Anne Beigneux

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Assessing the role of the glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) three-finger domain in binding lipoprotein lipase
    Anne P Beigneux
    Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 286:19735-43. 2011
  2. pmc Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons
    Anne P Beigneux
    Department of Medicine Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, and Children s Hospital Oakland Research Institute 94609, USA
    Cell Metab 5:279-91. 2007
  3. pmc Agpat6--a novel lipid biosynthetic gene required for triacylglycerol production in mammary epithelium
    Anne P Beigneux
    Division of Cardiology, Department of Internal Medicine, University of California, Los Angeles, CA 90095, USA
    J Lipid Res 47:734-44. 2006
  4. pmc GPIHBP1, a GPI-anchored protein required for the lipolytic processing of triglyceride-rich lipoproteins
    Anne P Beigneux
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Lipid Res 50:S57-62. 2009
  5. pmc Chylomicronemia with a mutant GPIHBP1 (Q115P) that cannot bind lipoprotein lipase
    Anne P Beigneux
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Arterioscler Thromb Vasc Biol 29:956-62. 2009
  6. pmc GPIHBP1 and lipolysis: an update
    Anne P Beigneux
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    Curr Opin Lipidol 20:211-6. 2009
  7. pmc Highly conserved cysteines within the Ly6 domain of GPIHBP1 are crucial for the binding of lipoprotein lipase
    Anne P Beigneux
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Biol Chem 284:30240-7. 2009
  8. pmc Glycosylation of Asn-76 in mouse GPIHBP1 is critical for its appearance on the cell surface and the binding of chylomicrons and lipoprotein lipase
    Anne P Beigneux
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Lipid Res 49:1312-21. 2008
  9. pmc The acidic domain of GPIHBP1 is important for the binding of lipoprotein lipase and chylomicrons
    Peter Gin
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Biol Chem 283:29554-62. 2008
  10. ncbi request reprint Prenylcysteine lyase deficiency in mice results in the accumulation of farnesylcysteine and geranylgeranylcysteine in brain and liver
    Anne Beigneux
    Gladstone Institute of Cardiovascular Disease and the Cardiovascular Research Institute, University of California, San Francisco, California 94141 9100, USA
    J Biol Chem 277:38358-63. 2002

Research Grants

  1. New Avenues in GPIHBP1 Research
    Anne Beigneux; Fiscal Year: 2009
  2. New Avenues in GPIHBP1 Research
    Anne Beigneux; Fiscal Year: 2010
  3. New Avenues in GPIHBP1 Research
    Anne Beigneux; Fiscal Year: 2009

