Research Topics
Genomes and GenesSpecies | Anne BeigneuxSummaryAffiliation: University of California Country: USA Publications
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Publications
Assessing the role of the glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) three-finger domain in binding lipoprotein lipaseAnne P Beigneux
Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
J Biol Chem 286:19735-43. 2011..Our studies demonstrate that the Ly6 domain of GPIHBP1 is important for the ability of GPIHBP1 to bind and transport LPL...- Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicronsAnne P Beigneux
Department of Medicine Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, and Children s Hospital Oakland Research Institute 94609, USA
Cell Metab 5:279-91. 2007..Expression of GPIHBP1 in cultured cells confers the ability to bind both LpL and chylomicrons. These studies strongly suggest that GPIHBP1 is an important platform for the LpL-mediated processing of chylomicrons in capillaries... - Agpat6--a novel lipid biosynthetic gene required for triacylglycerol production in mammary epitheliumAnne P Beigneux
Division of Cardiology, Department of Internal Medicine, University of California, Los Angeles, CA 90095, USA
J Lipid Res 47:734-44. 2006..Thus, we identified a novel glycerolipid acyltransferase of the ER, AGPAT6, which is crucial for the production of milk fat by the mammary gland... - GPIHBP1, a GPI-anchored protein required for the lipolytic processing of triglyceride-rich lipoproteinsAnne P Beigneux
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
J Lipid Res 50:S57-62. 2009..Here, we review recent progress in understanding GPIHBP1 and discuss its role in lipolysis... - Chylomicronemia with a mutant GPIHBP1 (Q115P) that cannot bind lipoprotein lipaseAnne P Beigneux
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
Arterioscler Thromb Vasc Biol 29:956-62. 2009..Because GPIHBP1 deficiency causes chylomicronemia in mice, we sought to determine whether some cases of chylomicronemia in humans could be attributable to defective GPIHBP1 proteins... - GPIHBP1 and lipolysis: an updateAnne P Beigneux
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA
Curr Opin Lipidol 20:211-6. 2009..This review will provide an update on the structure of GPIHBP1, a 28-kDa glycosylphosphatidylinositol-anchored glycoprotein, and its role in the lipolytic processing of triglyceride-rich lipoproteins... - Highly conserved cysteines within the Ly6 domain of GPIHBP1 are crucial for the binding of lipoprotein lipaseAnne P Beigneux
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
J Biol Chem 284:30240-7. 2009..In this assay, wild-type soluble GPIHBP1 bound LPL avidly, but the cysteine mutants did not. Thus, our studies suggest that a structurally intact Ly6 domain (in addition to the acidic domain) is essential for LPL binding... - Glycosylation of Asn-76 in mouse GPIHBP1 is critical for its appearance on the cell surface and the binding of chylomicrons and lipoprotein lipaseAnne P Beigneux
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
J Lipid Res 49:1312-21. 2008..These studies demonstrate that N-glycosylation of GPIHBP1 is important for the trafficking of GPIHBP1 to the cell surface... - The acidic domain of GPIHBP1 is important for the binding of lipoprotein lipase and chylomicronsPeter Gin
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
J Biol Chem 283:29554-62. 2008..These studies indicate that the acidic domain of GPIHBP1 is important and that electrostatic interactions play a key role in ligand binding... 
Prenylcysteine lyase deficiency in mice results in the accumulation of farnesylcysteine and geranylgeranylcysteine in brain and liverAnne Beigneux
Gladstone Institute of Cardiovascular Disease and the Cardiovascular Research Institute, University of California, San Francisco, California 94141 9100, USA
J Biol Chem 277:38358-63. 2002..We conclude that prenylcysteine lyase does play a physiologic role in cleaving prenylcysteines in mammals, but the absence of this activity does not lead to major pathologic consequences...- Abnormal patterns of lipoprotein lipase release into the plasma in GPIHBP1-deficient miceMichael M Weinstein
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
J Biol Chem 283:34511-8. 2008..The differences in LPL release after intravenous heparin and Intralipid strongly suggest that GPIHBP1 represents an important binding site for LPL in vivo... - Normal binding of lipoprotein lipase, chylomicrons, and apo-AV to GPIHBP1 containing a G56R amino acid substitutionPeter Gin
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA
Biochim Biophys Acta 1771:1464-8. 2007.... - GPIHBP1 is responsible for the entry of lipoprotein lipase into capillariesBrandon S J Davies
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
Cell Metab 12:42-52. 2010..Our experiments define the function of GPIHBP1 in triglyceride metabolism and provide a mechanism for the transport of LPL into capillaries... - Blocking the secretion of hepatic very low density lipoproteins renders the liver more susceptible to toxin-induced injuryJohan Björkegren
