Kevin Behrns

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. ncbi request reprint The University of Florida Department of Surgery: building a stronger tomorrow on yesterday's foundation
    Kevin E Behrns
    Department of Surgery, University of Florida, Gainesville, Florida 32610, USA
    Am Surg 78:12-9. 2012
  2. ncbi request reprint Faculty clinical quality goals drive improvement in University HealthSystem Consortium outcome measures
    Kevin E Behrns
    Department of Surgery, University of Florida, Gainesville, Florida 32610, USA
    Am Surg 78:749-54. 2012
  3. doi request reprint Surgical therapy of pancreatic pseudocysts
    Kevin E Behrns
    Department of Surgery, Division of General and GI Surgery, University of Florida, P O Box 100286, 1600 SW Archer Rd, Gainesville, FL 32610, USA
    J Gastrointest Surg 12:2231-9. 2008
  4. doi request reprint Local resection of the pancreatitic head for pancreatic pseudocysts
    Kevin E Behrns
    Division of General Surgery, Department of Surgery, University of Florida, Gainesville, FL 32610, USA
    J Gastrointest Surg 12:2227-30. 2008
  5. ncbi request reprint Early ERCP for gallstone pancreatitis: for whom and when?
    Kevin E Behrns
    Department of Surgery, University of Florida, PO Box 100286, 1600 SW Archer Road, Gainesville, FL 32610, USA
    J Gastrointest Surg 12:629-33. 2008
  6. ncbi request reprint Laparoscopic pancreatic surgery: what now and what next?
    Elizabeth A Warner
    Department of Surgery, University of Florida, 1600 SW Archer Road, Room 6164, Box 100109, Gainesville, FL 32610, USA
    Curr Gastroenterol Rep 11:128-33. 2009
  7. doi request reprint Braun enteroenterostomy is associated with reduced delayed gastric emptying and early resumption of oral feeding following pancreaticoduodenectomy
    Steven N Hochwald
    Division of Surgical Oncology and Endocrine Surgery, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    J Surg Oncol 101:351-5. 2010
  8. doi request reprint Impaired autophagy: A mechanism of mitochondrial dysfunction in anoxic rat hepatocytes
    Jae Sung Kim
    Department of Surgery, University of Florida, Gainesville, FL, USA
    Hepatology 47:1725-36. 2008
  9. ncbi request reprint Endoscopic sphincterotomy permits interval laparoscopic cholecystectomy in patients with moderately severe gallstone pancreatitis
    T Ryan Heider
    Division of Gastrointestinal Surgery, Department of Surgery, University of North Carolina, Chapel Hill, USA
    J Gastrointest Surg 10:1-5. 2006
  10. ncbi request reprint A national comparison of surgical versus percutaneous drainage of pancreatic pseudocysts: 1997-2001
    John M Morton
    Department of Surgery, Stanford School of Medicine, Stanford, California 94305 5655, USA
    J Gastrointest Surg 9:15-20; discussion 20-1. 2005