Collaborators

Detail Information

Publications27

  1. pmc Assessing the role of the glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) three-finger domain in binding lipoprotein lipase
    Anne P Beigneux
    Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 286:19735-43. 2011
    ..Our studies demonstrate that the Ly6 domain of GPIHBP1 is important for the ability of GPIHBP1 to bind and transport LPL...
  2. pmc Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons
    Anne P Beigneux
    Department of Medicine Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, and Children s Hospital Oakland Research Institute 94609, USA
    Cell Metab 5:279-91. 2007
    ..Expression of GPIHBP1 in cultured cells confers the ability to bind both LpL and chylomicrons. These studies strongly suggest that GPIHBP1 is an important platform for the LpL-mediated processing of chylomicrons in capillaries...
  3. pmc Agpat6--a novel lipid biosynthetic gene required for triacylglycerol production in mammary epithelium
    Anne P Beigneux
    Division of Cardiology, Department of Internal Medicine, University of California, Los Angeles, CA 90095, USA
    J Lipid Res 47:734-44. 2006
    ..Thus, we identified a novel glycerolipid acyltransferase of the ER, AGPAT6, which is crucial for the production of milk fat by the mammary gland...
  4. pmc GPIHBP1, a GPI-anchored protein required for the lipolytic processing of triglyceride-rich lipoproteins
    Anne P Beigneux
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Lipid Res 50:S57-62. 2009
    ..Here, we review recent progress in understanding GPIHBP1 and discuss its role in lipolysis...
  5. pmc Chylomicronemia with a mutant GPIHBP1 (Q115P) that cannot bind lipoprotein lipase
    Anne P Beigneux
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Arterioscler Thromb Vasc Biol 29:956-62. 2009
    ..Because GPIHBP1 deficiency causes chylomicronemia in mice, we sought to determine whether some cases of chylomicronemia in humans could be attributable to defective GPIHBP1 proteins...
  6. pmc GPIHBP1 and lipolysis: an update
    Anne P Beigneux
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    Curr Opin Lipidol 20:211-6. 2009
    ..This review will provide an update on the structure of GPIHBP1, a 28-kDa glycosylphosphatidylinositol-anchored glycoprotein, and its role in the lipolytic processing of triglyceride-rich lipoproteins...
  7. pmc Highly conserved cysteines within the Ly6 domain of GPIHBP1 are crucial for the binding of lipoprotein lipase
    Anne P Beigneux
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Biol Chem 284:30240-7. 2009
    ..In this assay, wild-type soluble GPIHBP1 bound LPL avidly, but the cysteine mutants did not. Thus, our studies suggest that a structurally intact Ly6 domain (in addition to the acidic domain) is essential for LPL binding...
  8. pmc Glycosylation of Asn-76 in mouse GPIHBP1 is critical for its appearance on the cell surface and the binding of chylomicrons and lipoprotein lipase
    Anne P Beigneux
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Lipid Res 49:1312-21. 2008
    ..These studies demonstrate that N-glycosylation of GPIHBP1 is important for the trafficking of GPIHBP1 to the cell surface...
  9. pmc The acidic domain of GPIHBP1 is important for the binding of lipoprotein lipase and chylomicrons
    Peter Gin
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Biol Chem 283:29554-62. 2008
    ..These studies indicate that the acidic domain of GPIHBP1 is important and that electrostatic interactions play a key role in ligand binding...
  10. ncbi request reprint Prenylcysteine lyase deficiency in mice results in the accumulation of farnesylcysteine and geranylgeranylcysteine in brain and liver
    Anne Beigneux
    Gladstone Institute of Cardiovascular Disease and the Cardiovascular Research Institute, University of California, San Francisco, California 94141 9100, USA
    J Biol Chem 277:38358-63. 2002
    ..We conclude that prenylcysteine lyase does play a physiologic role in cleaving prenylcysteines in mammals, but the absence of this activity does not lead to major pathologic consequences...
  11. pmc Abnormal patterns of lipoprotein lipase release into the plasma in GPIHBP1-deficient mice
    Michael M Weinstein
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Biol Chem 283:34511-8. 2008
    ..The differences in LPL release after intravenous heparin and Intralipid strongly suggest that GPIHBP1 represents an important binding site for LPL in vivo...
  12. pmc Normal binding of lipoprotein lipase, chylomicrons, and apo-AV to GPIHBP1 containing a G56R amino acid substitution
    Peter Gin
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA
    Biochim Biophys Acta 1771:1464-8. 2007
    ....
  13. pmc GPIHBP1 is responsible for the entry of lipoprotein lipase into capillaries
    Brandon S J Davies
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell Metab 12:42-52. 2010
    ..Our experiments define the function of GPIHBP1 in triglyceride metabolism and provide a mechanism for the transport of LPL into capillaries...
  14. ncbi request reprint Blocking the secretion of hepatic very low density lipoproteins renders the liver more susceptible to toxin-induced injury
    Johan Björkegren
    Gladstone Institute of Cardiovascular Disease, Cardiovascular Research Institute, University of California, San Francisco 94110, USA