Gladstone Institute of Cardiovascular Disease, Cardiovascular Research Institute, University of California, San Francisco 94110, USA
J Biol Chem 277:5476-83. 2002..Our results suggest that blocking lipoprotein secretion in the liver may increase the susceptibility of the liver to certain toxic challenges... - Binding preferences for GPIHBP1, a glycosylphosphatidylinositol-anchored protein of capillary endothelial cellsPeter Gin
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
Arterioscler Thromb Vasc Biol 31:176-82. 2011..To define the ability of GPIHBP1 to bind other lipase family members and other apolipoproteins (apos) and lipoproteins... - The expression of GPIHBP1, an endothelial cell binding site for lipoprotein lipase and chylomicrons, is induced by peroxisome proliferator-activated receptor-gammaBrandon S J Davies
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
Mol Endocrinol 22:2496-504. 2008..We conclude that GPIHBP1 is regulated by dietary factors and by PPARgamma... - GPIHBP1: an endothelial cell molecule important for the lipolytic processing of chylomicronsStephen G Young
Department of Medicine Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
Curr Opin Lipidol 18:389-96. 2007..To summarize recent data indicating that glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) plays a key role in the lipolytic processing of chylomicrons... - Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesityLaurent Vergnes
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
J Lipid Res 47:745-54. 2006..Thus, Agpat6 plays a unique role in determining triglyceride content and composition in adipose tissue and liver that cannot be compensated by other members of the Agpat family... - Chylomicronemia elicits atherosclerosis in mice--brief reportMichael M Weinstein
Departments of Medicine, University of California, Los Angeles, USA
Arterioscler Thromb Vasc Biol 30:20-3. 2010..In this study, we examined susceptibility to atherosclerosis in Gpihbp1-deficient mice (Gpihbp1(-/-)), which manifest severe chylomicronemia as a result of defective lipolysis... - Cholesterol intake modulates plasma triglyceride levels in glycosylphosphatidylinositol HDL-binding protein 1-deficient miceMichael M Weinstein
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, USA
Arterioscler Thromb Vasc Biol 30:2106-13. 2010..To determine whether plasma triglyceride levels in adult Glycosylphosphatidylinositol HDL-binding protein 1 (GPIHBP1)-deficient (Gpihbp1(-/-)) mice would be sensitive to cholesterol intake... - ESCRT-III dysfunction causes autophagosome accumulation and neurodegenerationJin A Lee
Gladstone Institute of Neurological Disease and Department of Neurology, University of California, San Francisco, California 94158, USA
Curr Biol 17:1561-7. 2007.... - Sick euthyroid syndrome is associated with decreased TR expression and DNA binding in mouse liverAnne P Beigneux
Department of Medicine, University of California San Francisco, 94121, USA
Am J Physiol Endocrinol Metab 284:E228-36. 2003..We propose that decreased RXR expression is limiting for RXR/TR DNA binding at 4 h, whereas the reduction in both TR and RXR levels results in further decreased binding at 16 h... - ATP-citrate lyase deficiency in the mouseAnne P Beigneux
Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA 94141, USA
J Biol Chem 279:9557-64. 2004..The Acly knockout allele is useful for identifying cell types with a high demand for acetyl-CoA synthesis... - Reduction in cytochrome P-450 enzyme expression is associated with repression of CAR (constitutive androstane receptor) and PXR (pregnane X receptor) in mouse liver during the acute phase responseAnne P Beigneux
Department of Medicine, University of California San Francisco, Metabolism Section, Medical Service, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
Biochem Biophys Res Commun 293:145-9. 2002..These findings represent one possible molecular mechanism underlying sepsis-induced repression of Cyp enzymes... - AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferaseYan Qun Chen
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
J Biol Chem 283:10048-57. 2008..Our data indicate that AGPAT6 is a microsomal GPAT, and we propose renaming this enzyme GPAT4... - Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-RafMartin O Bergo
Gladstone Institute of Cardiovascular Disease, San Francisco, California 94141 9100, USA
J Clin Invest 113:539-50. 2004..These studies identify Icmt as a potential target for reducing the growth of K-Ras- and B-Raf-induced malignancies... - Lipoprotein size and susceptibility to atherosclerosis--insights from genetically modified mouse modelsMurielle M Veniant
Amgen Inc, One Amgen Center Drive, Thousand Oaks, CA 91320 1799, USA
Curr Drug Targets 9:174-89. 2008..Defining the extent of atherosclerosis in these mice should provide new insights into the atherogenicity of large, triglyceride-rich lipoproteins...
Research Grants
- New Avenues in GPIHBP1 ResearchAnne Beigneux; Fiscal Year: 2009....
- New Avenues in GPIHBP1 ResearchAnne Beigneux; Fiscal Year: 2010....
- New Avenues in GPIHBP1 ResearchAnne Beigneux; Fiscal Year: 2009....