Juliane I Beier

Summary

Affiliation: University of Louisville
Country: USA

Publications

  1. pmc Mechanisms and cell signaling in alcoholic liver disease
    Juliane I Beier
    Department of Pharmacology and Toxicology, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    Biol Chem 391:1249-64. 2010
  2. pmc Plasminogen activator inhibitor-1 deficient mice are protected from angiotensin II-induced fibrosis
    Juliane I Beier
    Department of Pharmacology and Toxicology, University of Louisville Health Sciences Center, KY 40292, USA
    Arch Biochem Biophys 510:19-26. 2011
  3. pmc Fibrin accumulation plays a critical role in the sensitization to lipopolysaccharide-induced liver injury caused by ethanol in mice
    Juliane I Beier
    Department of Pharmacology and Toxicology, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    Hepatology 49:1545-53. 2009
  4. pmc PAI-1 plays a protective role in CCl4-induced hepatic fibrosis in mice: role of hepatocyte division
    Claudia von Montfort
    Dept of Pharmacology and Toxicology, Univ of Louisville Health Sciences Center, Louisville, KY 40292, USA
    Am J Physiol Gastrointest Liver Physiol 298:G657-66. 2010
  5. pmc PKCepsilon plays a causal role in acute ethanol-induced steatosis
    J Phillip Kaiser
    Department of Pharmacology and Toxicology, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    Arch Biochem Biophys 482:104-11. 2009
  6. pmc Contribution of the sympathetic hormone epinephrine to the sensitizing effect of ethanol on LPS-induced liver damage in mice
    Claudia von Montfort
    Department of Pharmacology and Toxicology, James Graham Brown Cancer Center, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    Am J Physiol Gastrointest Liver Physiol 294:G1227-34. 2008
  7. pmc New role of resistin in lipopolysaccharide-induced liver damage in mice
    Juliane I Beier
    Department of Pharmacology and Toxicology, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    J Pharmacol Exp Ther 325:801-8. 2008
  8. pmc Chronic subhepatotoxic exposure to arsenic enhances hepatic injury caused by high fat diet in mice
    Min Tan
    Department of Pharmacology and Toxicology, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    Toxicol Appl Pharmacol 257:356-64. 2011
  9. doi request reprint Alcoholic liver disease and the potential role of plasminogen activator inhibitor-1 and fibrin metabolism
    Juliane I Beier
    Department of Pharmacology and Toxicology and University of Louisville Alcohol Research Center, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    Exp Biol Med (Maywood) 237:1-9. 2012
  10. doi request reprint PKCε contributes to chronic ethanol-induced steatosis in mice but not inflammation and necrosis
    J Phillip Kaiser
    Department of Pharmacology and Toxicology, University of Louisville Health Sciences Center, Louisville, Kentucky University of Louisville Alcohol Research Center, Louisville, Kentucky
    Alcohol Clin Exp Res 38:801-9. 2014

