Kiflai Bein

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc LPS-treated macrophage cytokines repress surfactant protein-B in lung epithelial cells
    Kiflai Bein
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219 3130, USA
    Am J Respir Cell Mol Biol 49:306-15. 2013
  2. pmc JUN-CCAAT/enhancer-binding protein complexes inhibit surfactant-associated protein B promoter activity
    Kiflai Bein
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, PA 15219 3130, USA
    Am J Respir Cell Mol Biol 45:436-44. 2011
  3. pmc Functional genomic assessment of phosgene-induced acute lung injury in mice
    George D Leikauf
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, PA 15219, USA
    Am J Respir Cell Mol Biol 49:368-83. 2013
  4. pmc Integrative assessment of chlorine-induced acute lung injury in mice
    George D Leikauf
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, PA 15219 3130, USA
    Am J Respir Cell Mol Biol 47:234-44. 2012
  5. pmc Haplotype association mapping of acute lung injury in mice implicates activin a receptor, type 1
    George D Leikauf
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219 3130, USA
    Am J Respir Crit Care Med 183:1499-509. 2011
  6. pmc Integrative metabolome and transcriptome profiling reveals discordant energetic stress between mouse strains with differential sensitivity to acrolein-induced acute lung injury
    James P Fabisiak
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219 3130, USA
    Mol Nutr Food Res 55:1423-34. 2011
  7. pmc Endothelial dysfunction and claudin 5 regulation during acrolein-induced lung injury
    An Soo Jang
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219 3130, USA
    Am J Respir Cell Mol Biol 44:483-90. 2011
  8. doi request reprint Acrolein - a pulmonary hazard
    Kiflai Bein
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219 3130, USA
    Mol Nutr Food Res 55:1342-60. 2011
  9. pmc Functional genomics of chlorine-induced acute lung injury in mice
    George D Leikauf
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, 100 Technology Drive, Pittsburgh, PA 15219 3130, USA
    Proc Am Thorac Soc 7:294-6. 2010
  10. pmc Surfactant-associated protein B is critical to survival in nickel-induced injury in mice
    Kiflai Bein
    Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219 3130, USA
    Am J Respir Cell Mol Biol 41:226-36. 2009

Collaborators

Detail Information

Publications10

  1. pmc LPS-treated macrophage cytokines repress surfactant protein-B in lung epithelial cells
    Kiflai Bein
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219 3130, USA
    Am J Respir Cell Mol Biol 49:306-15. 2013
    ....
  2. pmc JUN-CCAAT/enhancer-binding protein complexes inhibit surfactant-associated protein B promoter activity
    Kiflai Bein
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, PA 15219 3130, USA
    Am J Respir Cell Mol Biol 45:436-44. 2011
    ..These findings support the idea that heterodimerization between JUN and C/EBP-α and/or C/EBP-β targets JUN to the Sftpb promoter, thereby mediating its inhibitory regulatory role...
  3. pmc Functional genomic assessment of phosgene-induced acute lung injury in mice
    George D Leikauf
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, PA 15219, USA
    Am J Respir Cell Mol Biol 49:368-83. 2013
    ..In addition, a gene with a suggestive SNP association, Itga9, is linked to transforming growth factor β1 signaling, which previously has been associated with the susceptibility to ALI in mice. ..
  4. pmc Integrative assessment of chlorine-induced acute lung injury in mice
    George D Leikauf
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, PA 15219 3130, USA
    Am J Respir Cell Mol Biol 47:234-44. 2012
    ..The leading candidate genes associated with increased susceptibility to acute lung injury in mice included Klf4, Sema7a, Tns1, Aacs, and a gene that encodes an amino acid carrier, Slc38a4...
  5. pmc Haplotype association mapping of acute lung injury in mice implicates activin a receptor, type 1
    George D Leikauf
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219 3130, USA
    Am J Respir Crit Care Med 183:1499-509. 2011
    ..Because acute lung injury is a sporadic disease produced by heterogeneous precipitating factors, previous genetic analyses are mainly limited to candidate gene case-control studies...
  6. pmc Integrative metabolome and transcriptome profiling reveals discordant energetic stress between mouse strains with differential sensitivity to acrolein-induced acute lung injury
    James P Fabisiak
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219 3130, USA
    Mol Nutr Food Res 55:1423-34. 2011
    ..A respiratory irritant, acrolein is generated by overheating cooking oils or by domestic cooking using biomass fuels, and is in environmental tobacco smoke, a health hazard in the restaurant workplace...
  7. pmc Endothelial dysfunction and claudin 5 regulation during acrolein-induced lung injury
    An Soo Jang
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219 3130, USA
    Am J Respir Cell Mol Biol 44:483-90. 2011
    ..The phosphorylation status of these transcription factors was consistent with the observed CLDN5 alteration. Preservation of endothelial CLDN5 may be a novel clinical approach for ALI therapy...
  8. doi request reprint Acrolein - a pulmonary hazard
    Kiflai Bein
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219 3130, USA
    Mol Nutr Food Res 55:1342-60. 2011
    ..Consequent to its pathophysiological impact, acrolein contributes to the morbidly and mortality associated with acute lung injury and COPD, and possibly asthma and lung cancer...
  9. pmc Functional genomics of chlorine-induced acute lung injury in mice
    George D Leikauf
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, 100 Technology Drive, Pittsburgh, PA 15219 3130, USA
    Proc Am Thorac Soc 7:294-6. 2010
    ..Gene-targeted mice then could be used to test the functional significance of susceptibility candidate genes, which could be valuable in revealing novel insights into the biology of acute lung injury...
  10. pmc Surfactant-associated protein B is critical to survival in nickel-induced injury in mice
    Kiflai Bein
    Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219 3130, USA
    Am J Respir Cell Mol Biol 41:226-36. 2009
    ..Together, these findings support the idea that maintenance of SFTPB expression is critical to survival during acute lung injury...