Research Grants

Collaborators

Detail Information

Publications24

  1. ncbi request reprint The University of Florida Department of Surgery: building a stronger tomorrow on yesterday's foundation
    Kevin E Behrns
    Department of Surgery, University of Florida, Gainesville, Florida 32610, USA
    Am Surg 78:12-9. 2012
    ..It fosters an environment where faculty, residents, students, and staff challenge long-held traditions with the goal of improving the health of our patients, the quality of our care, and the vitality of our work environment...
  2. ncbi request reprint Faculty clinical quality goals drive improvement in University HealthSystem Consortium outcome measures
    Kevin E Behrns
    Department of Surgery, University of Florida, Gainesville, Florida 32610, USA
    Am Surg 78:749-54. 2012
    ..Quality goals assigned to individual faculty members are associated with decreased average LOS index, PSIs, and HACs. Focused, relevant quality assignments that are tied to compensation improve patient safety and outcomes...
  3. doi request reprint Surgical therapy of pancreatic pseudocysts
    Kevin E Behrns
    Department of Surgery, Division of General and GI Surgery, University of Florida, P O Box 100286, 1600 SW Archer Rd, Gainesville, FL 32610, USA
    J Gastrointest Surg 12:2231-9. 2008
    ..This review will focus on the surgical therapy of pancreatic pseudocysts in the context of the underlying pathophysiology and alternative nonoperative therapies...
  4. doi request reprint Local resection of the pancreatitic head for pancreatic pseudocysts
    Kevin E Behrns
    Division of General Surgery, Department of Surgery, University of Florida, Gainesville, FL 32610, USA
    J Gastrointest Surg 12:2227-30. 2008
    ..Patients with an enlarged pancreatic head or duodenal or biliary obstruction are ideal candidates for LRPH. In addition, patients with symptomatic pseudocysts in the pancreatic head can be adequately treated with these operations...
  5. ncbi request reprint Early ERCP for gallstone pancreatitis: for whom and when?
    Kevin E Behrns
    Department of Surgery, University of Florida, PO Box 100286, 1600 SW Archer Road, Gainesville, FL 32610, USA
    J Gastrointest Surg 12:629-33. 2008
    ..A multicenter trial designed to study the effect of early ERCP in severe pancreatitis only may provide additional useful information in patients with documented gallstones...
  6. ncbi request reprint Laparoscopic pancreatic surgery: what now and what next?
    Elizabeth A Warner
    Department of Surgery, University of Florida, 1600 SW Archer Road, Room 6164, Box 100109, Gainesville, FL 32610, USA
    Curr Gastroenterol Rep 11:128-33. 2009
    ..Nonetheless, major advances in minimally invasive pancreatic surgery will continue as technology and skill sets advance...
  7. doi request reprint Braun enteroenterostomy is associated with reduced delayed gastric emptying and early resumption of oral feeding following pancreaticoduodenectomy
    Steven N Hochwald
    Division of Surgical Oncology and Endocrine Surgery, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    J Surg Oncol 101:351-5. 2010
    ..A Braun enteroenterostomy has been shown to decrease bile reflux following gastric resection. We hypothesize that addition of Braun enteroenterostomy during PD would reduce the sequelae of DGE...
  8. doi request reprint Impaired autophagy: A mechanism of mitochondrial dysfunction in anoxic rat hepatocytes
    Jae Sung Kim
    Department of Surgery, University of Florida, Gainesville, FL, USA
    Hepatology 47:1725-36. 2008
    ..Conclusion: Calpain 2-mediated degradation of Atg7 and Beclin-1 impairs mitochondrial autophagy, and this subsequently leads to MPT-dependent hepatocyte death after A/R...
  9. ncbi request reprint Endoscopic sphincterotomy permits interval laparoscopic cholecystectomy in patients with moderately severe gallstone pancreatitis
    T Ryan Heider
    Division of Gastrointestinal Surgery, Department of Surgery, University of North Carolina, Chapel Hill, USA
    J Gastrointest Surg 10:1-5. 2006
    ..Hospital discharge of these patients permits interval laparoscopic cholecystectomy, but close follow-up is necessary in these potentially ill patients...
  10. ncbi request reprint A national comparison of surgical versus percutaneous drainage of pancreatic pseudocysts: 1997-2001
    John M Morton
    Department of Surgery, Stanford School of Medicine, Stanford, California 94305 5655, USA
    J Gastrointest Surg 9:15-20; discussion 20-1. 2005
    ....
  11. ncbi request reprint Primary cirrhotic hepatocytes resist TGFbeta-induced apoptosis through a ROS-dependent mechanism
    Dalliah Black
    Division of Gastrointestinal Surgery, Department of Surgery, University of North Carolina, 320 Medical Wing E, Chapel Hill, NC 27599 7081, USA
    J Hepatol 40:942-51. 2004
    ..The purpose of this study was to determine if dysregulated hepatocyte growth occurs through deficient apoptosis...
  12. doi request reprint Surgical management of failed endoscopic treatment of pancreatic disease
    Kimberly A Evans
    Division of General Surgery, Department of Surgery, University of Florida, P O Box 100286, 1600 SW Archer Road, Gainesville, FL 32610, USA
    J Gastrointest Surg 12:1924-9. 2008
    ..Endoscopic therapy of acute and chronic pancreatitis has decreased the need for operative intervention. However, a significant proportion of patients treated endoscopically require definitive surgical management for persistent symptoms...
  13. pmc Transforming growth factor beta mediates hepatocyte apoptosis through Smad3 generation of reactive oxygen species
    Dalliah Black
    Department of Surgery, 4024 Burnett Womack Building, CB 7050, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Biochimie 89:1464-73. 2007
    ..In conclusion, TGFbeta-induced hepatocyte apoptosis occurs through Smad3 dependent activation of ROS with subsequent activation of the MPT and caspases...
