40 intron 6 poly-T length, age at onset, and neuropathology of AD in individuals with APOE ε3/ε3
    Ge Li
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA
    Alzheimers Dement 9:554-61. 2013
    ..This study investigates the association between TOMM40 poly-T length, age at onset, and neuropathology in individuals with Alzheimer's disease (AD) with the apolipoprotein E (APOE) ε3/ε3 allele...
  12. pmc Cerebrospinal fluid concentration of brain-derived neurotrophic factor and cognitive function in non-demented subjects
    Ge Li
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA
    PLoS ONE 4:e5424. 2009
    ..We tested hypothesis that reduced CSF BDNF is associated with age-related cognitive decline...
  13. pmc Association of cerebrospinal fluid Aβ42 with A2M gene in cognitively normal subjects
    Steven P Millard
    Northwest Network VISN 20 Mental Illness Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, USA Electronic address
    Neurobiol Aging 35:357-64. 2014
    ..These results suggest that genetic variation within the A2M gene influences CSF Aβ(42) levels...
  14. pmc Genetics of Alzheimer disease
    Lynn M Bekris
    Department of Medicine, University of Washington School of Medicine, Seattle, WA 98108, USA
    J Geriatr Psychiatry Neurol 23:213-27. 2010
    ..Identification of these genes has led to a number of animal models that have been useful to study the pathogenesis underlying AD. In this article, we provide an overview of the clinical and genetic features of AD...
  15. pmc The spectrum of mutations in progranulin: a collaborative study screening 545 cases of neurodegeneration
    Chang En Yu
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
    Arch Neurol 67:161-70. 2010
    ..However, it is unclear whether some rare FTD-related GRN variants are pathogenic and whether neurodegenerative disorders other than FTD can also be caused by GRN mutations...
  16. doi request reprint MicroRNA in Alzheimer's disease: an exploratory study in brain, cerebrospinal fluid and plasma
    Lynn M Bekris
    Department of Geriatric GRECC, Research, Education, and Clinical Centers, VA Puget Sound Health Care System, Seattle, WA 98108, USA
    Biomarkers 18:455-66. 2013
    ..Plasma miR-15a was found to be associated with plaque score in the independent sample. In conclusion, miRNA present in human biofluids may offer utility as biomarkers of AD...
  17. pmc Genetic mapping at 3-kilobase resolution reveals inositol 1,4,5-triphosphate receptor 3 as a risk factor for type 1 diabetes in Sweden
    Jared C Roach
    Institute for Systems Biology, Seattle, WA 98103, USA
    Am J Hum Genet 79:614-27. 2006
    ..0%-31.0%) suggests that variation within ITPR3 reflects an important contribution to T1D in Sweden. Two-locus regression analysis supports an influence of ITPR3 variation on T1D that is distinct from that of any MHC class II gene...
  18. ncbi request reprint Antibodies to GAD65 and peripheral nerve function in the DCCT
    Robert D Hoeldtke
    Department of Medicine, West Virginia University, Morgantown, WV 26506 9159, USA
    J Neuroimmunol 185:182-9. 2007
    ..248+/-.03 versus .278+/-.03). Epitope analysis, based on the blocking of conformational epitopes by recombinant Fab, revealed that the binding to multiple epitopes was decreased in the patients with neuropathy...
  19. pmc Mutations in the TSGA14 gene in families with autism spectrum disorders
    O Korvatska
    Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, 98195, USA
    Am J Med Genet B Neuropsychiatr Genet 156:303-11. 2011
    ..022). This is the first report of a possible link of a gene with a centrosomal function with familial autism...
  20. pmc Epigenetic signature and enhancer activity of the human APOE gene
    Chang En Yu
    Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, WA 98108, USA
    Hum Mol Genet 22:5036-47. 2013
    ....
  21. pmc Differential expression of the glutamate transporter GLT-1 in pancreas
    James S Meabon
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA
    J Histochem Cytochem 60:139-51. 2012
    ..Finally, glutamine synthetase was coexpressed with GLT-1 in islets, which suggests that, as with liver and brain, one possible role of GLT-1 in the pancreas is to support glutamine synthesis...
  22. ncbi request reprint GAD65 autoantibody epitopes in adult patients with latent autoimmune diabetes following GAD65 vaccination
    L M Bekris
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Diabet Med 24:521-6. 2007
    ..In this study we analysed the effect of rhGAD65 administration on the GAD65-specific autoimmune response...
  23. ncbi request reprint Glutamate cysteine ligase catalytic subunit promoter polymorphisms and associations with type 1 diabetes age-at-onset and GAD65 autoantibody levels
    L M Bekris
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Exp Clin Endocrinol Diabetes 115:221-8. 2007
    ..13-0.82). The GCLC -129 SNP and GCLC TNR appear to be in linkage disequilibrium (p-value<0.0001). These results suggest that GCLC promoter polymorphisms may influence GAD65Ab levels and may influence the age at which T1D is diagnosed...
  24. pmc TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis
    Vivianna M Van Deerlin
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Lancet Neurol 7:409-16. 2008
    ..Our aim was to investigate whether TARDBP is a candidate disease gene for familial ALS that is not associated with mutations in superoxide dismutase 1 (SOD1)...