Collaborators

Detail Information

Publications15

  1. pmc Mechanisms and cell signaling in alcoholic liver disease
    Juliane I Beier
    Department of Pharmacology and Toxicology, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    Biol Chem 391:1249-64. 2010
    ..The purpose of this review is to summarize the established and proposed mechanisms by which chronic alcohol abuse damages the liver and to highlight key signaling events known or hypothesized to mediate these effects...
  2. pmc Plasminogen activator inhibitor-1 deficient mice are protected from angiotensin II-induced fibrosis
    Juliane I Beier
    Department of Pharmacology and Toxicology, University of Louisville Health Sciences Center, KY 40292, USA
    Arch Biochem Biophys 510:19-26. 2011
    ..Furthermore, the current study proposes a new model of 'pure' hepatic fibrosis in mice with little inflammation or hepatocyte death...
  3. pmc Fibrin accumulation plays a critical role in the sensitization to lipopolysaccharide-induced liver injury caused by ethanol in mice
    Juliane I Beier
    Department of Pharmacology and Toxicology, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    Hepatology 49:1545-53. 2009
    ..These results also support the hypothesis that fibrin accumulation may play a critical role in the development of early alcohol-induced liver injury...
  4. pmc PAI-1 plays a protective role in CCl4-induced hepatic fibrosis in mice: role of hepatocyte division
    Claudia von Montfort
    Dept of Pharmacology and Toxicology, Univ of Louisville Health Sciences Center, Louisville, KY 40292, USA
    Am J Physiol Gastrointest Liver Physiol 298:G657-66. 2010
    ....
  5. pmc PKCepsilon plays a causal role in acute ethanol-induced steatosis
    J Phillip Kaiser
    Department of Pharmacology and Toxicology, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    Arch Biochem Biophys 482:104-11. 2009
    ..These data also suggest that PKCepsilon plays a causal role in at least the early phases of ethanol-induced liver injury...
  6. pmc Contribution of the sympathetic hormone epinephrine to the sensitizing effect of ethanol on LPS-induced liver damage in mice
    Claudia von Montfort
    Department of Pharmacology and Toxicology, James Graham Brown Cancer Center, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    Am J Physiol Gastrointest Liver Physiol 294:G1227-34. 2008
    ..These results also suggest that sympathetic tone may contribute to the initiation and progression of alcoholic liver disease...
  7. pmc New role of resistin in lipopolysaccharide-induced liver damage in mice
    Juliane I Beier
    Department of Pharmacology and Toxicology, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    J Pharmacol Exp Ther 325:801-8. 2008
    ..These data also suggest that resistin may have proinflammatory roles in mouse liver independent of its effects on insulin signaling, analogous to previous work in humans...
  8. pmc Chronic subhepatotoxic exposure to arsenic enhances hepatic injury caused by high fat diet in mice
    Min Tan
    Department of Pharmacology and Toxicology, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    Toxicol Appl Pharmacol 257:356-64. 2011
    ..These data indicate that subhepatotoxic arsenic exposure enhances the toxicity of HFD. These results also suggest that arsenic exposure might be a risk factor for the development of fatty liver disease in human populations...
  9. doi request reprint Alcoholic liver disease and the potential role of plasminogen activator inhibitor-1 and fibrin metabolism
    Juliane I Beier
    Department of Pharmacology and Toxicology and University of Louisville Alcohol Research Center, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    Exp Biol Med (Maywood) 237:1-9. 2012
    ..e. decreasing VLDL synthesis), inflammation (i.e. impairing fibrinolysis) and fibrosis (i.e. blunting matrix degradation), whereas the former is mediated by maintaining hepatocyte division after an injury...
  10. doi request reprint PKCε contributes to chronic ethanol-induced steatosis in mice but not inflammation and necrosis
    J Phillip Kaiser
    Department of Pharmacology and Toxicology, University of Louisville Health Sciences Center, Louisville, Kentucky University of Louisville Alcohol Research Center, Louisville, Kentucky
    Alcohol Clin Exp Res 38:801-9. 2014
    ..However, the role of PKCε in these pathologies is not yet known. The goal of this current work was to address this question in a model of chronic alcohol exposure using antisense oligonucleotides (ASO) against PKCε...
  11. pmc Subhepatotoxic exposure to arsenic enhances lipopolysaccharide-induced liver injury in mice
    Gavin E Arteel
    Department of Pharmacology and Toxicology, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    Toxicol Appl Pharmacol 226:128-39. 2008
    ..These results further suggest that arsenic levels in the drinking water may be a risk modifier for the development of chronic liver diseases...
  12. pmc Ethanol and dietary unsaturated fat (corn oil/linoleic acid enriched) cause intestinal inflammation and impaired intestinal barrier defense in mice chronically fed alcohol
    Irina A Kirpich
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Alcohol 47:257-64. 2013
    ..Therefore, dietary unsaturated fat (corn oil/LA enriched) is a significant contributing factor to EtOH-mediated intestinal inflammatory response and mucus layer alterations in rodents...
  13. pmc Advances in alcoholic liver disease
    Juliane I Beier
    Department of Pharmacology and Toxicology, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    Curr Gastroenterol Rep 13:56-64. 2011
    ..We also review why therapies related to these mechanisms have performed well in experimental animals and in vitro systems, but have not necessarily translated into effective therapy for humans with ALD...
  14. pmc Metformin prevents alcohol-induced liver injury in the mouse: Critical role of plasminogen activator inhibitor-1
    Ina Bergheim
    Department of Pharmacology and Toxicology and the James Graham Brown Cancer Center, University of Louisville Health Sciences Center, Louisville, Kentucky 40292, USA
    Gastroenterology 130:2099-112. 2006
    ..The biguanide drug metformin has recently been found to improve steatosis and liver damage in animal models and in humans with nonalcoholic steatohepatitis...
  15. doi request reprint Toxicant-associated steatohepatitis
    Banrida Wahlang
    Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Toxicol Pathol 41:343-60. 2013
    ..This article examines selected chemical exposures associated with TAFLD in human subjects or animal models and concisely reviews the closely related NAFLD and ALD...