    J Biol Chem 277:5476-83. 2002
    ..Our results suggest that blocking lipoprotein secretion in the liver may increase the susceptibility of the liver to certain toxic challenges...
  15. pmc Binding preferences for GPIHBP1, a glycosylphosphatidylinositol-anchored protein of capillary endothelial cells
    Peter Gin
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Arterioscler Thromb Vasc Biol 31:176-82. 2011
    ..To define the ability of GPIHBP1 to bind other lipase family members and other apolipoproteins (apos) and lipoproteins...
  16. pmc The expression of GPIHBP1, an endothelial cell binding site for lipoprotein lipase and chylomicrons, is induced by peroxisome proliferator-activated receptor-gamma
    Brandon S J Davies
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Mol Endocrinol 22:2496-504. 2008
    ..We conclude that GPIHBP1 is regulated by dietary factors and by PPARgamma...
  17. pmc GPIHBP1: an endothelial cell molecule important for the lipolytic processing of chylomicrons
    Stephen G Young
    Department of Medicine Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Curr Opin Lipidol 18:389-96. 2007
    ..To summarize recent data indicating that glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) plays a key role in the lipolytic processing of chylomicrons...
  18. pmc Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity
    Laurent Vergnes
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Lipid Res 47:745-54. 2006
    ..Thus, Agpat6 plays a unique role in determining triglyceride content and composition in adipose tissue and liver that cannot be compensated by other members of the Agpat family...
  19. pmc Chylomicronemia elicits atherosclerosis in mice--brief report
    Michael M Weinstein
    Departments of Medicine, University of California, Los Angeles, USA
    Arterioscler Thromb Vasc Biol 30:20-3. 2010
    ..In this study, we examined susceptibility to atherosclerosis in Gpihbp1-deficient mice (Gpihbp1(-/-)), which manifest severe chylomicronemia as a result of defective lipolysis...
  20. pmc Cholesterol intake modulates plasma triglyceride levels in glycosylphosphatidylinositol HDL-binding protein 1-deficient mice
    Michael M Weinstein
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, USA
    Arterioscler Thromb Vasc Biol 30:2106-13. 2010
    ..To determine whether plasma triglyceride levels in adult Glycosylphosphatidylinositol HDL-binding protein 1 (GPIHBP1)-deficient (Gpihbp1(-/-)) mice would be sensitive to cholesterol intake...
  21. ncbi request reprint ESCRT-III dysfunction causes autophagosome accumulation and neurodegeneration
    Jin A Lee
    Gladstone Institute of Neurological Disease and Department of Neurology, University of California, San Francisco, California 94158, USA
    Curr Biol 17:1561-7. 2007
    ....
  22. ncbi request reprint Sick euthyroid syndrome is associated with decreased TR expression and DNA binding in mouse liver
    Anne P Beigneux
    Department of Medicine, University of California San Francisco, 94121, USA
    Am J Physiol Endocrinol Metab 284:E228-36. 2003
    ..We propose that decreased RXR expression is limiting for RXR/TR DNA binding at 4 h, whereas the reduction in both TR and RXR levels results in further decreased binding at 16 h...
  23. pmc ATP-citrate lyase deficiency in the mouse
    Anne P Beigneux
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA 94141, USA
    J Biol Chem 279:9557-64. 2004
    ..The Acly knockout allele is useful for identifying cell types with a high demand for acetyl-CoA synthesis...
  24. ncbi request reprint Reduction in cytochrome P-450 enzyme expression is associated with repression of CAR (constitutive androstane receptor) and PXR (pregnane X receptor) in mouse liver during the acute phase response
    Anne P Beigneux
    Department of Medicine, University of California San Francisco, Metabolism Section, Medical Service, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Biochem Biophys Res Commun 293:145-9. 2002
    ..These findings represent one possible molecular mechanism underlying sepsis-induced repression of Cyp enzymes...
  25. pmc AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase
    Yan Qun Chen
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    J Biol Chem 283:10048-57. 2008
    ..Our data indicate that AGPAT6 is a microsomal GPAT, and we propose renaming this enzyme GPAT4...
  26. pmc Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf
    Martin O Bergo
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94141 9100, USA
    J Clin Invest 113:539-50. 2004
    ..These studies identify Icmt as a potential target for reducing the growth of K-Ras- and B-Raf-induced malignancies...
  27. pmc Lipoprotein size and susceptibility to atherosclerosis--insights from genetically modified mouse models
    Murielle M Veniant
    Amgen Inc, One Amgen Center Drive, Thousand Oaks, CA 91320 1799, USA
    Curr Drug Targets 9:174-89. 2008
    ..Defining the extent of atherosclerosis in these mice should provide new insights into the atherogenicity of large, triglyceride-rich lipoproteins...

Research Grants3

  1. New Avenues in GPIHBP1 Research
    Anne Beigneux; Fiscal Year: 2009
    ....
  2. New Avenues in GPIHBP1 Research
    Anne Beigneux; Fiscal Year: 2010
    ....
  3. New Avenues in GPIHBP1 Research
    Anne Beigneux; Fiscal Year: 2009
    ....