  14. pmc Basal reactive oxygen species determine the susceptibility to apoptosis in cirrhotic hepatocytes
    Jay Raval
    Department of Surgery, University of North Carolina, Chapel Hill, NC 27599, USA
    Free Radic Biol Med 41:1645-54. 2006
    ..In conclusion, cirrhotic hepatocytes have a nonfocal distribution of ROS. However, normal and cirrhotic hepatocytes exhibit mitochondrial localization of ROS that is necessary for apoptosis...
  15. ncbi request reprint NFkappaB inhibition decreases hepatocyte proliferation but does not alter apoptosis in obstructive jaundice
    Mark A Bird
    Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7081, USA
    J Surg Res 114:110-7. 2003
    ..We hypothesized that NFkappaB inhibition would decrease hepatocyte proliferation and potentiate hepatocyte apoptosis in a rat model of extrahepatic biliary obstruction...
  16. ncbi request reprint Transforming growth factor-beta1 induces hepatocyte apoptosis by a c-Jun independent mechanism
    Charles M Samson
    Department of Surgery, The University of North Carolina, Chapel Hill 27599, USA
    Surgery 132:441-9. 2002
    ..We hypothesized that autocrine expression of activated TGF-beta1 (Ad5aTGF-beta1) would increase c-jun expression in rat liver and limit hepatic regeneration by inducing apoptosis...
  17. doi request reprint Murine cirrhosis induces hepatocyte epithelial mesenchymal transition and alterations in survival signaling pathways
    Takashi Nitta
    Department of Surgery, Division of General and Gastrointestinal GI Surgery, University of Florida, Gainesville, FL, USA
    Hepatology 48:909-19. 2008
    ..CLDH demonstrated increased basal p-extracellular signal-regulated kinase expression that was independent of Smad and PI3K/Akt signaling. Inhibition of the MAPK pathway produced a marked increase in CLDH apoptosis...
  18. ncbi request reprint Cirrhotic hepatocytes exhibit decreased TGFbeta growth inhibition associated with downregulated Smad protein expression
    Patricia A Lange
    Division of Gastrointestinal Surgery, Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7081, USA
    Biochem Biophys Res Commun 313:546-51. 2004
    ..Furthermore, cirrhotic hepatocytes had decreased DNA binding activity at 120 min following TGFbeta treatment. In conclusion, decreased Smad protein expression may impair TGFbeta-mediated growth inhibition in cirrhotic hepatocytes...
  19. ncbi request reprint Molecular and cellular features of hepatic regeneration
    Dalliah Black
    Department of Surgery, Division of Gastrointestinal Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7081, USA
    J Surg Res 117:306-15. 2004
  20. ncbi request reprint Acute vagotomy does not augment the systemic inflammatory response in patients with peptic ulcer disease
    T Ryan Heider
    Department of Surgery, Division of Gastrointestinal Surgery, University of North Carolina, Chapel Hill, North Carolina 27599 7081, USA
    Am Surg 70:342-6. 2004
    ..This clinical study demonstrated that acute truncal vagotomy does not increase the risk of the systemic inflammatory response in surgical patients with complicated peptic ulcer disease...
  21. pmc The natural history of pancreatitis-induced splenic vein thrombosis
    T Ryan Heider
    Department of Surgery, Division of Gastrointestinal Surgery, and Center for Pancreatic and Biliary Disorders, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Ann Surg 239:876-80; discussion 880-2. 2004
    ..To determine the natural history of pancreatitis-induced splenic vein thrombosis with particular attention to the risk of gastric variceal hemorrhage...
  22. ncbi request reprint TNF alpha-induced hepatocyte apoptosis is associated with alterations of the cell cycle and decreased stem loop binding protein
    Dalliah Black
    Department of Surgery, University of North Carolina at Chapel Hill, 27599, USA
    Surgery 135:619-28. 2004
    ..Our aim was to determine if inhibition of NF kappa B alters cell cycle characteristics in hepatocytes treated with tumor necrosis factor alpha (TNF alpha)...
  23. ncbi request reprint A scientist revisits the atrophy-hypertrophy complex: hepatic apoptosis and regeneration
    Dalliah M Black
    Division of Gastrointestinal Surgery, University of North Carolina, Box 7210, Chapel Hill, NC 27599 7210, USA
    Surg Oncol Clin N Am 11:849-64. 2002
    ..Further insight into the cellular and molecular mechanisms that initiate hepatocyte replication after contralateral atrophy may allow the development of novel therapeutic treatments or adjuncts...
  24. ncbi request reprint Cholestasis induces murine hepatocyte apoptosis and DNA synthesis with preservation of the immediate-early gene response
    Mark A Bird
    Departments of Surgery, Pathology, and Medicine, University of North Carolina at Chapel Hill, 27599 7210, USA
    Surgery 131:556-63. 2002
    ..The aim of this study was to determine whether the immediate-early gene response in hepatic regeneration remains intact in extrahepatic cholestasis...

Research Grants8

  1. GROWTH CONTROL OF NORMAL AND CIRRHOTIC HEPATOCYTES
    Kevin Behrns; Fiscal Year: 2003
    ..Identification of novel or differentially regulated hepatocyte growth control genes may provide information about altered growth control of cirrhotic hepatocytes. ..
  2. GROWTH CONTROL OF NORMAL AND CIRRHOTIC HEPATOCYTES
    Kevin Behrns; Fiscal Year: 2003
    ..We will continue to seek counsel from our K08 mentors (Drs. David Brenner and Lola Reid) and use liberally the UNC Center for Gastrointestinal Biology and Disease for core facilities such as the Molecular Imaging Core. ..
  3. GROWTH CONTROL OF NORMAL AND CIRRHOTIC HEPATOCYTES
    Kevin E Behrns; Fiscal Year: 2010
    ..3) To determine if cirrhotic human hepatocytes are resistant to TGFbeta-induced apoptosis via mechanisms that are operative in a murine model. ..